News archive for Basic and Translational Neuroscience

Aromatic amino acid hydroxylases (AAAHs) like PAH, TH, and TPH are essential for producing key neurotransmitters and require iron and tetrahydrobiopterin to function. This study screened 307 histone deacetylase inhibitors and found that compounds like panobinostat can inhibit AAAHs at low micromolar concentrations, suggesting new therapeutic applications for these inhibitors.