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Wiig Lab

High-Salt Diet Causes Expansion of the Lymphatic Network and Increased Lymph Flow in Skin and Muscle of Rats

The group focuses on the space outside the blood vessels, i.e. the interstitium and lymph vessel function, mostly in skin.

We have developed methods for isolation of interstitial fluid in tissues where such fluid is not readily available, like tumours, bone marrow and skin. We have developed imaging methods for measurement of lymph flow in experimental animals and a mass spectrometry based method to quantify multiple proteins in interstitial fluid and their distribution volume in the tissue.

Our recent focus is the role of the skin interstitium and its macrophages in controlling blood pressure. This is a new and emerging field of research, introducing the skin as a regulator of blood pressure and brings us into the field of interstitial fluid lymphatic vessel (patho)physiology and immunology that may influence our view on salt and water homeostasis in the body.

The Wiig lab is part of the cardiovascular research group at the Department of Biomedicine.

NEW RESEARCH
VEGF-B overexpressing heart is sensitized to develop heart failure in DOCA-salt hypertensive rats

VEGF-B: A more balanced approach to cardiac angiogenesis?

A new study undertaken at UiB does answer one set of questions, however, raises many more with regards to the potential use of specific VEGF isoforms in order to promote re-vascularisation in heart failure.

NEW RESEARCH
Abodominal aorta acts as a reference for the input function.Tracer distribution mostly in the kidney cortex.

PET CT evaluation of glomerular filtration rate (GFR) in rats

We have established a new method to use Positron emission tomography CT (PET CT) to evaluate Glomerular Filtration Rate (GFR) in rats. GFR is a pivotal parameter for kidney function. The traditional method to evaluate GFR is cumbersome with several time-points for blood and urine sampling. Imaging...

Principal Investigator

The lab is headed by Professor Helge Wiig (visit his personal page).