- E-postLeif.Oltedal@uib.no
- BesøksadresseBygg for biologiske basalfag, 8 etg.
- PostadressePostboks 78045020 Bergen
As a neuroscientist I am particularly interested in the neurobiological mechanisms of major depressive disorders and their treatment with various forms of neurostimulation therapies
Leif Oltedal is a consultant neuroradiologist (50%) at Haukeland University Hospital and associate professor (50%) at the Department of Clinical Medicine, Faculty of Medicine, University of Bergen (UiB) in Norway. He is affiliated to the Mohn Medical Imanging and Visualization Centre (MMIV) .
I lead the Neurostimulation and Brain imaging research group at the Department of Clinical Medicine in Bergen and research projects on electroconvulsive therapy (ECT) at MMIV. I am also the leader of the Global ECT-MRI Research Collaboration (GEMRIC), which is a network of researchers who use magnetic resonance imaging (MRI) to study the effects of ECT on the brain.
My research interests concern the structure and functioning of the human brain and spans from basic neuroscience disciplines such as anatomy and patch-clamp electrophysiology to clinical oriented research with neuroimaging in psychiatry and radiology. I am particularly interested in the mechanisms underlying mental disorders and how neurostimulation can be used as an effective therapeutic option. In radiology I am also involved in the development of novel MRI techniques for precision diagnostics or brain tumors (gliomas).
For an overview of recent publications, please see Google Scholar:
https://scholar.google.com/citations?user=L_sc0DQAAAAJ
- (2024). Stable glioma incidence and increased patient survival over the past two decades in Norway: a nationwide registry-based cohort study. Acta Oncologica. 83-94.
- (2024). Longitudinal resting-state network connectivity changes in electroconvulsive therapy patients compared to healthy controls. Brain Stimulation. 140-147.
- (2023). Sex-specifics of ECT outcome. Journal of Affective Disorders. 243-248.
- (2023). Neurobiological mechanisms of ECT and TMS treatment in depression: study protocol of a multimodal magnetic resonance investigation. BMC Psychiatry.
- (2023). Feasibility of deep learning-based tumor segmentation for target delineation and response assessment in grade-4 glioma using multi-parametric MRI. Neuro-Oncology Advances (NOA).
- (2023). Exploring New Electroencephalogram Parameters in Electroconvulsive Therapy. Journal of ECT. 20-30.
- (2023). Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression. Molecular Psychiatry.
- (2023). Electroconvulsive therapy triggers a reversible decrease in brain N-acetylaspartate. Frontiers in Psychiatry.
- (2023). Effective resting-state connectivity in severe unipolar depression before and after electroconvulsive therapy. Brain Stimulation. 1128-1134.
- (2023). Development and validation of a multimodal neuroimaging biomarker for electroconvulsive therapy outcome in depression: A multicenter machine learning analysis. Psychological Medicine.
- (2022). Multimodal multi-center analysis of electroconvulsive therapy effects in depression: Brainwide gray matter increase without functional changes. Brain Stimulation. 1065-1072.
- (2021). Short and long-term effects of single and multiple sessions of electroconvulsive therapy on brain gray matter volumes. Brain Stimulation. 1330-1339.
- (2021). Neural Substrates of Psychotic Depression: Findings From the Global ECT-MRI Research Collaboration. Schizophrenia Bulletin. 1-10.
- (2021). Elevated body weight modulates subcortical volume change and associated clinical response following electroconvulsive therapy. Journal of Psychiatry & Neuroscience.
- (2021). Accounting for symptom heterogeneity can improve neuroimaging models of antidepressant response after electroconvulsive therapy. Human Brain Mapping. 1-12.
- (2020). Structural changes induced by electroconvulsive therapy are associated with clinical outcome. Brain Stimulation. 696-704.
- (2020). Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study. Immunity,Inflammation and Disease. 342-359.
- (2020). Anterior cingulate gamma-aminobutyric acid concentrations and electroconvulsive therapy. Brain and Behavior. 1-11.
- (2020). A Longitudinal Comparison Between Depressed Patients Receiving Electroconvulsive Therapy and Healthy Controls on Specific Memory Functions. The Primary Care Companion for CNS Disorders (PCC).
- (2019). The effect of electroconvulsive therapy (ECT) on serum tryptophan metabolites. Brain Stimulation. 1135-1142.
- (2019). International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen-ECT-ic). European Archives of Psychiatry and Clinical Neuroscience. 1-12.
- (2019). Improved characterization of cerebral infarction using combined tissue T2 and high b-value diffusion MRI in post-thrombectomy patients: a feasibility study. Acta Radiologica. 1294-1300.
- (2019). Electric field causes volumetric changes in the human brain. eLIFE. 1-20.
- (2019). Depressive Symptom Dimensions in Treatment-Resistant Major Depression and Their Modulation With Electroconvulsive Therapy. Journal of ECT. 1-7.
- (2019). Brain changes induced by electroconvulsive therapy are broadly distributed. Biological Psychiatry. 451-461.
- (2018). Volume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy. Biological Psychiatry. 574-581.
- (2017). The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy. NeuroImage: Clinical. 422-432.
- (2017). Brain morphology in school-aged children with prenatal opioid exposure: A structural MRI study. Early Human Development. 33-39.
- (2016). Opposite brain laterality in analogous auditory and visual tests. Laterality: Asymmetries of Body, Brain and Cognition. 690-702.
- (2015). Effects of ECT in treatment of depression: Study protocol for a prospective neuroradiological study of acute and longitudinal effects on brain structure and function. BMC Psychiatry. 10 sider.
- (2010). Transient release kinetics of rod bipolar cells revealed by capacitance measurement of exocytosis from axon terminals in rat retinal slices. Journal of Physiology. 1469-1487.
- (2010). Electrical coupling and passive membrane properties of AII amacrine cells. Journal of Neurophysiology. 1456-1466.
- (2009). Passive membrane properties and electrotonic signal processing in retinal rod bipolar cells. Journal of Physiology. 829-849.
- (2008). Vesicular release of glutamate from hippocampal neurons in culture: an immunocytochemical assay. Experimental Brain Research. 479-492.
- (2008). Electrical Synapses Between AII Amacrine Cells: Dynamic Range and Functional Consequences of Variation in Junctional Conductance. Journal of Neurophysiology. 3305-3322.
- (2007). Patch clamp investigations and compartmental modeling of rod bipolar axon terminals in an in vitro thin slice preparation of the mammalian retina. Journal of Neurophysiology. 1171-1187.
- (2007). Antibodies to CRMP3-4 associated with limbic encephalitis and thymoma. Clinical and Experimental Immunology. 16-22.
- (2004). Intramolecular protein-protein and protein-lipid interactions control the conformation and subcellular targeting of neuronal Ykt6. Journal of Cell Science. 4495-4508.
- (2003). Sec6 is localized to the plasma membrane of mature synaptic terminals and is transported with secretogranin II-containing vesicles. Neuroscience. 73-85.
- (2018). GEMRIC: now and the future.
- (2001). Sec6 and sec8 may have different roles in neuronal vesicle targeting.
- (2009). Electrical recordings from a presynaptic terminal - a study of passive membrane properties and exocytosis.
- (2004). CRMP3 antibodies associated with limbic encephalitis and thymoma. Journal of Neuroimmunology.
- (2024). The Dark and Gloomy Brain: Grey Matter Volume Alterations in Major Depressive Disorder-Fine-Grained Meta-Analyses. Depression and Anxiety.
- (2024). Neurobiological mechanisms of electroconvulsive therapy for depression: Insights into hippocampal volumetric increases from clinical and preclinical studies. Journal of Neurochemistry.
- (2021). The Neurobiological Effects of Electroconvulsive Therapy Studied Through Magnetic Resonance: What Have We Learned, and Where Do We Go? Biological Psychiatry. 1-10.
- (2021). Magnetic resonance spectroscopy in depressed subjects treated with electroconvulsive therapy—A systematic review of literature. Frontiers in Psychiatry. 1-10.
- (2019). Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative. International journal of bipolar disorders. 1-10.
- (2022). Hjernemetastasar – diagnostikk og behandling. Tidsskrift for Den norske legeforening. 1-7.
- (2013). ECT og kognitive bivirkninger. BestPractice Psykiatri/Nevrologi/Geriatri. 23-25.
1) ECT og nevroradiologi
- Elektrokonvulsiv terapi (ECT) brukes ved alvorlig, terapiresistent depresjon. Prosjektet undersøker akutte og langsiktige effekter av ECT. Deltagerne i studien undersøkes med avansert MR før, under og etter behandling. En av hypotesene som undersøkes er om ECT stimulerer nydannelse av hjerneceller. Dette kan ikke påvises direkte med MR, men øket volum av grå substans er et indirekte tegn på nevrotrofiske effekter. Vi vil også se etter endringer i hjernens signalstoffer (nevrotransmittere) og i hvit substans. I tillegg til bildeundersøkelser utredes pasientene grundig med nevropsykologiske tester før og etter behandling.
The GEMRIC study - info om internasjonalt samarbeid og her
2) RSI i nevroradiologi
- Restriction Spectrum Imaging (RSI; utviklet ved UCSD) er en metode for MR diffusjonsavbildning som kan skille intracellulært vann (restricted water) fra vann i ekstracellulærvæsken (hindered water). Metoden er ny og prosjektet vil undersøke om/hvordan RSI kan gi ny informasjon om ulike patologiske prosesser som standard klinisk diffusjonsavbildning ikke gir.