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Hormone Laboratory Research Group

The Rho GTPase RND3 regulates adipocyte lipolysis. Dankel SN, Røst TH, Kulyté A, Fandalyuk Z, Skurk T, Hauner H, Sagen JV, Rydén M, Arner P, Mellgren G. Metabolism, 2019 Dec;101:153999. doi: 10.1016/j.metabol.2019.153999. Epub 2019 Oct 28.

IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. Bjune JI, Haugen C, Gudbrandsen OA, Nordbø OP, Nielsen HJ, Våge V, Njølstad PR, Sagen JV, Dankel SN, Mellgren G. Int J Obes (Lond), 2019 Nov;43(11):2151-2162.

 The homeobox factor Irx3 maintains adipogenic identity. Bjune JI, Dyer L, Røsland GV, Tronstad KJ, Njølstad PR, Sagen   JV, Dankel SN, Mellgren G. Metabolism, 2019 Nov 18;103:154014. doi: 10.1016/j.metabol.2019.154014.

 Gene editing - a collective responsibility. Dankel DJ, Dankel SN. Tidsskrift for den Norske Lægeforening, 2019 Nov 4;   4;139(16).

Testicular ultrasound to stratify hormone references in a cross-sectional Norwegian study of male puberty. Madsen A, Oehme NB, Roelants M, Bruserud IS, Eide GE, Viste K, Bjerknes R, Almås B, Rosendahl K, Sagen JV, Mellgren G, Juliusson PB. J Clin Endocrinol Metab. 2019 Oct 26. pii: dgz094. doi:10.1210/clinem/dgz094 

Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis. Gudbrandsen OA, Dankel SN, Skumsnes L, Flølo TN, Folkestad OH, Nielsen HJ, Våge V, Mohn AC, Nedrebø BG, Sagen JV, Fernø J, Mellgren G. Sci Rep. 9 Oct 15; 9(1):14817. doi: 10.1038/s41598-019-51347-x.PMID: 31616017 Free PMC article.

Glucagon Control on Food Intake and Energy Balance. Al-Massadi O, Fernø J, Diéguez C, Nogueiras R, Quiñones M. Int J Mol Sci. 2019 Aug 11;20(16):3905. doi: 10.3390/ijms20163905.PMID: 31405212 Free PMC article. Review.

TMAO, creatine and 1-methylhistidine in serum and urine are potential biomarkers of cod and salmon intake: a randomised clinical trial in adults with overweight or obesity. Hagen IV, Helland A, Bratlie M, Midttun Ø, McCann A, Sveier H, Rosenlund G, Mellgren G, Ueland PM, Gudbrandsen OA. Eur J Nutr. 2019 Aug 10. doi: 10.1007/s00394-019-02076-4. 

Urine and plasma concentrations of amino acids and plasma vitamin status differ, and are differently affected by salmon intake, in obese Zucker fa/fa rats with impaired kidney function and in Long-Evans rats with healthy kidneys. Drotningsvik A, Midttun Ø, Vikøren LA, McCann A, Ueland PM, Mellgren G, Gudbrandsen OA. Br J Nutr. 2019 Aug 9:1-12  

Drug monitoring of tamoxifen metabolites predicts vaginal dryness and verifies a low discontinuation rate from the Norwegian Prescription Database. Helland T, Hagen KB, Haugstøyl ME, Kvaløy JT, Lunde S, Lode K, Lind RA, Gripsrud BH, Jonsdottir K, Gjerde J, Bifulco E, Hustad S, Jonassen J, Aas T, Lende TH, Lien EA, Janssen EAM, Søiland H, Mellgren G. Breast Cancer Res Treat 2019 Aug;177(1):185-195.  

Retained NK Cell Phenotype and Functionality in Non-alcoholic Fatty Liver Disease. Stiglund N, Strand K, Cornillet M, Stål P, Thorell A, Zimmer CL, Näslund E, Karlgren S, Nilsson H, Mellgren G, Fernø J, Hagström H, Björkström NK. Front Immunol. 2019 Jun 4;10:1255. doi: 10.3389/fimmu.2019.01255. eCollection 2019.PMID: 31214196 Free PMC article.

Exciting advances in GPCR-based drugs discovery for treating metabolic disease and future perspectives. Quiñones M, Fernø J, Diéguez C, Nogueiras R, Al-Massadi O. Expert Opin Drug Discov. 2019 May;14(5):421-431. doi: 10.1080/17460441.2019.1583642. Epub 2019 Mar 1. PMID: 30821530 Review.

Plasma Amino Acids and Incident Type 2 Diabetes in Patients With Coronary Artery Disease. McCann A, Giil LM, Ulvik A, Seifert R, Rebnord EW, Pedersen ER, Svingen GFT, Meyer K, Strand E, Dankel S, Ueland PM, Nygård OK. Diabetes Care, 2019 Apr 29. pii: dc182217.

Membrane metallo-endopeptidase (Neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes.  Ramirez A, Dankel S, Cai W, Sakaguchi M, Kasif S, Kahn CR. Mol Metab. 2019 Apr;22;21-36.

Prognostic impact of genetic variants of CYP19A1 and UGT2B17 in a randomized trial for endocrine-responsive postmenopausal breast cancer. Johansson H, Aristarco V, Gandini S, Gjerde J, Macis D, Guerrieri-Gonzaga A, Serrano D, Lazzeroni M, Rajasekaran A, Williard CV, Mellgren G, DeCensi A, Bonanni B. Pharmacogenomics J. 2019 Apr 10. doi: 10.1038/s41397-019-0087-z.  

Effects of low doses of fish and milk proteins on glucose regulation and markers of insulin sensitivity in overweight adults: a randomised, double blind study. Hovland IH, Leikanger IS, Stokkeland O, Waage KH, Mjøs SA, Brokstad KA, McCann A, Ueland PM, Slizyte R, Carvajal A, Mellgren G, Remman T, Høgøy I, Gudbrandsen OA. Eur J Nutr. 2019 Apr 10. doi: 10.1007/s00394-019-01963-0.  

Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice. Svärd J, Røst TH, Sommervoll CEN, Haugen C, Gudbrandsen OA, Mellgren AE, Rødahl E, Fernø J, Dankel SN, Sagen JV, Mellgren G. Sci Rep. 2019 Mar 15;9(1):4614. doi: 10.1038/s41598-018-37501-x.PMID: 30874564 Free PMC article.