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Eirik Bratland

Researcher
  • E-mailEirik.Bratland@uib.no
  • Phone+47 55 97 58 46
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Aslaksen, Sigrid; Wolff, Anette Susanne Bøe; Vigeland, Magnus Dehli; Breivik, Lars Ertesvåg; Sheng, Ying; Oftedal, Bergithe Eikeland; Skinningsrud, Beate; Undlien, Dag Erik; Selmer, Kaja Kristine; Husebye, Eystein Sverre; Bratland, Eirik. 2019. Identification and characterization of rare Toll-like receptor 3 variants in patients with autoimmune Addison’s disease. Journal of translational autoimmunity.
  • Aslaksen, Sigrid; Methlie, Paal; Vigeland, Magnus Dehli; Jøssang, Dag Eirik; Wolff, Anette Susanne Bøe; Sheng, Ying; Oftedal, Bergithe Eikeland; Skinningsrud, Beate; Undlien, Dag Erik; Selmer, Kaja Kristine; Husebye, Eystein Sverre; Bratland, Eirik. 2019. Coexistence of congenital adrenal hyperplasia and autoimmune Addison's disease. Frontiers in Endocrinology. 1-5.
  • Hellesen, Alexander; Bratland, Eirik. 2018. The potential role for infections in the pathogenesis of autoimmune Addison?s disease. Clinical and Experimental Immunology. 1-12.
  • Hjøllo, Torunn; Bratland, Eirik; Steinsland, Hans; Radunovic, Matej; Langeland, Nina; Hanevik, Kurt. 2018. Longitudinal cohort study of serum antibody responses towards Giardia lamblia variant-specific surface proteins in a non-endemic area. Experimental parasitology. 66-72.
  • Hellesen, Alexander; Bratland, Eirik; Husebye, Eystein Sverre. 2018. Autoimmune Addison's disease – An update on pathogenesis. Annales d'Endocrinologie. 157-163.
  • Bahador, Marzieh; Gras Navarro, Andrea; Rahman, Mohummad Aminur; Dominguez Valentin, Mev; Sarowar, Shahin; Ulvestad, Elling; Njølstad, Gro; Lie, Stein Atle; Kristoffersen, Einar Klæboe; Bratland, Eirik; Enger, Martha Chekenya. 2017. Increased infiltration and tolerised antigen-specific CD8+ TEM cells in tumor but not peripheral blood have no impact on survival of HCMV+ glioblastoma patients. Oncoimmunology. 1-15.
  • Bruserud, Øyvind; Bratland, Eirik; Hellesen, Alexander; Delaleu, Nicolas; Reikvam, Håkon; Oftedal, Bergithe Eikeland; Wolff, Anette Susanne Bøe. 2017. Altered immune activation and IL-23 signaling in response to Candida albicans in autoimmune polyendocrine syndrome type 1. Frontiers in Immunology. 1-10.
  • Hetemäki, Iivo; Jarva, Hanna; Kluger, Nicolas; Baldauf, Hanna-Mari; Laakso, Sini; Bratland, Eirik; Husebye, Eystein Sverre; Kisand, Kai; Ranki, Annamari; Peterson, Pärt; Arstila, T.Petteri. 2016. Anticommensal responses are associated with regulatory T cell defect in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients. Journal of Immunology. 2955-2964.
  • Edvardsen, Kine Susann Waade; Hellesen, Alexander; Husebye, Eystein Sverre; Bratland, Eirik. 2016. Analysis of cellular and humoral immune responses against cytomegalovirus in patients with autoimmune Addison's disease. Journal of Translational Medicine.
  • Bruserud, Øyvind; Oftedal, Bergithe Eikeland; Landegren, Nils; Erichsen, Martina Moter; Bratland, Eirik; Lima, Kari; Jørgensen, Anders Palmstrøm; Myhre, Anne Grethe; Svartberg, Johan; Fougner, Kristian J; Bakke, Åsne; Nedrebø, Bjørn Gunnar; Mella, Bjarne; Breivik, Lars Ertesvåg; Viken, Marte K; Knappskog, Per; Cuida Marthinussen, Ileana Mihaela; Løvås, Kristian; Kämpe, Olle; Wolff, Anette Susanne Bøe; Husebye, Eystein Sverre. 2016. A longitudinal follow-up of autoimmune polyendocrine syndrome type 1. Journal of Clinical Endocrinology and Metabolism. 2975-2983.
  • Edvardsen, Kine Susann Waade; Bjånesøy, Trine Elholm; Hellesen, Alexander; Breivik, Lars Ertesvåg; Bakke, Marit; Husebye, Eystein Sverre; Bratland, Eirik. 2015. Peripheral blood cells from patients with autoimmune Addison's disease poorly respond to interferons in vitro, despite elevated serum levels of interferon-inducible chemokines. Journal of Interferon and Cytokine Research. 759-770.
  • Fichna, Marta; Zurawek, Magdalena; Bratland, Eirik; Husebye, Eystein Sverre; Kasperlik-Zaluska, Anna; Czarnocka, Barbara; Januszkiewicz-Lewandowska, Danuta; Nowak, Jerzy. 2015. Interleukin-2 and subunit alpha of its soluble receptor in autoimmune Addison's disease - An association study and expression analysis. Autoimmunity. 100-107.
  • Astor, Marianne; Løvås, Kristian; Wolff, Anette Susanne Bøe; Nedrebø, Bjørn Gunnar; Bratland, Eirik; Steen-Johnsen, Jon; Husebye, Eystein Sverre. 2015. Hypomagnesemia and functional hypoparathyroidism due to novel mutations in the Mg-channel TRPM6. Endocrine Connections. 215-222.
  • Oftedal, Bergithe Eikeland; Hellesen, Alexander; Erichsen, Martina Moter; Bratland, Eirik; Vardi, Ayelet; Perheentupa, Jaakko; Kemp, E. Helen; Fiskerstrand, Torunn; Viken, Marte K; Weetman, Anthony P.; Fleishman, Sarel J.; Banka, Siddharth; Newman, William G.; Sewell, William A. Carrock; Sozaeva, Leila S.; Zayats, Tetyana; Haugarvoll, Kristoffer; Orlova, Elizaveta M.; Haavik, Jan; Johansson, Stefan; Knappskog, Per; Løvås, Kristian; Wolff, Anette Susanne Bøe; Abramson, Jakub; Husebye, Eystein Sverre. 2015. Dominant mutations in the autoimmune regulator AIRE are associated with common organ-specific autoimmune diseases. Immunity. 1185-1196.
  • Hellesen, Richard Alexander; Edvardsen, Kine Susann Waade; Breivik, Lars Ertesvåg; Husebye, Eystein Sverre; Bratland, Eirik. 2014. The effect of types I and III interferons on adrenocortical cells and its possible implications for autoimmune Addison's disease. Clinical and Experimental Immunology. 351-362.
  • Dawoodji, Amina; Chen, Ji-Li; Shepherd, Dawn; Dalin, Frida; Tarlton, Andrea; Alimohammadi, Mohammad; Penna-Martinez, Marissa; Meyer, Gesine; Mitchell, Anna L.; Gan, Earn H.; Bratland, Eirik; Bensing, Sophie; Husebye, Eystein Sverre; Pearce, Simon H.; Badenhoop, Klaus; Kämpe, Olle; Cerundolo, Vincenzo. 2014. High frequency of cytolytic 21-hydroxylase-specific CD8+ T cells in autoimmune Addison's disease patients. Journal of Immunology. 2118-2126.
  • Brønstad, Ingeborg; Breivik, Lars Ertesvåg; Methlie, Paal; Wolff, Anette Susanne Bøe; Bratland, Eirik; Nermoen, Ingrid; Løvås, Kristian; Husebye, Eystein Sverre. 2014. Functional studies of novel CYP21A2 mutations detected in Norwegian patients with congenital adrenal hyperplasia. Endocrine Connections. 67-74.
  • Brønstad, Ingeborg; Skinningsrud, Beate; Bratland, Eirik; Løvås, Kristian; Undlien, Dag Erik; Husebye, Eystein Sverre; Wolff, Anette Susanne Bøe. 2014. CYP21A2 polymorphisms in patients with autoimmune Addison's disease, and linkage disequilibrium to HLA risk alleles. European Journal of Endocrinology. 743-750.
  • Bjånesøy, Trine Elholm; Kulle, Bettina; Bratland, Eirik; Reiner, Andrew Henry; Islam, Shahinul; Husebye, Eystein Sverre; Bakke, Marit. 2014. Altered DNA methylation profile in Norwegian patients with Autoimmune Addison's Disease. Molecular Immunology. 208-216.
  • Breivik, Lars Ertesvåg; Oftedal, Bergithe Eikeland; Wolff, Anette Susanne Bøe; Bratland, Eirik; Orlova, Elizaveta M.; Husebye, Eystein Sverre. 2014. A novel cell-based assay for measuring neutralizing autoantibodies against type I interferons in patients with autoimmune polyendocrine syndrome type 1. Clinical Immunology. 220-227.
  • Bratland, Eirik; Hellesen, Alexander; Husebye, Eystein Sverre. 2013. Induction of CXCL10 chemokine in adrenocortical cells by stimulation through toll-like receptor 3. Molecular and Cellular Endocrinology. 75-83.
  • Bratland, Eirik; Magitta, Ng'weina Francis; Wolff, Anette Susanne Bøe; Ekern, Trude; Knappskog, Per; Kämpe, Olle; Haavik, Jan; Husebye, Eystein Sverre. 2013. Autoantibodies against aromatic amino acid hydroxylases in patients with autoimmune polyendocrine syndrome type 1 target multiple antigenic determinants and reveal regulatory regions crucial for enzymatic activity. Immunobiology. 899-909.
  • Bratland, Eirik; Husebye, Eystein Sverre. 2011. Cellular immunity and immunopathology in autoimmune Addison’s disease. Molecular and Cellular Endocrinology. 180-190.
  • Bratland, Eirik; Bredholt, Geir; Mellgren, Gunnar; Knappskog, Per; Mozes, Edna; Husebye, Eystein Sverre. 2009. The purification and application of biologically active recombinant steroid cytochrome P450 21-hydroxylase: The major autoantigen in autoimmune Addison's disease. Journal of Autoimmunity. 58-67.
  • Bratland, Eirik; Skinningsrud, B; Undlien, Dag Erik; Mozes, Edna; Husebye, Eystein Sverre. 2009. T Cell Responses to Steroid Cytochrome P450 21-Hydroxylase in Patients with Autoimmune Primary Adrenal Insufficiency. Journal of Clinical Endocrinology and Metabolism. 5117-5124.
  • Oftedal, Bergithe Eikeland; Wolff, Anette Susanne Bøe; Bratland, Eirik; Kämpe, Olle; Perheentupa, Jaakko; Myhre, Anne Grethe; Meager, Anthony; Purushothaman, Radhika; Ten, Svetlana; Husebye, Eystein Sverre. 2008. Radioimmunoassay for autoantibodies against interferon omega; its use in the diagnosis of autoimmune polyendocrine syndrome type I. Clinical Immunology. 163-169.
  • Bratland, Eirik; Wolff, Anette Susanne Bøe; Haavik, Jan; Kämpe, Olle; Sköldberg, Filip; Perheentupa, Jaakko; Bredholt, Geir; Knappskog, Per; Husebye, Eystein S.Junior. 2007. Epitope mapping of human aromatic L-amino acid decarboxylase. Biochemical and Biophysical Research Communications - BBRC. 692-698.
  • Husebye, Eystein S.Junior; Bratland, Eirik; Bredholt, Geir; Fridkin, Mati; Dayan, Molly; Mozes, Edna. 2006. The substrate-binding domain of 21-hydroxylase, the main autoantigen in autoimmune Addison's disease, is an immunodominant T cell epitope. Endocrinology. 2411-2416.
Doctoral dissertation
  • Hellesen, Alexander. 2016. Immuno-endocrine interactions in autoimmune Addison's disease.
  • Edvardsen, Kine Susann Waade. 2015. Autoimmunity and viral immunity in Addison’s disease.
  • Bratland, Eirik. 2009. Cellular immunity in autoimmune Addison's disease : T cell responses to steroid cytochrome P450 21-hydroxylase.
Abstract
  • Brønstad, Ingeborg; Skinningsrud, Beate; Wolff, Anette Susanne Bøe; Bratland, Eirik; Løvås, Kristian; Knappskog, Per; Undlien, Dag Erik; Husebye, Eystein Sverre. 2013. Characterisation of the CYP21A2 Gene in Patients with Autoimmune Addison's Disease. Scandinavian Journal of Immunology. 310-310.
  • Hellesen, A; Bratland, Eirik; Husebye, Eystein Sverre. 2012. Poly (I:C)-induced CXCL10 production in adrenocortical cells - implications for autoimmune Addison's disease? Immunology. 300-301.
  • Bratland, Eirik; Hellesen, Richard Alexander; Husebye, Eystein Sverre. 2012. Mice deficient for the autoimmune regulator, Aire, display altered T cell responses against 21-hydroxylase, the major autoantigen in autoimmune Addison's disease. Immunology. 542-542.
  • Hetemaki, I; Jarva, H; Tervo, H.; Bratland, Eirik; Kisand, K; Peterson, P; Arstila, TP. 2012. Increased antibody levels against gut commensals are associated with regulatory T cell defect in patients with APECED. Immunology. 421-421.
  • Hellesen, Richard Alexander; Bratland, Eirik; Husebye, Eystein Sverre. 2011. Endogenous Production of CXC Chemokine Ligand 10 (CXCL10) by Adrenocortical Cells and its Implications for Autoimmune Addison's Disease. Scandinavian Journal of Immunology. 371-371.
  • Bratland, Eirik; Husebye, Eystein Sverre. 2010. The Possible Roles of Interferon-Gamma, CXC Chemokine Ligand 10 (CXCL10) and the CXCR3 Circuit in the Pathogenesis of Autoimmune Addison's Disease. Scandinavian Journal of Immunology. 479-480.
  • Bratland, Eirik; Husebye, Eystein Sverre. 2008. 21-hydroxylase as a T cell autoantigen in autoimmune Addison's disease. Scandinavian Journal of Immunology. 191-191.
  • Bratland, Eirik; Wolff, Anette Susanne Bøe; Haavik, Jan; Kämpe, Olle; Sköldberg, Filip; Perheentupa, Jaakko; Bredholt, Geir; Knappskog, Per; Husebye, Eystein Sverre. 2007. Epitope mapping of human aromatic L-amino acid decarboxylase. Scandinavian Journal of Immunology. 592-592.
Poster
  • Breivik, Lars Ertesvåg; Oftedal, Bergithe Eikeland; Bratland, Eirik; Wolff, Anette Susanne Bøe; Orlova, Elizaveta; Husebye, Eystein Sverre. 2013. A novel cell-based assay for measuring neutralizing autoantibodies against type I interferons in patients with APS-1.

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