Cell stress

Recent publications / Nyere publikasjoner

Main content

Chavali, Yddal, Bilfulco, Mannsåker, Røise, Law, Frøyset, Grellscheid and Fladmark (2023) Progressive motor and non-motor symptoms in Park7 knockout zebrafish. Int. J. Mol. Sci. https://www.mdpi.com/2222384

Førde J-L, Reiten IN, Fladmark KE, Kittang AO and Herfindal L (2022) New software tool for computer assisted in vivo high-content analysis of transplanted fluorescent cells in intact zebrafish larvae. Biology Open Nov. 10.1242/bio.059530 

Gharbi, N., Røise, D., Førre, J.E., Edson, A.J., Hushagen, H.A., Tronci, V., Frøyset, A-K., Fladmark, K.E. (2021) Reintroduction of DJ-1 in Müller Cells Inhibits Retinal Degeneration in the DJ-1 Deficient Retina. Antioxidants https://doi.org/10.3390/antiox10121862

Edson, A.J., Hushagen, H.A., Fladmark, K.E. (2020) DJ-1 in astrocytic neuroprotection to oxidative stress. In Oxidative Stress and Dietary Antioxidants in Neurological Diseases Ed Preedy, V. Academic Press.

Penna C, Femminò S, Tapparo M, Lopatina T, Fladmark KE, Ravera F, Comità S, Alloatti G, Giusti I, Dolo V, Camussi G, Pagliaro P, Brizzi MF. The Inflammatory Cytokine IL-3 Hampers Cardioprotection Mediated by Endothelial Cell-Derived Extracellular Vesicles Possibly via Their Protein Cargo. Cells. 2020 Dec 23;10(1):13. doi: 10.3390/cells10010013

Edson, A.J., Hushagen, H.A., Frøyset, AK., Elda, I., Khan, E.A., Di Stefano, A., Fladmark, K.E. (2019) Dysregulation in the brain protein profile of zebrafish lacking the Parkinson’s disease related protein DJ-1. Mol. Neurobiol. DOI: 10.1007/s12035-019-01667-w

Frøyset AK Edson AJ, Gharbi N, Khan EA, Dondorp D, Bai Q, Tiraboschi E, Suster ML, Connolly JB, Burton EA, and Fladmark KE. (2018) Astroglial DJ-1 over-expression up-regulates proteins involved in redox regulation and is neuroprotective in vivo. Redox Biol. 16:237-247.

Egea et al (2017) European Contribution to the study of ROS: A Summary of the Findings and Prospects for the Future from the COST Action BM1203 (EU-ROS). Redox Biology https://doi.org/10.1016/j.redox.2017.05.007

Frøyset AK, Khan EA, Fladmark KE (2016) Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of BMAA. Sci Reports 6:29631.

Pajares M, Jimineze-Moreno N, Dias I, Debelec B, Vucetic M, Fladmark KE, Basaga H, Ribaric S, Milisav I, Cuadrado A (2015) Redox control of protein degradation. Redox Biology 6:409-20.

Ree RM, Myklebust L, Thiel P, Foyn H, Fladmark KE, and Arnesen T (2015) The N-terminal acetyltransferase Naa10 is essential for zebrafish development. Bioscience Reports Aug. 6

Proteomic tools to elucidate the molecular action of microalgal toxins. In Toxins and biologically active compounds from microalgae. Ed Rossini GP Fladmark KE (2014) (Book chapter)

Identification of dynamic changes in proteins associated with the cellular cytoskeleton after exposure to okadaic acid. Opsahl JA, Ljostveit S, Solstad T, Risa K, Roepstorff P, and Fladmark KE (2013) Marine Drugs11:1763-82.

Comparative analysis of IgM sub-variants in salmonid fish and identification of a residue in m3 which is essential for MAb4C10 reactivity. KamilA, RaaeA, Fjelldal PG, Koppang EO, Fladmark KE, Hordvik I (2013)Fish and Shellfish Immunology 34: 667-72.

Nodularin exposure induces SOD1 phosphorylation and distrupts SOD1 co-localization with actin. Hjørnevik LV, Fismen L, Young FM, Solstad T , Fladmark KE (2012) . Toxins 4:1482-1499.

Dietary lysine imbalance affects muscle proteome in zebrafish (Danio rerio): a comparative 2D-DIGE study. de Vareilles M, Conceição L, Gómez-Requeni P, Kousoulaki K, Richard N, Rodrigues P, Fladmark, KE, Rønnestad I, (2012) Marine Biotechnology 14:643-654. 

Impact of dietary protein hydrolysates on skeleton quality and proteome in Diplodus sargus larvae. de Vareilles M, Richard N, Gavaia PJ, Silva TS., Cordeiro O, Guerreiro I, Yúfera M, Batista I, Pires C, Pousão-Ferreira P, Rodrigues PM, Rønnestad I, Fladmark KE, Conceição LEC (2012) J Appl Ichthyol 28: 477-87.

Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines Oveland E, Wergeland L, Hovland R, Lorens JB, Gjertsen BT, Fladmark KE.  Cell Biol Toxicol. 2012 Mar 16.

Increased interaction between DJ-1 and the Mi-2/ nucleosome remodelling and deacetylase complex during cellular stress. Opsahl JA, Hjornevik LV, Bull VH, Fismen L, Froyset AK, Gromyko D, Solstad T, Fladmark KE.  Proteomics. 2010;10(7):1494-504.

Acyloxymethyl Esterification of Nodularin-R and Microcystin-LA Produces Inactive Protoxins that Become Reactivated and Produce Apoptosis inside Intact Cells. Herfindal L, Kasprzykowski F, Schwede F, Lankiewicz L, Fladmark KE, Lukomska J, Wahlsten M, Sivonen K, Grzonka Z, Jastorff B, Døskeland SO J Med Chem 2009 Epub 2009 aug.

Proteomic response of human neuroblastoma cells to azaspiracid-1. Kellmann R, Schaffner CA, Grønset TA, Satake M, Ziegler M, Fladmark KE. J Proteomics. 2009 May 2;72(4):695-707. Epub 2009 Mar 5.

Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells. Oveland E, Gjertsen BT, Wergeland L, Selheim F, Fladmark KE, Hovland R. Leuk Res. 2009 Feb;33(2):276-87. Epub 2008 Aug 8.

Identification of a novel phosphorylation site of acyl-CoA binding protein (ACBP) in nodularin-induced apoptotic hepatocytes. Solstad T, Fismen L, Garberg H, Fladmark KE. Exp Cell Res. 2008 Jun 10;314(10):2141-9. Epub 2008 Mar 30.

Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv. Målen H, Berven FS, Fladmark KE, Wiker HG. Proteomics. 2007 May;7(10):1702-18.

CaM-kinaseII-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. Krakstad C, Herfindal L, Gjertsen BT, Bøe R, Vintermyr OK, Fladmark KE, Døskeland SO. Cell Death Differ. 2006 Jul;13(7):1191-202. Epub 2005 Nov 25.

Algal toxins as guidance to identify phosphoproteins with key roles in apoptotic cell death. Solstad T, Fladmark KE. Curr Pharm Biotechnol. 2006 Jun;7(3):209-15. Review.

Proteomics approaches to elucidate oncogenic tyrosine kinase signaling in myeloid malignancies. Oveland E, Fladmark KE, Wergeland L, Gjertsen BT, Hovland R. Curr Pharm Biotechnol. 2006 Jun;7(3):185-98. Review.