SF Fibrosis Conference, 2018
The role of the fibrotic stroma - barrier or support?
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SIU Fibrosis conference, June 7-8, 2018
San Francisco
Venue: Aldea conference centre, UCSF
Organizers: Donald Gullberg and Valerie Weaver
Business meeting SIU - Upcoming student exchanges
| June 7th | Session 1a. Cell-ECM interactions - Chair: C. McCulloch (UoT) | Notes |
| 8.30 – 9.10 | 1. Donald Gullberg, University of Bergen Integrin α11β1 - a fibroblast protein with a role in fibrosis | |
| 9.15 – 9.55 | 2. Andrew Leask, University of Western Ontario Fibroblast-specific expression of CCN2 is required for activation of cancer asssociated-fibroblasts, angiogenesis and metastasis in a murine mode of melanoma | External |
| 10.00-10.20 | Coffee | |
| Session 1b. Cell-ECM interactions - Chair: D. Gullberg (UiB, UCSF) | ||
| 10.20-11.00 | 3. Christopher McCulloch, University of Toronto Role of Flightless in Remodeling of the Fibrotic Stroma | |
| 11.05-11.45 | 4. Boris Hinz, University of Toronto Macrophage-Myofibroblast (Mis-) Communication | External |
| 11.50-12.30 | 5. Dean Sheppard, UCSF Targeting TGFbeta-activing integrins to treat tissue fibrosis and cancer | |
| 12.35-13.00 | Lunch | |
| Session 2a. Tumor stroma associated fibrosis - Chair: V. Weaver (UCSF) | ||
| 13.00-13.40 | 6. Roya Navab, University of Toronto Desmoplasia is associated with poor prognosis and carcinoma-associated fibroblasts heterogeneity in non-small cell lung cancer | |
| 13.45-14.25 | 7. Valerie Weaver, UCSF Tumor stiffness and hypoxia | |
| 14.30-15.05 | 8. Neil Bhowmick, Cedars Sinail Medical Centre, Los Angeles The role of glutamine in fibroblastic activation and tumor progression | External |
| 15.10-15.25 | Coffee | |
| Session 2b. Tumor stroma associated fibrosis - Chair: D. Sheppard (UCSF) | ||
| 15.25-16.05 | 9. Zena Werb, UCSF Tissue fibrosis and hypoxia in aggressive, basal-like breast cancers | |
| 16.10-16.50 | 10. Tushar Desai, Stanford Mapping Wnt signaling niches at cellular resolution in intact lung during IPF progression | External |
| 16.55-17.30 | Business meeting SIU - Upcoming student exchanges | |
| 19.00 | Dinner – for speakers and some other invited guests | |
| June 8th | Session 3a. Mechanisms of fibrosis - Chair: B. Hinz (UoT) | |
| 8.30 - 9.10 | 11. Ari Molofsky, UCSF Mesenchymal - immune crosstalk at lymphocyte tissue niches | |
| 9.15 - 9.55 | 12. Yang Chen, MD Anderson Cancer Centre, Houston Fibrosis and Cancer Metastasis | External |
| 10.00-10.20 | Coffee | |
| Session 3b. Mechanisms of fibrosis - Chair: R. Navab (UoT) | ||
| 10.20-10.50 | 13. Tien Peng, UCSF Stromal diversity and plasticity in the maintenance of organ function andfibrotic repair | |
| 10.55-11.30 | 14.Tammy Chang, UCSF The Role of Focal Adhesion Kinase in Hepatic Fibrogenesis | |
| 11.35-12.10 | 15. Ori Maller, UCSF A reciprocal interplay between tissue fibrosis and tumor immunity in breast cancer | |
| 12.15-13.00 | Lunch | |
| Session 4. Emerging anti-fibrotic therapies - Chair: S. Porter (Fibrogen) | ||
| 13.00-13.40 | 16. Bernard Coulie, Pliant Therapeutics Developing target engagement and inhibition tools to de-risk the clinical development of a dual selective αvβ6/αvβ1 integrin inhibitor in IPF and otherfibrotic diseases | |
| 13.45-14.25 | 17. Eduard Gorina, Fibrogen Pamrevlumab vs placebo in patients with IPF. Results of a Phase 2 Clinical Trial | |
| 14.30-15.10 | 18. Kenneth E. Lipson, Fibrogen Activity and mechanism of pamrevlumab (anti-CTGF) in a mouse radiation-induced lung fibrosis model | |
| 15.15-15.35 | Coffee |
Financed: SIU
Transport information
See the attached information regarding extra shuttle bus to conference site: Updated conference info SF June7-8.pdf
Shuttle bus pick up instructions:
Shuttle bus pick-up will be at 401 Parnassus Avenue on the side of road where traffic goes east.
Pick-up area will be in area marked shuttle buses, same area where shuttle buses Gold leave for Mission bay.
Bus will have sign saying "Fibrosis meeting" in windshield, and there will be a sign on curb as well.
Bus will have a maximum pick-up time of 5 minutes 7.55- 8.00, so please be on time.
POSTER BOARDS
To all participants of Fibrosis conference in SF June 7-8,
We have rented poster screens that will be up all of Thursday and Friday to enable poster discussion in lunches and coffee breaks. Please write Donald Gullberg if you are bringing a poster.
Confirmed Speakers
Zena Werb, UCSF
Dean Sheppard, UCSF
Boris Hinz, UoT
Yang Chen, MD Anderson Cancer Ctr
Christopher McCulloch, UoT
Donald Gullberg, UiB
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