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Hormone Laboratory Research Group

IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. Bjune JI, Haugen C, Gudbrandsen O, Nordbø OP, Nielsen HJ, Våge V, Njølstad PR, Sagen JV, Dankel SN, Mellgren G. Int J Obes (Lond). 2018 Dec 11  

Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress. González-García I, Contreras C, Estévez-Salguero Á, Ruíz-Pino F, Colsh B, Pensado I, Liñares-Pose L, Rial-Pensado E, Martínez de Morentin PB, Fernø J, Diéguez C, Nogueiras R, Le Stunff H, Magnan C, Tena-Sempere M, López M. Cell Rep. 2018 Oct 9;25(2):413-423.e5. doi: 10.1016/j.celrep.2018.09.038.PMID: 30304681 Free PMC article.

Salmon Fillet Intake Led to Higher Serum Triacylglycerol in Obese Zucker Fa/Fa Rats But Not in Normolipidemic Long-Evans Rats. Vikøren LA, Drotningsvik A, Mjøs SA, Mellgren G, Gudbrandsen OA. Nutrients. 2018 Oct 8;10(10). pii: E1459. doi: 10.3390/nu10101459.  

mTOR signaling in the arcuate nucleus of the hypothalamus mediates the anorectic action of estradiol. González-García I, Martínez de Morentin PB, Estévez-Salguero Á, Contreras C, Romero-Picó A, Fernø J, Nogueiras R, Diéguez C, Tena-Sempere M, Tovar S, López M. J Endocrinol. 2018 Sep;238(3):177-186. doi: 10.1530/JOE-18-0190. Epub 2018 Jun 18. PMID: 29914932 Free PMC article.

p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1. Quiñones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-Tóvolli R, García-Caceres C, Hernandez-Bautista R, Lam BYH, Beiroa D, Sanchez-Rebordelo E, Senra A, Malagon JA, Valerio P, Fondevila MF, Fernø J, Malagon MM, Contreras R, Pfluger P, Brüning JC, Yeo G, Tschöp M, Diéguez C, López M, Claret M, Kloppenburg P, Sabio G, Nogueiras R. Nat Commun. 2018 Aug 24; 9(1):3432. doi: 10.1038/s41467-018-05711-6.PMID: 30143607 Free PMC article.

A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells. Bozickovic O, Skartveit L, Engelsen AST, Helland T, Jonsdottir K, Flågeng MH, Fenne IS, Janssen E, Lorens JB, Bjørkhaug L, Sagen JV, Mellgren G. J Steroid Biochem Mol Biol. 2018 Jul 23. pii: S0960-0760(17)30406-5. doi: 10.1016/j.jsbmb.2018.07.011.  

LC-MS/MS based profiling and dynamic modelling of the steroidogenesis pathway in adrenocarcinoma H295R cells.Ahmed KEM,  Frøysa HG, Karlsen OA, Sagen JV, Mellgren G, Verhaegen S, Ropstad E, Goksøyr A, Kellmann R. Toxicol In Vitro. 2018 Jul 11;52:332-341. doi: 10.1016/j.tiv.2018.07.002.  

Intake of Baked Cod Fillet Resulted in Lower Serum Cholesterol and Higher Long Chain n-3 PUFA Concentrations in Serum and Tissues in Hypercholesterolemic Obese Zucker fa/fa Rats. Vikøren LA, Drotningsvik A, Bergseth MT, Mjøs SA, Austgulen MH, Mellgren G, Gudbrandsen OA. Nutrients. 2018 Jun 28;10(7).  

Daily Intake of Protein from Cod Residual Material Lowers Serum Concentrations of Nonesterified Fatty Acids in Overweight Healthy Adults: A Randomized Double-Blind Pilot Study. Vildmyren I, Cao HJV, Haug LB, Valand IU, Eng Ø, Oterhals Å, Austgulen MH, Halstensen A, Mellgren G, Gudbrandsen OA. Mar Drugs. 2018 Jun 5;16(6).  

The Effect of Lean-Seafood and Non-Seafood Diets on Fasting and Postprandial Serum Metabolites and Lipid Species: Results from a Randomized Crossover Intervention Study in Healthy Adults. Schmedes M, Balderas C, Aadland EK, Jacques H, Lavigne C, Graff IE, Eng Ø, Holthe A, Mellgren G, Young JF, Sundekilde UK, Liaset B, Bertram HC. Nutrients. 2018 May 11;10(5). pii: E598. doi: 10.3390/nu10050598.  

Plasma ANGPTL-4 is Associated with Obesity and Glucose Tolerance: Cross-Sectional and Longitudinal Findings. Barja-Fernandez S, Moreno-Navarrete JM, Folgueira C, Xifra G, Sabater M, Castelao C, Fernø J, Leis R, Diéguez C, Casanueva FF, Ricart W, Seoane LM, Fernandez-Real JM, Nogueiras R. Mol Nutr Food Res. 2018 May;62(10):e1800060. doi: 10.1002/mnfr.201800060. Epub 2018 Apr 30. PMID: 29536615 Clinical Trial.

The Effect of Lean-Seafood and Non-Seafood Diets on Fecal Metabolites and Gut Microbiome: Results From a Randomized Crossover Intervention Study. Schmedes M, Brejnrod AD, Aadland EK, Kiilerich P, Kristiansen K, Jacques H, Lavigne C, Graff IE, Eng Ø, Holthe A, Mellgren G, Young JF, Sundekilde UK, Liaset B, Bertram HC. Mol Nutr Food Res. 2018 Mar 6. doi: 10.1002/mnfr.201700976.  

The short cosyntropintest revisited - new normal reference range using LCMSMS. Ueland GÅ, Methlie P, Øksnes M, Thordarson HB, Sagen J, Kellmann R, Mellgren G, Ræder M, Dahlqvist P, Dahl SR, Thorsby PM, Løvås K, Husebye ES. J Clin Endocrinol Metab. 2018 Feb 14. doi: 10.1210/jc.2017-02602.  

Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis. Porteiro B, Fondevila MF, Buque X, Gonzalez-Rellan MJ, Fernandez U, Mora A, Beiroa D, Senra A, Gallego R, Fernø J, López M, Sabio G, Dieguez C, Aspichueta P, Nogueiras R. Mol Metab. 2018 Feb 8: 132-143. doi: 10.1016/j.molmet.2017.12.005. Epub 2017 Dec 15. PMID: 29290620 Free PMC article.

Inflammatory markers, the tryptophan-kynurenine pathway, and vitamin B status after bariatric surgery. Christensen MHE, Fadnes DJ, Røst TH, Pedersen ER, Andersen JR, Våge V, Ulvik A, Midttun Ø, Ueland PM, Nygård OK, Mellgren G. PLoS One. 2018 Feb 5;13(2):e0192169. doi: 10.1371/journal.pone.0192169. eCollection 2018.  

Diets containing salmon fillet delay development of high blood pressure and hyperfusion damage in kidneys in obese Zucker fa/fa rats. Vikøren LA, Drotningsvik A, Mwakimonga A, Leh S, Mellgren G, Gudbrandsen OA. J Am Soc Hypertens. 2018 Feb 2. pii: S1933-1711(18)30007-X. doi: 10.1016/j.jash.2018.01.006.