Tuberculosis Research Group
Tuberculosis (TB), one of the oldest known human diseases, is still one of the major causes of morbidity and mortality globally. Over 90% of TB cases occur in low- and middle-income countries that have fragile healthcare infrastructures and constrained resources.
The only currently available vaccine for TB was developed about a century ago. TB treatment is long-term and multi-drug resistance is an emerging threat. There is a great need to develop better preventive, diagnostic, and therapeutic tools to curb the epidemic.
Our main research topics are:
- Pathogenesis of human Post-Primary TB (by using the human archival tissue material of the pre-antibiotic era) to generate knowledge base for better vaccines and host-directed therapies
- Development of better diagnostic tests
- Feasibility of implementation of new diagnostic test/s in routine health system settings
- Development of better biomarkers for measurement of therapeutic response
- Disease transmission and infection risk
- Association between Tuberculosis and Obstructive Lung Diseases and Allergies
- Pathogenesis of human Post-Primary Tuberculosis: Novel insights from Norwegian archival tissue material of the pre-antibiotic era
- Risk of infection with Mycobacterium tuberculosis in a low tuberculosis prevalence setting
- Association between tuberculosis and obstructive lung diseases and allergies
- Biomarkers in tuberculosis: implications for improved diagnosis, monitoring treatment response, and host-directed therapies
- Proteomic and bioinformatic studies of the host therapeutic response to tuberculosis treatment
- Improving diagnosis of extrapulmonary tuberculosis by implementation of a sensitive and specific assay in routine tuberculosis diagnostics
- Localization and characterization of dormant bacilli and host response in chronic tuberculosis and immune evasion strategies of mycobacteria
- Development of new diagnostic test for extrapulmonary tuberculosis
This picture is taken of the group's collaborating partner/institution in TB research in Pakistancollaborating partner/institution in TB research in Pakistan, the Tuberculosis DOTS unit at the Gulab Devi Chest Hospital Research Cell.