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University of Bergen
Mette Nåmdal Vesterhus's picture

Mette Nåmdal Vesterhus

Professor, Full Professor, Head of Teaching
Department of Clinical Science
  • E-mailmette.vesterhus@uib.no
  • Phone+47 55 97 52 69
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
    5009 Bergen
  • Postal Address
    Postboks 7804
    5020 Bergen

Mette Vesterhus, M.D. (UiB 1999), Ph.D. (UiB 2009), works as Full Professor at the University of Bergen and Senior Consulting Gastroenterologist & Hepatologist at Haraldsplass Deaconess Hospital in Bergen, Norway. With a particular focus on primary sclerosing cholangitis (PSC) and other autoimmune liver diseases, her main areas of interest are prognostic biomarkers and non-invasive assessment of liver fibrosis (including liver elastography), as well as clinical trials in autoimmune liver diseases. She is Group Leader of the Haraldsplass Liver Research Group and Clinical Group Bergen of the Norwegian PSC Research Center (NoPSC) and National PI for the Strategic Prospective Scandinavian PSC Biobank (ScandPSC).  Internationally, she is a Board Member of the International PSC Study Group as well as the UEG Meeting of Members.  

Academic article
  • Show author(s) (2023). Whole blood RNA sequencing identifies transcriptional differences between primary sclerosing cholangitis and ulcerative colitis. JHEP Reports.
  • Show author(s) (2023). Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis. Hepatology. 269-288.
  • Show author(s) (2023). Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma. Journal of Hepatology. 93-108.
  • Show author(s) (2023). Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation. Journal of Hepatology. 955-966.
  • Show author(s) (2023). A global action agenda for turning the tide on fatty liver disease. Hepatology.
  • Show author(s) (2022). Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis. JHEP Reports. 1-10.
  • Show author(s) (2022). Improvement of cholestatic episodes in patients with benign recurrent intrahepatic cholestasis (BRIC) treated with rifampicin. A long-term follow-up. Scandinavian Journal of Gastroenterology.
  • Show author(s) (2022). Impact on follow-up strategies in patients with primary sclerosing cholangitis. Liver international (Print). 12 pages.
  • Show author(s) (2022). Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4 (ITIH4) in Autoimmune Cholestatic Liver Diseases. Journal of Clinical and Translational Hepatology (JCTH). 796-802.
  • Show author(s) (2022). Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis. European Radiology Experimental. 9 pages.
  • Show author(s) (2021). Fluctuating biomarkers in primary sclerosing cholangitis: A longitudinal comparison of alkaline phosphatase, liver stiffness, and ELF. JHEP Reports. 1-10.
  • Show author(s) (2021). Controlled Attenuation Parameter in Healthy Individuals Aged 8-70 Years. Ultrasound International Open. E6-E13.
  • Show author(s) (2021). Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease. JHEP Reports. 1-11.
  • Show author(s) (2021). Circulating Macrophage Activation Markers Predict Transplant-Free Survival in Patients With Primary Sclerosing Cholangitis. Clinical and Translational Gastroenterology. e00315-e00315.
  • Show author(s) (2021). Associations of neopterin and kynurenine–tryptophan ratio with survival in primary sclerosing cholangitis. Scandinavian Journal of Gastroenterology. 443-452.
  • Show author(s) (2020). Point shear wave elastography and the effect of physical exercise, alcohol consumption, and respiration in healthy adults. Ultrasound International Open. E54-E61.
  • Show author(s) (2020). Liver elastography in healthy children using three different systems - how many measurements are necessary? Ultraschall in der Medizin. 1-10.
  • Show author(s) (2020). Liver Elastography in Primary Sclerosing Cholangitis Patients Using Three Different Scanner Systems. Ultrasound in Medicine and Biology. 1854-1864.
  • Show author(s) (2020). Effects of Tumor Necrosis Factor Antagonists in Patients With Primary Sclerosing Cholangitis. Clinical Gastroenterology and Hepatology. 2295-2304.e2.
  • Show author(s) (2020). Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation. Hepatology.
  • Show author(s) (2020). Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis. Gastroenterology.
  • Show author(s) (2019). Normal Liver Stiffness Values in Children: A Comparison of Three Different Elastography Methods. Journal of Pediatric Gastroenterology and Nutrition - JPGN. 706-712.
  • Show author(s) (2019). Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis. Liver international (Print). 371-381.
  • Show author(s) (2019). Cholangiocarcinoma is associated with a raised enhanced liver fibrosis score independent of primary sclerosing cholangitis. European Journal of Clinical Investigation.
  • Show author(s) (2019). Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis. Scientific Reports.
  • Show author(s) (2018). Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis. Alimentary Pharmacology and Therapeutics. 179-189.
  • Show author(s) (2018). Primary sclerosing cholangitis risk estimate tool (PREsTo) predicts outcomes of the disease: A derivation and validation study using machine learning. Hepatology. 1-11.
  • Show author(s) (2018). Liver elasticity in healthy individuals by two novel shear-wave elastography systems-Comparison by age, gender, BMI and number of measurements. PLOS ONE. 1-16.
  • Show author(s) (2018). Follow-up magnetic resonance imaging/3D-magnetic resonance cholangiopancreatography in patients with primary sclerosing cholangitis: challenging for experts to interpret. Alimentary Pharmacology and Therapeutics. 169-178.
  • Show author(s) (2018). Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System. Hepatology. 2120-2135.
  • Show author(s) (2017). Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner. Gut. 1135-1145.
  • Show author(s) (2017). Repeatability of shear wave elastography in liver fibrosis phantoms—Evaluation of five different systems. PLOS ONE. 1-16.
  • Show author(s) (2017). Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. Journal of Hepatology. 1214-1222.
  • Show author(s) (2017). Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study. Liver international (Print). 1554-1561.
  • Show author(s) (2017). Assessing liver stiffness by 2-D shear wave elastography in a healthy cohort. Ultrasound in Medicine and Biology. 332-341.
  • Show author(s) (2017). Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis. Liver international (Print). 458-465.
  • Show author(s) (2017). Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis. Hepatology. 137-144.
  • Show author(s) (2016). Ultrasound and point shear wave elastography in livers of patients with primary sclerosing cholangitis. Ultrasound in Medicine and Biology. 2146-2155.
  • Show author(s) (2016). The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls. Gut. 611-619.
  • Show author(s) (2016). Prognostic biomarkers and surrogate end points in PSC. Liver international (Print). 1748-1751.
  • Show author(s) (2016). In vitro comparison of five different elastography systems for clinical applications, using strain and shear wave technology. Ultrasound in Medicine and Biology. 2572-2588.
  • Show author(s) (2016). In Vitro Comparison of Five Different Elastography Systems for Clinical Applications, Using Strain and Shear Wave Technology. Ultrasound in Medicine and Biology. 2572-2588.
  • Show author(s) (2016). Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function. United European Gastroenterology Journal (UEG Journal). 532-541.
  • Show author(s) (2016). Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis. Liver international (Print). 1370-1377.
  • Show author(s) (2016). Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation. Mucosal Immunology.
  • Show author(s) (2015). Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis. Hepatology. 188-197.
  • Show author(s) (2014). Review article: Controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis. Alimentary Pharmacology and Therapeutics. 282-301.
  • Show author(s) (2014). Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid. Diabetes. 259-269.
  • Show author(s) (2013). Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (Maturity-Onset Diabetes of the young). PLOS ONE. 11 pages.
  • Show author(s) (2011). The role of pancreatic imaging in monogenic diabetes. Nature Reviews Endocrinology.
  • Show author(s) (2011). Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE. Journal of Biological Chemistry. 34593-34605.
  • Show author(s) (2010). Pancreatic Function in Carboxyl-Ester Lipase Knockout Mice. Pancreatology (Print). 467-476.
  • Show author(s) (2008). Reduced pancreatic volume in hepatocyte nuclear factor 1A-maturity-onset diabetes of the young. Journal of Clinical Endocrinology and Metabolism (JCEM). 3505-3509.
  • Show author(s) (2008). Pancreatic Exocrine Dysfunction in Maturity-Onset Diabetes of the Young Type 3. Diabetes Care. 306-310.
  • Show author(s) (2008). Neurological features and enzyme therapy in patients with endocrine and exocrine pancreas dysfunction due to CEL mutations. Diabetes Care. 1738-1740.
  • Show author(s) (2008). Lack of pancreatic body and tail in HNF1B mutation carriers. Diabetic Medicine. 782-787.
Lecture
  • Show author(s) (2021). ULTRASOUND EVALUATION OF PSC.
  • Show author(s) (2021). PSC - What is that disease exactly?
  • Show author(s) (2021). Juvenile PSC/ASC: The adult side.
  • Show author(s) (2021). ELF Test in PSC - should we start using it?
  • Show author(s) (2021). 2.linjebehandling ved PBC og AIH.
  • Show author(s) (2017). Ultralyd Elastografi.
  • Show author(s) (2017). Måling av vevsstivhet på fantomer med fire ulike «shear wave» elastografisystemer.
Academic lecture
  • Show author(s) (2016). Quantification of tissue elasticity in vitro using three clinical shear wave elastography platforms on liver fibrosis phantoms.
  • Show author(s) (2016). Elastography of the Liver in Primary Sclerosing Cholangitis.
  • Show author(s) (2015). O082 : THE GUT MICROBIOTA IN PRIMARY SCLEROSING CHOLANGITIS DIFFERS FROM THAT OF HEALTHY CONTROLS AND ULCERATIVE COLITIS PATIENTS WITHOUT BILIARY DISEASE.
  • Show author(s) (2015). In vitro quantification and reproducibility of elasticity measurements using five different elastography systems.
Editorial
  • Show author(s) (2022). Gode TIPS ved alvorlig leversykdom. Tidsskrift for Den norske legeforening.
Feature article
  • Show author(s) (2022). Vi trenger en ny strategi for leversykdom. Tidsskrift for Den norske legeforening. 6 pages.
Letter to the editor
  • Show author(s) (2023). FIB-4-testen som beslutningsverktøy. Tidsskrift for Den norske legeforening.
  • Show author(s) (2021). Reply to: "Both tacrolimus and mycophenylate mophetil should be considered second-line therapy for autoimmune hepatitis". Journal of Hepatology. 755-756.
Doctoral dissertation
  • Show author(s) (2009). Monogenic diabetes and pancreatic exocrine dysfunction in mouse and man.
Academic chapter/article/Conference paper
  • Show author(s) (2015). Point shear wave elastography of the liver in primary sclerosing cholangitis. 2 pages.
Abstract
  • Show author(s) (2015). Elasticity Mearsurements Using Four Different Ultrasound Scanners. Ultrasound in Medicine and Biology. 148-149.
  • Show author(s) (2007). Pancreatic exocrine deficiency is common in MODY 3. Diabetologia. S123-S123.
Poster
  • Show author(s) (2020). P117 Biomarkers of extracellular matrix remodelling are associated with intestinal fibrosis assessed by magnetic resonance enterography and accumulated intestinal damage (Lémann index): the IBSEN study.
  • Show author(s) (2017). ASSESSING LIVER STIFFNESS USING 2D-SHEAR WAVE ELASTOGRAPHY IN A HEALTHY COHORT.
  • Show author(s) (2015). Point shear wave elastography of the liver in primary sclerosing cholangitis.
  • Show author(s) (2015). P1174: Microbiota-dependent marker trimethylamine-N-oxide (TMAO) is associated with the severity of primary sclerosing cholangitis.
  • Show author(s) (2015). MICROBIOTA-DEPENDENT MARKER TRIMETHYLAMINE-N-OXIDE (TMAO) IS ASSOCIATED WITH THE SEVERITY OF PRIMARY SCLEROSING CHOLANGITIS.
  • Show author(s) (2015). In vitro quantification and reproducibility of elasticity measurements using four different ultrasound scanners.
Academic literature review
  • Show author(s) (2023). Noninvasive evaluation of fibrosis in adult biliary diseases. Current Opinion in Gastroenterology. 83-88.
  • Show author(s) (2021). Klinisk oversiktsartikkel: Diagnostikk og behandling av autoimmun hepatitt. Tidsskrift for Den norske legeforening. 8 pages.
  • Show author(s) (2021). Advancing the global public health agenda for NAFLD: a consensus statement. Nature reviews: Gastroenterology & hepatology.
  • Show author(s) (2020). Second-line and third-line therapy for autoimmune hepatitis: A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group. Journal of Hepatology. 1-12.
  • Show author(s) (2020). Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities. Journal of gastroenterology. 588-614.
  • Show author(s) (2017). Primary sclerosing cholangitis - a comprehensive review. Journal of Hepatology. 1298-1323.
  • Show author(s) (2012). The role of pancreatic imaging in monogenic diabetes mellitus. Nature Reviews Endocrinology. 148-159.
Article in business/trade/industry journal
  • Show author(s) (2023). Primær skleroserende kolangitt. Tidsskrift for Den norske legeforening.
  • Show author(s) (2020). Prioriteringsråd for fordøyelsessykdommer under korona-pandemien. NGF-nytt. 16-17.

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