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Leif Oltedal

Associate Professor
  • E-mailLeif.Oltedal@uib.no
  • Phone+47 55 58 63 65
  • Visitor Address
    Haukeland Universitetssykehus Laboratoriebygget, 7. etg. Heis øst
  • Postal Address
    Postboks 7804
    5020 Bergen
Academic article
  • Aarsland, Tore Ivar Malmei; Leskauskaite, Ieva; Midttun, Øivind; Ulvik, Arve; Ueland, Per Magne; Oltedal, Leif; Erchinger, Vera Jane; Ødegaard, Ketil Joachim; Haavik, Jan; Kessler, Ute. 2019. The effect of electroconvulsive therapy (ECT) on serum tryptophan metabolites. Brain Stimulation. 1-8.
  • Ousdal, Olga Therese; Argyelan, Miklos; Narr, Katherine L.; Abbott, Christopher; Wade, Benjamin; Vandenbulcke, Mathieu; Urretavizcaya, Mikel; Tendolkar, Indira; Takamiya, Akihiro; Stek, Max L.; Soriano-Mas, Carles; Redlich, Ronny; Paulson, Olaf B.; Oudega, Mardien L.; Opel, Nils; Nordanskog, Pia; Kishimoto, Taishiro; Kämpe, Robin; Jørgensen, Anders; Hanson, Lars G.; Hamilton, J. Paul; Espinoza, Randall; Emsell, Louise; van Eijndhoven, Philip; Dols, Annemieke; Dannlowski, Udo; Cardoner, Narcis; Bouckaert, Filip; Anand, Amit; Bartsch, Hauke; Kessler, Ute; Ødegaard, Ketil Joachim; Dale, Anders; Oltedal, Leif. 2019. Brain changes induced by electroconvulsive therapy are broadly distributed. Biological Psychiatry. 1-11.
  • Oltedal, Leif; Narr, Katherine L.; Abbott, Christopher; Anand, Amit; Argyelan, Miklos; Bartsch, Hauke; Dannlowski, Udo; Dols, Annemieke; van Eijndhoven, Philip; Emsell, Louise; Erchinger, Vera Jane; Espinoza, Randall; Hahn, Tim; Hanson, Lars G.; Hellemann, Gerhard; Jørgensen, Martin Balslev; Kessler, Ute; Oudega, Mardien L.; Paulson, Olaf B.; Redlich, Ronny; Sienaert, Pascal; Stek, Max L.; Tendolkar, Indira; Vandenbulcke, Mathieu; Ødegaard, Ketil Joachim; Dale, Anders. 2018. Volume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy. Biological Psychiatry. 574-581.
  • Oltedal, Leif; Bartsch, Hauke; Sørhaug, Ole Johan Evjenth; Kessler, Ute; Abbott, Christopher; Dols, Annemieke; Stek, Max L; Ersland, Lars; Emsell, Louise; van Eijndhoven, Philip; Argyelan, Miklos; Tendolkar, Indira; Nordanskog, Pia; Hamilton, Paul; Jorgensen, Martin Balslev; Sommer, Iris E; Heringa, Sophie M; Draganski, Bogdan; Redlich, Ronny; Dannlowski, Udo; Kugel, Harald; Bouckaert, Filip; Sienaert, Pascal; Anand, Amit; Espinoza, Randall; Narr, Katherine L; Holland, Dominic; Dale, Anders M; Ødegaard, Ketil Joachim. 2017. The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy. NeuroImage: Clinical. 422-432.
  • Sirnes, Eivind; Oltedal, Leif; Bartsch, Hauke; Eide, Geir Egil; Elgen, Irene Bircow; Aukland, Stein Magnus. 2017. Brain morphology in school-aged children with prenatal opioid exposure: A structural MRI study. Early Human Development. 33-39.
  • Oltedal, Leif; Hugdahl, Kenneth. 2016. Opposite brain laterality in analogous auditory and visual tests. Laterality: Asymmetries of Body, Brain and Cognition. 690-702.
  • Oltedal, Leif; Kessler, Ute; Ersland, Lars; Grüner, Renate; Andreassen, Ole Andreas; Haavik, Jan; Hoff, Per Ivar; Hammar, Åsa; Dale, Anders Martin; Hugdahl, Kenneth; Ødegaard, Ketil Joachim. 2015. Effects of ECT in treatment of depression: Study protocol for a prospective neuroradiological study of acute and longitudinal effects on brain structure and function. BMC Psychiatry. 10 pages.
  • Oltedal, Leif; Hartveit, Espen. 2010. Transient release kinetics of rod bipolar cells revealed by capacitance measurement of exocytosis from axon terminals in rat retinal slices. Journal of Physiology. 1469-1487.
  • Veruki, Margaret Lin; Oltedal, Leif; Hartveit, Espen. 2010. Electrical coupling and passive membrane properties of AII amacrine cells. Journal of Neurophysiology. 1456-1466.
  • Oltedal, Leif; Veruki, Margaret Lin; Hartveit, Espen. 2009. Passive membrane properties and electrotonic signal processing in retinal rod bipolar cells. Journal of Physiology. 829-849.
  • Oltedal, Leif; Haglerød, Camilla; Furmanek, Tomasz; Davanger, Svend. 2008. Vesicular release of glutamate from hippocampal neurons in culture: an immunocytochemical assay. Experimental Brain Research. 479-492.
  • Veruki, Margaret Lin; Oltedal, Leif; Hartveit, Espen. 2008. Electrical Synapses Between AII Amacrine Cells: Dynamic Range and Functional Consequences of Variation in Junctional Conductance. Journal of Neurophysiology. 3305-3322.
  • Oltedal, Leif; Mørkve, Svein Harald; Veruki, Margaret Lin; Hartveit, Espen. 2007. Patch clamp investigations and compartmental modeling of rod bipolar axon terminals in an in vitro thin slice preparation of the mammalian retina. Journal of Neurophysiology. 1171-1187.
  • Knudsen, Anette; Bredholt, Geir; Storstein, Anette Margrethe; Oltedal, Leif; Davanger, Svend; Krossnes, Bård Kronen; Honnorat, Jérôme; Vedeler, Christian A. 2007. Antibodies to CRMP3-4 associated with limbic encephalitis and thymoma. Clinical and Experimental Immunology. 16-22.
  • Hasegawa, H; Yang, ZF; Oltedal, L; Davanger, Svend; Hay, JC. 2004. Intramolecular protein-protein and protein-lipid interactions control the conformation and subcellular targeting of neuronal Ykt6. Journal of Cell Science. 4495-4508.
  • Vik-Mo, EO; Oltedal, L; Hoivik, EA; Kleivdal, H; Eidet, J; Davanger, Svend. 2003. Sec6 is localized to the plasma membrane of mature synaptic terminals and is transported with secretogranin II-containing vesicles. Neuroscience. 73-85.
Academic lecture
  • Oltedal, Leif. 2018. GEMRIC: now and the future.
  • Davanger, Svend; Vik-Mo, Einar O.; Oltedal, Leif; Høivik, Erling Andrè; Eidet, Jo. 2001. Sec6 and sec8 may have different roles in neuronal vesicle targeting.
Abstract
  • Knudsen, Anette; Bredholt, Geir; Storstein, A.; Oltedal, L; Davanger, Svend; Vedeler, Christian A. 2004. CRMP3 antibodies associated with limbic encephalitis and thymoma. Journal of Neuroimmunology.
Academic literature review
  • Scott, Jan; Hidalgo-Mazzei, Diego; Strawbridge, Rebecca; Young, Allan; Resche-Rigon, Matthieu; Etain, Bruno; Andreassen, Ole Andreas; Bauer, Michael; Bennabi, Djamila; Blamire, Andrew M.; Boumezbeur, Fawzi; Brambilla, Paolo; Cattane, Nadia; Cattaneo, Annamaria; Chupin, Marie; Coello, Klara; Cointepas, Yann; Colom, Francesc; Cousins, David A.; Dubertret, Caroline; Duchesnay, Edouard; Ferro, Adele; Garcia-Estela, Aitana; Goikolea, Jose; Grigis, Antoine; Haffen, Emmanuel; Høegh, Margrethe Collier; Jakobsen, Petter; Kalman, Janos L.; Kessing, Lars V.; Klohn-Saghatolislam, Farah; Lagerberg, Trine Vik; Landén, Mikael; Lewitzka, Ute; Lutticke, Ashley; Mazer, Nicolas; Mazzelli, Monica; Mora, Cristina; Muller, Thorsten; Mur-Mila, Estanislao; Ødegaard, Ketil Joachim; Oltedal, Leif; Pålsson, Erik; Papadopoulos Orfanos, Dimitri; Papiol, Sergi; Perez-Sola, Victor; Reif, Andreas; Ritter, Philipp; Rossi, Roberto; Schulze, Thomas; Senner, Fanny; Smith, Fiona E.; Squarcina, Letizia; Steen, Nils Eiel; Thelwall, Pete E.; Varo, Cristina; Vieta, Eduard; Vinberg, Maj; Wessa, Michele; Westlye, Lars Tjelta; Bellivier, Frank. 2019. Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative. 1-10.

More information in national current research information system (CRIStin)

  • Karunamuni RA, White NS, Fromm A, Moen G, Grüner ER, Dale AM & Oltedal L. (2019). Improved characterization of cerebral infarction using combined tissue T2 and high b-value diffusion MRI in post-thrombectomy patients – a feasibility study. Acta Radiologica. 9:284
  • Oltedal L, Narr KL, Abbott C, Anand A, Argyelan M, Bartsch H, Dannlowski U, Dols A, van Eijndhoven P, Emsel L, Erchinger VJ, Espinoza R, Hahn T, Hanson LG, Hellemann G, Jorgensen MB, Kessler U, Oudega ML, Paulson OB, Redlich R, Sienaert P, Stek ML, Tendolkar I, Vandenbulcke M, Oedegaard KJ, Dale AM. (2018). Volume of the human hippocampus and clinical response following electroconvulsive therapy. Biological Psychiatry. 84: 574-581.
  • Oltedal L, Bartsch H, Sorhaug OJE, Kessler U, Abbott C, Dols A, Stek ML, Ersland L, Emsell L, van Eijndhoven P, Argyelan P, Tendolkar P, Nordanskog P, Hamilton P, Jorgensen MB, Sommer IE, Heringa S, Draganski B, Redlich R, Dannlowski U, Kugel H, Bouckaert F, Sienaert P, Anand A, Espinoza R, Narr KL, Holland D, Dale AM & Oedegaard KJ. (2017). The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy. Neuroimage: Clinical. 14: 424-432.
  • Sirnes E, Oltedal L, Bartsch H, Eide GE, Elgen IB & Aukland SM. (2017). Brain morphology in school-aged children with prenatal opioid exposure: A structural MRI study. Early Hum Dev. 106:33-39
  • Oltedal L& Hugdahl K. (2016). Opposite brain laterality in analogous auditory and visual tests. Laterality. 20:1-13.
  • Oltedal L, Kessler U, Ersland L, Grüner R, Andreassen OA, Haavik J, Hoff PI, Hammar Å, Dale AM, Hugdahl K and Oedegaard KJ. (2015). Effects of ECT in treatment of depression: Study protocol for a prospective neuroradiological study of acute and longitudinal effects on brain structure and function. BMC Psychiatry. 15:94.
  • Oltedal L& Hartveit E. (2010). Transient release kinetics of rod bipolar cells revealed by capacitance measurement of exocytosis from axon terminals in rat retinal slices. J Physiol. 588:1469-87. 
  • Veruki ML, Oltedal L& Hartveit E. (2010). Electrical coupling and passive membrane properties of AII amacrine cells. J Neurophysiol. 103:1456-66. 
  • Oltedal L, Veruki ML & Hartveit E. (2009). Passive membrane properties and electrotonic signal processing in retinal rod bipolar cells. J Physiol. 587:829-49. 
  • Veruki ML, Oltedal L& Hartveit E. (2008). Electrical synapses between AII amacrine cells: dynamic range and functional consequences of variation in junctional conductance. J Neurophysiol. 100:3305-22. 
  • Oltedal L, Haglerød C, Furmanek T & Davanger S. (2008). Vesicular release of glutamate from hippocampal neurons in culture: An immunocytochemical assay. Exp Brain Res. 184:479-92. 
  • Knudsen A, Bredholt G, Storstein A, Oltedal L, Davanger S, Krossnes B, Honnorat J & Vedeler CA. (2007). Antibodies to CRMP3-4 associated with limbic encephalitis and thymoma. Clin Exp Immunol. 149:16-22.
  • Oltedal L, Mørkve SH, Veruki ML & Hartveit E. (2007). Patch-clamp investigations and compartmental modeling of rod bipolar axon terminals in an in vitro thin-slice preparation of the mammalian retina. J Neurophysiol. 97:1171-87.
  • Hasegawa H, Yang Z, Oltedal L, Davanger S & Hay JC. (2004). Intramolecular protein-protein and protein-lipid interactions control the conformation and subcellular targeting of neuronal Ykt6. J Cell Sci. 117:4495-508.
  • Vik-Mo EO, Oltedal L, Hoivik EA, Kleivdal H, Eidet J & Davanger S. (2003). Sec6 is localized to the plasma membrane of mature synaptic terminals and is transported with secretogranin II-containing vesicles. Neuroscience. 119:73-85.

1) The Global ECT-MRI Research Collaboration (GEMRIC

- The GEMRIC was established in 2015 and defined as a Global network for determining the mechanisms of action of Electroconvulsive Therapy using Magnetic Resonance Imaging through Collaboration.

- Currently 21 sites are contributing to GEMRIC.  The collaboration is coordinated by Dr. Leif Oltedal, and the   common data repository is located at the University of Bergen. 

2) ECT and Neuroradiology

- Electroconvulsive therapy, acute and longitudinal effects. Studied by MRI (Structural, diffusion (RSI), MR spectroscopy (including Glutamate and GABA)); Neuropsychological tests and blood samples. See protocol paper here.

3) RSI in neuroradiological imaging

- Restriction Spectrum Imaging (RSI) to characterize diffusion signal in cerebral infarction. Restricted versus hindered diffusion.