We study mechanisms of molecular crosstalk inside and between cells in the tumor and tissue microenvironment, including signaling, metabolism and extracellular matrix interactions. We are using multidisciplinary approaches involving molecular and cellular biology, animal research, computational approaches and translational research to characterize mechanisms of disease and drugs. The different research groups in this unit focus on specific (patho)mechanistic aspects related to metabolic dysfunction, inflammation, fibrosis and immune system dysregulation, in cancer and other diseases such as cardiovascular disease and ME/CFS. The research groups have widespread collaborations with academic, clinical, and industrial partners.