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Hartveit/Veruki Lab

Coupled A II amacrine cells in the retina

Retinal Microcircuits

Synaptic interactions in the retina: receptors, mechanisms, circuits and networks

Our lab is interested in the cellular and molecular basis of synaptic transmission and synaptic integration in the central nervous system. Our main goal is to understand the synaptic and cellular mechanisms employed by identified neurons and specific microcircuits for signal processing. The primary techniques we use are targeted patch-clamp recording of visually-identified neurons, 2-photon imaging and computational modeling. 

Figure: Two retinal interneurons (AII amacrines) imaged with 2-photon microscopy. Copyright: Espen Hartveit

Current projects include:

  1. Multi-photon excitation imaging combined with patch-clamp recording to elucidate the mechanisms of retinal signal processing
  2. Quantitative morphological reconstructions of single neurons by computer-aided manual tracing of image stacks acquired with multi-photon excitation microscopy 
  3. Development of compartmental models of single neurons to study passive and active properties involved in signal processing
  4. Simultaneous multi-electrode recordings from neurons in specific microcircuits within the inner retina 
  5. Confocal and STED microscopy to localize receptors and synaptic proteins to individual neurons and circuits
Neuroscience
Mikroskopisk bilde av en nervecelle i netthinnen

Extrasynaptic glutamate receptors in the retina

The Retinal Microcircuits Research Group investigates how neurons in the retina communicate to produce vision. In their latest study, they looked outside the conventional neural circuits and found some unexpected receptor molecules in unexpected locations.

News
Eye exhibition opening

Opened a new eye exhibition

Doctoral candidates from around the world have gathered to communicate their research on the retina. The result is an interactive eye exhibit at VilVite Science Center.

2nd Annual Meeting and Winter School
http://www.etn-switchboard.eu
Nov 06

switchBoard - In the Eye of the Observer: Visual Processing at the Heart of the Retina

In November 2017, the University of Bergen hosted the second annual meeting and winter school for members of the Innovative Training Network "switchBoard"

Our research is supported by the Research Council of Norway, NevroNor, European Commission's Horizon 2020 programme Marie Curie Actions ITN, the University of Bergen, Helse Vest, Odd Fellow Medical-Scientific Research Fund, and INCF.

http://www.etn-switchboard.eu

We are partners in switchBoard - In the Eye of the Observer: Visual Processing at the Heart of the Retina

switchBoard is an In Innovative Training Network (ITN) funded by the European Commission's Horizon 2020 programme under the Marie Curie Actions.