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News archive for Neurotargeting

Ebselen, a promising drug candidate against cancer, bipolar disorder and the virus infection Covid-19, covalently bonds to cysteine residues in 14-3-3 adaptor proteins, triggering 14-3-3 destabilization and degradation in cells and intact brain tissue when used in therapeutic concentrations, potentially explaining the behavioral and anti-neoplastic effects of this drug.
Our research project BIOPROM (Biomimetic Proteolipid Multilayers - Structure and Properties) was awarded a research grant of 12 MNOK by the Research Council of Norway. The BIOPROM project will reveal unprecedented details of the molecular structure and properties of myelin, from the nano to the meso scale.
Fundamentally new discoveries in biology or medicine are rare. The mentioned article is an example of such a discovery. The findings of this study will probably soon be found in standard textbooks in biochemistry and physiology.
Research conducted by ADHD researcher Berit Skretting Solberg shows a strong connection between ADHD in children and parents. The sons had the highest absolute risk, but the daughters had the highest relative risk.
Petri Kursula receive the prize for best teacher in preclinical medicine 2020.
Carnosine plays an important roles as antioxidant, pH buffer, and neuromodulator and recently received increasing attention as biomarker for many disease states such as Alzheimer disease and Parkinson disease. The Neurotargeting group at the Department of Biomedicine discovered a novel enzyme, Glutamate Decarboxylase Like 1 (GADL1) that plays a role in carnosine production.
Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy in humans, linked to mutations in dozens of different genes. Two of these genes encode the proteins GDAP1 and NDRG1. We have solved the crystal structures of these two proteins, in order to better understand their structure, function, and involvement in disease.
Myelin, the insulative multilamellar sheath that enwraps axons, speeds up our nerve impulses by two orders of magnitude – a prerequisite for an efficient nervous system that we humans and other vertebrates enjoy. Myelin gains its structure and function from a high abundance of lipids and proteins, many of which are specific to this enigmatic biological system.
An important European-funded initiative has been launched to explore how common molecular mechanisms may link metabolic disorders, especially type 2 diabetes and obesity, with brain disorders such as Alzheimer's disease, obsessive-compulsive disorder, and autism spectrum disorders. Jan Haavik and Aurora Martinez from the Department of Biomedicine are the norwegian participants.
Researchers at the University of Bergen looked if there is a connection between the mode of delivery and the genetics of children’s intelligence.
Kandidaten vil holde prøveforelsning og forsvare avhandlingen: “The Characterization of Disordered Membrane-Binding Proteins of Myelin: A Biophysical Approach"
Kandidaten vil forsvare avhandlingen “Attention-deficit/hyperactivity disorder and autoimmune diseases: etiological relationships and therapeutic possibilities”
Attention-deficit/hyperactivity disorder and autoimmune diseases: etiological relationships and therapeutic possibilities
Enzymet Tyrosine Hydroksylase er viktig for livet. Neurologiske, psykiatriske og kardiovaskulære sykdommer oppstår når dets katalytiske funksjon er svekket. Forskere ved Institutt for biomedisin beskriver hvordan ny innsikt i proteinet kan bidra til å utvikle ny medisin.
There is a clear connection between specific genes and ADHD. This is the result of a large international study where UiB-researchers have played an important role, led by Professor Jan Haavik.
Arc er et protein som er gjerne omtalt som hukommelsens hovedregulator. Det har likhet med noen virusproteiner, og kan danne virus-lignende capsid partikkler. Vi har lykket til å oppløse den tredimensjonale strukturen for første gang.
Professor Jan Haavik, head of the Neurotargeting Research Group and KG Jebsen Center for Research on Neuropsychiatric Disorders, was recently elected as a member of the Norwegian Academy of Sciences and Letters.
Compared with adult men with ADHD, adult ADHD women have an increased risk of experiencing anxiety and depression, shows a new UiB study. Men with ADHD in contrast suffer more from substance abuse and schizophrenia.

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