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Gene Therapy

Suicide gene therapy with lentiviral vectors and a prodrug in a clinically relevant animal model for human glioblastoma. The therapeutic group (virus + prodrug) shows dramatic reduction in tumour size on MRI compared to control groups. Modified from Huszt
Suicide gene therapy with lentiviral vectors and a prodrug in a clinically relevant animal model for human glioblastoma. The therapeutic group (virus + prodrug) shows dramatic reduction in tumour size on MRI compared to control groups. Modified from Huszthy et al., PLOS One 2009. Copyright PLOS One.

Hovedinnhold

Gene therapy is a new experimental therapy and defined as the delivery of a therapeutic gene into a cell. Viruses are most often used as delivery vehicles because they have during their evolution developed mechanisms to efficiently introduce their genome into many different cell types. By gene therapy, viruses are modified to deliver a therapeutic gene instead of their genome into cells.