EvoMaps

This project aims to adapt the in situ sequencing approach (Svedlund et al., EBioMedicine, 2019; Lomakin et al., Nature, 2022) to the Hyperion mass imaging system in order to enable a simultaneous mapping of genetic alterations and protein based cell typing and signaling pathway activation in diagnostic tissue sections. With this approach, the group hopes to be able to identify the regulatory mechanisms beyond subclonal expansion in DCIS and how they relate to tumor progression and the development of radioresistant traits.