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Paul Johan Høl

Senior Engineer, Researcher
  • E-mailPaul.Hol@uib.no
  • Phone+47 55 58 54 43+47 404 66 729
  • Visitor Address
    Biomatlab, Laboratoriebygget
    5021 Bergen
    Room 
    7332
  • Postal Address
    Postboks 7804
    5020 Bergen

My research activities focus on biomaterials, i.e. artificial materials used in reconstructive surgery, which may have huge clinical impact in terms of usage and diversity. The associated research topics span from applied research to basic. The project area "Orthopedic biomaterials" has had an expertise function in Helse Bergen. The activities are designed to involve biomechanical, biological and chemical effects of artificial materials used on humans. The activity is based on clinical aspects, and is therefore translational; from clinic to laboratory. The biomaterial laboratory (BioMatLab) is situated in the new laboratory facilities at Haukeland University Hospital and Department of Clinical Medicine, UiB, which provides a unique opportunity to connect basic research with clinical activities in the field of biomaterials.
There is a strong collaboration with the Norwegian Arthroplasty Register in Bergen, which represents an important body for identifying longevity of joint replacements. 
I have extensive experience in clinical and biological issues, which started with the analysis of trace metals in lung tissue in the Master thesis and continued with my PhD work on the chemical analysis of a large clinical material taken from patients with dental amalgam fillings.
The activities that were started in the postdoctoral period, is further developed under my stipend from Bergen Medical Research Foundation (2010-2013). The project deals with the clinical and biological effects of implants that remain in the body. This is performed by characterize the degradation products in tissue and blood from patients with different types of implants, and correlate with clinical analysis, such as effects on bone cells and immune system.
The ongoing and planned activities will broaden the knowledge of biological and clinical consequences of artificial biomaterials, which can be used in developing new and safer materials.

Selected publications
  • Høl, Paul Johan; Gjerdet, Nils Roar; Jonung, Torbjörn. 2019. Corrosion and metal release from overlapping arterial stents under mechanical and electrochemical stress - An experimental study. Journal of The Mechanical Behavior of Biomedical Materials. 93: 31-35. doi: 10.1016/j.jmbbm.2019.02.001
  • Høl, Paul Johan; Kristoffersen, Einar Klæboe; Gjerdet, Nils Roar; Pellowe, Amanda. 2018. Novel nanoparticulate and ionic titanium antigens for hypersensitivity testing. International Journal of Molecular Sciences. 19:1101: 1-18. doi: 10.3390/ijms19041101
  • Kutzner, Ines; Halland, Geir; Høl, Paul Johan; Furnes, Ove; Gøthesen, Øystein; Figved, Wender; Ellison, Peter. 2017. Early aseptic loosening of a mobile-bearing total knee replacement: A case-control study with retrieval analyses. Acta Orthopaedica. 89: 77-83. Published 2017-11-06. doi: 10.1080/17453674.2017.1398012
  • Varsi, Kristin; Bolann, Bjørn Johan; Torsvik, Ingrid Kristin; Eik, Tina Constanse Rosvold; Høl, Paul Johan; Monsen, Anne Lise Bjørke. 2017. Impact of maternal selenium status on infant outcome during the first 6 months of life. Nutrients. 9. doi: 10.3390/nu9050486
  • Jonitz-Heincke, Anika; Tillmann, Jenny; Klinder, Annett; Krüger, Simone; Kretzer, Jan Philippe; Høl, Paul Johan; Paulus, Alexander C.; Bader, Rainer. 2017. The impact of metal ion exposure on the cellular behavior of human osteoblasts and PBMCs: In vitro analyses of osteolytic processes. Materials. 10:734: 1-15. Published 2017-07-03. doi: 10.3390/ma10070734
  • Grosse, Susann; Haugland, Hans Kristian; Lilleng, Peer Kåre; Ellison, Peter; Hallan, Geir; Høl, Paul Johan. 2015. Wear particles and ions from cemented and uncemented titanium-based hip prostheses - A histological and chemical analysis of retrieval material. Journal of Biomedical Materials Research. Part B - Applied biomaterials. 103: 709-717. doi: 10.1002/jbm.b.33243
  • Høl, Paul Johan; Furnes, Ove; Hallan, Geir; Gjerdet, Nils Roar. 2019. Kontrollen av medisinske implantater kan bli bedre. Dagens medisin. 3. 1 pages. Published 2019-02-07.
  • Høl, Paul Johan; Gjerdet, Nils Roar; Jonung, Torbjörn. 2019. Corrosion and metal release from overlapping arterial stents under mechanical and electrochemical stress - An experimental study. Journal of The Mechanical Behavior of Biomedical Materials. 93: 31-35. doi: 10.1016/j.jmbbm.2019.02.001
  • Refsum, Anders Myhre; Nguyen, Uy Viet; Gjertsen, Jan Erik; Espehaug, Birgitte; Fenstad, Anne Marie; Lein, Regina Küfner; Ellison, Peter; Høl, Paul Johan; Furnes, Ove. 2019. Cementing technique for primary knee arthroplasty: a scoping review. Acta Orthopaedica. 1-8. doi: 10.1080/17453674.2019.1657333
  • Strandenes, Eivind; Ellison, Peter; Mølster, Anders; Gjerdet, Nils Roar; Moldestad, Irene Ohlen; Høl, Paul Johan. 2019. Strength of Pulvertaft modifications: tensile testing of porcine flexor tendons. Journal of Hand Surgery, European Volume. 1-5. Published 2019-04-10. doi: 10.1177/1753193419841522
  • Ellison, Peter; Høl, Paul Johan; Babic, Ankica. 2018. An individual patient outcome tool for joint replacement patients. Studies in Health Technology and Informatics. 251: 129-132. doi: 10.3233/978-1-61499-880-8-129
  • Høl, Paul Johan; Kristoffersen, Einar Klæboe; Gjerdet, Nils Roar; Pellowe, Amanda. 2018. Novel nanoparticulate and ionic titanium antigens for hypersensitivity testing. International Journal of Molecular Sciences. 19:1101: 1-18. doi: 10.3390/ijms19041101
  • Jonitz-Heincke, Anika; Tillmann, Jenny; Ostermann, Melanie; Springer, Armin; Bader, Rainer; Høl, Paul Johan; Cimpan, Mihaela Roxana. 2018. Label-free monitoring of uptake and toxicity of endoprosthetic wear particles in human cell cultures. International Journal of Molecular Sciences. 19:3486: 1-14. Published 2018-11-06. doi: 10.3390/ijms19113486
  • Jonitz-Heincke, Anika; Tillmann, Jenny; Klinder, Annett; Krüger, Simone; Kretzer, Jan Philippe; Høl, Paul Johan; Paulus, Alexander C.; Bader, Rainer. 2017. The impact of metal ion exposure on the cellular behavior of human osteoblasts and PBMCs: In vitro analyses of osteolytic processes. Materials. 10:734: 1-15. Published 2017-07-03. doi: 10.3390/ma10070734
  • Kutzner, Ines; Halland, Geir; Høl, Paul Johan; Furnes, Ove; Gøthesen, Øystein; Figved, Wender; Ellison, Peter. 2017. Early aseptic loosening of a mobile-bearing total knee replacement: A case-control study with retrieval analyses. Acta Orthopaedica. 89: 77-83. Published 2017-11-06. doi: 10.1080/17453674.2017.1398012
  • Varsi, Kristin; Bolann, Bjørn Johan; Torsvik, Ingrid Kristin; Eik, Tina Constanse Rosvold; Høl, Paul Johan; Monsen, Anne Lise Bjørke. 2017. Impact of maternal selenium status on infant outcome during the first 6 months of life. Nutrients. 9. doi: 10.3390/nu9050486
  • Allouni, Zouhir Ekeland; Gjerdet, Nils Roar; Cimpan, Mihaela Roxana; Høl, Paul Johan. 2015. The effect of blood protein adsorption on cellular uptake of anatase TiO2 nanoparticles. International Journal of Nanomedicine. 10: 687-695. doi: 10.2147/IJN.S72726
  • Grosse, Susann; Haugland, Hans Kristian; Lilleng, Peer Kåre; Ellison, Peter; Hallan, Geir; Høl, Paul Johan. 2015. Wear particles and ions from cemented and uncemented titanium-based hip prostheses - A histological and chemical analysis of retrieval material. Journal of Biomedical Materials Research. Part B - Applied biomaterials. 103: 709-717. doi: 10.1002/jbm.b.33243
  • Grosse, Susann; Høl, Paul Johan; Lilleng, Peer Kåre; Haugland, Hans Kristian; Hallan, Geir. 2014. COMPARISON OF WEAR PARTICLE EXPOSURE AND TISSUE REACTIONS IN PATIENTS WITH CEMENTED AND UNCEMENTED TITANIUM HIP PROSTHESES THAT FAILED DUE TO OSTEOLYSIS. Bone & Joint Journal Orthopaedic Proceedings Supplement. 96-B: 41-41. Published 2014-07-01.
  • Allouni, Zouhir Ekeland; Høl, Paul Johan; Cauqui, Miguel Angel; Gjerdet, Nils Roar; Cimpan, Mihaela Roxana. 2012. Role of physicochemical characteristics in the Uptake of TiO2 nanoparticles by fibroblasts. Toxicology in Vitro. 26: 469-479. doi: 10.1016/j.tiv.2012.01.019
  • Ellison, Peter; Hallan, Geir; Høl, Paul Johan; Gjerdet, Nils Roar; Havelin, Leif Ivar. 2012. Coordinating retrieval and register studies improves postmarket surveillance. Clinical Orthopaedics and Related Research. 470: 2995-3002. Published 2012-06-22. doi: 10.1007/s11999-012-2430-4
  • Hallan, Geir; Espehaug, Birgitte; Furnes, Ove; Wangen, Helge; Høl, Paul Johan; Ellison, Peter; Havelin, Leif Ivar. 2012. Is there still a place for the cemented titanium femoral stem? 10,108 cases from the Norwegian Arthroplasty Register. Acta Orthopaedica. 83: 1-6. doi: 10.3109/17453674.2011.645194
  • Flatebø, Rigmor Siri; Høl, Paul Johan; Leknes, Knut N.; Kosler, Jan; Lie, Stein Atle; Gjerdet, Nils Roar. 2011. Mapping of titanium particles in peri-implant oral mucosa by Laser Ablation Inductively Coupled Plasma Mass Spectrometry and high-resolution optical darkfield microscopy. Journal of Oral Pathology & Medicine. 40: 412-420. doi: 10.1111/j.1600-0714.2010.00958.x
  • Allouni, Zouhir Ekeland; Cimpan, Mihaela Roxana; Høl, Paul Johan; Skodvin, Tore; Gjerdet, Nils Roar. 2009. Agglomeration and Sedimentation of TiO2 Nanoparticles in Cell Culture Medium. Colloids and Surfaces B: Biointerfaces. 68: 83-87. Published 2009-01-01. doi: 10.1016/j.colsurfb.2008.09.014
  • Høl, Paul Johan; Mølster, Anders; Gjerdet, Nils Roar. 2008. Should the galvanic combination of titanium and stainless steel surgical implants be avoided? Injury. 39: 161-169. doi: 10.1016/j.injury.2007.07.015
  • Vamanu, Carmen Irina; Cimpan, Mihaela Roxana; Høl, Paul Johan; Sørnes, Steinar; Lie, Stein Atle; Gjerdet, Nils Roar. 2008. Induction of cell death by TiO2 nanoparticles: studies on a human monoblastoid cell line. Toxicology in Vitro. 22: 1689-1696. doi: 10.1016/j.tiv.2008.07.002
  • Vamanu, Carmen Irina; Høl, Paul Johan; Allouni, Zouhir Ekeland; Elsayed, Said; Gjerdet, Nils Roar. 2008. Formation of potential titanium antigens based on protein binding to titanium dioxide nanoparticles. International Journal of Nanomedicine. 3: 69-74.
  • Høl, Paul Johan. 2007. Skrivegruppa for PhD-kandidatar under biomaterialparaplyen. Bergen Open Research Archive (BORA). 7 pages.
  • Høl, Paul Johan; Mølster, Anders; Gjerdet, Nils Roar; Bell, Karin; Sætersdal, Chr; Gjertsen, Jan-Erik. 2006. Hip fracture implants increase serum metal levels. Scandinavian Journal of Clinical and Laboratory Investigation. 66: 705-716. doi: 10.1080/00365510600939877
  • Høl, Paul Johan; Mølster, Anders; Gjerdet, Nils Roar; Bell, Karin; Sætersdal, Christian; Gjertsen, Jan-Erik. 2006. Hip fracture implants increase serum metal levels. Scandinavian Journal of Clinical and Laboratory Investigation.
  • Høl, Paul Johan; Bell, Karin; Gjerdet, Nils Roar; Mølster, Anders. 2005. Nickel contamination from an intravenous catheter used for infusion. Scandinavian Journal of Clinical and Laboratory Investigation.
  • Høl, Paul Johan; Bell, Karin; Mølster, Anders; Gjerdet, Nils Roar. 2005. Nickel contamination from an intravenous catheter used for infusion. Scandinavian Journal of Clinical and Laboratory Investigation. 65: 221-225. doi: 10.1080/00365510510013578
  • Høl, Paul Johan. 2003. Trace elements in persons with dental amalgam. : The role of a chelating agent.

More information in national current research information system (CRIStin)

Bergen Implant Retrieval center for Implants

My on-going project is about improving performance and safety of clinical biomaterials. 

Bergen retrieval center for implants is collecting and analyzing joint prostheses that have failed due to aseptic loosening, often in combination with osteolysis or other immunological reactions.

I have specialised in trace element analysis, mainly on clinically related samples. Main elements of interest are Co, Cr, Zr, Mo, Ni and Ti measured by ICP-MS.

Read more: https://www.researchgate.net/project/Bergen-Retrieval-Center-for-Implants

 

 

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