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University of Bergen
Janka Babickova's picture

Janka Babickova

Researcher
Department of Clinical Science
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  • E-mailjanka.babickova@uib.no
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
    5009 Bergen
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Show author(s) (2022). Six-week inhalation of lead oxide nanoparticles in mice affects antioxidant defense, immune response, kidneys, intestine and bones. Environmental Science: Nano. 751-766.
  • Show author(s) (2022). Reduced α-galactosidase A activity in zebrafish (Danio rerio) mirrors distinct features of Fabry nephropathy phenotype. Molecular Genetics and Metabolism Reports. 1-11.
  • Show author(s) (2022). Gene Expression Analysis in gla-Mutant Zebrafish Reveals Enhanced Ca<sup>2+</sup> Signaling Similar to Fabry Disease. International Journal of Molecular Sciences.
  • Show author(s) (2022). Extracellular DNA concentrations in various aetiologies of acute kidney injury. Scientific Reports. 11 pages.
  • Show author(s) (2022). Dynamics of Plasma and Urinary Extracellular DNA in Acute Kidney Injury. International Journal of Molecular Sciences. 1-8.
  • Show author(s) (2021). Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys. Pharmaceutics.
  • Show author(s) (2021). The Effect of Melatonin on Periodontitis . International Journal of Molecular Sciences. 1-11.
  • Show author(s) (2021). Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model. Journal of Cellular and Molecular Medicine. 7407-7417.
  • Show author(s) (2020). Plasma Concentrations of Extracellular DNA in Acute Kidney Injury. Diagnostics (Basel). 1-12.
  • Show author(s) (2020). Nuclear and Mitochondrial Circulating Cell-Free DNA Is Increased in Patients With Inflammatory Bowel Disease in Clinical Remission. Frontiers in medicine. 1-8.
  • Show author(s) (2020). A collagen-binding protein enables molecular imaging of kidney fibrosis in vivo. Kidney International. 609-614.
  • Show author(s) (2019). Six-week inhalation of CdO nanoparticles in mice: The effects on immune response, oxidative stress, antioxidative defense, fibrotic response, and bones. Food and Chemical Toxicology (FCT).
  • Show author(s) (2019). Oxidative Stress in Animal Models of Acute and Chronic Renal Failure. Disease Markers. 1-11.
  • Show author(s) (2019). AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction. Physiological Reports. 1-20.
  • Show author(s) (2018). Extracellular DNA as a prognostic and therapeutic target in mouse colitis under DNase I treatment. Folia biologica (Praha). 10-15.
Poster
  • Show author(s) (2018). Fabry nephropathy: Transcriptome sequencing of microdissected renal compartments from archival kidney biopsies at baseline, and after 5 & 10 years of enzyme replacement therapy.
Academic literature review
  • Show author(s) (2020). Oxidative stress in the pathophysiology of kidney disease: Implications for noninvasive monitoring and identification of biomarkers. Oxidative Medicine and Cellular Longevity. 1-11.
  • Show author(s) (2018). Cell-free nucleic acids in urine as potential biomarkers of kidney disease. Journal of Applied Biomedicine. 157-164.
  • Show author(s) (2018). Cell-free DNA: the role in pathophysiology and as a biomarker in kidney diseases. Expert Reviews in Molecular Medicine. 1-14.

More information in national current research information system (CRIStin)

European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement (No. 842619-DIE_CKD).

About the project:

Chronic kidney disease (CKD) is a major cause of morbidity and mortality, affecting over 10 % of the adult population. Regardless of the primary case, the progressed stage is characterized by scarring of all anatomical elements of the kidney - glomeruli, tubulointerstitium, and vasculature referred to as renal fibrosis. Tubulointerstitial fibrosis has largely been viewed as a consequence of glomerular scarring, reflecting hypoxia downstream from the scarred glomeruli. Novel data suggest that ongoing communication between the glomerular and tubular compartments (tubuloglomerular feedback) plays an important role in the progression of renal fibrosis. Particularly, injury to the tubular compartments leads to more pronounced glomerular injury in the future. DIE_CKD is designed to uncover the range and mechanisms of tubular injuries involved in the pathogenic tubuloglomerular feedback. To achieve the project objectives, double/quadruple transgenic mice with the possibility of time-dependent, subsequent injury to different compartments of the kidney will be used. This unique approach will enable a direct study of how the injury to tubular compartments predisposes glomeruli to more severe injury. Detailed analysis of the mechanisms behind these effects will be performed. The experimental data will be further confirmed in human renal biopsies of patients with Fabry disease with progressed CKD and renal fibrosis. A comprehensive histopathological assessment of long-term prognosis of sequential biopsies will be performed to analyze the involvement of individual compartments over time.

Publications:

https://www.asn-online.org/education/kidneyweek/2021/program-abstract.as...

https://www.asn-online.org/education/kidneyweek/2020/program-abstract.as...

https://pubmed.ncbi.nlm.nih.gov/36207374/

https://pubmed.ncbi.nlm.nih.gov/35328821/

https://pubmed.ncbi.nlm.nih.gov/32082479/

https://pubmed.ncbi.nlm.nih.gov/32168933

https://pubmed.ncbi.nlm.nih.gov/36613802/

 

Dissemination:

https://cordis.europa.eu/article/id/442761-molecular-breakthrough-gives-...