Lasse Neset
Main content
Background
Master of Science in Biomedical Sciences, University of Bergen, 2023. The project was performed under the supervision of Petri Kursula at the Department of Biomedicine. I completed a structural study of the Activity-regulated cytoskeleton-associated (Arc) protein using SAXS, X-ray crystallography and cryo-EM, among other structural biology methods.
Bachelor of Science in Molecular Biology, University of Bergen, 2020
PhD project
Chondroitin sulfate proteoglycan-4 (CSPG4/NG2) is a transmembrane proteoglycan that is overexpressed in tumour and angiogenic tissue in 50% of glioblastoma (GBM) biopsies. My project is focusing on overexpression and purification of recombinant CSPG4/NG2, in order to solve the 3D structure of full-length CSPG4/NG2 using cryo-EM. This structure will be used to design small-molecule inhibitors that bind to CSPG4/NG2 and provide the first treatment targeting this tumour associated antigen that drives malignant progression of GBM, and several other aggressive cancers.
