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Circulation physiology

The common denominator of the researchers in the group is circulatory physiology with an emphasis on fluid exchange and cardiovascular physiology. Our approach is integrative and translational, involving animal and cellular models for human disease. This joint expertise makes it possible to address a broad range of research questions and a central element in the group’s research is the investigation of the capillary exchange into the interstitium.

  • Normal physiology

    The interstitial fluid, extracellular matrix and tissue microenvironment is central for our research. The interstitial fluid is not readily accessible, and members of the group have been working to establish novel methods for fluid isolation.

  • Inflammation

    A long lasting research theme in the group has been the “active role” of the loose connective tissues in acute inflammation and burn injuries. Under these circumstances Pif becomes more negative, rather than positive, during the initial stages of oedema development, in burn injuries as low as -150 mmHg.

  • Tumours

    Isolation of interstitial fluid in tumours has recently been successful in tumours (and skin serving as a reference) using centrifugation and an increased G-force. Recently we have become interested in the role of the lymphatics in fluid volume regulation.

  • Cardiac pathophysiology – Ischemia reperfusion

    This translational research is aimed at identifying adjunctive pharmacologic treatments to enhance myocardial tolerance to ischemia/reperfusion induced stress applying both interventional and cardiothoracic experimental setups.