- E-mailLeif.Oltedal@uib.no
- Visitor AddressMohn Medical Imaging and Visualization CentreDepartment of Radiology, Haukeland University Hospital5021 BergenRoomL119, Sentralblokken
- Postal AddressPostboks 78045020 Bergen
Neuroradiology
Magnetic Resonance Imaging (MRI)
Selected publications
Blanken MAJT, Oudega ML, Hoogendoorn AW, Sonnenberg CS, Rhebergen D, Klumpers UMH, Van Diermen L, Birkenhager T, Schrijvers D, Redlich R, Dannlowski U, Heindel W, Coenjaerts M, Nordanskog P, Oltedal L, Kessler U, Frid LM, Takamiya A, Kishimoto T, Jorgensen MB, Jorgensen A, Bolwig T, Emsell L, Sienaert P, Bouckaert F, Abbott CC, Péran P, Arbus C, Yrondi A, Kiebs M, Philipsen A, van Waarde JA, Prinsen E, van Verseveld M, Van Wingen G , ten Doesschate F, Camprodon JA ,Kritzer M, Barbour T, Argyelan M, Cardoner N, Urretavizcaya M, Soriano-Mas C, Narr KL, Espinoza RT, Prudic J, Rowny S, van Eijndhoven P, Tendolkar I, Dols A. (2023) Sex-specifics of ECT outcome. J. Affect. Disord.
van de Mortel LA, Bruin WB, Thomas RM, Abbott C, Argyelan M, van Eijndhoven P, Mulders P, Narr K, Tendolkar I, Verdijk JPAJ, van Waarde JA, Bartsch H, Oltedal L, van Wingen GA. Multimodal multi-center analysis of electroconvulsive therapy effects: brainwide gray matter increase without functional changes. (2022) Brain stimulation.
Takamiya A, Dols A, Emsell L, Abbott C, Yrondi A, Soriano Mas C, Jorgensen MB, Nordanskog P, Rhebergen D, van Exel E, Oudega ML, Bouckaert F, Vandenbulcke M, Sienaert P, Péran P, Cano M, Cardoner N, Jorgensen A, Paulson OB, Hamilton P, Kampe R, Bruin W, Bartsch H, Ousdal OT, Kessler U, van Wingen G, Oltedal L, Kishimoto T. (2022) Neural substrates of late-life psychotic depression: Findings from the Global ECT-MRI Research Collaboration. Schizophrenia Bulletin.
Brancati GE, Brekke N, Bartsch H, Evjenth Sørhaug OJ, Ousdal OT, Hammar Å, Schuster PM, Oedegaard KJ, Kessler U and Oltedal L (2021). Short and long-term effects of single and multiple sessions of electroconvulsive therapy on brain gray matter volumes. Brain stimulation.
Ousdal OT, Brancatei GE, Kessler U, Erchinger V, Dale AM, Abbott C & Oltedal L (2021). The neurobiological effects of electroconvulsive therapy studied through magnetic resonance – what have we learnt and where do we go? Biological Psychiatry.
Erchinger VJ, Ersland L, Aukland SA, Abbott CC and Oltedal L (2021). Magnetic resonance spectroscopy in depressed subjects treated with electroconvulsive therapy – a systematic review of literature. Frontiers in Psychiatry
Erchinger VJ, Miller J, Jones T, Kessler U, Bustillo J, Haavik J, Petrillo J, Ziomek G, Hammar Å, Oedegaard KJ, Calhoun VD, McClintock SM,Ersland L, Oltedal L, Abbott CC (2020). Anterior cingulate gamma-aminobutyric acid concentrations and electroconvulsive therapy. Brain and Behavior
Ousdal OT, Gjestad R and Oltedal L (2020). Reply to: Clinical Relevance of Brain Changes After Electroconvulsive Therapy: Is There Really No Link at All? Biol Psychiatry
Mulders PCR, Llera S, Beckmann CF, […] , Oltedal L, […] , Abbott CC, van Eijndhoven PFE and Tendolkar I. Structural changes induced by electroconvulsive therapy are associated with clinical outcome. (2020). Brain Stimulation
Argyelan M, Oltedal L, Deng ZD, Wade B [GEMRIC] & Abbott CC. Electrical field cause volumetric changes in the human brain. (2019). eLife
Ousdal OT, [GEMRIC] and Oltedal L. (2019). Brain changes induced by electroconvulsive therapy are broadly distributed. Biological Psychiatry
Malmei Aarsland TI, Leskauskaite I, Midttun Ø, Ulvik A, Ueland PM, Oltedal L, Erchinger VJ, Oedegaard KJ, Haavik J, Kessler U. (2019). The effect of electroconvulsive therapy (ECT) on serum tryptophan metabolites. Brain Stimulation
Karunamuni RA, White NS, Fromm A, Moen G, Grüner ER, Dale AM & Oltedal L. (2019). Improved characterization of cerebral infarction using combined tissue T2 and high b-value diffusion MRI in post-thrombectomy patients – a feasibility study. Acta Radiologica
Gewin V. & Oltedal L. (2018). Formalize agreements. Nature (Interview)
Oltedal L, Narr KL, Abbott C, Anand A, [GEMRIC], Vandenbulcke M, Oedegaard KJ, Dale AM. (2018). Volume of the human hippocampus and clinical response following electroconvulsive therapy. Biological Psychiatry
Oltedal L, Bartsch H, Sorhaug OJE, [...], Dale AM & Oedegaard KJ. (2017). The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy. Neuroimage: Clinical
Sirnes E, Oltedal L, Bartsch H, Eide GE, Elgen IB & Aukland SM. (2017). Brain morphology in school-aged children with prenatal opioid exposure: A structural MRI study. Early Hum Dev
Oltedal L & Hugdahl K. (2016). Opposite brain laterality in analogous auditory and visual tests. Laterality
Oltedal L, Kessler U, Ersland L, Grüner R, Andreassen OA, Haavik J, Hoff PI, Hammar Å, Dale AM, Hugdahl K and Oedegaard KJ. (2015). Effects of ECT in treatment of depression: Study protocol for a prospective neuroradiological study of acute and longitudinal effects on brain structure and function. BMC Psychiatry
Oltedal L & Hartveit E. (2010). Transient release kinetics of rod bipolar cells revealed by capacitance measurement of exocytosis from axon terminals in rat retinal slices. J Physiol
Veruki ML, Oltedal L & Hartveit E. (2010). Electrical coupling and passive membrane properties of AII amacrine cells. J Neurophysiol
Oltedal L, Veruki ML & Hartveit E. (2009). Passive membrane properties and electrotonic signal processing in retinal rod bipolar cells. J Physiol
Veruki ML, Oltedal L & Hartveit E. (2008). Electrical synapses between AII amacrine cells: dynamic range and functional consequences of variation in junctional conductance. J Neurophysiol
Oltedal L, Haglerød C, Furmanek T & Davanger S. (2008). Vesicular release of glutamate from hippocampal neurons in culture: An immunocytochemical assay. Exp Brain Res
Oltedal L, Mørkve SH, Veruki ML & Hartveit E. (2007). Patch-clamp investigations and compartmental modeling of rod bipolar axon terminals in an in vitro thin-slice preparation of the mammalian retina. J Neurophysiol
Hasegawa H, Yang Z, Oltedal L, Davanger S & Hay JC. (2004). Intramolecular protein-protein and protein-lipid interactions control the conformation and subcellular targeting of neuronal Ykt6. J Cell Sci
Vik-Mo EO, Oltedal L, Hoivik EA, Kleivdal H, Eidet J & Davanger S. (2003). Sec6 is localized to the plasma membrane of mature synaptic terminals and is transported with secretogranin II-containing vesicles. Neuroscience
For complete publications list, see below
- (2023). Sex-specifics of ECT outcome. Journal of Affective Disorders. 243-248.
- (2022). Multimodal multi-center analysis of electroconvulsive therapy effects in depression: Brainwide gray matter increase without functional changes. Brain Stimulation. 1065-1072.
- (2021). Short and long-term effects of single and multiple sessions of electroconvulsive therapy on brain gray matter volumes. Brain Stimulation. 1330-1339.
- (2021). Neural Substrates of Psychotic Depression: Findings From the Global ECT-MRI Research Collaboration. Schizophrenia Bulletin. 1-10.
- (2021). Elevated body weight modulates subcortical volume change and associated clinical response following electroconvulsive therapy. Journal of Psychiatry & Neuroscience.
- (2021). Accounting for symptom heterogeneity can improve neuroimaging models of antidepressant response after electroconvulsive therapy. Human Brain Mapping. 1-12.
- (2020). Structural changes induced by electroconvulsive therapy are associated with clinical outcome. Brain Stimulation. 696-704.
- (2020). Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study. Immunity,Inflammation and Disease. 342-359.
- (2020). Anterior cingulate gamma-aminobutyric acid concentrations and electroconvulsive therapy. Brain and Behavior. 1-11.
- (2020). A Longitudinal Comparison Between Depressed Patients Receiving Electroconvulsive Therapy and Healthy Controls on Specific Memory Functions. The Primary Care Companion for CNS Disorders (PCC).
- (2019). The effect of electroconvulsive therapy (ECT) on serum tryptophan metabolites. Brain Stimulation. 1135-1142.
- (2019). International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen-ECT-ic). European Archives of Psychiatry and Clinical Neuroscience. 1-12.
- (2019). Improved characterization of cerebral infarction using combined tissue T2 and high b-value diffusion MRI in post-thrombectomy patients: a feasibility study. Acta Radiologica. 1294-1300.
- (2019). Electric field causes volumetric changes in the human brain. eLIFE. 1-20.
- (2019). Depressive Symptom Dimensions in Treatment-Resistant Major Depression and Their Modulation With Electroconvulsive Therapy. Journal of ECT. 1-7.
- (2019). Brain changes induced by electroconvulsive therapy are broadly distributed. Biological Psychiatry. 451-461.
- (2018). Volume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy. Biological Psychiatry. 574-581.
- (2017). The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy. NeuroImage: Clinical. 422-432.
- (2017). Brain morphology in school-aged children with prenatal opioid exposure: A structural MRI study. Early Human Development. 33-39.
- (2016). Opposite brain laterality in analogous auditory and visual tests. Laterality: Asymmetries of Body, Brain and Cognition. 690-702.
- (2015). Effects of ECT in treatment of depression: Study protocol for a prospective neuroradiological study of acute and longitudinal effects on brain structure and function. BMC Psychiatry. 10 pages.
- (2010). Transient release kinetics of rod bipolar cells revealed by capacitance measurement of exocytosis from axon terminals in rat retinal slices. Journal of Physiology. 1469-1487.
- (2010). Electrical coupling and passive membrane properties of AII amacrine cells. Journal of Neurophysiology. 1456-1466.
- (2009). Passive membrane properties and electrotonic signal processing in retinal rod bipolar cells. Journal of Physiology. 829-849.
- (2008). Vesicular release of glutamate from hippocampal neurons in culture: an immunocytochemical assay. Experimental Brain Research. 479-492.
- (2008). Electrical Synapses Between AII Amacrine Cells: Dynamic Range and Functional Consequences of Variation in Junctional Conductance. Journal of Neurophysiology. 3305-3322.
- (2007). Patch clamp investigations and compartmental modeling of rod bipolar axon terminals in an in vitro thin slice preparation of the mammalian retina. Journal of Neurophysiology. 1171-1187.
- (2007). Antibodies to CRMP3-4 associated with limbic encephalitis and thymoma. Clinical and Experimental Immunology. 16-22.
- (2004). Intramolecular protein-protein and protein-lipid interactions control the conformation and subcellular targeting of neuronal Ykt6. Journal of Cell Science. 4495-4508.
- (2003). Sec6 is localized to the plasma membrane of mature synaptic terminals and is transported with secretogranin II-containing vesicles. Neuroscience. 73-85.
- (2013). Cases for juniors.
- (2018). GEMRIC: now and the future.
- (2001). Sec6 and sec8 may have different roles in neuronal vesicle targeting.
- (2021). Reply to: Clinical Relevance of Brain Changes After Electroconvulsive Therapy: Is There Really No Link at All? Biological Psychiatry. e15-e16.
- (2009). Electrical recordings from a presynaptic terminal - a study of passive membrane properties and exocytosis.
- (2004). CRMP3 antibodies associated with limbic encephalitis and thymoma. Journal of Neuroimmunology.
- (2021). ECT’s Effects on the Brain’s Motor Coordination.
- (2018). Research Agenda of the Mohn Medical Imaging and Visualization Centre in Bergen, Norway.
- (2017). Lipidomics in Patients Receiving ECT.
- (2015). Use of electroconvulsive therapy in postpartum affective disorder. A systematic review of the literature.
- (2013). Project outline: Effects of ECT in treatment of major depression. A prospective neuroradiological study of acute and longitudinal effects on brain structure and function.
- (2012). A dichoptic analog to the Bergen dichotic listening paradigm: A pilot study. .
- (2009). Passive membrane properties of AII amacrine cells.
- (2002). Pyramidal cell antibodies associated with limbic encephalitis and thymoma.
- (2021). The Neurobiological Effects of Electroconvulsive Therapy Studied Through Magnetic Resonance: What Have We Learned, and Where Do We Go? Biological Psychiatry. 1-10.
- (2021). Magnetic resonance spectroscopy in depressed subjects treated with electroconvulsive therapy—A systematic review of literature. Frontiers in Psychiatry. 1-10.
- (2019). Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative. International journal of bipolar disorders. 1-10.
- (2022). Hjernemetastasar – diagnostikk og behandling. Tidsskrift for Den norske legeforening. 1-7.
- (2013). ECT og kognitive bivirkninger. BestPractice Psykiatri/Nevrologi/Geriatri. 23-25.
- (2018). Formalize agreements. Nature. 402-402.
More information in national current research information system (CRIStin)
I lead the Neurostimulation and brain imaging research group and the following ongoing studies
1) The Global ECT-MRI Research Collaboration (GEMRIC)
- The GEMRIC was established in 2015 and defined as a Global network for determining the mechanisms of action of Electroconvulsive Therapy using Magnetic Resonance Imaging through Collaboration. The collaboration is coordinated by Dr. Leif Oltedal, and the common data repository is located at the University of Bergen.
2) ECT and Neuroradiology (ECTMRI)
- Electroconvulsive therapy, acute and longitudinal effects https://mmiv.no/ect/. Studied by MRI (Structural, diffusion (RSI), MR spectroscopy (including Glutamate and GABA)); Neuropsychological tests and blood samples. See protocol paper here. Web page in Norwegian here.
3) Neurobiological mechanism of ECT and rTMS treatment (FundECT). An observational study which includes patients with moderate and severe depression who receive electroconvulsive therapy or repetetive Transcranial Magnetic Stimulation at Haukeland Univeristy Hospital.
In addition to the above projects I am involed in a number of ongoing studies in Neuroradiology and Psychiatry.
Previous projects
RSI in neuroradiological imaging
- Restriction Spectrum Imaging (RSI) to characterize diffusion signal in cerebral infarction. Restricted versus hindered diffusion.