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University of Bergen
Pediatric Follow-up Group

Kidney disease early in life

Main content

  • GFR methodology; multipoint iohexol clearance and simplified methods to evaluate kidney function in children.
  • Consequences of prematurity and low birth weight on kidney function
  • Kidney biopsies - structural findings and transcriptomics
  • Urinary tract infections in childhood
  • The Renal Research Group | University of Bergen (uib.no)

 

Peer review publications

  1. Smerkous D, Mauer M, Tøndel C, Svarstad E, Gubler MC, Nelson RG, Oliveira JP, Sargolzaeiaval F, Najafian B. Development of an automated estimation of foot process width using deep learning in kidney biopsies from patients with Fabry, minimal change, and diabetic kidney diseases. Kidney Int. 2023 Sep 27:S0085-2538(23)00675-0. doi: 10.1016/j.kint.2023.09.011. Epub ahead of print. PMID: 37774924.
  2. Elsaid HOA, Rivedal M, Skandalou E, Svarstad E, Tøndel C, Birkeland E, Eikrem Ø, Babickova J, Marti HP, Furriol J. Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla-/- zebrafish model of Fabry disease. J Transl Med. 2023 Sep 5;21(1):591. doi: 10.1186/s12967-023-04475-y. PMID: 37670295; PMCID: PMC10478213.
  3. Salvador CL, Flemmen PTK, Tøndel C, Bliksrud YT, Tsui EFF, Brun A, Bjerre A, Mørkrid L. Renal function, sex and age influence purines and pyrimidines in urine and could lead to diagnostic misinterpretation. Mol Genet Metab. 2023 Jul 5;140(3):107649. doi: 10.1016/j.ymgme.2023.107649. Epub ahead of print. PMID: 37517327.
  4. Lillås BS, Tøndel C, Melsom T, Eriksen BO, Marti HP, Vikse BE. Response to Birth Weight and Renal Functional Reserve in Adults. Kidney Int Rep. 2023 Jun 17;8(8):1700-1701. doi: 10.1016/j.ekir.2023.06.012. PMID: 37547517; PMCID: PMC10403668.
  5. Delaleu N, Marti HP, Strauss P, Sekulic M, Osman T, Tøndel C, Skrunes R, Leh S, Svarstad E, Nowak A, Gaspert A, Rusu E, Kwee I, Rinaldi A, Flatberg A, Eikrem O. Systems analyses of the Fabry kidney transcriptome and its response to enzyme replacement therapy identified and cross-validated enzyme replacement therapy-resistant targets amenable to drug repurposing. Kidney Int. 2023 Oct;104(4):803-819. doi: 10.1016/j.kint.2023.06.029. Epub 2023 Jul 5. PMID: 37419447.
  6. Lillås BS, Tøndel C, Melsom T, Eriksen BO, Marti HP, Vikse BE. Renal Functional Response-Association With Birth Weight and Kidney Volume. Kidney Int Rep. 2023 Feb 20;8(5):1034-1042. doi: 10.1016/j.ekir.2023.02.1079. PMID: 37180504; PMCID: PMC10166784.
  7. Braun F, Abed A, Sellung D, Rogg M, Woidy M, Eikrem O, Wanner N, Gambardella J, Laufer SD, Haas F, Wong MN, Dumoulin B, Rischke P, Mühlig A, Sachs W, von Cossel K, Schulz K, Muschol N, Gersting SW, Muntau AC, Kretz O, Hahn O, Rinschen MM, Mauer M, Bork T, Grahammer F, Liang W, Eierhoff T, Römer W, Hansen A, Meyer-Schwesinger C, Iaccarino G, Tøndel C, Marti HP, Najafian B, Puelles VG, Schell C, Huber TB. Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy. J Clin Invest. 2023 Jun 1;133(11):e157782. doi: 10.1172/JCI157782. PMID: 37014703; PMCID: PMC10232004.
  8. Gjerstad AC, Skrunes R, Tøndel C, Åsberg A, Leh S, Klingenberg C, Døllner H, Hammarstrøm C, Bjerre AK. Kidney biopsy diagnosis in childhood in the Norwegian Kidney Biopsy Registry and the long-term risk of kidney replacement therapy: a 25-year follow-up. Pediatr Nephrol. 2023 Apr;38(4):1249-1256. doi: 10.1007/s00467-022-05706-y. Epub 2022 Aug 22. PMID: 35994104; PMCID: PMC9925570.
  9. Smeets NJL, Teunissen EMM, van der Velden K, van der Burgh MJP, Linders DE, Teesselink E, Moes DAR, Tøndel C, Ter Heine R, van Heijst A, Schreuder MF, de Wildt SN. Glomerular filtration rate in critically ill neonates and children: creatinine-based estimations versus iohexol-based measurements. Pediatr Nephrol. 2023 Apr;38(4):1087-1097. doi: 10.1007/s00467-022-05651-w. Epub 2022 Aug 2. PMID: 35916956; PMCID: PMC9925555.
  10. Grodås KTM, Døllner H, Thaulow CM, Knudsen PK, Tønnessen A, Skeibrok M, Klingenberg C. Gentamicin serum concentration measurement in children. Tidsskr Nor Laegeforen. 2023 Jan 16;143(1). English, Norwegian. doi: 10.4045/tidsskr.22.0238. PMID: 36655955.
  11. Elsaid HOA, Tjeldnes H, Rivedal M, Serre C, Eikrem Ø, Svarstad E, Tøndel C, Marti HP, Furriol J, Babickova J. Gene Expression Analysis in gla-Mutant Zebrafish Reveals Enhanced Ca2+ Signaling Similar to Fabry Disease. Int J Mol Sci. 2022 Dec 26;24(1):358. doi: 10.3390/ijms24010358. PMID: 36613802; PMCID: PMC9820748.
  12. Tøndel C, Thurberg BL, DasMahapatra P, Lyn N, Maski M, Batista JL, George K, Patel H, Hariri A. Clinical relevance of globotriaosylceramide accumulation in Fabry disease and the effect of agalsidase beta in affected tissues. Mol Genet Metab. 2022 Dec;137(4):328-341. doi: 10.1016/j.ymgme.2022.10.005. Epub 2022 Oct 29. PMID: 36334424.
  13. Najafian B, Silvestroni A, Sokolovskiy A, Tøndel C, Svarstad E, Obrisca B, Ismail G, Holida MD, Mauer M. A novel unbiased method reveals progressive podocyte globotriaosylceramide accumulation and loss with age in females with Fabry disease. Kidney Int. 2022 Jul;102(1):173-182. doi: 10.1016/j.kint.2022.03.023. Epub 2022 Apr 26. PMID: 35483528; PMCID: PMC9233139.
  14. Elsaid HOA, Furriol J, Blomqvist M, Diswall M, Leh S, Gharbi N, Anonsen JH, Babickova J, Tøndel C, Svarstad E, Marti HP, Krause M. Reduced α-galactosidase A activity in zebrafish (Danio rerio) mirrors distinct features of Fabry nephropathy phenotype. Mol Genet Metab Rep. 2022 Feb 17;31:100851. doi: 10.1016/j.ymgmr.2022.100851. PMID: 35242583; PMCID: PMC8857658.
  15. Eide TT, Hufthammer KO, Brun A, Brackman D, Svarstad E, Tøndel C. Accuracy of single intravenous access iohexol GFR in children is hampered by marker contamination. Sci Rep. 2021 Dec 1;11(1):23224. doi: 10.1038/s41598-021-02759-1. PMID: 34853376; PMCID: PMC8636567.
  16. Lillås BS, Tøndel C, Aßmus J, Vikse BE. Low birthweight is associated with lower glomerular filtration rate in middle-aged mainly healthy women. Nephrol Dial Transplant. 2021 Dec 31;37(1):92-99. doi: 10.1093/ndt/gfaa306. PMID: 33313893; PMCID: PMC8719610.
  17. Tøndel C, Marti HP. Cardiovascular changes in young renal failure patients. Clin Kidney J. 2021 Nov 11;15(2):183-185. doi: 10.1093/ckj/sfab223. PMID: 35145633; PMCID: PMC8825223.z
  18. Thaulow CM, Lindemann PC, Klingenberg C. Antibiotic resistance in paediatric UTIs in Norway. Tidsskr Nor Laegeforen. 2021 Jun 8;141(10). English, Norwegian. doi: 10.4045/tidsskr.20.0889. PMID: 34182746.
  19. Najafian B, Tøndel C, Svarstad E, Gubler MC, Oliveira JP, Mauer M. Accumulation of Globotriaosylceramide in Podocytes in Fabry Nephropathy Is Associated with Progressive Podocyte Loss. J Am Soc Nephrol. 2020 Apr;31(4):865-875. doi: 10.1681/ASN.2019050497. Epub 2020 Mar 3. PMID: 32127409; PMCID: PMC7191924.
  20. Thorsteinsdottir H, Salvador CL, Mjøen G, Lie A, Sugulle M, Tøndel C, Brun A, Almaas R, Bjerre A. Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation. Dis Markers. 2020 Feb 6;2020:6162892. doi: 10.1155/2020/6162892. PMID: 32089755; PMCID: PMC7026715.
  21. Lillås BS, Tøndel C, Gjerde A, Vikse BE. Measurement of renal functional response using iohexol clearance-a study of different outpatient procedures. Clin Kidney J. 2019 Nov 26;14(1):181-188. doi: 10.1093/ckj/sfz167. PMID: 33564417; PMCID: PMC7857819.
  22. Vollsæter M, Halvorsen T, Markestad T, Øymar K, Ueland PM, Meyer K, Midttun Ø, Bjørke-Monsen AL. Renal function and blood pressure in 11 year old children born extremely preterm or small for gestational age. PLoS One. 2018 Oct 12;13(10):e0205558. doi: 10.1371/journal.pone.0205558. PMID: 30312323; PMCID: PMC6185834.
  23. Salvador CL, Tøndel C, Rowe AD, Bjerre A, Brun A, Brackman D, Mørkrid L. Estimating glomerular filtration rate in children: evaluation of creatinine- and cystatin C-based equations. Pediatr Nephrol. 2019 Feb;34(2):301-311. doi: 10.1007/s00467-018-4067-3. Epub 2018 Aug 31. PMID: 30171354.
  24. Lerch C, Shroff R, Wan M, Rees L, Aitkenhead H, Kaplan Bulut I, Thurn D, Karabay Bayazit A, Niemirska A, Canpolat N, Duzova A, Azukaitis K, Yilmaz E, Yalcinkaya F, Harambat J, Kiyak A, Alpay H, Habbig S, Zaloszyc A, Soylemezoglu O, Candan C, Rosales A, Melk A, Querfeld U, Leifheit-Nestler M, Sander A, Schaefer F, Haffner D; 4C study consortium; ESPN CKD-MBD working group. Effects of nutritional vitamin D supplementation on markers of bone and mineral metabolism in children with chronic kidney disease. Nephrol Dial Transplant. 2018 Dec 1;33(12):2208-2217. doi: 10.1093/ndt/gfy012. PMID: 29481636.
  25. Tøndel C, Salvador CL, Hufthammer KO, Bolann B, Brackman D, Bjerre A, Svarstad E, Brun A. Iohexol plasma clearance in children: validation of multiple formulas and single-point sampling times. Pediatr Nephrol. 2018 Apr;33(4):683-696. doi: 10.1007/s00467-017-3841-y. Epub 2017 Nov 13. PMID: 29134449; PMCID: PMC5859061.
  26. Svarstad E, Leh S, Skrunes R, Kampevold Larsen K, Eikrem Ø, Tøndel C. Bedside Stereomicroscopy of Fabry Kidney Biopsies: An Easily Available Method for Diagnosis and Assessment of Sphingolipid Deposits. Nephron. 2018;138(1):13-21. doi: 10.1159/000479751. Epub 2017 Aug 26. PMID: 28848191.
  27. Salvador CL, Tøndel C, Rowe AD, Bjerre A, Brun A, Brackman D, Bolstad N, Mørkrid L. Renal Function Influences Diagnostic Markers in Serum and Urine: A Study of Guanidinoacetate, Creatine, Human Epididymis Protein 4, and Neutrophil Gelatinase-Associated Lipocalin in Children. J Appl Lab Med. 2017 Nov 1;2(3):297-308. doi: 10.1373/jalm.2016.022145. PMID: 33636843.
  28. Skrunes R, Tøndel C, Leh S, Larsen KK, Houge G, Davidsen ES, Hollak C, van Kuilenburg ABP, Vaz FM, Svarstad E. Long-Term Dose-Dependent Agalsidase Effects on Kidney Histology in Fabry Disease. Clin J Am Soc Nephrol. 2017 Sep 7;12(9):1470-1479. doi: 10.2215/CJN.01820217. Epub 2017 Jun 16. PMID: 28625968; PMCID: PMC5586567.
  29. Eikrem Ø, Skrunes R, Tøndel C, Leh S, Houge G, Svarstad E, Marti HP. Pathomechanisms of renal Fabry disease. Cell Tissue Res. 2017 Jul;369(1):53-62. doi: 10.1007/s00441-017-2609-9. Epub 2017 Apr 12. PMID: 28401309.
  30. Schiffmann R, Hughes DA, Linthorst GE, Ortiz A, Svarstad E, Warnock DG, West ML, Wanner C; Conference Participants. Screening, diagnosis, and management of patients with Fabry disease: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference. Kidney Int. 2017 Feb;91(2):284-293. doi: 10.1016/j.kint.2016.10.004. Epub 2016 Dec 18. PMID: 27998644.
  31. Tøndel C, Bolann B, Salvador CL, Brackman D, Bjerre A, Svarstad E, Brun A. Iohexol plasma clearance in children: validation of multiple formulas and two-point sampling times. Pediatr Nephrol. 2017 Feb;32(2):311-320. doi: 10.1007/s00467-016-3436-z. Epub 2016 Jul 1. Erratum in: Pediatr Nephrol. 2017 Feb;32(2):375-376. PMID: 27369694; PMCID: PMC5203838.
  32. Skrunes R, Svarstad E, Kampevold Larsen K, Leh S, Tøndel C. Reaccumulation of globotriaosylceramide in podocytes after agalsidase dose reduction in young Fabry patients. Nephrol Dial Transplant. 2017 May 1;32(5):807-813. doi: 10.1093/ndt/gfw094. PMID: 27190352.
  33. Najafian B, Tøndel C, Svarstad E, Sokolovkiy A, Smith K, Mauer M. One Year of Enzyme Replacement Therapy Reduces Globotriaosylceramide Inclusions in Podocytes in Male Adult Patients with Fabry Disease. PLoS One. 2016 Apr 15;11(4):e0152812. doi: 10.1371/journal.pone.0152812. PMID: 27081853; PMCID: PMC4833322.
  34. Salvador CL, Tøndel C, Mørkrid L, Bjerre A, Brun A, Bolann B, Brackman D, Bergan S. Glomerular filtration rate measured by iohexol clearance: A comparison of venous samples and capillary blood spots. Scand J Clin Lab Invest. 2015;75(8):710-6. doi: 10.3109/00365513.2015.1091091. PMID: 26426851.
  35. Tøndel C, Kanai T, Larsen KK, Ito S, Politei JM, Warnock DG, Svarstad E. Foot process effacement is an early marker of nephropathy in young classic Fabry patients without albuminuria. Nephron. 2015;129(1):16-21. doi: 10.1159/000369309. Epub 2014 Dec 17. PMID: 25531941.
  36. Mauer M, Glynn E, Svarstad E, Tøndel C, Gubler MC, West M, Sokolovskiy A, Whitley C, Najafian B. Mosaicism of podocyte involvement is related to podocyte injury in females with Fabry disease. PLoS One. 2014 Nov 11;9(11):e112188. doi: 10.1371/journal.pone.0112188. PMID: 25386848; PMCID: PMC4227696.
  37. van der Tol L, Svarstad E, Ortiz A, Tøndel C, Oliveira JP, Vogt L, Waldek S, Hughes DA, Lachmann RH, Terryn W, Hollak CE, Florquin S, van den Bergh Weerman MA, Wanner C, West ML, Biegstraaten M, Linthorst GE. Chronic kidney disease and an uncertain diagnosis of Fabry disease: approach to a correct diagnosis. Mol Genet Metab. 2015 Feb;114(2):242-7. doi: 10.1016/j.ymgme.2014.08.007. Epub 2014 Aug 20. PMID: 25187469.
  38. Tøndel C, Bostad L, Larsen KK, Hirth A, Vikse BE, Houge G, Svarstad E. Agalsidase benefits renal histology in young patients with Fabry disease. J Am Soc Nephrol. 2013 Jan;24(1):137-48. doi: 10.1681/ASN.2012030316. PMID: 23274955; PMCID: PMC3537211.
  39. Tøndel C, Vikse BE, Bostad L, Svarstad E. Safety and complications of percutaneous kidney biopsies in 715 children and 8573 adults in Norway 1988-2010. Clin J Am Soc Nephrol. 2012 Oct;7(10):1591-7. doi: 10.2215/CJN.02150212. Epub 2012 Jul 26. PMID: 22837269; PMCID: PMC3463204.
  40. Najafian B, Svarstad E, Bostad L, Gubler MC, Tøndel C, Whitley C, Mauer M. Progressive podocyte injury and globotriaosylceramide (GL-3) accumulation in young patients with Fabry disease. Kidney Int. 2011 Mar;79(6):663-670. doi: 10.1038/ki.2010.484. Epub 2010 Dec 15. PMID: 21160462; PMCID: PMC3640823.
  41. Tøndel C, Ramaswami U, Aakre KM, Wijburg F, Bouwman M, Svarstad E. Monitoring renal function in children with Fabry disease: comparisons of measured and creatinine-based estimated glomerular filtration rate. Nephrol Dial Transplant. 2010 May;25(5):1507-13. doi: 10.1093/ndt/gfp658. Epub 2009 Dec 27. PMID: 20038520.
  42. Cybulla M, Walter KN, Schwarting A, Divito R, Feriozzi S, Sunder-Plassmann G; European FOS Investigators Group. Kidney transplantation in patients with Fabry disease. Transpl Int. 2009 Apr;22(4):475-81. doi: 10.1111/j.1432-2277.2008.00824.x. Epub 2009 Jan 22. PMID: 19207191.
  43. Aakre KM, Tøndel C, Brun A, Svarstad E. The MDRD equation may mask decline of glomerular filtration rate in Fabry patients with normal or nearly normal kidney function. Clin Nephrol. 2009 Feb;71(2):118-24. doi: 10.5414/cnp71118. PMID: 19203503.
  44. Tøndel C, Bostad L, Hirth A, Svarstad E. Renal biopsy findings in children and adolescents with Fabry disease and minimal albuminuria. Am J Kidney Dis. 2008 May;51(5):767-76. doi: 10.1053/j.ajkd.2007.12.032. Epub 2008 Mar 20. Erratum in: Am J Kidney Dis. 2009 Mar;53(3):567. PMID: 18436087.
  45. Tøndel C, Bostad L, Laegreid LM, Houge G, Svarstad E. Prominence of glomerular and vascular changes in renal biopsies in children and adolescents with Fabry disease and microalbuminuria. Clin Ther. 2008;30 Suppl B:S42. doi: 10.1016/s0149-2918(08)80036-7. PMID: 18395135.
  46. Svarstad E, Bostad L, Kaarbøe O, Houge G, Tøndel C, Lyngdal PT, Iversen BM. Focal and segmental glomerular sclerosis (FSGS) in a man and a woman with Fabry's disease. Clin Nephrol. 2005 May;63(5):394-401. doi: 10.5414/cnp63394. PMID: 15909601.
  47. Misselwitz J, Hesse V, Markestad T. Nephrocalcinosis, hypercalciuria and elevated serum levels of 1,25-dihydroxyvitamin D in children. Possible link to vitamin D toxicity. Acta Paediatr Scand. 1990 Jun-Jul;79(6-7):637-43. doi: 10.1111/j.1651-2227.1990.tb11528.x. PMID: 2386055.
 

 

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31.10.2023