- Visitor AddressDep. of Medicine, Haukeland university hospital5021 Bergen
- Postal AddressPostboks 78045020 Bergen
Trond Bruun, M.D., Ph.D. is head of the Infectious Diseases Section at Haukeland University Hospital in Bergen, Norway. He is also associate professor at Department of Clinical Science, University of Bergen. His main research interest is the field of skin and soft tissue infections, particularly erysipelas, cellulitis and necrotizing fasciitis caused by Streptococcus pyogenes and Streptococcus dysgalactiae. The streptococcal studies focus primarily on clinical epidemiology, clinical features and treatment of severe infections in relation to the host and causative bacteria and their traits. At present, Bruun and the streptococcal research group at the University of Bergen participate in the PERMIT and PERAID projects (https://permedinfect.com/) funded by Nordsforsk and EU. These projects aims to boost personalized medicine (PM) in severe infectious diseases, specifically focusing on life-threatening necrotizing soft tissue infections (NSTI) and sepsis.
- (2023). Systemic immune activation profiles in streptococcal necrotizing soft tissue infections: A prospective multicenter study. Clinical Immunology.
- (2022). Clinical Characteristics and Histopathology in Suspected Necrotizing Soft Tissue Infections. Open Forum Infectious Diseases. 7 pages.
- (2022). Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections. BMC Medicine.
- (2020). Risk factors and Predictors of Mortality in Streptococcal Necrotizing Soft-Tissue Infections: A Multicenter Prospective Study. Clinical Infectious Diseases. 293-300.
- (2020). Non-purulent skin and soft tissue infections: predictive power of a severity score and the appropriateness of treatment in a prospective cohort. Infectious Diseases. 361-371.
- (2019). Patient's characteristics and outcomes in necrotising soft-tissue infections: results from a Scandinavian, multicentre, prospective cohort study. Intensive Care Medicine. 1241-1251.
- (2019). Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections. Nature Communications. 1-15.
- (2018). Pivotal Role of Preexisting Pathogen-Specific Antibodies in the Development of Necrotizing Soft-Tissue Infections. Journal of Infectious Diseases. 44-52.
- (2018). Necrotizing soft tissue infections ? a multicentre, prospective observational study (INFECT): protocol and statistical analysis plan. Acta Anaesthesiologica Scandinavica. 272-279.
- (2018). Aetiology and clinical features of facial cellulitis: a prospective study. Infectious Diseases. 27-34.
- (2017). Association between cytokine response, the LRINEC score and outcome in patients with necrotising soft tissue infection: A multicentre, prospective study. Scientific Reports. 1-12.
- (2016). Etiology of cellulitis and clinical prediction of streptococcal disease: A prospective study. Open Forum Infectious Diseases.
- (2016). Early Response in Cellulitis: A Prospective Study of Dynamics and Predictors. Clinical Infectious Diseases. 1034-1041.
- (2015). Increased cytotoxicity and streptolysin O activity in group G streptococcal strains causing invasive tissue infections. Scientific Reports.
- (2013). Necrotizing soft tissue infections caused by Streptococcus pyogenes and Streptococcus dysgalactiae subsp equisimilis of groups C and G in western Norway. Clinical Microbiology and Infection (CMI). E545-E550.
- (2011). Invasive group A, C and G streptococcal disease in western Norway: virulence gene profiles, clinical features and outcomes. Clinical Microbiology and Infection (CMI). 358-364.
- (2010). Clinical, microbiological and molecular characteristics of six cases of group A streptococcal meningitis in western Norway. Scandinavian Journal of Infectious Diseases. 665-671.
- (2016). Etiology of cellulitis and the validity of new and old methods. Clinical Infectious Diseases. 954-955.
- (2016). Clinical and bacterial diversity in streptococcal skin and soft tissue disease.
- (2021). Antibiotic-loaded bone cement in prevention of periprosthetic joint infections in primary total knee arthroplasty: A register-based multicentre randomised controlled non-inferiority trial (ALBA trial). BMJ Open. 1-8.
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