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Leif Oltedals bilde

Leif Oltedal

Førsteamanuensis
  • E-postLeif.Oltedal@uib.no
  • Besøksadresse
    Bygg for biologiske basalfag, 8 etg.
  • Postadresse
    Postboks 7804
    5020 Bergen
Vitenskapelig artikkel
  • Vis forfatter(e) 2020. Structural changes induced by electroconvulsive therapy are associated with clinical outcome. Brain Stimulation. 696-704.
  • Vis forfatter(e) 2020. Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study. Immunity,Inflammation and Disease. 342-359.
  • Vis forfatter(e) 2020. Anterior cingulate gamma-aminobutyric acid concentrations and electroconvulsive therapy. Brain and Behavior. 1-11.
  • Vis forfatter(e) 2020. A Longitudinal Comparison Between Depressed Patients Receiving Electroconvulsive Therapy and Healthy Controls on Specific Memory Functions. The Primary Care Companion for CNS Disorders (PCC).
  • Vis forfatter(e) 2019. The effect of electroconvulsive therapy (ECT) on serum tryptophan metabolites. Brain Stimulation. 1135-1142.
  • Vis forfatter(e) 2019. International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen-ECT-ic). European Archives of Psychiatry and Clinical Neuroscience. 1-12.
  • Vis forfatter(e) 2019. Improved characterization of cerebral infarction using combined tissue T2 and high b-value diffusion MRI in post-thrombectomy patients: a feasibility study. Acta Radiologica. 1294-1300.
  • Vis forfatter(e) 2019. Electric field causes volumetric changes in the human brain. eLIFE. 1-20.
  • Vis forfatter(e) 2019. Depressive Symptom Dimensions in Treatment-Resistant Major Depression and Their Modulation With Electroconvulsive Therapy. Journal of ECT. 1-7.
  • Vis forfatter(e) 2019. Brain changes induced by electroconvulsive therapy are broadly distributed. Biological Psychiatry. 451-461.
  • Vis forfatter(e) 2018. Volume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy. Biological Psychiatry. 574-581.
  • Vis forfatter(e) 2017. The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy. NeuroImage: Clinical. 422-432.
  • Vis forfatter(e) 2017. Brain morphology in school-aged children with prenatal opioid exposure: A structural MRI study. Early Human Development. 33-39.
  • Vis forfatter(e) 2016. Opposite brain laterality in analogous auditory and visual tests. Laterality: Asymmetries of Body, Brain and Cognition. 690-702.
  • Vis forfatter(e) 2015. Effects of ECT in treatment of depression: Study protocol for a prospective neuroradiological study of acute and longitudinal effects on brain structure and function. BMC Psychiatry. 10 sider.
  • Vis forfatter(e) 2010. Transient release kinetics of rod bipolar cells revealed by capacitance measurement of exocytosis from axon terminals in rat retinal slices. Journal of Physiology. 1469-1487.
  • Vis forfatter(e) 2010. Electrical coupling and passive membrane properties of AII amacrine cells. Journal of Neurophysiology. 1456-1466.
  • Vis forfatter(e) 2009. Passive membrane properties and electrotonic signal processing in retinal rod bipolar cells. Journal of Physiology. 829-849.
  • Vis forfatter(e) 2008. Vesicular release of glutamate from hippocampal neurons in culture: an immunocytochemical assay. Experimental Brain Research. 479-492.
  • Vis forfatter(e) 2008. Electrical Synapses Between AII Amacrine Cells: Dynamic Range and Functional Consequences of Variation in Junctional Conductance. Journal of Neurophysiology. 3305-3322.
  • Vis forfatter(e) 2007. Patch clamp investigations and compartmental modeling of rod bipolar axon terminals in an in vitro thin slice preparation of the mammalian retina. Journal of Neurophysiology. 1171-1187.
  • Vis forfatter(e) 2007. Antibodies to CRMP3-4 associated with limbic encephalitis and thymoma. Clinical and Experimental Immunology. 16-22.
  • Vis forfatter(e) 2004. Intramolecular protein-protein and protein-lipid interactions control the conformation and subcellular targeting of neuronal Ykt6. Journal of Cell Science. 4495-4508.
  • Vis forfatter(e) 2003. Sec6 is localized to the plasma membrane of mature synaptic terminals and is transported with secretogranin II-containing vesicles. Neuroscience. 73-85.
Faglig foredrag
  • Vis forfatter(e) 2013. Cases for juniors.
Vitenskapelig foredrag
  • Vis forfatter(e) 2018. GEMRIC: now and the future.
  • Vis forfatter(e) 2001. Sec6 and sec8 may have different roles in neuronal vesicle targeting.
Brev til redaktøren
  • Vis forfatter(e) 2020. Reply to: Clinical Relevance of Brain Changes After Electroconvulsive Therapy: Is There Really No Link at All? Biological Psychiatry.
Doktorgradsavhandling
  • Vis forfatter(e) 2009. Electrical recordings from a presynaptic terminal - a study of passive membrane properties and exocytosis.
Sammendrag/abstract
  • Vis forfatter(e) 2004. CRMP3 antibodies associated with limbic encephalitis and thymoma. Journal of Neuroimmunology.
Poster
  • Vis forfatter(e) 2018. Research Agenda of the Mohn Medical Imaging and Visualization Centre in Bergen, Norway.
  • Vis forfatter(e) 2015. Use of electroconvulsive therapy in postpartum affective disorder. A systematic review of the literature.
  • Vis forfatter(e) 2013. Project outline: Effects of ECT in treatment of major depression. A prospective neuroradiological study of acute and longitudinal effects on brain structure and function.
  • Vis forfatter(e) 2012. A dichoptic analog to the Bergen dichotic listening paradigm: A pilot study. .
  • Vis forfatter(e) 2009. Passive membrane properties of AII amacrine cells.
  • Vis forfatter(e) 2002. Pyramidal cell antibodies associated with limbic encephalitis and thymoma.
Vitenskapelig oversiktsartikkel/review
  • Vis forfatter(e) 2021. The Neurobiological Effects of Electroconvulsive Therapy Studied Through Magnetic Resonance: What Have We Learned, and Where Do We Go? Biological Psychiatry. 1-10.
  • Vis forfatter(e) 2021. Magnetic resonance spectroscopy in depressed subjects treated with electroconvulsive therapy—A systematic review of literature. Frontiers in Psychiatry. 1-10.
  • Vis forfatter(e) 2019. Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative. International journal of bipolar disorders. 1-10.
Fagartikkel
  • Vis forfatter(e) 2013. ECT og kognitive bivirkninger. BestPractice Psykiatri/Nevrologi/Geriatri. 23-25.
Intervju tidsskrift
  • Vis forfatter(e) 2018. Formalize agreements. Nature. 402-402.

Se fullstendig oversikt over publikasjoner i CRIStin.

1) ECT og nevroradiologi

- Elektrokonvulsiv terapi (ECT) brukes ved alvorlig, terapiresistent depresjon. Prosjektet undersøker akutte og langsiktige effekter av ECT. Deltagerne i studien undersøkes med avansert MR før, under og etter behandling. En av hypotesene som undersøkes er om ECT stimulerer nydannelse av hjerneceller. Dette kan ikke påvises direkte med MR, men øket volum av grå substans er et indirekte tegn på nevrotrofiske effekter. Vi vil også se etter endringer i hjernens signalstoffer (nevrotransmittere) og i hvit substans. I tillegg til bildeundersøkelser utredes pasientene grundig med nevropsykologiske tester før og etter behandling.

ECTMRI - info om norsk studie

The GEMRIC study - info om internasjonalt samarbeid  og her

2) RSI i nevroradiologi

- Restriction Spectrum Imaging (RSI; utviklet ved UCSD) er en metode for MR diffusjonsavbildning som kan skille intracellulært vann (restricted water) fra vann i ekstracellulærvæsken (hindered water). Metoden er ny og prosjektet vil undersøke om/hvordan RSI kan gi ny informasjon om ulike patologiske prosesser som standard klinisk diffusjonsavbildning ikke gir.