Prof. Jochen Wittbrodt, Heidelberg University, Germany
Dr. Jochen Wittbrodt, Professor of Developmental Biology and Physiology at the Centre for Organismal Studies at Heidelberg University, will present: "Medaka as a population genomics resource-mapping gene-by-environment loci in a vertebrate model-"
Hovedinnhold
Complex traits arise through the interplay of genes and environment, but separating these effects is difficult in human studies. Model organisms allow genetics and environmental conditions to be controlled, allowing to study more complex interactions between genes and environmental factors.Here, we used 76 inbred medaka strains from the Medaka Inbred Kiyosu–Karlsruhe (MIKK) panel to analyze multiple traits. We address how heart rate changes with temperature. Using genetic mapping in F2 animals, we identified 16 genomic regions linked to heart rate variation. Many of these showed complex effects involving temperature, gene interactions, and dominance. We experimentally tested four candidate genes and confirmed temperature-sensitive effects on heart rate.Other traits investigated include retinal features, regeneration, morphological traits including whole body morphometrics.
Visit Prof. Wittbrodt's webpage.
