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Artikkelen heter "Association of Medication Use and 8-Year Mortality Risk in Patients With Parkinson Disease Drug-Wide Trial Emulation"

Observational Study > Neurology 2025 Aug 12;105(3):e213783.

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The winning paper is well-written, presenting a clear and impactful message with significant implications for future research. The study is well designed and uses robust and innovative methodology which aligns well with real-world clinical applications. The methodological framework demonstrated in this paper can be readily applied to future pharmacoepidemiologic studies for other diseases and serves as a proof of concept for high-throughput emulated target trials as a methodological approach.

The study demonstrates how the integration of big data, advanced statistical methods, and programming is transforming pharmacoepidemiology and paving the way for more effective treatment strategies. The findings could help accelerate therapeutic advancements for a disease with limited treatment options. Based on the results, one of the candidate drugs showing potential disease-modifying effects is now undergoing further investigation in biological cell models.