- E-postfekadu.yadetie@uib.no
- BesøksadresseThormøhlens gate 53 A/B5006 Bergen
- PostadressePostboks 78035020 Bergen
Jeg har doktorgrad i molekylærbiologi fra Universitetet i Bergen i 2001. Jeg har lang forskningserfaring innen miljøtoksikologi, med spesialkompetanse i å anvende genomikk-baserte metoder. I min første postdoc ved NTNU (2001-2004) fikk jeg kompetanse innen funksjonell genomikk-baserte forskningsmetoder som for eksempel DNA mikroarray. Videre jobbet jeg som forker innen genomikk og toksikogenomikk ved Michael Sars Senter for Marin molekylærbiologi ved bruk av modellorganismen Oikopleura.
Siden doktorgrad arbeidet om miljøtoksikologi, mine hoved forsknings interesser har vært å studere hvordan miljøkjemikalier påvirker marine organismer, hovedsakelig ved bruk av fisk som modellorganismer. I over ti år som forsker (siden 2009) i Miljøtoksikologi gruppen (BIO, Universitetet i Bergen) har jeg gjort stor innsatts i å utvikle og bruke toksikogenomikk/omics-baserte metoder (hovedsakelig transkriptomikk) for å studere effekter av miljøkjemikalier mest i torsk (i prosjekter som iCod1, iCod2.0 og dCod1.0), samt andre fiskearter og Calanus (Nansen Legacy-prosjektet). Forsknings arbeidet omfatter for eksempel undersøkelse av effekter og virknings mekanismer samt utvikling av biomarkører for miljøgifter som hormonforstyrrende stoffer, metylkvikksølv, persistente organiske miljøgifter, «emerging contaminants» og petroleum forbindelser.
- (2023). Spawning time in adult polar cod (Boreogadus saida) altered by crude oil exposure, independent of food availability. Journal of Toxicology and Environmental Health, Part A. 1-24.
- (2023). Integrative omics-analysis of lipid metabolism regulation by peroxisome proliferator-activated receptor a and b agonists in male Atlantic cod. Frontiers in Physiology. 17 sider.
- (2023). Establishment of killer whale (Orcinus orca) primary fibroblast cell cultures and their transcriptomic responses to pollutant exposure. Environment International. 11 sider.
- (2023). Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua). Journal of Applied Toxicology. 1859-1871.
- (2022). Transcriptome responses in copepods Calanus finmarchicus, Calanus glacialis and Calanus hyperboreus exposed to phenanthrene and benzo[a]pyrene. Marine Genomics. 1-13.
- (2022). Single PFAS and PFAS mixtures affect nuclear receptor- and oxidative stress-related pathways in precision-cut liver slices of Atlantic cod (Gadus morhua). Science of the Total Environment.
- (2022). Photo-enhanced toxicity of crude oil on early developmental stages of Atlantic cod (Gadus morhua). Science of the Total Environment. 17 sider.
- (2022). Intestinal permeability and gene expression after polyethylene and polyamide microplastic ingestion in Wistar rats. Toxicology Letters. 35-41.
- (2022). Agonistic and potentiating effects of perfluoroalkyl substances (PFAS) on the Atlantic cod (Gadus morhua) peroxisome proliferator-activated receptors (Ppars). Environment International. 15 sider.
- (2021). Transcriptome responses in polar cod (Boreogadus saida) liver slice culture exposed to benzo[a]pyrene and ethynylestradiol: insights into anti-estrogenic effects. Toxicology in Vitro. 10 sider.
- (2021). Bioaccumulation of mercury and transcriptional responses in tusk (Brosme brosme), a deep-water fish from a Norwegian fjord. Chemosphere. 14 sider.
- (2020). ReCodLiver0.9: Overcoming Challenges in Genome-Scale Metabolic Reconstruction of a Non-model Species. Frontiers in Molecular Biosciences. 10 sider.
- (2020). Quantitative transcriptomics, and lipidomics in evaluating ovarian developmental effects in Atlantic cod (Gadus morhua) caged at a capped marine waste disposal site. Environmental Research. 1-11.
- (2020). Proteomics and lipidomics analyses reveal modulation of lipid metabolism by perfluoroalkyl substances in liver of Atlantic cod (Gadus morhua). Aquatic Toxicology. 13 sider.
- (2020). Molecular and Functional Properties of the Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a. Environmental Science and Technology. 1033-1044.
- (2020). Application of quantitative transcriptomics in evaluating the ex vivo effects of per- and polyfluoroalkyl substances on Atlantic cod (Gadus morhua) ovarian physiology. Science of the Total Environment. 1-11.
- (2019). Modulation of neuro-dopamine homeostasis in juvenile female Atlantic cod (Gadus morhua) exposed to polycyclic aromatic hydrocarbons and perfluoroalkyl substances. Environmental Science and Technology. 7036-7044.
- (2019). Effects of agricultural pesticides in aquafeeds on wild fish feeding on leftover pellets near fish farms. Frontiers in Genetics. 1-18.
- (2019). Contaminant accumulation and biological responses in Atlantic cod (Gadus morhua) caged at a capped waste disposal site in Kollevåg, Western Norway. Marine Environmental Research. 39-51.
- (2018). RNA-Seq analysis of transcriptome responses in Atlantic cod (Gadus morhua) precision-cut liver slices exposed to benzo[a]pyrene and 17α-ethynylestradiol. Aquatic Toxicology. 174-186.
- (2017). Quantitative proteomics analysis reveals perturbation of lipid metabolic pathways in the liver of Atlantic cod (Gadus morhua) treated with PCB 153. Aquatic Toxicology. 19-28.
- (2016). Quantitative analyses of the hepatic proteome of methylmercury-exposed Atlantic cod (Gadus morhua) suggest oxidative stress-mediated effects on cellular energy metabolism. BMC Genomics. 1-15.
- (2014). Liver transcriptome analysis of Atlantic cod (Gadus morhua) exposed to PCB 153 indicates effects on cell cycle regulation and lipid metabolism. BMC Genomics.
- (2013). Global transcriptome analysis of Atlantic cod (Gadus morhua) liver after in vivo methylmercury exposure suggests effects on energy metabolism pathways. Aquatic Toxicology. 314-325.
- (2012). Conservation and divergence of chemical defense system in the tunicate Oikopleura dioica revealed by genome wide response to two xenobiotics. BMC Genomics. 17 sider.
- (2010). Plasticity of Animal Genome Architecture Unmasked by Rapid Evolution of a Pelagic Tunicate. Science. 1381-1385.
- (2005). Identification of novel growth factor-responsive genes in neuroendocrine gastrointestinal tumour cells. British Journal of Cancer. 1506-16.
- (2004). XHM: a system for detection of potential cross hybridizations in DNA microarrays. BMC Bioinformatics.
- (2004). Gene expression based classification of gastric carcinoma. . Cancer Letters. 227-237.
- (2003). Liver gene expression in rats in response to the peroxisome proliferator-activated receptor-alpha agonist ciprofibrate. Physiological Genomics. 9-19.
- (2002). Effects of 4-nonylphenol on gene expression of pituitary hormones in juvenile Atlantic salmon (Salmo salar). . Aquatic Toxicology. 113-129.
- (2001). In vivo modulation of nonylphenol-induced zonagenesis and vitellogenesis by the antiestrogen, 3,3'4,4'-tetrachlorobiphenyl (PCB-77) in juvenile fish. Environmental Toxicology and Pharmacology. 5-15.
- (1999). Salmon Eggshell Protein Expression: A Marker for Environmental Estrogens. Marine Biotechnology. 252-260.
- (1999). Induction of hepatic estrogen receptor in juvenile Atlantic salmon in vivo by the environmental estrogen, 4-nonylphenol. Science of the Total Environment. 201-210.
- (2022). Seasonal Cruise Q3: Cruise Report . 27. 27. .
- (2023). Dexamethasone-associated metabolic effects in Atlantic cod.
- (2022). Complex mixture and omics responses in Atlantic cod: a time- and dose-response study.
- (2019). A draft metabolic reconstruction of Atlantic cod (Gadus morhua) liver: how to and what for?
- (2018). Marine Pollution Monitoring for Contaminants Using Biomarkers.
- (2018). Characterization of the Atlantic cod (Gadus morhua) Aryl hydrocarbon receptors Ahr1a and Ahr2a.
- (2018). Toxicogenomics of Atlantic cod.
- (2023). Toxicogenomics using precision-cut liver slice culture in fish .
- (2022). Multigenerational effects of crude oil in Atlantic cod early life stages.
- (2022). Effects of parental exposure to a crude oil water-soluble fraction on the fertilization success and embryo development in Atlantic cod (Gadus morhua).
- (2021). Genomic responses to pollutants in Arctic fish and copepod species.
- (2020). Polar cod and Goliat: How an oil spill may affect polar cod reproduction.
- (2020). Adapting a liver slice culture method for ex vivo toxicological studies in arctic and sub-arctic fish species during sampling cruises.
- (2020). ANTIESTROGENIC EFFECTS OF BENZO[a]PYRENE REVEALED BY TRANSCRIPTOME ANALYSIS IN POLAR COD LIVER SLICE CULTURE.
- (2020). A multi-omics approach to study Ppar-mediated regulation of lipid metabolism in Atlantic cod (Gadus morhua).
- (2019). dCOD 1.0: DECODING THE SYSTEMS TOXICOLOGY OF ATLANTIC COD (GADUS MORHUA) – HIGHLIGHTS SO FAR.
- (2019). Toxicogenomic responses in Atlantic cod (Gadus morhua) after treatment with selected environmental contaminants in vivo and ex vivo.
- (2019). In vitro assessment of estrogenic and androgenic effects of bisphenols on Atlantic cod (Gadus morhua).
- (2019). Effects of agricultural pesticides in aquafeeds on wild fish feeding on leftover pellets near fish farms. Conference talk.
- (2019). EFFECTS OF SELECTED ENVIRONMENTAL ESTROGENS ON EXPRESSION OF FIBROBLAST GROWTH FACTOR SIGNALING PATHWAY GENES IN THE LIVER OF ATLANTIC COD (GADUS MORHUA) IN VIVO AND EX VIVO.
- (2019). Contaminant accumulation and biological responses in Atlantic cod (Gadus morhua) exposed to polycyclic aromatic hydrocarbons and perfluoroalkyl substances.
- (2019). Biological responses of Atlantic cod (Gadus morhua) exposed to polycyclic aromatic hydrocarbons and perfluoroalkyl substances.
- (2019). Assessment of endocrine disrupting effects of bisphenols in Atlantic cod (Gadus morhua) using luciferase reporter assays and precision-cut liver slices.
- (2018). dCOD 1.0: DECODING THE SYSTEMS TOXICOLOGY OF ATLANTIC COD (GADUS MORHUA).
- (2018). The nuclear receptor complement of Atlantic cod (Gadus morhua) as potential targets for endocrine disrupting compounds.
- (2018). RNA-seq analysis of transcriptome responses in Atlantic cod (Gadus morhua) precision cut liver slices exposed to benzo[a]pyrene and 17α-ethynylestradiol.
- (2018). RNA-seq analysis of transcriptome responses in Atlantic cod (Gadus morhua) precision cut liver slices exposed to benzo[a]pyrene and 17α-ethynylestradiol.
- (2018). Marine Environmental Pollution and Monitoring Using Biomarkers in Fish.
- (2018). Ecotoxicological responses in Atlantic cod (Gadus morhua) after caging at a capped waste disposal site in Kollevåg, Western Norway .
- (2018). Ecotoxicological responses in Atlantic cod (Gadus morhua) after caging at a capped waste disposal site in Kollevåg, Western Norway .
- (2018). Discovering pathway perturbations with topological edge set enrichment analysis (TESEA).
- (2018). Characterization of the aryl hydrocarbon receptors Ahr1a and Ahr2a in Atlantic cod (Gadus morhua).
- (2018). Characterization of the aryl hydrocarbon receptors Ahr1a and Ahr2a in Atlantic cod (Gadus morhua).
- (2018). Characterization of the Atlantic cod (Gadus morhua) Aryl hydrocarbon receptors Ahr1a and Ahr2a.
- (2018). Characterization of the Atlantic cod (Gadus morhua) Aryl hydrocarbon receptors Ahr1a and Ahr2a.
- (2017). PRECISION-CUT LIVER SLICES (PCLS) FOR TOXICOGENOMIC STUDIES IN ATLANTIC COD (Gadus morhua): THE dCOD 1.0 PROJECT.
- (2017). Integrative transcriptome and proteome analysis reveals perturbation of lipid metabolic pathways in the liver of Atlantic cod (Gadus morhua) treated with PCB 153.
- (2017). Ecotoxicological responses in Atlantic cod (Gadus morhua) after caging at a capped waste disposal site in Kollevåg, Western Norway .
- (2017). CHARACTERIZATION OF THE ARYL HYDROCARBON RECEPTORS AHR1B AND AHR2 IN ATLANTIC COD (GADUS MORHUA).
- (2016). Toxicogenomics as a tool for understanding responses to pollutants in organisms: Using Atlantic cod (Gadus morhua) and a systems biology approach to environmental toxicology.
- (2016). Integrative -omics analyses reveal perturbation of lipid metabolic pathways in the liver of Atlantic cod (Gadus morhua) exposed to the persistent organic pollutant PCB 153.
- (2011). Genome-wide gene expression and proteome analysis of cod (Gadus morhua) liver after treatment with methylmecury and PCB153.
- (2012). Integrative environmental genomics of cod (Gadus morhua) reveal the mechanisms underlying MeHg- and PCB153 induced toxicity. Comparative Biochemistry and Physiology A. S49-S49.
- (2022). Transcriptome responses in copepods Calanus finmarchicus, Calanus glacialis and Calanus hyperboreus exposed to phenanthrene and benzo[a]pyrene.
- (2022). Reproductive development in polar cod (Boreogadus saida) exposed to crude oil and food variability.
- (2021). Development of a battery of Atlantic cod receptor-based reporter bioassays for assessing environmental toxicity of sediments and chemicals.
- (2019). dCOD 1.0: DECODING THE SYSTEMS TOXICOLOGY OF ATLANTIC COD (GADUS MORHUA) – HIGHLIGHTS SO FAR.
- (2019). Sensitivity of adult polar cod (Boreogadus saida) to the water-soluble fraction of crude oil under low and high food regimes.
- (2019). In vitro assessment of estrogenic effects of bisphenols on Atlantic cod (Gadus morhua).
- (2019). Evaluation of estrogenic effects of bisphenols using luciferase reporter assay and Atlantic cod (Gadus morhua) liver slice culture.
- (2019). A draft metabolic reconstruction of Atlantic cod (Gadus morhua) liver .
- (2018). Persistent homology and network analyses reveal key gene interactions affected by environmental pollutants in Atlantic cod.
- (2017). dCod 1.0: decoding the systems toxicology of Atlantic cod (Gadus morhua).
- (2017). dCod 1.0: decoding the systems toxicology of Atlantic cod (Gadus morhua) - WP8: biomarkers and xenosensors.
- (2017). dCod 1.0: decoding the systems toxicology of Atlantic cod (Gadus morhua) - WP8: biomarkers and xenosensors.
- (2017). dCod 1.0 decoding the systems toxicology of Atlantic cod.
- (2017). Using precision-cut liver slices (PCLS) and luciferase reporter gene assays to characterise the aryl hydrocarbon receptors (Ahr) in Atlantic cod (Gadus morhua).
- (2017). Using precision-cut liver slices (PCLS) and luciferase reporter gene assays to characterise the aryl hydrocarbon receptors (Ahr) in Atlantic cod (Gadus morhua).
- (2017). Using precision cut liver slices (PCLS) for studying effects of environmental contaminants on the Atlantic cod (Gadus morhua) lipid metabolism.
- (2017). Studying estrogenic effects of environmental pollutants by using the Atlantic cod (Gadus morhua) estrogen receptor α and a reporter gene assay.
- (2017). Ecotoxicological responses in Atlantic cod (Gadus morhua) following caging near a previously capped waste disposal site in Kollevågen, Askøy, Norway .
- (2017). Ecotoxicological responses in Atlantic cod (Gadus morhua) following caging near a previously capped waste disposal site in Kollevågen, Askøy, Norway .
- (2017). Ecotoxicological responses in Atlantic cod (Gadus morhua) following caging near a previously capped waste disposal site in Kollevågen, Askøy, Norway .
- (2016). Systems Toxicology Studies to Investigate Mechanisms of Toxicity of Environmental Chemicals Using Atlantic cod (Gadus morhua) as a Model Organism.
- (2016). Integrated analysis of transcriptome and proteome reveals perturbation of lipid metabolic pathways in the liver of Atlantic cod (Gadus morhua) treated with the persistent organic pollutant PCB 153 .
- (2016). Effektar på lipidmetabolismen til atlanterhavstorsk (Gadus morhua) etter eksponering mot enkeltsambindingar og blandingar av miljøgiftar.
- (2005). Gene expression analysis and clinical diagnosis. Clinica Chimica Acta.