Selected publications

Nygaard G, Herfindal L, Asrud KS, Bjørnstad R, Kopperud RK, Oveland E, Berven FS, Myhren L, Hoivik EA, Lunde THF, Bakke M, Døskeland SO, Selheim F (2017) Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression. Sci Rep 7(1):8725. doi: 10.1038/s41598-017-08975-y.

Kopperud RK, Rygh CB, Karlsen TV, Krakstad C, Kleppe R, Hoivik EA, Bakke M, Tenstad O, Selheim F, Lidén Å, Madsen L, Pavlin T, Taxt T, Kristiansen K, Curry FE, Reed RK, Døskeland SO (2017) Increased microvascular permeability in mice lacking Epac1 (Rapgef3). Acta Physiol 219(2):441-452. doi: 10.1111/apha.12697.

Van Damme P, Kalvik TV, Starheim KK, Jonckheere V, Myklebust LM, Menschaert G, Varhaug JE, Gevaert K, Arnesen T (2016) A role for human N-terminal acetyltransferase Naa30 in maintaining mitochondrial integrity. Mol Cell Proteomics 15(11):3361-3372.

Hernandez-Valladares M, Aasebø E, Mjaavatten O, Vaudel M, Bruserud Ø, Berven F, Selheim F (2016) Reliable FASP-based procedures for optimal quantitative proteomic and phosphoproteomic analysis on samples from acute myeloid leukemia patients. Biol Proced Online 18:13. doi: 10.1186/s12575-016-0043-0

Love NR, Pollak N, Dölle C, Niere M, Chen YY, Oliveri P, Amaya E, Patel S, Ziegler M (2015) NAD kinase controls animal NADP biosynthesis and is modulated via evolutionarily divergent calmodulin-dependent mechanisms. Proc Natl Acad Sci USA 112, 1386-1391

Myklebust LM, Van Damme P, Støve SI, Dörfel MJ, Abboud A, Kalvik TV, Grauffel C, Jonckheere V, Wu Y, Swensen J, Kaasa H, Liszczak G, Marmorstein R, Reuter N, Lyon GJ, Gevaert K, Arnesen T (2015) Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. Hum Mol Genet 24(7):1956-76.

Aksnes H, Van Damme P, Goris M, Starheim KK, Marie M, Støve SI, Hoel C, Kalvik TV, Hole K, Glomnes N, Furnes C, Ljostveit S, Ziegler M, Niere M, Gevaert K, Arnesen T (2015) An Organellar N-alpha Acetyltransferase, Naa60, Acetylates Cytosolic N-termini of Transmembrane Proteins and Maintains Golgi Integrity. Cell Rep 10(8):1362-74. 

Bjanesoy TE, Andreassen BK, Bratland E, Reiner A, Islam S, Husebye ES, Bakke M (2014) Altered DNA methylation profile in Norwegian patients with Autoimmune Addison's Disease. Mol Immunol 59(2):208-16. doi: 10.1016/j.molimm.2014.02.018.

Aasebø E, Vaudel M, Mjaavatten O, Gausdal G, Van der Burgh A, Gjertsen BT, Døskeland SO, Bruserud Ø, Berven F, Selheim F (2014) Performance of Super-SILAC based quantitative proteomics for comparison of different acute myeloid leukemia (AML) cell lines. Proteomics 14(17-18):1971-6. doi: 10.1002/pmic.201300448.

Aesoy R, Gradin K, Aasrud KS, Hoivik EA, Ruas JL, Poellinger L, Bakke M (2014) Regulation of CDKN2B expression by interaction of Arnt with Miz-1--a basis for functional integration between the HIF and Myc gene regulatory pathways. Mol Cancer 11;13:54. doi: 10.1186/1476-4598-13-54.

Stavrum AK, Heiland I, Schuster S, Puntervoll P, Ziegler M (2013) Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data. J Biol Chem 288, 34555-34566

Gausdal G, Wergeland A, Skavland J, Nguyen E, Pendino F, Rouhee N, McCormack E, Herfindal L, Kleppe R, Havemann U, Schwede F, Bruserud O, Gjertsen BT, Lanotte M, Ségal-Bendirdjian E, Døskeland SO (2013) Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. Cell Death Dis 4:e516. doi: 10.1038/cddis.2013.39.

Marie M, Dale HA, Kouprina N, Saraste J (2012). Division of the intermediate compartment at the onset of mitosis provides a mechanism for Golgi inheritance. J Cell Sci 125, 5403-5416.

Chiarugi A, Dölle C, Felici R, Ziegler M (2012) The NAD metabolome - a key determinant of cancer cell biology. Nature Rev. Cancer 12, 741-752

Huseby S, Gausdal G, Keen TJ, Kjærland E, Krakstad C, Myhren L, Brønstad K, Kunick C, Schwede F, Genieser HG, Kleppe R, Døskeland SO (2011) Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription. Cell Death Dis 2:e237. doi: 10.1038/cddis.2011.124.

Nikiforov A, Dölle C, Niere M, Ziegler M (2011) Pathways and subcellular compartmentation of NAD biosynthesis in human cells: From entry of extracellular precursors to mitochondrial NAD generation. J Biol Chem 286, 21767-21778

Van Damme P, Hole K, Pimenta-Marques A, Helsens K, Vandekerckhove J, Martinho RG, Gevaert K, Arnesen T (2011) NatF Contributes to an Evolutionary Shift in Protein N-Terminal Acetylation and Is Important for Normal Chromosome Segregation. PLoS Genet 7(7):e1002169.

Hoivik EA, Bjanesoy TE, Mai O, Okamoto S, Minokoshi Y, Shima Y, Morohashi K, Boehm U, Bakke M (2011) DNA methylation of intronic enhancers directs tissue-specific expression of steroidogenic factor 1/adrenal 4 binding protein (SF-1/Ad4BP). Endocrinology 152(5):2100-12. doi: 10.1210/en.2010-1305.

Marie M, Dale HA, Sannerud R Saraste J (2009). The function of the intermediate compartment in pre-Golgi trafficking involves its stable connection with the centrosome. Mol Biol Cell 20, 4458-4470.

Arnesen T, Van Damme P, Polevoda B, Helsens K, Evjenth R, Colaert N, Varhaug JE, Vandekerckhove J, Lillehaug JR, Sherman F, Gevaert K (2009) Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. Proc Natl Acad Sci USA 106:8157-8162.

Gausdal G, Gjertsen BT, McCormack E, Van Damme P, Hovland R, Krakstad C, Bruserud Ø, Gevaert K, Vandekerckhove J, Døskeland SO (2008) Abolition of stress-induced protein synthesis sensitizes leukemia cells to anthracycline-induced death. Blood 111(5):2866-77. doi: 10.1182/blood-2007-07-103242.

Saraste J and Goud B (2007). Functional symmetry of endomembranes. Mol Biol Cell 18, 1430-1436.

Berger F, Lau C, Ziegler M (2007) Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1. Proc Natl Acad Sci USA 104, 3765-3770

Sandal T, Aumo L, Hedin L, Gjertsen BT, Døskeland SO (2003) Irod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis. Mol Biol Cell 14(8):3292-304.

Saraste J and Svensson K (1991). Distribution of the intermediate elements operating in ER to Golgi transport. J Cell Sci 100, 415-430.

Saraste J and Kuismanen E (1984). Pre- and post-Golgi vacuoles operate in the transport of Semliki Forest virus membrane glycoproteins to the cell surface. Cell 38, 535-549.