Home
  • E-mailClive.Bramham@uib.no
  • Phone+47 55 58 60 32
  • Visitor Address
    Department of Biomedicine
    Jonas Lies vei 91
    5009 Bergen, Norway
  • Postal Address
    Postboks 7804
    5020 Bergen

The overriding goal is to explain how information is physically stored and represented in the brain, and how these processes are disrupted, altered, or destroyed in disorders of cognition including memory loss. Our research focus is the molecular control of synaptic plasticity. We aim to uncover the logic of synaptic plasticity at the level of protein synthesis, protein functional properties, and the dynamics of protein interaction networks.

Specific research areas:

  • Arc as a master regulator of long-term synaptic plasticity and cognition
  • Translational control of synaptic plasticity
  • Non-coding RNA regulation and function in synaptic plasticity

POSTDOC AVAILABLE:  Two-photon brain imaging - FRET - Optogenetics - Synaptic plasticity

Deadline: November 4, 2018. Applications must be submitted through the JobbNorge website. Jobbnorge ID: 158877

Papers by topic

 

ARC 

Hallin, EI, Eriksen, M., Baryshnikov, S., Nikolaienko, Grødem, S., Hosokawa, Y.

Hayashi, Y., *Bramham, C.R. and *Kursula, P.  (2018) Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities.

J. Neurochem. doi.org/10.1111/jnc.14556.  

 

Nikolaienko, O., Patil, S, Eriksen, M.S., and Bramham, C.R., (2018) Arc protein: a flexible hub for synaptic plasticity and cognition. Semin Cell Dev Biol, 77:33-42.

dx.doi.org/10.1016/j.semcdb.2017.09.006

 

Nair, R.R., Patil S., Tiron, A, Kanhema, T., Panja, D., Schiro, L., Parobzak, K., Wilczynski, G., and Bramham, C.R. (2017) Dynamic Arc SUMOylation and selective interaction with F-actin binding protein drebrin A in LTP consolidation in vivo.

Front Synaptic Neurosci. doi: 10.3389/fnsyn.2017.00008

 

Gozdz, A., Nikolaienko, O., Urbanska, M., Cymerman, I.A., Sitkiewicz, E., Dadlez, M., Bramham. C.R., and Jaworski, J (2017) GSK3α and GSK3β phosphorylate Arc and regulate its degradation. Front Mol Neurosci. http://doi: 10.3389/fnmol.2017.00192

 

Nikolaienko O, Eriksen MS, Patil S, Bito H, and Bramham CR (2017)  Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization. Neuroscience 360:68–80. http://doi: 10.1016/j.neuroscience.2017.07.026.

 

Myrum, C., Soulé, J., Bittins, M., Cavagnini, K., Eriksen, M.S., Goff, K., Ziemek, S., Patil, S., Szum, A., Nair, R.R. and Bramham, C.R. (2017) Arc interacts with the integral ER protein, calnexin. Frontiers Cell Neurosci. doi.org/10.3389/fncel.2017.00294.

 

Kuipers, S., Trentani, A., Tiron, A, Mao, X., Kuhl, D., and Bramham, C.R.  (2016) BDNF-induced LTP is associated with rapid Arc-dependent enhancement in adult hippocampal neurogenesis. Scientific Reports, http://doi: 10.1038/srep21222.

 

Myrum,C., Baumann, A., Bustad, H.J., Flydal, M.I., Mariaule,V., Alvira, S., Cuéllar, J., Soulé, J., Valpuesta J.M., Márquez, J.A., *Martinez, A., and *Bramham,C.R. (2015) Arc is a flexible modular protein capable of reversible self-oligomerization. Biochem J. 468, 145-158. http://doi 10.1042/BJ20141446

 

Myrum C, Giddaluru S, Jacobsen K, Espeseth T, Nyberg L, Lundervold A J, Haavik J, Nilsson L, Reinvang I, Steen V M, Johansson S, Wibrand K, *Le Hellard S, and *Bramham C R. (2015) Common variants in the ARC gene are not associated with cognitive abilities. Brain and Behavior, doi: 10.1002/brb3.376.

 

Soule J, Alme MN, Myrum C, Schubert M, Kanhema T, Bramham CR (2012) Balancing Arc synthesis, mRNA decay, and proteasomal degradation: maximal protein expression triggered by REM sleep-like bursts of muscarinic cholinergic receptor stimulation.

J Biological Chemistry, 287(26): 22354-66.

 

Wibrand, K., Pai, B., Siripornmongcolchai, T, Bittins, M., Berentsen, B., Ofte, M.L,  Weigel, A., Skaftnesmo, K.O., and Bramham C.R.   (2012) MicroRNA regulation of the synaptic plasticity related gene Arc. PLoS ONE 7(7): e41688.

 

Bramham CR, Alme MN, Bittins M, Kuipers SD, Nair RR, Pai B, Panja D, Schubert M, Soule J, Tiron A, Wibrand K (2010) The Arc of synaptic memory. Exp Brain Res 200:125-140.

 

Kuipers SD, Tiron A, Soule J, Messaoudi E, Trentani A, Bramham CR (2009) Selective survival and maturation of adult-born dentate granule cells expressing the immediate early gene Arc/Arg3.1. PLoS ONE 4(3): e4885.

 

Bramham CR, Worley PF, Moore MJ, Guzowski JF (2008) The immediate early gene Arc/Arg.1: regulation, mechanisms, and function. J Neurosci. 27(39): 10445-10455.

 

Soule J, Penke-Verdier Z, Alme M, Kanhema T, Laroche S, Bramham CR (2008) Object-place recognition learning triggers rapid induction of plasticity-related immediate early genes and synaptic proteins  in the rat dentate gyrus.   Neural Plasticity, Article ID 269097, 12 pages.    

Messaoudi,E., Kanhema,T., Soule,J., Tiron,A., Dagyte,G., da Silva,B., and Bramham,C.R.  (2007) Sustained Arc synthesis controls LTP consolidation through regulation of local actin polymerization in the dentate gyrus in vivo.  J. Neurosci. 27: 10445-10455.  

 

Ying SW, Futter M, Rosenblum K, Webber MJ, Hunt SP, Bliss TV, Bramham CR (2002) Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci 22: 1532-1540.

 

 

BDNF

Panja, D and Bramham, C.R. (2017) BDNF function in long-term synaptic plasticity in the dentate gyrus in vivo:  methods for local drug delivery and biochemical analysis of translation. In: Neuromethods. Humana Press. doi.org/10.1007/7657_2017_7

 

Kuipers, S., Trentani, A., Tiron, A, Mao, X., Kuhl, D., and Bramham, C.R.  (2016) BDNF-induced LTP is associated with rapid Arc-dependent enhancement in adult hippocampal neurogenesis. Scientific Reports, doi: 10.1038/srep21222.

 

Panja, D., Kenney, J.W., D’Andrea, L., Zalfa, F., Vedeler, A., Wibrand, K., Fukunaga, R., Bagni, C., Proud, C.G., and Bramham, C.R. (2014). Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. Cell Rep. 9, 1430–1445.

 

Panja, D., and Bramham, C. R. (2014). BDNF mechanisms in late LTP formation: a synthesis and breakdown. Neuropharmacology, 76: 664-676 . doi:10.1016/j.neuropharm.2013.06.024

 

Coppens, C. M., Siripornmongcolchai, T., Wibrand, K., Alme, M. N., Buwalda, B., de Boer, S. F., Koolhaas, J. M., and Bramham, C. R. (2011) Social defeat during adolescence and adulthood differentially induce BDNF-regulated immediate early genes. Front Behav. Neurosci. 5:72., Epub Nov 2.

 

Messaoudi,E., Kanhema,T., Soule,J., Tiron,A., Dagyte,G., da Silva,B., and Bramham,C.R.  (2007) Sustained Arc synthesis controls LTP consolidation through regulation of local actin polymerization in the dentate gyrus in vivo.  J. Neurosci. 27: 10445-10455.  

 

Alme MN, Wibrand K, Dagestad G, Bramham CR (2007) Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation. Neural Plast 2007: 26496. PMID: 18301726

 

Wibrand K, Messaoudi E, Havik B, Steenslid V, Løvlie R, Steen VM, and Bramham CR (2006) Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in the adult rat dentate gyrus in vivo. Eur J Neurosci 23: 1501-1511.

 

Kanhema, T.,  Dagestad, G., Panja, D., Messaoudi, E., Haavik, B., Ying, S.W.,  Nairn, A.C., Sonenberg, N. and Bramham, C.R.  (2006) Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control.  J Neurochem. 99:1328-1337.   

 

Bramham,C.R  and Messaoudi, E. (2005) BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis.  Prog. Neurobiol, 76: 99-125. 

 

Gooney, M., Messaoudi, E., Maher, F.O., *Bramham, C.R., and *Lynch, M.A. (2004) BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signalling events. Neurbiol Aging.  25: 1323-1331.

 

Ying SW, Futter M, Rosenblum K, Webber MJ, Hunt SP, Bliss TV, Bramham CR (2002) Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci 22: 1532-1540.

 

Messaoudi E, Ying SW, Kanhema T, Croll SD, Bramham CR (2002) BDNF triggers transcription-dependent, late phase LTP in vivo. J Neurosci 22: 7453-7461.

 

Messaoudi, E., Bårdsen, K.,  Srebro, B., and C.R. Bramham (1998) Acute intrahippocampal infusion of brain-derived neurotrophic factor induces lasting potentiation of synaptic transmission in the rat dentate gyrus.  J. Neurophysiol. 79: 496-499.

 

Translational control and dendritic protein synthesis

 

Bramham, C.R., Jensen, K, and Proud, CG. (2016) Tuning specific translation in cancer metastasis and synaptic memory: control at the MNK-eIF4E axis.  Trends in Biochemistry, 41: 847-858. dx.doi.org/10.1016/j.tibs.2016.07.008.

 

Panja, D., Kenney, J.W., D’Andrea, L., Zalfa, F., Vedeler, A., Wibrand, K., Fukunaga, R., Bagni, C., Proud, C.G., and Bramham, C.R. (2014). Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. Cell Rep. 9, 1430–1445.

 

Grønli, J., Soulé, J., and Bramham, C.R. (2014). Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress. Front. Behav. Neurosci. 7, 1–18.

 

Grønli,J., Dagestad,G., Milde,A.M., Murison,R., and Bramham,C.R. (2012). Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: Regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation. Behav. Brain Res. 235, 251-262.

 

Panja, D., Dagyte, G., Bidinosti, M.,. Wibrand, K.,  Kristiansen, A.M., Sonenberg, N., and Bramham, C.R.  (2009) Novel translational control in Arc-dependent long-term potentiation consolidation in vivo.  J. Biological Chemistry 284: 31498-31511.  

 

Bramham, C.R.  (2008) Local protein synthesis, actin dynamics, and LTP consolidation.

Curr Opin Neurobiol. 18: 524-531.

 

Bramham C. R. and Wells D. G. (2007) Dendritic mRNA: transport, translation, and function. Nature Rev Neurosci, 8 (10): 776 – 789.

 

Dagestad,G., Messaoudi,E., and Bramham,C.R. (2006). Chronic fluoxetine induces region specific changes in translation factor eIF4E and eEF2 activity in the rat brain.  Eur J Neurosci., 23: 2814-2818.

 

Kanhema, T.,  Dagestad, G., Panja, D., Messaoudi, E., Haavik, B., Ying, S.W.,  Nairn, A.C., Sonenberg, N. and Bramham, C.R.  (2006) Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control.  J Neurochem. 99:1328-1337.   

 

Håvik, B., Røkke, H., Bårdsen, K., Davanger, S. and Bramham, C.R. (2003) High-frequency bursts trigger rapid delivery of pre-existing CaMKII mRNA to synapses: a mechanism in dendritic protein synthesis during long-term potentiation in adult awake rats.  Eur. J. Neurosci., 17: 2679-2689.

 

 

Gene expression and non-coding RNAs

 

Maag, J.L.V. Panja, D, Kaczorowski, D.C. Peters, T.J., Bramham, C.R., Wibrand, K.,    and Dinger, M.E.  (2017) Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo. BMC Genomics. 18 (2017) 250. doi:10.1186/s12864-017-3621-x.

 

Maag, J.L.V., Panja,D., Sporild, I, Patil, S., Kaczorowski, D.C., *Bramham, C.R., *Dinger, M., and *Wibrand, K. (2015) Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity. Frontiers in Neuroscience.  9:351. doi:10.3389/fnins.2015.00351

 

Pai, B., Siripornmongcolchai, T., Berentsen, B., Pakzad, A., Vieuille, C., Pallesen, S., Pajak, M., Simpson, T.I., Armstrong, J.D., Wibrand, K., and Bramham, C.R. (2014). NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo. Front. Cell. Neurosci. 7, 1–15.

 

Wibrand, K., Pai, B., Siripornmongcolchai, T, Bittins, M., Berentsen, B., Ofte, M.L,  Weigel, A., Skaftnesmo, K.O., and Bramham C.R.   (2012) MicroRNA regulation of the synaptic plasticity related gene Arc. PLoS ONE 7(7): e41688.

 

Wibrand, K., Panja, D., Tiron, A., Ofte, M.L., Skaftnesmo, K. Sohn-Lee, C., Pena, J., Tuschl, T. and Bramham, C.R. (2010) Differential regulation of mature and precursor microRNA expression by NMDAR and metabotropic glutamate receptor expression activation during LTP in the dentate gyrus in vivo. Eur J Neurosci 31: 636-645.

 

Håvik, B., Røkke, H., Dagyte, G., Stavrum, A-K., *Bramham, C.R., and *Steen, V.M. (2007) Synaptic activity-induced global gene expression patterns in the dentate gyrus of adult behaving rats: induction of immunity-linked gene sets. (*Equal contribution).  Neuroscience, 148: 925-936.

 

Wibrand K, Messaoudi E, Havik B, Steenslid V, Løvlie R, Steen VM, and Bramham CR (2006) Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in the adult rat dentate gyrus in vivo. Eur J Neurosci 23: 1501-1511.

 

Human Genetics

 

Myrum, C., Nikolaienko, O. Bramham, C.R. Haavik, J., and Zayats, T. Implication of the APP gene in intellectual abilities. (2017) J Alz Dis. 59(2):723-735. doi: 10.3233/JAD-170049.

 

Myrum C, Giddaluru S, Jacobsen K, Espeseth T, Nyberg L, Lundervold A J, Haavik J, Nilsson L, Reinvang I, Steen V M, Johansson S, Wibrand K, *Le Hellard S, and *Bramham C R. (2015) Common variants in the ARC gene are not associated with cognitive abilities. Brain and Behavior, doi: 10.1002/brb3.376.

 

Havik, B., Degenhardt, F. A., Johansson, S., Fernandes, C. P., Hinney, A., Scherag, A., Lybaek, H., Djurovic, S., Christoforou, A., Ersland, K. M., Giddaluru, S., O'Donovan, M. C., Owen, M. J., Craddock, N., Muhleisen, T. W., Mattheisen, M., Schimmelmann, B. G., Renner, T., Warnke, A., Herpertz-Dahlmann, B., Sinzig, J., Albayrak, O., Rietschel, M., Nothen, M. M., Bramham, C. R., Werge, T., Hebebrand, J., Haavik, J., Andreassen, O. A., Cichon, S., Steen, V. M., and Le Hellard S. (2012) DCLK1 Variants are associated across schizophrenia and attention deficit/hyperactivity disorder PLoS ONE 7, e35424

 

Le Hellard S, Havik B, Espeseth T, Breilid H, Lovlie R, Luciano M, Gow AJ, Harris SE, Starr JM, Wibrand K, Lundervold AJ, Porteous DJ, Bramham CR, Deary IJ, Reinvang I, Steen VM (2009) Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities. PLoS One 4:e7534.

 

Publications in CRIStin database with links:

 

  • Hallin, Erik Ingmar; Eriksen, Maria Steene; Baryshnikov, Sergei; Nikolaienko, Oleksii; Grødem, Sverre; Hosokawa, Tomohisa; Hayashi, Yasunori; Bramham, Clive R.; Kursula, Petri. 2018. Structure of monomeric full‐length ARC sheds light on molecular flexibility, protein interactions, and functional modalities. Journal of Neurochemistry. doi: https://doi.org/10.1111/jnc.14556
  • Gozdz, Agata; Nikolaienko, Oleksii; Urbanska, Malgorzata; Cymerman, Iwona; Sitkiewicz, Ewa; Blazejczyk, Magdalena; Dadlez, Michal; Bramham, Clive R.; Jaworski, Jacek. 2017. GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation. Frontiers in Molecular Neuroscience. 10. doi: 10.3389/fnmol.2017.00192
  • Leal, Graciano; Comprido, Diogo; de Luca, Pasqualino; Morais, Eduardo; Rodrigues, Luís; Mele, Miranda; Santos, Ana R.; Costa, Rui O.; Pinto, Maria Joana; Patil, Sudarshan; Berentsen, Birgitte; Afonso, Pedro; Carreto, Laura; Li, Ka Wan; Pinheiro, Paulo; Almeida, Ramiro D.; Santos, Manuel A. S.; Bramham, Clive R.; Duarte, Carlos B. 2017. The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons. eNeuro. 4. doi: 10.1523/ENEURO.0268-17.2017
  • Maag, Jesper L.V.; Kaczorowski, Dominik C.; Panja, Debabrata; Peters, Timothy J.; Bramham, Clive R.; Wibrand, Karin; Dinger, Marcel E. 2017. Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo. BMC Genomics. 18. doi: 10.1186/s12864-017-3621-x
  • Marti, Andrea Rørvik; Patil, Sudarshan; Mrdalj, Jelena; Meerlo, Peter; Skrede, Silje; Pallesen, Ståle; Pedersen, Torhild; Bramham, Clive R.; Grønli, Janne. 2017. No escaping the rat race: simulated night shift work alters the time-of-day variation in BMAL1 translational activity in the prefrontal cortex. Frontiers in Neural Circuits. 11:70: 1-12. doi: 10.3389/fncir.2017.00070
  • Myrum, Craig; Nikolaienko, Oleksii; Bramham, Clive R.; Haavik, Jan; Zayats, Tetyana. 2017. Implication of the APP gene in intellectual abilities. Journal of Alzheimer's Disease. 59: 723-735. doi: 10.3233/JAD-170049
  • Myrum, Craig; Soule, Jonathan; Bittins, Margarethe; Cavagnini, Kyle; Goff, Kevin; Ziemek, Silje Karina; Eriksen, Maria Steene; Patil, Sudarshan; Szum, Adrian; Nair Raveendran, Rajeevkumar; Bramham, Clive R. 2017. Arc interacts with the integral endoplasmic reticulum protein, calnexin. Frontiers in Cellular Neuroscience. 11:294: 1-12. doi: 10.3389/fncel.2017.00294
  • Nair Raveendran, Rajeevkumar; Patil, Sudarshan; Tiron, Adrian; Kanhema, Tambudzai; Panja, Debabrata; Schiro, Lars Erik; Parobczak, Kamil; Wilczynski, Grzegorz M; Bramham, Clive R. 2017. Dynamic Arc SUMOylation and selective interaction with F-actin-binding protein Drebrin A in LTP consolidation in vivo. Frontiers in Synaptic Neuroscience. 9:8: 1-|14. doi: 10.3389/fnsyn.2017.00008
  • Nikolaienko, Oleksii; Eriksen, Maria Steene; Patil, Sudarshan; Bito, Haruhiko; Bramham, Clive R. 2017. Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization. Neuroscience. 360: 68-80. doi: 10.1016/j.neuroscience.2017.07.026
  • Nikolaienko, Oleksii; Patil, Sudarshan; Eriksen, Maria Steene; Bramham, Clive R. 2017. Arc protein: a flexible hub for synaptic plasticity and cognition. Seminars in Cell and Developmental Biology. 77: 33-42. doi: 10.1016/j.semcdb.2017.09.006
  • Bojovic, Ognjen; Bramham, Clive R.; Tjølsen, Arne. 2016. Stimulation-induced expression of immediate early gene proteins in the dorsal horn is increased in neuropathy. Scandinavian Journal of Pain. 10: 43-51. doi: 10.1016/j.sjpain.2015.09.002
  • Bramham, Clive R.; Jensen, KB; Proud, CG. 2016. Tuning specific translation in cancer metastasis and synaptic memory: control at the MNK-eIF4E axis. TIBS -Trends in Biochemical Sciences. Regular ed.. doi: 10.1016/j.tibs.2016.07.008
  • Kuipers, SD; Trentani, Andrea; Patil, Sudarshan; Tiron, Adrian; Mao, Xiaosong; Kuhl, Dietmar; Bramham, Clive R. 2016. BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis. Scientific Reports.
  • Kuipers, Sjoukje; Trentani, Andrea; Tiron, Adrian; Mao, Xiaosong; Kuhl, Dietmar; Bramham, Clive R. 2016. BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis. Scientific Reports. 6:21222. doi: 10.1038/srep21222
  • Maag, Jesper L.V.; Panja, Debabrata; Sporild, Ida; Patil, Sudarshan; Kaczorowski, Dominik C.; Bramham, Clive R.; Dinger, Marcel E.; Wibrand, Karin. 2016. Corrigendum to Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity [Front. Neurosci. (2015), 9:351. doi: 10.3389/fnins.2015.00351]. Frontiers in Neuroscience. 10:354: 1-1. doi: 10.3389/fnins.2016.00354
  • Szum, Adrian M.; Bramham, Clive R. 2016. The localization and function of Arc in the neuronal cell nucleus. UiB. 25 pages.
  • Bojovic, Ognjen; Bramham, Clive R.; Tjølsen, Arne. 2015. Chronic morphine treatment enhances sciatic nerve stimulation-induced immediate early gene expression in the rat dorsal horn. Acta Neurobiologiae Experimentalis. 75: 305-313.
  • Bojovic, Ognjen; Panja, Debabrata; Bittins, Margarethe; Bramham, Clive R.; Tjølsen, Arne. 2015. Time course of immediate early gene protein expression in the spinal cord following conditioning stimulation of the sciatic nerve in rats. PLoS ONE. 10:e0123604. doi: 10.1371/journal.pone.0123604
  • Hall, Malgorzata H.; Magalska, Adriana; Malinowska, Monika; Ruszczycki, Blazej; Czaban, Iwona; Patel, Satyam; Ambrozek-Latecka, Magdalena; Zolocinska, Ewa; Broszkiewicz, Hanna; Parobczak, Kamil; Nair Raveendran, Rajeevkumar; Rylski, Marcin; Pawlak, Robert; Bramham, Clive R.; Wilczynski, Grzegorz M. 2015. Localization and regulation of PML bodies in the adult mouse brain. Brain Structure and Function. Published ahead of print. 15 pages. doi: 10.1007/s00429-015-1053-4
  • Maag, Jesper L.V.; Panja, Debabrata; Sporild, Ida; Patil, Sudarshan; Kaczorowski, Dominik C.; Bramham, Clive R.; Dinger, Marcel E.; Wibrand, Karin. 2015. Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity. Frontiers in Neuroscience. 9:351. doi: 10.3389/fnins.2015.00351
  • Myrum, Craig; Baumann, Anne; Bustad, Helene J.; Flydal, Marte Innselset; Mariaule, Vincent; Alvira, Sara; Cuéllar, Jorge; Haavik, Jan; Soulé, Jonathan; Valpuesta, José María; Márquez, José Antonio; Martinez, Aurora; Bramham, Clive R. 2015. Arc is a flexible modular protein capable of reversible self-oligomerization. Biochemical Journal. 468: 145-158. doi: 10.1042/BJ20141446
  • Myrum, Craig; Giddaluru, Sudheer; Jacobsen, Kaya Kvarme; Espeseth, Thomas; Nyberg, Lars; Lundervold, Astri; Haavik, Jan; Nilsson, Lars-Göran; Reinvang, Ivar; Steen, Vidar Martin; Johansson, Stefan; Wibrand, Karin; Le Hellard, Stephanie; Bramham, Clive R. 2015. Common variants in the ARC gene are not associated with cognitive abilities. Brain and Behavior. 5. 8 pages. doi: 10.1002/brb3.376
  • Segev, Yifat; Barrera, Iliana; Ounallah-Saad, Hadile; Wibrand, Karin; Sporild, Ida; Livne, Adva; Rosenberg, Tali; David, Orit; Mints, Meshi; Bramham, Clive R.; Rosenblum, Kobi. 2015. PKR inhibition rescues memory deficit and atf4 overexpression in apoe ε4 human replacement mice. Journal of Neuroscience. 35: 12986-12993. doi: 10.1523/JNEUROSCI.5241-14.2015
  • Bramham, Clive R.; Panja, Debabrata. 2014. BDNF regulation of synaptic structure, function, and plasticity. Neuropharmacology. 76: 601-602. doi: 10.1016/j.neuropharm.2013.08.012
  • Grønli, Janne; Soule, Jonathan; Bramham, Clive R. 2014. Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress. Frontiers in Behavioral Neuroscience. 7:224. 18 pages. doi: 10.3389/fnbeh.2013.00224
  • Panja, Debabrata; Bramham, Clive R. 2014. BDNF mechanisms in late LTP formation: A synthesis and breakdown. Neuropharmacology. 76: 664-676. doi: 10.1016/j.neuropharm.2013.06.024
  • Panja, Debabrata; Kenney, Justin W.; D'Andrea, Laura; Zalfa, Francesca; Vedeler, Anni; Wibrand, Karin; Fukunaga, Rikiro; Bagni, Claudia; Proud, Christopher G.; Bramham, Clive R. 2014. Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. Cell reports. 9: 1430-1445. doi: 10.1016/j.celrep.2014.10.016
  • Schubert, Manja; Panja, Debabrata; Haugen, Mette; Bramham, Clive R.; Vedeler, Christian A. 2014. Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta Neuropathologica. 128: 835-852. doi: 10.1007/s00401-014-1351-6
  • Sreenivasa, Pai Balagopal; Siripornmongcolchai, Taweeporn; Berentsen, Birgitte; Pakzad, Ashraf Fathpour; Vieuille, Christel Marie; Pallesen, Ståle; Pajak, Maciej; Simpson, T. Ian; Armstrong, J. Douglas; Wibrand, Karin; Bramham, Clive R. 2014. NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo. Frontiers in Cellular Neuroscience. 7:285. doi: 10.3389/fncel.2013.00285
  • Bergersen, Linda Hildegard; Bramham, Clive R.; Hugdahl, Kenneth; Sander, Miriam; Storm-Mathisen, Jon. 2013. The changing brain – Insights into the mechanisms of neural and behavioral adaptation to the environment. Neuroscience. 247: 412-422. doi: 10.1016/j.neuroscience.2013.04.012
  • Wibrand, Karin; Berge, Kjetil; Messaoudi, Michael; Duffaud, Anais; Panja, Debabrata; Bramham, Clive R.; Burri, Lena. 2013. Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats. Lipids in Health and Disease. 12. 13 pages. doi: 10.1186/1476-511X-12-6
  • Bramham, Clive R.; Fathpour, Ashraf Pakzad. 2012. Remodeling of the microRNA-induced silencing complex during LTP in the adult rat brain in vivo. Institutt for biomedisin, Universitetet i Bergen.
  • Dziembowska, Magdalena; Milek, Jacek; Janusz, Aleksandra; Rejmak, Emilia; Romanowska, Ewelina; Gorkiewicz, Tomasz; Tiron, Adrian; Bramham, Clive R.; Kaczmarek, Leszek. 2012. Activity-dependent local translation of matrix metalloproteinase-9. Journal of Neuroscience. 32: 14538-14547. doi: 10.1523/JNEUROSCI.6028-11.2012
  • Gal-Ben-Ari, Shunit; Kenney, Justin W.; Ounalla-Saad, Hadile; Taha, Elham; David, Orit; Levitan, David; Gildish, Iness; Panja, Debabrata; Sreenivasa, Pai Balagopal; Wibrand, Karin; Simpson, T. Ian; Proud, Christopher G.; Bramham, Clive R.; Armstrong, J. Douglas; Rosenblum, Kobi. 2012. Consolidation and translation regulation. Learning & memory (Cold Spring Harbor, N.Y.). 19: 410-422. doi: 10.1101/lm.026849.112
  • Grønli, Janne; Dagestad, Grethe; Milde, Anne Marita; Murison, Robert; Bramham, Clive R. 2012. Chronic mild stress abolishes a relationship between sleep architecture and translational control. Journal of Sleep Research. 21: 41-41.
  • Grønli, Janne; Dagestad, Grethe; Milde, Anne Marita; Murison, Robert; Bramham, Clive R. 2012. Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: Regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation. Behavioural Brain Research. 235: 251-262. doi: 10.1016/j.bbr.2012.08.008
  • Håvik, Bjarte; Degenhardt, Franziska A.; Johansson, Stefan; Duarte Fernandes, Carla; Hinney, Anke; Scherag, André; Lybæk, Helle; Djurovic, Srdjan; Christoforou, Andrea; Ersland, Kari; Giddaluru, Sudheer; O'Donovan, Michael C.; Owen, Michael J.; Craddock, Nick; Mühleisen, Thomas W.; Mattheisen, Manuel; Schimmelmann, Benno G.; Renner, Tobias J.; Warnke, Andreas; Herpertz-Dahlmann, Beate; Sinzig, Judith; Albayrak, Özgür; Rietschel, Marcella; Nöthen, Markus M.; Bramham, Clive R.; Werge, Thomas; Hebebrand, Johannes; Haavik, Jan; Andreassen, Ole Andreas; Cichon, Sven; Steen, Vidar Martin; Le Hellard, Stephanie. 2012. DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder. PLoS ONE. 7. 12 pages. doi: 10.1371/journal.pone.0035424
  • Soule, Jonathan; Alme, Maria Nordheim; Myrum, Craig; Schubert, Manja; Kanhema, Tambudzai; Bramham, Clive R. 2012. Balancing arc synthesis, mRNA decay, and proteasomal degradation : maximal protein expression triggered by rapid eye movement sleep-like bursts of muscarinic cholinergic receptor stimulation. Journal of Biological Chemistry. 287: 22354-22366. doi: 10.1074/jbc.M112.376491
  • Wibrand, Karin; Sreenivasa, Pai Balagopal; Siripornmongcolchai, Taweeporn; Bittins, Margarethe; Berentsen, Birgitte; Ofte, May Lillian; Weigel, Arwed; Skaftnesmo, Kai Ove; Bramham, Clive R. 2012. MicroRNA regulation of the synaptic plasticity-related gene arc. PLoS ONE. 7. 15 pages. doi: 10.1371/journal.pone.0041688
  • Coppens, Caroline M; Siripornmongcolchai, Taweeporn; Wibrand, Karin; Alme, Maria Nordheim; Buwalda, Bauke; de Boer, Sietse F; Koolhaas, Jaap M; Bramham, Clive R. Evjen. 2011. Social defeat during adolescence and adulthood differentially induce BDNF-regulated immediate early genes. Frontiers in Behavioral Neuroscience. 5. doi: 10.3389/fnbeh.2011.00072
  • Håvik, Bjarte; Le Hellard, Stephanie; Rietschel, Marcella; Lybæk, Helle; Djurovic, Srdjan; Mattheisen, Manuel; Mühleisen, Thomas W.; Degenhardt, Franziska A.; Priebe, Lutz; Maier, Wolfgang; Breuer, Rene; Schulze, Thomas G.; Agartz, Ingrid; Melle, Ingrid; Hansen, Thomas; Bramham, Clive R. Evjen; Nöthen, Markus M.; Stevens, Beth; Werge, Thomas; Andreassen, Ole Andreas; Cichon, Sven; Steen, Vidar Martin. 2011. The Complement Control-Related Genes CSMD1 and CSMD2 Associate to Schizophrenia. Biological Psychiatry. 70: 35-42. doi: 10.1016/j.biopsych.2011.01.030
  • Bidinosti, Michael; Ran, Israeli; Sanchez-Carbente, Maria R.; Martineau, Yvan; Gingras, Anne-Claude; Gkogkas, Christos; Raught, Brian; Bramham, Clive R. Evjen; Sossin, Wayne S.; Costa-Mattioli, Mauro; DesGroseillers, Luc; Lacaille, Jean-Claude; Sonenberg, Nahum. 2010. Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. Molecular Cell. 37: 797-808. doi: 10.1016/j.molcel.2010.02.022
  • Bramham, Clive R. Evjen; Alme, Maria Nordheim; Bittins, Margarethe; Kuipers, Sjoukje; Nair, Rajeevkumar R; Pai, Balagopal Sreenivasa; Panja, Debabrata; Schubert, Manja; Soule, Jonathan; Tiron, Adrian; Wibrand, Karin. 2010. The Arc of synaptic memory. Experimental Brain Research. 200: 125-140. doi: 10.1007/s00221-009-1959-2
  • Wibrand, Karin; Panja, Debabrata; Tiron, Adrian; Ofte, May Lillian; Skaftnesmo, Kai Ove; S-Lee, Cherin; Pena, John T.G.; Tuschl, Thomas; Bramham, Clive R. Evjen. 2010. Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo. European Journal of Neuroscience. 31: 636-645. doi: 10.1111/j.1460-9568.2010.07112.x
  • Bramham, Clive R. Evjen; Panja, Debabrata; Tiron, Adrian; Nair, Rajeevkumar R; Wibrand, Karin; Kuipers, S. 2009. Arc/Arg3.1 synthesis and control of LTp consolidation in the adult dentate gyrus in vivo. European Neuropsychopharmacology. 19: S190-S190.
  • Jedlicka, Peter; Schwarzacher, Stephan W.; Winkels, Raphael; Kienzler, Friederike; Frotscher, Michael; Bramham, Clive R. Evjen; Schultz, Christian; Orth, Carlos Bas; Deller, Thomas. 2009. Impairment of in vivo theta-burst long term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle. Hippocampus. 19: 130-140. doi: 10.1002/hipo.20489
  • Kuipers, Sjoukje; Tiron, Adrian; Soule, Jonathan; Messaoudi, Elhoucine; Trentani, Andrea; Bramham, Clive R. Evjen. 2009. Selective survival and maturation of adult-born dentate granule cells expressing the immediate early gene Arc/Arg3.1. PLoS ONE. 4. doi: 10.1371/journal.pone.0004885
  • Le Hellard, Stephanie; Håvik, Bjarte; Espeseth, Thomas; Breilid, Harald; Løvlie, Roger; Luciano, Michelle; Gow, Alan J.; Harris, Sarah E.; Starr, John M.; Wibrand, Karin; Lundervold, Astri; Porteous, David J.; Bramham, Clive R. Evjen; Deary, Ian J.; Reinvang, Ivar; Steen, Vidar Martin. 2009. Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are Associated with memory and general cognitive abilities. PLoS ONE. 4. doi: 10.1371/journal.pone.0007534
  • Panja, Debabrata; Dagyte, Girstaute; Bidinosti, Mivhael; Wibrand, Karin; Kristiansen, Åse-Marit; Sonenberg, Nahum; Bramham, Clive R. Evjen. 2009. Novel Translational Control in Arc-dependent Long Term Potentiation Consolidation in Vivo. Journal of Biological Chemistry. 284: 31498-31511. doi: 10.1074/jbc.M109.056077
  • Bramham, Clive R. Evjen. 2008. Local protein synthesis, actin dynamics, and LTP consolidation. Current Opinion in Neurobiology. 18: 524-531. doi: 10.1016/j.conb.2008.09.013
  • Bramham, Clive R. Evjen; Worley, PF; Moore, MJ; Guzowski, JF. 2008. The immediate early gene arc/arg3.1: regulation, mechanisms, and function. Journal of Neuroscience. 28: 11760-11767. doi: 10.1523/JNEUROSCI.3864-08.2008
  • Grønli, Janne; Dagestad, Grethe; Milde, Anne Marita; Murison, Robert; Portas, Chiara Maria; Bramham, Clive R. Evjen. 2008. Sleep deprivation as an antidepressant treatment following chronic mild stress: effects on translation factor EIF4E and EEF2 activity. Journal of Sleep Research. 17: 221-221.
  • Haugan, Frøydis; Wibrand, Karin; Fiskå, Atle; Bramham, Clive R. Evjen; Tjølsen, Arne. 2008. Stability of long term facilitation and expression of zif268 and Arc in the spinal cord dorsal horn is modulated by conditioning stimulation within the physiological frequency range of primary afferent fibers. Neuroscience. 154: 1568-1575. doi: 10.1016/j.neuroscience.2008.05.010
  • Soule, Jonathan; Penke-Verdier, Z; Kanhema, Tambudzai; Alme, Maria Nordheim; Laroche, S; Bramham, Clive R. Evjen. 2008. Object-place recognition learning triggers rapid induction of plasticity-related immediate early genes and synaptic proteins in the rat dentate gyrus. Neural Plasticity. 2008. doi: 10.1155/2008/269097
  • Alme, Maria Nordheim; Wibrand, Karin; Dagestad, Grethe; Bramham, Clive R. Evjen. 2007. Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation. Journal of Neural Plasticity.
  • Bramham, Clive R. Evjen. 2007. Control of synaptic consolidation in the dentate gyrus: mechanisms, functions, and therapeutic implications. Progress in Brain Research. 163: 453-471. doi: 10.1016/S0079-6123(07)63025-8
  • Bramham, Clive R. Evjen; Wells, DG. 2007. Dendritic mRNA: transport, translation and function. Nature Reviews Neuroscience. 8: 776-789. doi: 10.1038/nrn2150
  • Håvik, Bjarte; Bramham, Clive R. Evjen. 2007. Additive viability-loss following hsp70/hsc70 double interference and Hsp90 inhibition in two breast cancer cell lines. Oncology Reports. 17: 1501-1510.
  • Håvik, Bjarte; Røkke, Håvard; Dagyte, Girstaute; Stavrum, Anne-Kristin; Bramham, Clive R. Evjen; Steen, Vidar Martin. 2007. Synaptic activity-induced global gene expression patterns in the dentate gyrus of adult behaving rats: Induction of immunity-linked genes. Neuroscience. 148: 925-936. doi: 10.1016/j.neuroscience.2007.07.024
  • Messaoudi, Elhoucine; Kanhema, Tambudzai; Soule, Jonathan; Tiron, Adrian; Dagyte, Girstaute; da Silva, Bruno; Bramham, Clive R. Evjen. 2007. Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus In vivo. Journal of Neuroscience. 27: 10445-10445. doi: 10.1523/JNEUROSCI.2883-07.2007
  • Dagestad, Grethe; Kuipers, Sjoukje; Messaoudi, Elhoucine; Bramham, Clive R. Evjen. 2006. Chronic fluoxetine induces region-specific changes in translation factor eIF4E and eEF2 activity in the rat brain. European Journal of Neuroscience. 23: 2814-2818. doi: 10.1111/j.1460-9568.2006.04817.x
  • Grønli, Janne; Bramham, Clive R. Evjen; Murison, Robert; Kanhema, Tambudzai; Fiske, Eldbjørg; Bjorvatn, Bjørn; Ursin, Reidun; Portas, Chiara Maria. 2006. Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper. Pharmacology, Biochemistry and Behavior. 85: 842-849. doi: 10.1016/j.pbb.2006.11.021
  • Kanhema, Tambudzai; Dagestad, Grethe; Panja, Debabrata; Tiron, Adrian; Messaoudi, Elhoucine; Håvik, Bjarte; Ying, Ming; Nairn, Angus C.; Sonenberg, Nahum; Bramham, Clive R. Evjen. 2006. Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control. Journal of Neurochemistry. 99: 1328-1337.
  • Kuipers, Sjoukje; Bramham, Clive R. Evjen. 2006. Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: New insights and implications for therapy. Current opinion in drug discovery & development. 9: 580-586.
  • Kuipers, Sjoukje; Trentani, Andrea; Westenbroek, Christel; Bramham, Clive R. Evjen; Korf, Jakob; Kema, Ido P.; Ter Horst, Gert J.; Den Boer, Johan A. 2006. Unique patterns of FOS, phospho-CREB and BrdU immunoreactivity in the female rat brain following chronic stress and citalopram treatment. Neuropharmacology. 50: 428-440.
  • Soule, Jonathan; Messaoudi, Elhoucine; Bramham, Clive R. Evjen. 2006. Brain-derived neurotrophic factor and control of synaptic consolidation in the adult brain. Biochemical Society Transactions. 34: 600-604.
  • Wibrand, Karin; Messaoudi, Elhoucine; Håvik, Bjarte; Steenslid, Vibeke; Løvlie, Roger; Steen, Vidar Martin; Bramham, Clive R. Evjen. 2006. Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in adult rat dentate gyrus in vivo. European Journal of Neuroscience. 23: 1501-1511. doi: 10.1111/j.1460-9568.2006.04687
  • Bramham, Clive R. Evjen. 2005. Molecular mechanisms of synaptic consolidation during sleep: BDNF function and dendritic protein synthesis. Behavioral and Brain Sciences. 28.
  • Bramham, Clive R. Evjen; Messaoudi, El Houcine. 2005. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol. Progress in Neurobiology. 76: 99-125.
  • Grønli, Janne; Murison, Robert; Kanhema, Tambudzai; Fiske, Eldbjørg; Bjorvatn, Bjørn; Sørensen, Eli; Portas, Chiara Maria; Bramham, Clive R. Evjen; Ursin, Reidun. 2005. Chronic mild stress, an animal model of depression, affects the expression of BDNF and 5-HT levels over the sleep/wake cycle in hippocampus in rats. Sleep. 28.
  • Gooney, M; Messaoudi, El Houcine; Maher, F O; Bramham, Clive R. Evjen; Lynch, M.A. 2004. BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signalling events. Neurobiology of Aging. 25: 1323-1333.
  • Bramham, Clive R. Evjen. 2003. Trophic factors and plasticity. In:
    • Kiel, Universität zu. 2003. Neurodegenerative diseases: mechanisms and principles of rational treatment. Baltic Summer School Course Book.
  • Ernfors, Patrick; Bramham, Clive R. Evjen. 2003. The coupling of a TrkB tyrosine residue to LTP. TINS - Trends in Neurosciences. 26: 171-173.
  • Bramham, Clive R. Evjen. 2002. Making memories last: brain-derived neurotrophic factor (BDNF) as a trigger for synaptic consolidation. 123-124. In:
    • Tjølsen, Arne; Berge, Odd-Geir. 2002. Pain and Brain; Festschrift Kjell Hole 70 years. Universitetet i Bergen. ISBN: 82-90952-45-7.
  • Bramham, Clive R. Evjen; Messaoudi, Elhoucine; Bårdsen, Kjetil. 2002. Neurotrophins and synaptic plasticity in the adult hippocampus. 61-77. In:
    • Lester, D.S.; Slikker, W.; Lazarovici, P. 2002. Site-selective neurotoxicity.
  • McCutchen, Mary E.; Bramham, Clive R. Evjen; Pozzo-Miller, Lucas. 2002. Modulation of neuronal calcium signaling by neurotrophic factors. International Journal of Developmental Neuroscience. 20: 199-207.
  • Messaoudi, Elhoucine; Ying, Shui-Wang; Kanhema, Tambudzai; Croll, Susan D.; Bramham, Clive R. Evjen. 2002. Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo. Journal of Neuroscience. 22: 7453-7461.
  • Tyler, W.J.; Alonso, M; Bramham, Clive R. Evjen; Pozzo-Miller, Lucas. 2002. From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Learning & memory (Cold Spring Harbor, N.Y.). 9: 224-237.
  • Ying, Shui-Wang; Futter, Marie; Rosenblum, Kobi; Webber, Mark J; Hunt, Stephen P.; Bliss, Timothy V.P.; Bramham, Clive R. Evjen. 2002. Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. Journal of Neuroscience. 22: 1532-1540.
  • Valentine, Gerald; Chakravarty, Sumana; Sarvey, John; Bramham, Clive R. Evjen; Herkenham, Miles. 2000. Fragile X (fmr1) mRNA expression is differentially regulated in two adult models of activity-dependent gene expression. Brain Research. Molecular Brain Research. 75: 337-341.
  • Thomas, G; Toska, Karen; Bramham, Clive R. Evjen; Haavik, Jan. 1999. Mitogen and stress activated protein kinase signaling pathways: emerging functions in the nervous system. Recent Research Developments in Neurochemistry. 2: 71-89.
  • Thomas, Gareth; Toska, Karen; Bramham, Clive R. Evjen; Haavik, Jan. 1999. MAP and SAP kinase signaling pathways: emerging functions in the nervous system. Recent Research Developmental in Neurochemistry. 2: 71-89.
  • Bramham, Clive R. Evjen. 1998. Phasic boosting of medial perforant path-evoked granule cell output time-locked to spontaneous dentate EEG spikes in awake rats. Journal of Neurophysiology. 79: 2825-2832.
  • Bramham, Clive R. Evjen. 1998. Neurotrophin regulation of synaptic plasticity in the adult nervous system. In:
    • Lester, D. 1998. Site-specific neurotoxicity.
  • Bramham, Clive R. Evjen; Alhers, S.; Sarvey, J. 1998. Acute cold stress leading to elevated corticosterone neither enhances synaptic efficacy nor impairs tetanus-evoked LTP in the dentate gyrus of free moving rats. Brain Research. 789: 245-255.
  • Messaoudi, Elhoucine; Srebro, Boleslaw; Bramham, Clive R. Evjen. 1998. Acute intrahippocampal infusion of BDNF induces lasting potentiation of synaptic transmission in the rat dentate gyrus. Journal of Neurophysiology. 79: 496-499.
  • Bramham, Clive R. Evjen; Sarvey, John M. 1996. Endogenous Activation of µ and -1 Opioid Receptors Is Required for Long-Term Potentiation Induction in the Lateral Perforant Path: Dependence on GABAergic Inhibition. Journal of Comparative Neurology. 16: 8123-8131.
  • Bramham, Clive R. Evjen; Southard, Teresa; Sarvey, John M; Herkenham, Miles; Brady, Linda S. 1996. Unilateral LTP triggers bilateral increases in hippocampal neurotrophin and trk receptor mRNA expression in behaving rats: Evidence for interhemisp communication. Journal of Comparative Neurology. 368: 371-382.
  • Bramham, Clive R. Evjen. 1992. In vivo studies on long-term potentiation (LTP) in the dentate gyrus : role of opioid and NMDA receptors, and modulation by behavioral state. Department of Physiology, University of Bergen, Bergen. 1 pages.
  • Bramham, Clive R. Evjen; Milgram, N. W.; Srebro, Boleslaw. 1991. Activation of AP5-sensitive NMDA-receptors is required to induce LTP of synaptic transmission in the lateral perforant path. European Journal of Neuroscience. 3: 1300-1308.
  • Bramham, Clive R. Evjen; Milgram, N. W.; Srebro, Boleslaw. 1991. Delta opioid receptor activation is required to induce LTP of synaptic transmission in the lateral perforant path in vivo. Brain Research. 567: 42-50.
  • Lynch, M. A.; Clements, M. P.; Voss, K. L.; Bramham, Clive R. Evjen; Bliss, T. V. P. 1991. Is arachidonic acid a retrograde messenger in long-term potentiation? Biochemical Society Transactions. 19: 391-396.

More information in national current research information system (CRIStin)

In vivo electrophysiological studies of synaptic plasticity combined with genetic and local pharmacological manipulations.

Live-cell imaging in primary neuronal cultures, brain tissue slices, and intact rodents. Two-photon laser-scanning microscopy.  FRET imaging and single-particle tracking.  Single-cell electroporation.

Biochemical analysis of signal transduction mechanisms, protein-protein interactions, and functional analysis of post-translational modifications.  

  • Arc as a master regulator of long-term synaptic plasticity 
  • Translational control of synaptic plasticity
  • Non-coding RNA regulation and function in synaptic plasticity

Links to funded projects:

Molecular control of Arc protein. Research Council of Norway, Top Research Project.

Synaptic circuit protection in Alzheimer´s disease (AD) and Huntington´s disease (HD). CircProt. EU-H2020: Joint programme in Neurodegenerative disorders

 

POSTDOC AVAILABLE:  Two-photon brain imaging - FRET - Optogenetics - Synaptic plasticity

Deadline: November 4, 2018. Applications must be submitted through the JobbNorge website. Jobbnorge ID: 158877

Research groups

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