Nyhetsarkiv for Neurotargeting forskningsgruppe
Myelin, the insulative multilamellar sheath that enwraps axons, speeds up our nerve impulses by two orders of magnitude – a prerequisite for an efficient nervous system that we humans and other vertebrates enjoy. Myelin gains its structure and function from a high abundance of lipids and proteins, many of which are specific to this enigmatic biological system.
An important European-funded initiative has been launched to explore how common molecular mechanisms may link metabolic disorders, especially type 2 diabetes and obesity, with brain disorders such as Alzheimer's disease, obsessive-compulsive disorder, and autism spectrum disorders. Jan Haavik and Aurora Martinez from the Department of Biomedicine are the norwegian participants.
Researchers at the University of Bergen looked if there is a connection between the mode of delivery and the genetics of children’s intelligence.
Attention-deficit/hyperactivity disorder and autoimmune diseases: etiological relationships and therapeutic possibilities
Arc er et protein som er gjerne omtalt som hukommelsens hovedregulator. Det har likhet med noen virusproteiner, og kan danne virus-lignende capsid partikkler. Vi har lykket til å oppløse den tredimensjonale strukturen for første gang.
The Shank family of proteins functions as a molecular scaffold in the neuronal post-synaptic density, enabling numerous protein-protein interactions. Shanks are large multi-domain molecules, and one of the conserved domains is an SH3 domain. Using high-resolution X-ray crystallography, we show that the SH3 domain in the Shank family has lost its canonical ligand-binding site.
The molecular processes of myelin maturation are to a large extent still unknown. A coordinated interplay between regulatory and functional molecules must take place for correct timing of myelin membrane apposition and compaction, such that cytoplasmic channels are also formed in a correct way.
Professor Jan Haavik has been given the Helse Vest Research award 2016 for his research on discovering biological mechanisms that can cause ADHD-symptoms. He was rewarded the prize during the annual research conference of Helse Vest.
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