Hjem
Karl Johan Tronstads bilde

Karl Johan Tronstad

Professor
  • E-postKarl.Tronstad@uib.no
  • Telefon+47 55 58 64 33
  • Besøksadresse
    Jonas Lies vei 91
  • Postadresse
    Postboks 7804
    5020 Bergen
Vitenskapelig artikkel
  • Vis forfatter(e) (2021). Metformin treatment response is dependent on glucose growth conditions and metabolic phenotype in colorectal cancer cells. Scientific Reports. 1-10.
  • Vis forfatter(e) (2021). Blocking aerobic glycolysis by targeting pyruvate dehydrogenase kinase in combination with EGFR TKI and ionizing radiation increases therapeutic effect in non-small cell lung cancer cells. Cancers. 24 sider.
  • Vis forfatter(e) (2021). Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model. Journal of Cellular and Molecular Medicine. 7407-7417.
  • Vis forfatter(e) (2021). A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome. JCI Insight.
  • Vis forfatter(e) (2020). Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue. PLOS ONE. 1-16.
  • Vis forfatter(e) (2020). Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study. Frontiers in medicine. 1-15.
  • Vis forfatter(e) (2019). Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation. Mitochondrion (Amsterdam. Print). 97-110.
  • Vis forfatter(e) (2019). The homeobox factor Irx3 maintains adipogenic identity. Metabolism: Clinical and Experimental.
  • Vis forfatter(e) (2019). Neural stem cells of Parkinson's disease patients exhibit aberrant mitochondrial morphology and functionality. Stem Cell Reports. 878-889.
  • Vis forfatter(e) (2019). Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta neuropathologica communications. 1-19.
  • Vis forfatter(e) (2019). Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC. Cancer & Metabolism.
  • Vis forfatter(e) (2018). Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide. International Journal of Cancer. 1735-1745.
  • Vis forfatter(e) (2018). Introducing nano-scale quantitative polymerase chain reaction. Biochemical and Biophysical Research Communications - BBRC. 923-926.
  • Vis forfatter(e) (2017). The angiogenic switch leads to a metabolic shift in human glioblastoma. Neuro-Oncology. 383-393.
  • Vis forfatter(e) (2017). Peptide-mediated delivery of donor mitochondria improves mitochondrial function and cell viability in human cybrid cells with the MELAS A3243G mutation. Scientific Reports.
  • Vis forfatter(e) (2017). Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats. Journal of Lipid Research. 1362-1373.
  • Vis forfatter(e) (2016). Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome. JCI Insight.
  • Vis forfatter(e) (2016). Far-infrared radiation protects viability in a cell model of Spinocerebellar Ataxia by preventing polyQ protein accumulation and improving mitochondrial function. Scientific Reports.
  • Vis forfatter(e) (2015). Subcellular distribution of NAD+ between cytosol and mitochondria determines the metabolic profile of human cells. Journal of Biological Chemistry. 27644-27659.
  • Vis forfatter(e) (2015). A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology. Scientific Reports.
  • Vis forfatter(e) (2014). Automated quantification and integrative analysis of 2D and 3D mitochondrial shape and network properties. PLOS ONE.
  • Vis forfatter(e) (2013). Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA). Biochemical and Biophysical Research Communications - BBRC. 573-578.
  • Vis forfatter(e) (2011). Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. Acta Neuropathologica. 495-510.
  • Vis forfatter(e) (2010). Protein kinase A activators and the pan-PPAR agonist tetradecylthioacetic acid elicit synergistic anti-leukaemic effects in AML through CREB. Leukemia Research. 77-84.
  • Vis forfatter(e) (2010). Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairment. Journal of Cellular Biochemistry. 574-584.
  • Vis forfatter(e) (2009). Hyperoxic treatment induces mesenchymal to epithelial transition in a rat adenocarcinoma model. PLOS ONE.
  • Vis forfatter(e) (2009). Hyperoxia increases the uptake of 5-FU in mammary tumors independently of cganges in interstitial pressure and tumor stroma. BMC Cancer.
  • Vis forfatter(e) (2009). Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. Molecular Cancer.
  • Vis forfatter(e) (2008). Long term treatment with tetradecylthioacetic acid improves the antioxidant status in obese Zucker (fa/fa) rats. Drug Metabolism Letters. 138-145.
  • Vis forfatter(e) (2006). Is targeted chemotherapy an alternative to immunotherapy in chronic lymphocytic leukemia? Cancer Immunology and Immunotherapy. 221-228.
  • Vis forfatter(e) (2006). A bioactively modified fatty acid improves survival and impairs metastasis in preclinical models of acute leukemia. Clinical Cancer Research. 3525-3531.
  • Vis forfatter(e) (2005). The metabolic syndrome and the hepatic fatty acid drainage hypothesis. Biochimie. 15-20.
  • Vis forfatter(e) (2005). In vitro culture of human osteosarcoma cell lines: a comparison of functional characteristics for cell lines cultured in medium without and with fetal calf serum. Journal of Cancer Research and Clinical Oncology. 377-384.
  • Vis forfatter(e) (2005). Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? The Pharmacogenomics Journal. 298-304.
  • Vis forfatter(e) (2001). Growth reduction in glioma cells after treatment with tetradecylthioacetic acid: changes in fatty acid metabolism and oxidative status. Biochemical Pharmacology. 639-649.
  • Vis forfatter(e) (1999). In contrast with docosahexaenoic acid, eicosapentaenoic acid and hypolipidaemic derivatives decrease hepatic synthesis and secretion of triacyllycerol by decreased diacylglycerol acyltransferase activity and stimulation of fatty acid oxidation. Biochemical Journal. 191-197.
Faglig foredrag
  • Vis forfatter(e) (2018). ME/CFS - Energisvikt i kroppens celler .
  • Vis forfatter(e) (2018). Cellular Energetics in ME/CFS (public).
Populærvitenskapelig foredrag
  • Vis forfatter(e) (2018). Me-forskning i Bergen.
Vitenskapelig foredrag
  • Vis forfatter(e) (2018). Cellular Energetics in ME/CFS.
  • Vis forfatter(e) (2017). Defective energy metabolism in ME/CFS (Prosjektpresentasjon, NFR BehovME, 2017-2020).
  • Vis forfatter(e) (2013). Mitochondrial function, biogenesis and morphology in cellular stress.
  • Vis forfatter(e) (2012). Mitochondrial morphology and biogenesis in cellular stress.
  • Vis forfatter(e) (1998). Metabolic effects of 3-thia fatty acid in cancer cells.
Leserinnlegg
  • Vis forfatter(e) (2018). Kronisk utmattelsessyndrom og pyruvat dehydrogenasefunksjon . Tidsskrift for Den norske legeforening. 12-13.
  • Vis forfatter(e) (2017). Mer om pyruvat dehydrogenase og kronisk utmattelsessyndrom. Tidsskrift for Den norske legeforening.
  • Vis forfatter(e) (2017). Chronic fatigue syndrome and pyruvate dehydrogenase function. Tidsskrift for Den norske legeforening.
Anmeldelse
  • Vis forfatter(e) (2004). Book review: Lipid Biochemistry - An Introduction, 5th edn., edited by Michael I. Gurr, John L Harwood and Keith N. Frayn. Blackwell Science Ltd., Oxford (UK) 2002. European Journal of Lipid Science and Technology. 452-452.
Vitenskapelig kommentarutgave
  • Vis forfatter(e) (2018). Kronisk utmattelsessyndrom og pyruvat dehydrogenasefunksjon.
Hovedfagsoppgave
  • Vis forfatter(e) (1997). Proliferation of malignant rat glioma cells in reduced by the sulphur substituted fatty acid analogue tetradecylthioacetic acid; a stud on oxidative status (Cand. scient).
Mastergradsoppgave
  • Vis forfatter(e) (2020). Hunting metabolic changes in ME/CFS by investigating cellular responses to applied stress and patient serum factors.
  • Vis forfatter(e) (2020). Exploring passive transfer of Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) metabolic disturbances on cultured mouse- and human muscle cells.
  • Vis forfatter(e) (2019). The role of pyruvate dehydrogenase kinases (PDKs) in rewiring of cell metabolism under energy stress.
  • Vis forfatter(e) (2019). Alterations in cellular metabolism during development of cancer therapy resistance.
  • Vis forfatter(e) (2015). The Role of Persistent Organic Pollutants in Induction of Endoplasmic Reticulum Stress in Hepatocytes in vitro and in vivo.
  • Vis forfatter(e) (2014). The effect of tetradedecylthioacetic acid on insulin production and mitochondrial function in INS-1E β-cells.
  • Vis forfatter(e) (2014). Effekt av hypoksia på Annexin A2 i mitokondrier fra HepG2- og PC12-celler.
  • Vis forfatter(e) (2013). Metabolic reprogramming in Slug and Twist overexpressing MCF10A cells.
  • Vis forfatter(e) (2012). Mitochondrial function and metabolic stress tolerance in fibroblasts from patients with mutations in POLG.
  • Vis forfatter(e) (2012). A study of mitochondrial function, ROS and signaling in Twist overexpressing cells.
  • Vis forfatter(e) (2011). AMPK SOM REGULATOR AV MITOKONDRIELL BIOGENESE I EN NY REPORTER-­CELLEMODELL.
  • Vis forfatter(e) (2009). Possible interactions between EGFR vIII mediated regulation of proliferation and metabolism in glioma cells.
  • Vis forfatter(e) (2009). Mulige interaksjoner mellom tyrosin kinase reseptoren Axl, metabolisme og proliferasjon i brystkreftceller (MDA-MB-231).
  • Vis forfatter(e) (2008). Growth Factors and Cardioprotection; - with special reference to insulin and IGF-II survival signalling at ischemic reperfusion.
  • Vis forfatter(e) (2007). Mitocondrial metabolism and tumor growth control.
Doktorgradsavhandling
  • Vis forfatter(e) (2019). A study on features and markers of cellular metabolic rewiring.
  • Vis forfatter(e) (2017). A study of cellular metabolic flexibility under energy stress.
Sammendrag/abstract
  • Vis forfatter(e) (2012). A mitochondrial reporter system for studies on NRF-1/AMPK activity and regulation in viable cells. Biochimica et Biophysica Acta - Bioenergetics. S70-S70.
  • Vis forfatter(e) (2010). NG2 PROMOTES RESISTANCE TO IONIZING RADIATION BY ELEVATED PEROXIREDOXIN-1 AND DNA DAMAGE RESPONSE IN GLIOBLASTOMA MULTIFORME. Neuro-Oncology. 8-8.
  • Vis forfatter(e) (2008). Mitochondrial function in cancer cell line models. Biochimica et Biophysica Acta - Bioenergetics. S41-S41.
  • Vis forfatter(e) (2007). Synergistic anti-leukemic effect of protein kinase a activator and PPAR7agonist is independent of Bcl-2 status. Blood. 117B-117B.
Poster
  • Vis forfatter(e) (2018). Metabolic profiling of Colorectal cancer in 3D.
  • Vis forfatter(e) (2009). Hyperoxic Treatment induces Mesenchymal-to-Epithelial Transition in a Rat Adenocarcinoma Model.
  • Vis forfatter(e) (2004). PPAR-delta activation in relation to reduction of adipose tissue.
Errata
  • Vis forfatter(e) (2016). Corrigendum: A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology. Scientific Reports.
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) (2014). Regulation and quantification of cellular mitochondrial morphology and content. Current pharmaceutical design. 5634-5652.
  • Vis forfatter(e) (2010). Connexin-based signaling in acute myelogenous leukemia (AML). Biochimica et Biophysica Acta - Biomembranes. 1-8.
  • Vis forfatter(e) (2007). Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signalling. Expert opinion on therapeutic targets. 1055-1069.
  • Vis forfatter(e) (2006). Protein lysine acetylation in normal and leukaemic haematopoiesis: HDACs as possible therapeutic targets in adult AML. Expert opinion on therapeutic targets. 51-68.

Se fullstendig oversikt over publikasjoner i CRIStin.