Karl Johan Tronstads bilde

Karl Johan Tronstad

  • E-postKarl.Tronstad@uib.no
  • Telefon+47 55 58 64 33
  • Besøksadresse
    Jonas Lies vei 91
  • Postadresse
    Postboks 7804
    5020 Bergen
Vitenskapelig artikkel
  • 2020. Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue. PLOS ONE. 1-16.
  • 2020. Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study. Frontiers in medicine.
  • 2019. Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation. Mitochondrion (Amsterdam. Print). 97-110.
  • 2019. The homeobox factor Irx3 maintains adipogenic identity. Metabolism: Clinical and Experimental.
  • 2019. Neural stem cells of Parkinson's disease patients exhibit aberrant mitochondrial morphology and functionality. Stem Cell Reports. 878-889.
  • 2019. Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta neuropathologica communications. 1-19.
  • 2019. Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC. Cancer & Metabolism.
  • 2018. Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide. International Journal of Cancer. 1735-1745.
  • 2018. Introducing nano-scale quantitative polymerase chain reaction. Biochemical and Biophysical Research Communications - BBRC. 923-926.
  • 2017. The angiogenic switch leads to a metabolic shift in human glioblastoma. Neuro-Oncology. 383-393.
  • 2017. Peptide-mediated delivery of donor mitochondria improves mitochondrial function and cell viability in human cybrid cells with the MELAS A3243G mutation. Scientific Reports.
  • 2017. Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats. Journal of Lipid Research. 1362-1373.
  • 2016. Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome. JCI Insight.
  • 2016. Far-infrared radiation protects viability in a cell model of Spinocerebellar Ataxia by preventing polyQ protein accumulation and improving mitochondrial function. Scientific Reports.
  • 2015. Subcellular distribution of NAD+ between cytosol and mitochondria determines the metabolic profile of human cells. Journal of Biological Chemistry. 27644-27659.
  • 2015. A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology. Scientific Reports.
  • 2014. Automated quantification and integrative analysis of 2D and 3D mitochondrial shape and network properties. PLOS ONE.
  • 2013. Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA). Biochemical and Biophysical Research Communications - BBRC. 573-578.
  • 2011. Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. Acta Neuropathologica. 495-510.
  • 2010. Protein kinase A activators and the pan-PPAR agonist tetradecylthioacetic acid elicit synergistic anti-leukaemic effects in AML through CREB. Leukemia Research. 77-84.
  • 2010. Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairment. Journal of Cellular Biochemistry. 574-584.
  • 2009. Hyperoxic treatment induces mesenchymal to epithelial transition in a rat adenocarcinoma model. PLOS ONE.
  • 2009. Hyperoxia increases the uptake of 5-FU in mammary tumors independently of cganges in interstitial pressure and tumor stroma. BMC Cancer.
  • 2009. Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. Molecular Cancer.
  • 2008. Long term treatment with tetradecylthioacetic acid improves the antioxidant status in obese Zucker (fa/fa) rats. Drug Metabolism Letters. 138-145.
  • 2006. Is targeted chemotherapy an alternative to immunotherapy in chronic lymphocytic leukemia? Cancer Immunology and Immunotherapy. 221-228.
  • 2006. A bioactively modified fatty acid improves survival and impairs metastasis in preclinical models of acute leukemia. Clinical Cancer Research. 3525-3531.
  • 2005. The metabolic syndrome and the hepatic fatty acid drainage hypothesis. Biochimie. 15-20.
  • 2005. In vitro culture of human osteosarcoma cell lines: a comparison of functional characteristics for cell lines cultured in medium without and with fetal calf serum. Journal of Cancer Research and Clinical Oncology. 377-384.
  • 2005. Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? The Pharmacogenomics Journal. 298-304.
  • 2001. Growth reduction in glioma cells after treatment with tetradecylthioacetic acid: changes in fatty acid metabolism and oxidative status. Biochemical Pharmacology. 639-649.
  • 1999. In contrast with docosahexaenoic acid, eicosapentaenoic acid and hypolipidaemic derivatives decrease hepatic synthesis and secretion of triacyllycerol by decreased diacylglycerol acyltransferase activity and stimulation of fatty acid oxidation. Biochemical Journal. 191-197.
Faglig foredrag
  • 2018. ME/CFS - Energisvikt i kroppens celler .
  • 2018. Cellular Energetics in ME/CFS (public).
Populærvitenskapelig foredrag
  • 2018. Me-forskning i Bergen.
Vitenskapelig foredrag
  • 2018. Cellular Energetics in ME/CFS.
  • 2017. Defective energy metabolism in ME/CFS (Prosjektpresentasjon, NFR BehovME, 2017-2020).
  • 2013. Mitochondrial function, biogenesis and morphology in cellular stress.
  • 2012. Mitochondrial morphology and biogenesis in cellular stress.
  • 1998. Metabolic effects of 3-thia fatty acid in cancer cells.
  • 2018. Kronisk utmattelsessyndrom og pyruvat dehydrogenasefunksjon . Tidsskrift for Den norske legeforening. 12-13.
  • 2017. Mer om pyruvat dehydrogenase og kronisk utmattelsessyndrom. Tidsskrift for Den norske legeforening.
  • 2017. Chronic fatigue syndrome and pyruvate dehydrogenase function. Tidsskrift for Den norske legeforening.
  • 2004. Book review: Lipid Biochemistry - An Introduction, 5th edn., edited by Michael I. Gurr, John L Harwood and Keith N. Frayn. Blackwell Science Ltd., Oxford (UK) 2002. European Journal of Lipid Science and Technology. 452-452.
Vitenskapelig kommentarutgave
  • 2018. Kronisk utmattelsessyndrom og pyruvat dehydrogenasefunksjon.
  • 1997. Proliferation of malignant rat glioma cells in reduced by the sulphur substituted fatty acid analogue tetradecylthioacetic acid; a stud on oxidative status (Cand. scient).
  • 2020. Hunting metabolic changes in ME/CFS by investigating cellular responses to applied stress and patient serum factors.
  • 2020. Exploring passive transfer of Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) metabolic disturbances on cultured mouse- and human muscle cells.
  • 2019. The role of pyruvate dehydrogenase kinases (PDKs) in rewiring of cell metabolism under energy stress.
  • 2019. Alterations in cellular metabolism during development of cancer therapy resistance.
  • 2015. The Role of Persistent Organic Pollutants in Induction of Endoplasmic Reticulum Stress in Hepatocytes in vitro and in vivo.
  • 2014. The effect of tetradedecylthioacetic acid on insulin production and mitochondrial function in INS-1E β-cells.
  • 2014. Effekt av hypoksia på Annexin A2 i mitokondrier fra HepG2- og PC12-celler.
  • 2013. Metabolic reprogramming in Slug and Twist overexpressing MCF10A cells.
  • 2012. Mitochondrial function and metabolic stress tolerance in fibroblasts from patients with mutations in POLG.
  • 2012. A study of mitochondrial function, ROS and signaling in Twist overexpressing cells.
  • 2009. Possible interactions between EGFR vIII mediated regulation of proliferation and metabolism in glioma cells.
  • 2009. Mulige interaksjoner mellom tyrosin kinase reseptoren Axl, metabolisme og proliferasjon i brystkreftceller (MDA-MB-231).
  • 2008. Growth Factors and Cardioprotection; - with special reference to insulin and IGF-II survival signalling at ischemic reperfusion.
  • 2007. Mitocondrial metabolism and tumor growth control.
  • 2019. A study on features and markers of cellular metabolic rewiring.
  • 2017. A study of cellular metabolic flexibility under energy stress.
  • 2012. A mitochondrial reporter system for studies on NRF-1/AMPK activity and regulation in viable cells. Biochimica et Biophysica Acta - Bioenergetics. S70-S70.
  • 2008. Mitochondrial function in cancer cell line models. Biochimica et Biophysica Acta - Bioenergetics. S41-S41.
  • 2007. Synergistic anti-leukemic effect of protein kinase a activator and PPAR7agonist is independent of Bcl-2 status. Blood. 117B-117B.
  • 2018. Metabolic profiling of Colorectal cancer in 3D.
  • 2009. Hyperoxic Treatment induces Mesenchymal-to-Epithelial Transition in a Rat Adenocarcinoma Model.
  • 2004. PPAR-delta activation in relation to reduction of adipose tissue.
  • 2016. Corrigendum: A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology. Scientific Reports.
Vitenskapelig oversiktsartikkel/review
  • 2014. Regulation and quantification of cellular mitochondrial morphology and content. 5634-5652.
  • 2010. Connexin-based signaling in acute myelogenous leukemia (AML). 1-8.
  • 2007. Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signalling. 1055-1069.
  • 2006. Protein lysine acetylation in normal and leukaemic haematopoiesis: HDACs as possible therapeutic targets in adult AML. 51-68.

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