- E-postAurora.Martinez@uib.no
- Telefon+47 55 58 64 27
- BesøksadresseJonas Lies vei 915009 Bergen
- PostadressePostboks 78045020 Bergen
Aurora Martinez er leder av forskningsgruppen Biorecognition som studerer sammenhengen mellom biomolekylær struktur og funksjon for å forstå og utvikle nye terapeutiske muligheter for genetiske sykdommer, spesielt neurometabolske forstyrrelser som fenylketonuri (PKU) og mangler i dopaminsyntese.
Aurora er også en partner i KG Jebsen-senteret for nevropsykiatriske lidelser. I tillegg er hun også en partner i prosjektet "Molekylær kontroll av Arc protein: Dekoding av en master regulator av synaptisk plastisitet og kognisjon", koordinert av Clive Bramham, som mottar støtte fra Toppforsk Programmet (NFR).
- (2022). Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nature Communications.
- (2022). Screening for modulators of vesicular monoamine transporter 2 activity in transfected Hek293 cells using a fluorescent substrate.
- (2022). Does alpha-Synuclein modulate Tyrosine Hydoxylase activity?
- (2021). The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase. Nature Communications. 15 sider.
- (2021). Relevance of Electrostatics for the Interaction of Tyrosine Hydroxylase with Porous Silicon Nanoparticles. Molecular Pharmaceutics.
- (2021). Personalized medicine to improve treatment of dopa-responsive dystonia—a focus on tyrosine hydroxylase deficiency. Journal of Personalized Medicine. 28 sider.
- (2021). Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach. Cancers.
- (2021). HTSDSF Explorer, A Novel Tool to Analyze High-throughput DSF Screenings. Journal of Molecular Biology (JMB).
- (2021). Characterization of porphobilinogen deaminase mutants reveals that arginine-173 is crucial for polypyrrole elongation mechanism. iScience.
- (2021). Acute intermittent porphyria: An overview of therapy developments and future perspectives focusing on stabilisation of HMBS and proteostasis regulators. International Journal of Molecular Sciences. 25 sider.
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