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Leif Oltedal

Associate Professor
  • E-mailLeif.Oltedal@uib.no
  • Visitor Address
    Haukeland Universitetssykehus Laboratoriebygget, 7. etg. Heis øst
  • Postal Address
    Postboks 7804
    5020 Bergen

Neuroradiology

Magnetic Resonance Imaging (MRI)

Selected publications

  • Erchinger VJ, Ersland L, Aukland SA, Abbott CC and Oltedal L (2021). Magnetic resonance spectroscopy in depressed subjects treated with electroconvulsive therapy – a systematic review of literature. Frontiers in Psychiatry 

  • Erchinger VJ, Miller J, Jones T, Kessler U, Bustillo J, Haavik J, Petrillo J, Ziomek G, Hammar Å, Oedegaard KJ, Calhoun VD, McClintock SM,Ersland L, Oltedal L, Abbott CC (2020). Anterior cingulate gamma-aminobutyric acid concentrations and electroconvulsive therapy. Brain and Behavior 

  • Ousdal OT, Gjestad R and Oltedal L (2020). Reply to: Clinical Relevance of Brain Changes After Electroconvulsive Therapy: Is There Really No Link at All? Biol Psychiatry

  • Mulders PCR, Llera S, Beckmann CF, […] , Oltedal L, […] , Abbott CC, van Eijndhoven PFE and Tendolkar I. Structural changes induced by electroconvulsive therapy are associated with clinical outcome. (2020). Brain Stimulation

  • Argyelan M, Oltedal L, Deng ZD, Wade B [GEMRIC] & Abbott CC. Electrical field cause volumetric changes in the human brain. (2019). eLife

  • Ousdal OT, [GEMRIC] and Oltedal L. (2019). Brain changes induced by electroconvulsive therapy are broadly distributed. Biological Psychiatry

  • Malmei Aarsland TI, Leskauskaite I, Midttun Ø, Ulvik A, Ueland PM, Oltedal L, Erchinger VJ, Oedegaard KJ, Haavik J, Kessler U. (2019). The effect of electroconvulsive therapy (ECT) on serum tryptophan metabolites.  Brain Stimulation

  • Karunamuni RA, White NS, Fromm A, Moen G, Grüner ER, Dale AM & Oltedal L. (2019). Improved characterization of cerebral infarction using combined tissue T2 and high b-value diffusion MRI in post-thrombectomy patients – a feasibility study. Acta Radiologica

  • Gewin V. & Oltedal L. (2018). Formalize agreements. Nature (Interview)

  • Oltedal L, Narr KL, Abbott C, Anand A, [GEMRIC], Vandenbulcke M, Oedegaard KJ, Dale AM. (2018). Volume of the human hippocampus and clinical response following electroconvulsive therapy. Biological Psychiatry

  • Oltedal L, Bartsch H, Sorhaug OJE, [...], Dale AM & Oedegaard KJ. (2017). The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy. Neuroimage: Clinical

  • Sirnes E, Oltedal L, Bartsch H, Eide GE, Elgen IB & Aukland SM. (2017). Brain morphology in school-aged children with prenatal opioid exposure: A structural MRI study. Early Hum Dev

  • Oltedal L & Hugdahl K. (2016). Opposite brain laterality in analogous auditory and visual tests. Laterality

  • Oltedal L, Kessler U, Ersland L, Grüner R, Andreassen OA, Haavik J, Hoff PI, Hammar Å, Dale AM, Hugdahl K and Oedegaard KJ. (2015). Effects of ECT in treatment of depression: Study protocol for a prospective neuroradiological study of acute and longitudinal effects on brain structure and function. BMC Psychiatry

  • Oltedal L & Hartveit E. (2010). Transient release kinetics of rod bipolar cells revealed by capacitance measurement of exocytosis from axon terminals in rat retinal slices. J Physiol

  • Veruki ML, Oltedal L & Hartveit E. (2010). Electrical coupling and passive membrane properties of AII amacrine cells. J Neurophysiol 

  • Oltedal L, Veruki ML & Hartveit E. (2009). Passive membrane properties and electrotonic signal processing in retinal rod bipolar cells. J Physiol 

  • Veruki ML, Oltedal L & Hartveit E. (2008). Electrical synapses between AII amacrine cells: dynamic range and functional consequences of variation in junctional conductance. J Neurophysiol 

  • Oltedal L, Haglerød C, Furmanek T & Davanger S. (2008). Vesicular release of glutamate from hippocampal neurons in culture: An immunocytochemical assay. Exp Brain Res

  • Oltedal L, Mørkve SH, Veruki ML & Hartveit E. (2007). Patch-clamp investigations and compartmental modeling of rod bipolar axon terminals in an in vitro thin-slice preparation of the mammalian retina. J Neurophysiol

  • Hasegawa H, Yang Z, Oltedal L, Davanger S & Hay JC. (2004). Intramolecular protein-protein and protein-lipid interactions control the conformation and subcellular targeting of neuronal Ykt6. J Cell Sci

  • Vik-Mo EO, Oltedal L, Hoivik EA, Kleivdal H, Eidet J & Davanger S. (2003). Sec6 is localized to the plasma membrane of mature synaptic terminals and is transported with secretogranin II-containing vesicles. Neuroscience

 

For complete publications list, see below

Academic article
  • Show author(s) 2021. Short and long-term effects of single and multiple sessions of electroconvulsive therapy on brain gray matter volumes. Brain Stimulation. 1330-1339.
  • Show author(s) 2021. Accounting for symptom heterogeneity can improve neuroimaging models of antidepressant response after electroconvulsive therapy. Human Brain Mapping. 1-12.
  • Show author(s) 2020. Structural changes induced by electroconvulsive therapy are associated with clinical outcome. Brain Stimulation. 696-704.
  • Show author(s) 2020. Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study. Immunity,Inflammation and Disease. 342-359.
  • Show author(s) 2020. Anterior cingulate gamma-aminobutyric acid concentrations and electroconvulsive therapy. Brain and Behavior. 1-11.
  • Show author(s) 2020. A Longitudinal Comparison Between Depressed Patients Receiving Electroconvulsive Therapy and Healthy Controls on Specific Memory Functions. The Primary Care Companion for CNS Disorders (PCC).
  • Show author(s) 2019. The effect of electroconvulsive therapy (ECT) on serum tryptophan metabolites. Brain Stimulation. 1135-1142.
  • Show author(s) 2019. International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen-ECT-ic). European Archives of Psychiatry and Clinical Neuroscience. 1-12.
  • Show author(s) 2019. Improved characterization of cerebral infarction using combined tissue T2 and high b-value diffusion MRI in post-thrombectomy patients: a feasibility study. Acta Radiologica. 1294-1300.
  • Show author(s) 2019. Electric field causes volumetric changes in the human brain. eLIFE. 1-20.
  • Show author(s) 2019. Depressive Symptom Dimensions in Treatment-Resistant Major Depression and Their Modulation With Electroconvulsive Therapy. Journal of ECT. 1-7.
  • Show author(s) 2019. Brain changes induced by electroconvulsive therapy are broadly distributed. Biological Psychiatry. 451-461.
  • Show author(s) 2018. Volume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy. Biological Psychiatry. 574-581.
  • Show author(s) 2017. The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy. NeuroImage: Clinical. 422-432.
  • Show author(s) 2017. Brain morphology in school-aged children with prenatal opioid exposure: A structural MRI study. Early Human Development. 33-39.
  • Show author(s) 2016. Opposite brain laterality in analogous auditory and visual tests. Laterality: Asymmetries of Body, Brain and Cognition. 690-702.
  • Show author(s) 2015. Effects of ECT in treatment of depression: Study protocol for a prospective neuroradiological study of acute and longitudinal effects on brain structure and function. BMC Psychiatry. 10 pages.
  • Show author(s) 2010. Transient release kinetics of rod bipolar cells revealed by capacitance measurement of exocytosis from axon terminals in rat retinal slices. Journal of Physiology. 1469-1487.
  • Show author(s) 2010. Electrical coupling and passive membrane properties of AII amacrine cells. Journal of Neurophysiology. 1456-1466.
  • Show author(s) 2009. Passive membrane properties and electrotonic signal processing in retinal rod bipolar cells. Journal of Physiology. 829-849.
  • Show author(s) 2008. Vesicular release of glutamate from hippocampal neurons in culture: an immunocytochemical assay. Experimental Brain Research. 479-492.
  • Show author(s) 2008. Electrical Synapses Between AII Amacrine Cells: Dynamic Range and Functional Consequences of Variation in Junctional Conductance. Journal of Neurophysiology. 3305-3322.
  • Show author(s) 2007. Patch clamp investigations and compartmental modeling of rod bipolar axon terminals in an in vitro thin slice preparation of the mammalian retina. Journal of Neurophysiology. 1171-1187.
  • Show author(s) 2007. Antibodies to CRMP3-4 associated with limbic encephalitis and thymoma. Clinical and Experimental Immunology. 16-22.
  • Show author(s) 2004. Intramolecular protein-protein and protein-lipid interactions control the conformation and subcellular targeting of neuronal Ykt6. Journal of Cell Science. 4495-4508.
  • Show author(s) 2003. Sec6 is localized to the plasma membrane of mature synaptic terminals and is transported with secretogranin II-containing vesicles. Neuroscience. 73-85.
Lecture
  • Show author(s) 2013. Cases for juniors.
Academic lecture
  • Show author(s) 2018. GEMRIC: now and the future.
  • Show author(s) 2001. Sec6 and sec8 may have different roles in neuronal vesicle targeting.
Letter to the editor
  • Show author(s) 2020. Reply to: Clinical Relevance of Brain Changes After Electroconvulsive Therapy: Is There Really No Link at All? Biological Psychiatry.
Doctoral dissertation
  • Show author(s) 2009. Electrical recordings from a presynaptic terminal - a study of passive membrane properties and exocytosis.
Abstract
  • Show author(s) 2004. CRMP3 antibodies associated with limbic encephalitis and thymoma. Journal of Neuroimmunology.
Poster
  • Show author(s) 2018. Research Agenda of the Mohn Medical Imaging and Visualization Centre in Bergen, Norway.
  • Show author(s) 2015. Use of electroconvulsive therapy in postpartum affective disorder. A systematic review of the literature.
  • Show author(s) 2013. Project outline: Effects of ECT in treatment of major depression. A prospective neuroradiological study of acute and longitudinal effects on brain structure and function.
  • Show author(s) 2012. A dichoptic analog to the Bergen dichotic listening paradigm: A pilot study. .
  • Show author(s) 2009. Passive membrane properties of AII amacrine cells.
  • Show author(s) 2002. Pyramidal cell antibodies associated with limbic encephalitis and thymoma.
Academic literature review
  • Show author(s) 2021. The Neurobiological Effects of Electroconvulsive Therapy Studied Through Magnetic Resonance: What Have We Learned, and Where Do We Go? Biological Psychiatry. 9 pages.
  • Show author(s) 2021. Magnetic resonance spectroscopy in depressed subjects treated with electroconvulsive therapy—A systematic review of literature. Frontiers in Psychiatry. 1-10.
  • Show author(s) 2019. Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative. International journal of bipolar disorders. 1-10.
Article in business/trade/industry journal
  • Show author(s) 2013. ECT og kognitive bivirkninger. BestPractice Psykiatri/Nevrologi/Geriatri. 23-25.
Interview Journal
  • Show author(s) 2018. Formalize agreements. Nature. 402-402.

More information in national current research information system (CRIStin)

1) The Global ECT-MRI Research Collaboration (GEMRIC

- The GEMRIC was established in 2015 and defined as a Global network for determining the mechanisms of action of Electroconvulsive Therapy using Magnetic Resonance Imaging through Collaboration. The collaboration is coordinated by Dr. Leif Oltedal, and the   common data repository is located at the University of Bergen. 

2) ECT and Neuroradiology

- Electroconvulsive therapy, acute and longitudinal effects https://mmiv.no/ect/. Studied by MRI (Structural, diffusion (RSI), MR spectroscopy (including Glutamate and GABA)); Neuropsychological tests and blood samples. See protocol paper here.

3) RSI in neuroradiological imaging

- Restriction Spectrum Imaging (RSI) to characterize diffusion signal in cerebral infarction. Restricted versus hindered diffusion.