- E-postAurora.Martinez@uib.no
- Telefon+47 55 58 64 27
- BesøksadresseJonas Lies vei 91
- PostadressePostboks 78045020 Bergen
Aurora Martinez er leder av forskningsgruppen Biorecognition som studerer sammenhengen mellom biomolekylær struktur og funksjon for å forstå og utvikle nye terapeutiske muligheter for genetiske sykdommer, spesielt neurometabolske forstyrrelser som fenylketonuri (PKU) og mangler i dopaminsyntese.
Aurora er også en partner i KG Jebsen-senteret for nevropsykiatriske lidelser. I tillegg er hun også en partner i prosjektet "Molekylær kontroll av Arc protein: Dekoding av en master regulator av synaptisk plastisitet og kognisjon", koordinert av Clive Bramham, som mottar støtte fra Toppforsk Programmet (NFR).
- 2021. The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase. Nature Communications. 15 sider.
- 2021. Relevance of Electrostatics for the Interaction of Tyrosine Hydroxylase with Porous Silicon Nanoparticles. Molecular Pharmaceutics.
- 2021. Cysteine modification by ebselen reduces the stability and cellular levels of 14-3-3 Proteins. Molecular Pharmacology. 155-169.
- 2021. Characterization of porphobilinogen deaminase mutants reveals that arginine-173 is crucial for polypyrrole elongation mechanism. iScience.
- 2021. Acute intermittent porphyria: An overview of therapy developments and future perspectives focusing on stabilisation of hmbs and proteostasis regulators. International Journal of Molecular Sciences. 25 sider.
- 2020. Pathogenic variants of DNAJC12 and evaluation of the encoded cochaperone as a genetic modifier of hyperphenylalaninemia. Human Mutation. 1329-1338.
- 2020. Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase. Biochimie.
- 2020. G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 Is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury . Journal of Pain Research. 419-429.
- 2020. Differential scanning fluorimetry in the screening and validation of pharmacological chaperones for soluble and membrane proteins. 329-343. I:
- 2020. Protein Homeostasis Diseases: Mechanisms and Novel Therapies. Elsevier.
- 2020. Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif. The FEBS Journal.
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