Centre for International Health
Research | Tuberculosis Research Group

Tuberculosis Research Group

Tuberculosis (TB), one of the oldest known human diseases, is still one of the major causes of morbidity and mortality globally. Over 90% of TB cases occur in low- and middle-income countries that have fragile healthcare infrastructures and constrained resources.

Tehmina Mustafa and colleagues Zanzibar lab
Tehmina Mustafa

Main content

The only currently available vaccine for TB was developed about a century ago. TB treatment is long-term and multi-drug resistance is an emerging threat. There is a great need to develop better preventive, diagnostic, and therapeutic tools to curb the epidemic.

Our main research topics are:

  • Childhood tuberculosis and malnutrition
  • Development of better diagnostic tests
  • Feasibility of implementation of new diagnostic test/s in routine health system settings
  • Pathogenesis of human Post-Primary TB (by using the human archival tissue material of the pre-antibiotic era) to generate knowledge base for better vaccines and host-directed therapies
  • Development of better biomarkers for measurement of therapeutic response
  • Disease transmission and infection risk
  • Association between Tuberculosis and Obstructive Lung Diseases and Allergies


Current Projects

Previous Projects

  • Localization and characterization of dormant bacilli and host response in chronic tuberculosis and immune evasion strategies of mycobacteria
  • Development of new diagnostic test for extrapulmonary tuberculosis

Associated scientific staff

Associated PhD Candidates (Main Supervisor)

Associated Master Candidates (Main Supervisor)

  • Vijil Veettikkat (TM)
  • Rajeshwar (TM)
  • Biplob Kumar Mohanty, Defended 2023 (TM)
  • Sanjay Gyawali, Defended 2022 (CS)
  • Beatrice Normann, Defended 2022 (TM)
  • Varun Kumar Vijayakumar, defended 2021 (BA, TM-equal supervision)
  • Shizza Khalid, Defended 2021 (TM)
  • Robert N.Foncha, defended 2021(SGH) 
  • Prince C.Nnadozi, defended 2021 (SGH) 
  • Iman Muhammad Ali, Defended 2020 (TM)
  • Ahmad Barakat, Defended 2020 (TM)
  • Khadija Hassan Olow, Defended 2019 (TM)
  • Shoaib Hassan, Defended 2019 (TM)
  • Syeda Maryam Riaz, Defended 2018 (TM)

Yasir Shahzad, Defended 2016 (TM)

TB Group Partners

Research Collaborators from Norway


International Research Collaborators


  • Robert L Hunter.  Professor/Pathologist. Department of Pathology and Laboratory Medicine, Mc Govern Medical School, University of Texas, Huston, Texas, USA


  • Manju Raj Purohit. Peofessor/Pathologist. TB diagnostics, Drug resistance & Biomarkers. Department of Pathology, R. D. Gardi Medical College, Ujjain, (M P), India.


  • Atiqa Ambreen. Microbiologist, Gulab Devi Hospital, Professor Gulab Devi Educational Complex
  • Shiba Ishtiaq. Pathologist, Gulab Devi Hospital
  • Asif Loya. Pathologist. SKM hospital& Research Center, Pakistan.
  • Nauman Safdar. Public Health Specialist. The Indus Hospital, Pakistan/National TB Control Programme.
  • Ahmad Wali. Public Health Specialist, Provincial TB Control Programme
  • Shaper Mirza. Professor/Immunologist. Lahore University of Management Sciences (LUMS), Pakistan
  • Razia Fatima.  Chief Researcher, CMU (The common unit to manage TB, AIDS and Malaria)
  • Shaper Mirza. Lahore University of Management Sciences
  • Zarfishan Tahir.  Institute of Public Health-Lahore
  • Lubna Samad.  IRD- Interactive Research and Development


  • Andrey Marijani


  • Sayoki G Mfinanga: Professor. National Institute for Medical Research (NIMR), Muhimbili
  • William Muller. Pathologist. Mbeya Zonal Referral Hospital, Mbeya
  • Mbazi Senkoro


  • Msafiri Marijani: Pathologist. TB diagnostics and extrapulmonary TB. Mnazi Mmoja Hospital. Zanzibar, Tanzania

 The International Union Against Tuberculosis and Lung Disease (IUATLD: The TB Union)

Publications in International refereed Journals


Wali A, Safdar N, Ambreen A, Tahseen S, Mustafa T. 2023. Healthcare seeking pathways and diagnostic delays among 1 extra-pulmonary tuberculosis patients: a study from Pakistan. Public Health Action

Gyawali S, López-Cervantes JP, Johannessen A, Gislason T, Holm M, Janson C, Jögi R, Modig L, Schlünssen V, Mustafa T and Svanes C (2023). Maternal and paternal tuberculosis is associated with increased asthma and respiratory symptoms in their offspring: a study from Northern Europe. Front. Allergy 4:1193141. doi: 10.3389/falgy.2023.1193141

Ole Magnus Bjørgaas Helle, Mala Kanthali, Naish Akhtar, Manju Raj Purohit, Tehmina Mustafa. 2023. Significance of non-granulomatous cytomorphology on fine needle aspirate in lymphadenitis cases classified as tuberculous by using a composite reference standard. Diagnostic Cytopathology. 2023;51:575–583. DOI: 10.1002/dc.25167

Gyawali S, López-Cervantes JP, Jõgi NO, Mustafa T, Johannessen A, Janson C, Holm M, Modig L, Cramer C, Gislason T, Svanes C, Shigdel R. 2023. Previous tuberculosis infection associated with increased frequency of asthma and respiratory symptoms in a Nordic-Baltic multicentre population study. ERJ Open Res. 2023 May 22;9(3):00011-2023. doi: 10.1183/23120541.00011-2023. PMID: 37228275; PMCID: PMC10204863.

Barakat A, Birkeland E, Jørstad MD, El Hajj M, Marijani M, Døskeland A, Mjaavatten O, Berven FS, Mustafa T. Proteomic analysis of peripheral blood mononuclear cells isolated from patients with pulmonary tuberculosis: A pilot study from Zanzibar, Tanzania. PLoS One. 2023 Feb 14;18(2):e0281757. doi: 10.1371/journal.pone.0281757. PMID: 36787336; PMCID: PMC9928017.

Shizza Khalid, Atiqa Ambreen, Aasia Khaliq, Hafeez Ullah, Manal Mustafa, Tehmina Mustafa. 2023. Identification of host biomarkers from dried blood spots for monitoring treatment response in extrapulmonary tuberculosis. Sci Rep 13, 599 https://doi.org/10.1038/s41598-022-26823-6

Bazhenov AV, Mariandyshev AO, Hinderaker SG, Heldal E, Motus IY, Vasilyeva IA. Prevention of bronchial fistulas after pneumonectomies for selected cavitary drug resistant lung tuberculosis. Front Surg. 2023 Mar 30;10:1151137. doi: 10.3389/fsurg.2023.1151137. eCollection 2023. PMID: 37065999.

Banti AB, Winje BA, Hinderaker SG, Heldal E, Abebe M, Dangisso MH, Datiko DG. Prevalence and incidence of symptomatic pulmonary tuberculosis based on repeated population screening in a district in Ethiopia: a prospective cohort study. BMJ Open. 2023 Jul 30;13(7):e070594. doi: 10.1136/bmjopen-2022-070594. PMID: 37518077


Ulain N, Ali A, Khan M, Ullah Z, Shaheen L, Shareef N, Yasir M, Mustafa T. 2022. Improving diagnosis of tuberculous lymphadenitis by combination of cytomorphology and MPT64 immunostaining on cell blocks from the fine needle aspirates. PLoS ONE 17(10): e0276064. https://doi.org/10.1371/ journal.pone.0276064

Grønningen E, Nanyaro M, Sviland L, Ngadaya E, Muller W, Torres L, Mfinanga S, Mustafa T. 2022. Improved diagnosis of extrapulmonary tuberculosis in adults with and without HIV in Mbeya, Tanzania using the MPT64 antigen detection test. PLOS Glob Public Health 2(11): e0001317. https://doi.org/10.1371/journal. pgph.0001317

López-Cervantes JP, Shigdel R, Accordini S, Mustafa T, Jacobsen BR, Makvandi-Nejad S, Lerm M, Horsnell W, Svanes C. 2022. Parental TB associated with offspring asthma and rhinitis. Int J Tuberc Lung Dis 26(6):544–549

Tahseen, S., Ambreen, A., Ishtiaq, S. Khanzada FM, Safdar N, Sviland L, Mustafa T. 2022. The value of histological examination in the diagnosis of tuberculous lymphadenitis in the era of rapid molecular diagnosis. Sci Rep 12, 8949. https://doi.org/10.1038/s41598-022-12660-0

Vergeer SB, Oldenkamp R, Senkoro M, Mfinanga S, Hinderaker SG, van Leth F. Does distance to healthcare facility affect care-seeking for TB-related symptoms in Tanzania? Int J Tuberc Lung Dis. 2022;26(8):747-752. doi: 10.5588/ijtld.21.0662. PMID: 35898133.

Yaqoob A, Alvi MR, Fatima R, Najmi H, Samad Z, Nisar N, Haq AU, Javed B, Khan AW, Hinderaker SG. Geographic accessibility to childhood tuberculosis care in Pakistan. Glob Health Action. 2022;15(1):2095782. doi: 10.1080/16549716.2022.2095782. PMID: 35848796; PMCID: PMC9297715

Haq MU, Hinderaker SG, Fatima R, Qadeer E, Habib H, Hussain K, Khan AW. Are patients with pulmonary tuberculosis identified by active and by passive case detection different? A cross-sectional study in Pakistan. Int J Infect Dis. 2022 Aug;121:39-46. doi: 10.1016/j.ijid.2022.04.055. PMID: 35489633.

Banti AB, Datiko DG, Hinderaker SG, Heldal E, Dangisso MH, Mitiku GA, White RA, Winje BA. How many of persistent coughers have pulmonary tuberculosis? Population-based cohort study in Ethiopia. BMJ Open 2022, 24;12(5):e058466. doi: 10.1136/bmjopen-2021-058466.

Gureva T, Turkova A, Yablokova E, Smirnova P, Sveshnikova O, Zolotaya O, Nikishova E, Heldal E, Hinderaker S, Seddon JA, Mariandyshev A. Fluoroquinolone preventive therapy for children exposed to MDR-TB. Int J Tuberc Lung Dis. 2022;26(2):171-173. doi: 10.5588/ijtld.21.0443.


Ambreen, A., Tahseen, S., Wali, A., Jamil, M., Naqvi, S., Safdar, N., & Mustafa, T. 2021. Predictors of slow clinical response and extended treatment in patients with extra-pulmonary tuberculosis in Pakistan, A hospital-based prospective study. PloS one, 16(11), e0259801. https://doi.org/10.1371/journal.pone.0259801

Jenum, S., Tonby, K., Rueegg, C.S., Ruhwald M., Kristiansen, M.P., Bang, p.,  Olsen, I.C., Sellæg, K., Røstad, k., Mustafa, T., Taskénk., Kvale, D., Mortensen, R., Dyrhol-Riise, A.M. 2021. A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients. Nat Commun 12, 6774 (2021). https://doi.org/10.1038/s41467-021-27029-6

Farooq A, Aurangzeb B, Sheikh TK, Bashir H, Ghuncha M, Mustafa T. 2021. Successful OPD management of children at a secondary care hospital in Pakistan in a dengue fever epidemic and their clinical outcomes. J Trop Med:3296448 | https://doi.org/10.1155/2021/3296448

Grønningen, E., Nanyaro, M., Sviland, L. Ngadaya E, Muller W, Torres L, Mfinanga S, Mustafa T. MPT64 antigen detection test improves diagnosis of pediatric extrapulmonary tuberculosis in Mbeya, Tanzania. Sci Rep 11, 17540 (2021). https://doi.org/10.1038/s41598-021-97010-2

Hoel, I.M.; Ali, I. A.M.; Ishtiaq, S.; Sviland, L.; Wiker, H.; Mustafa, T. 2021. Immunochemistry-Based Diagnosis of Extrapulmonary Tuberculosis: A Strategy for Large-Scale Production of MPT64-Antibodies for Use in the MPT64 Antigen Detection Test. Antibodies, 10, 34. https://doi.org/10.3390/antib10030034

Vijayakumar VK, Mustafa T, Nore BK, Garatun-Tjeldstø KY, Næss Ø, Johansen OE, Aarli BB. 2021. Role of a Digital Clinical Decision-Support System in General Practitioners' Management of COPD in Norway. Int J Chron Obstruct Pulmon Dis. 13;16:2327-2336. doi: 10.2147/COPD.S319753. PMID: 34413641; PMCID: PMC8370595.

Farooq A, Sheikh TK, Syed F, Mustafa T. 2021. Paediatric Contacts of Adult COVID-19 Patients: Clinical Parameters, Risk Factors, and Outcome. Int J Pediatr. 24;2021:2141128. doi: 10.1155/2021/2141128. PMID: 34188687; PMCID: PMC8192208.

Karamat A, Ambreen A, Ishtiaq A, Tahseen S, Rahman MA, Mustafa T. 2021. Isolation of non-tuberculous mycobacteria among tuberculosis patients, a study from a tertiary care hospital in Lahore, Pakistan. BMC Infect Dis 21:381 https://doi.org/10.1186/s12879-021-06086-8

Ambreen A, Khaliq A, Naqvi SZH, Tahir A, Mustafa M, Chaudhary SU, Mirza S, Mustafa T. 2021. Host biomarkers for monitoring therapeutic response in extrapulmonary tuberculosis. Cytokine.;142:155499. doi: 10.1016/j.cyto.2021.155499. PMID: 33799008.

Yaqoob A, Hinderaker SG, Fatima R, Shewade HD, Nisar N, Wali A. Diagnosis of childhood tuberculosis in Pakistan: Are national guidelines used by private healthcare providers? Int J Infect Dis. 2021;107:291-297. doi: 10.1016/j.ijid.2021.04.055.

Ul Haq M, Hinderaker SG, Fatima R, Shewade HD, Heldal E, Latif A, Kumar AMV. Extending contact screening within a 50-meter radius of an index tuberculosis patient using Xpert MTB/RIF in urban Pakistan: Did it impact treatment outcomes? Int J Infect Dis. 2021; 27:S1201-9712(21)00065-5. doi: 10.1016/j.ijid.2021.01.054.

Yaqoob A, Hinderaker SG, Fatima R, Najmi H, Anwar-Ul-Haq. How do private practitioners in Pakistan manage children suspected having tuberculosis? A cross sectional study. BMC Public Health. 2021 Jan 7;21(1):71. doi: 10.1186/s12889-020-10053-4. PMID: 33413206


Hoel IM, Syre H, Skarstein I, Mustafa T. 2020. Xpert MTB/RIF Ultra for rapid diagnosis of extrapulmonary tuberculosis in a high-income low-tuberculosis prevalence setting. In press Scientific reports

Hoel IM, Sviland L, Syre H, Dyrhol-Riise AM, Skarstein I, Jebsen P, Wiker H, Mustafa T. 2020. Diagnosis of extrapulmonary tuberculosis using the MPT64 antigen detection test in a high-income low tuberculosis prevalence setting. BMC Infect Dis 20, 130. https://doi.org/10.1186/s12879-020-4852-z

Mustafa T, Wergeland I, Baba K, Pathak S, Hoosen AA, Dyrhol-Riise AM. Mycobacterial antigens in pleural fluid mononuclear cells to diagnose pleural tuberculosis in HIV co-infected patients. BMC Infect Dis. 2020 Jul 1;20(1):459. doi: 10.1186/s12879-020-05165-6. PMID: 32611401; PMCID: PMC7329517

Riaz SM, Bjune GA, Wiker HG, Sviland L, Mustafa T. 2020. Mycobacterial antigens accumulation in foamy macrophages in murine pulmonary tuberculosis lesions: association with necrosis and cavities. SJI. doi:10.1111/sji.12866

Tahseen S, Khanzada FM, Baloch AQ, Abbas Q, Bhutto MM, Alizai AW, Zaman S, Qasim Z, Durrani MN, Farough MK, Ambreen A, Safdar N, Mustafa T. 2020. Extrapulmonary tuberculosis in Pakistan - A nationwide multicenter retrospective study. PLoS ONE 15(4): e0232134. https://doi.org/10.1371/journal.pone.0232134

Tahseen S, Khanzada FM, Rizvi AH, Qadir M, Ghazal A, Baloch AQ, Mustafa T.  2020. Isoniazid resistance profile and associated levofloxacin and pyrazinamide resistance in rifampicin resistant and sensitive isolates from pulmonary and extrapulmonary tuberculosis patients in Pakistan: A laboratory based surveillance study 2015-19. PLoS ONE 15(9): e0239328. 


Ambreen A, Jamil M, Rahman MA, Mustafa T. 2019. Viable Mycobacterium tuberculosis in sputum after pulmonary tuberculosis cure. BMC Infect Dis19:923 https://doi.org/10.1186/s12879-019-4561-7

Bogdanova E, Mariandyshev O, Hinderaker SG, Nikishova E, Kulizhskaya A, Sveshnikova O, Grjibovski A, Heldal E, Mariandyshev A. Mass screening for active case finding of pulmonary tuberculosis in the Russian Federation: how to save costs. Int J Tuberc Lung Dis. 2019 ;23(7):830-837. doi: 10.5588/ijtld.18.0449.

Eliseev P, Hinderaker SG, Heldal E, Tarasova I, Grjibovski A, Mariandyshev A. Diagnosis and treatment of patients with pulmonary nontuberculous mycobacterial diseases in Arkhangelsk, Russia. Infect Genet Evol. 2019 Sep;73:358-361. doi: 10.1016/j.meegid.2019.05.022. Epub 2019 Jun 1.

Harries AD, Schwoebel V, Monedero-Recuero I, Aung TK, Chadha S, Chiang CY, Conradie F, Dongo JP, Heldal E, Jensen P, Nyengele JPK, Koura KG, Kumar AMV, Lin Y, Mlilo N, Nakanwagi-Mukwaya A, Ncube RT, Nyinoburyo R, Oo NL, Patel LN, Piubello A, Rusen ID, Sanda T, Satyanarayana S, Syed I, Thu AS, Tonsing J, Trébucq A, Zamora V, Zishiri C, Hinderaker SG, Aït-Khaled N, Roggi A, Caminero Luna J, Graham SM, Dlodlo RA, Fujiwara PI. Challenges and opportunities to prevent tuberculosis in people living with HIV in low-income countries. Int J Tuberc Lung Dis. 2019 Feb 1;23(2):241-251. doi: 10.5588/ijtld.18.0207.

Hoel IM, Jørstad MD, Marijani M, Ruhwald M, Mustafa T, Dyrhol-Riise AM. 2019. IP-10 dried blood spots assay monitoring treatment efficacy in extrapulmonary tuberculosis in a low-resource setting. Scientific reports, 9:3871.

Jørstad MD, Dyrhol-Riise AM, Aẞmus J, Marijani M, Sviland L, Mustafa T. 2019.  Evaluation of treatment response in extrapulmonary tuberculosis in a low-resource setting. BMC Inf Dis. DOI : 10.1186/s12879-019-4034-z

Machekera SM, Wilkinson E, Hinderaker SG, Mabhala M, Zishiri C, Ncube RT, Timire C, Takarinda KC, Sengai T, Sandy C. A comparison of the yield and relative cost of active tuberculosis case-finding algorithms in Zimbabwe. Public Health Action. 2019 Jun 21;9(2):63-68. doi: 10.5588/pha.18.0098.

Mortensen R, Clemmensen HS, Woodworth JS, Therkelsen ML, Mustafa T, Tonby K, Jenum S, Agger EM, Dyrhol-Riise AM, Andersen P. 2019. Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice. Communications Biology. 2:288. https://doi.org/10.1038/s42003-019-0530-3

Purohit MR, Purohit R. Mustafa T. 2019. Patient knowledge, health seeking behavior and diagnostic delay in extra-pulmonary tuberculosis: a hospital based study from central India. Tuberc Res Treat. vol. 2019. https://doi.org/10.1155/2019/4840561.

Razia Fatima, Aashifa Yaqoob, Ejaz Qadeer, Sven Gudmund Hinderaker, Aamer Ikram, Charalambos Sismanidis. Measuring and addressing the childhood tuberculosis reporting gaps in Pakistan: The first ever national inventory study among children. PLoS ONE 14(12) 2019: e0227186.

Razia Fatima, Aashifa Yaqoob, Ejaz Qadeer, Sven Gudmund Hinderaker, Einar Heldal, Rony Zachariah, Anthony D. Harries, Ajay M. V. Kumar. Building sustainable operational research capacity in Pakistan: starting with tuberculosis and expanding to other public health problems. Global Health Action 2019, 12: 1555215. DOI:10.1080/16549716.2018.1555215

Tahseen S, Ambreen A, Masood F, Qadir M, Hussain A, Jamil M , Safdar N, Sviland L, Mustafa T. 2019. Primary drug resistance in extra-pulmonary tuberculosis, a hospital based prospective study from Pakistan. Int J Tuberc Lung Dis. 23:900-06.


Jørstad MD, Aẞmus J, Marijani M, Sviland L, Mustafa T. 2018. Diagnostic delay in extrapulmonary tuberculosis and impact on patient morbidity: a study from Zanzibar. PLoS ONE 13(9): e0203593. https://doi.org/10.1371/journal.pone.0203593.

Jørstad MD, Marijani M, Dyrhol-Riise AM, Sviland L, Mustafa T. 2018. MPT64 antigen detection test improves routine diagnosis of extrapulmonary tuberculosis in a low-resource setting: A study from the tertiary care hospital in Zanzibar. PLoS ONE 13(5): e0196723. https://doi.org/10.1371/journal.pone.0196723

Mustafa T, Shahzad Y, Kiani A. 2018. A survey of knowledge, attitude, and practices of private retail pharmacies staff in tuberculosis care: study from Dera Ismail Khan City, Pakistan. J Pharm Policy Pract. 11:7. doi: 10.1186/s40545-018-0134-1.

earlier than 2018

Aw B, Ade S, Hinderaker SG, Dlamini N, Takarinda KC, Chiaa K, Feil A, Traoré A, Reid T. Childhood tuberculosis in Mauritania, 2010-2015: diagnosis and outcomes in Nouakchott and the rest of the country. Public Health Action. 2017, 21;7(3):199-205.

Gadoev J, Asadov D, Harries AD, Parpieva N, Tayler-Smith K, Isaakidis P, Ali E, Hinderaker SG, Ogtay G, Ramsay A, Jalolov A, Dara M. Recurrent tuberculosis and associated factors: A five - year countrywide study in Uzbekistan. PLoS One. 2017;4;12(5):e0176473. doi: 10.1371/journal.pone.0176473.

Khurshid A, Hinderaker SG, Heldal E, Fatima R, ul Haq M, Yaqoob A, Ansari A, Anwar K, Qadeer E, Kumar AMV. Did “Screeners” Increase Pediatric Tuberculosis Case Notification in Sindh, Pakistan? Journal of Tuberculosis Research, 2017, 5, 81-86.

Purohit M, Sviland L, Diwan R, Wiker HG, Mustafa T. 2017.  Rapid and specific diagnosis of extra-pulmonary tuberculosis by immunostaining of tissues and aspirates with anti-MPT64. Appl Immunohistochem Mol Morphol. 25:282-288. doi: 10.1097/PAI.0000000000000300. PMID: 26766121

Wali A, Kumar AMV, Hinderaker SG, Heldal E, Qadeer E, Fatima R, Ullah A, Safdar N, Yaqoob A, Anwar K, Ul Haq M. Pre-treatment loss to follow-up among smear-positive TB patients in tertiary hospitals, Quetta, Pakistan. Public Health Action. 2017, 21;7(1):21-25.

Y. Lin, C-Y Chiang, ID Rusen, SG Hinderaker, A Roldan, E Heldal, DA Enarson, L-X Zhang. Did FIDELIS projects contribute to the detection of new smear-positive pulmonary tuberculosis cases in China?  PHA 2016, 6(3):176-180

Kilale AM, Ngadaya E, Muhumuza J, Kagaruki GB, Lema YL, Ngowi BJ, Mfinanga SG, Hinderaker SG.  Who Has Mycobacterial Disease? A Cross Sectional Study in Agropastoral Communities in Tanzania. PLoS One. 2016;23;11(5):e0153711. doi:10.1371/journal.pone.0153711.

Mchunu G, van Griensven J, Hinderaker SG, Kizito W, Sikhondze W, Manzi M, Dlamini T, Harries AD. High mortality in tuberculosis patients despite HIV interventions in Swaziland. Public Health Action. 2016 21;6(2):105-10. doi: 10.5588/pha.15.0081.

Senkoro M, Kumar AMV, Chinnakali P, Mfinanga SG, Egwaga S, Kamara V, van Leth F, Hinderaker SG. Population impact of factors associated with prevalent pulmonary tuberculosis in Tanzania. Int J Tuberc Lung Dis 2016; 20(10):1326–1333

Senkoro M, Mfinanga S, Egwaga S, Mtandu R, Kamara DV, Basra D, Fundikira L, Kahwa A, Shirima R, Range N, Hinderaker SG, van Leth F. Prevalence of pulmonary tuberculosis in adult population of Tanzania: a national survey, 2012. Int J Tuberc Lung Dis. 2016; 20(8):1014-21.   doi: 10.5588/ijtld.15.0340.

Avong YK, Isaakidis P, Hinderaker SG, Van den Bergh R, Ali E, Obembe BO, Ekong E, Adebamowo C, Ndembi N, Okuma J, Osakwe A, Oladimeji O, Akang G, Obasanya JO, Eltayeb O,  Agbaje AV, Abimiku1 A, Mensah CO, Dakum PS. Doing No Harm? Adverse Events in a Nation- Wide Cohort of Patients with Multidrug-Resistant Tuberculosis in Nigeria. PLOSOne 2015; 10(3): e0120161.

Daniels JF, Khogali M, Mohr E, Cox V, Moyo S, Edginton M, Hinderaker SG, Meintjes G, Hughes J, De Azevedo V, van Cutsem G, Cox HS. Time to ART Initiation among Patients Treated for Rifampicin-Resistant Tuberculosis in Khayelitsha, South Africa: Impact on Mortality and Treatment Success. PLoS One. 2015;10(11):e0142873. doi: 10.1371/journal.pone.0142873

Fatima R, Qadeer E, Hinderaker SG, Yaqoob A, Enarson DA, Bassili A, ul Haq M, Javed B. Can the number of patients with presumptive tuberculosis lost in the general health services in Pakistan be reduced? Int J Tuberc Lung Dis 2015; 19(6):654-656.

Mustafa T, Brokstad KA, Mfinanga S, Wiker HG. 2015. Multiplex analysis of thirteen pro- and anti- inflammatory serum cytokines and chemokines in Tanzanian patients with tuberculous lymphadenitis. Tuberc Res Treat. 2015:561490.

Gadoev J, Asado D, TillashaykhovM, Tayler-Smith K, Isaakidis P, Dadu A, de Colombani P, Hinderaker SG, Parpieva N, Ulmasova D, Jalolov A, Hamraev A,  Ali E, van den Boom M, Hammerich A, Gozalov O, Dara M. Factors Associated with Unfavorable Treatment Outcomes in New and Previously Treated TB Patients in Uzbekistan: A Five Year Countrywide Study. PLoSOne 2015; 10(6):e0128907.

Kilale AM,Ngadaya E, Kagaruki GB, Lema YL, Muhumuza J, Ngowi BJ, Mfinanga GS, Hinderaker SG. Knowledge and Perceptions about Tuberculosis in Agropastoral Communities in Northern Tanzania: A Cross-Sectional Study. Brit J Med & Med Res 2015;10(3):1-8. DOI: 10.9734/BJMMR/2015/18973

Kilale AM, Ngadaya E, Kagaruki GB, Lema YL, Muhumuza J, Ngowi BJ, Mfinanga GS, Hinderaker SG. Experienced and Perceived Risks of Mycobacterial Diseases: A Cross Sectional Study among Agropastoral Communities in Northern Tanzania. PLoS ONE 2015; 10(6): e0130180. doi:10.1371/journal. pone.0130180.

Purohit MR, Mustafa T. 2015. Laboratory Diagnosis of Extra-pulmonary Tuberculosis (EPTB) in Resource-constrained Setting: State of the Art, Challenges and the Need. J Clin Diagn Res. 2015;9(4)

Rifat M, Hall J, Oldmeadow C, Husain A, Hinderaker SG, Milton AH. Factors related to previous tuberculosis treatment of patients with multidrug-resistant tuberculosis in Bangladesh. BMJ Open. 2015 8;5(9):e008273. doi: 10.1136/bmjopen-2015-008273.

Senkoro M, Hinderaker SG, Mfinanga GS, Range N, Kamara DV, Egwaga S, van Leth F. Health care-seeking behaviour among people with cough in Tanzania: findings from a tuberculosis prevalence survey. Int J Tuberc Lung Dis 2015; 19(6):640-646.

Fatima R, Qadeer E, Enarson DA, Hinderaker SG, Harris R, Yaqoob A, Bassili A. Investigation of presumptive tuberculosis cases by private health providers: lessons learnt from a survey in Pakistan. Public Health Action 2014; 4(2):110-112.

Fatima R, Harris RJ, Enarson DA, Hinderaker SG, Qadeer E, Ali K, Bassilli A. Estimating tuberculosis burden and case detection in Pakistan. Int J Tuberc Lung Dis 2014; 18(1):55-60.

Fatima R, Qadeer E, Enarson DA, Creswell J, Stevens RH, Hinderaker SG, Anwar K, ul Haq M. Success of active tuberculosis case detection among high-risk groups in urban slums in Pakistan. Int J Tuberc Lung Dis. 2014 Sep;18(9):1099-104. doi: 10.5588/ijtld.14.0001. Erratum in: Int J Tuberc Lung Dis. 2014 Dec;18(12):1526. Anwar, K [added]; Stevens, R [corrected to Stevens, R H].

Mi F, Jiang G, Du J, Li L, Yue W, Harries AD, Hinderaker SG, Lin Y. Is resistance to anti-tuberculosis drugs associated with type 2 diabetes mellitus? A register review in Beijing, China. Global Health Action 2014; 7:24022.

Mustafa T, Leversen NA, Sviland L, Wiker HG. 2014. Differential in vivo expression of mycobacterial antigens in Mycobacterium tuberculosis infected lungs and lymph node tissues. BMC Infect Dis 14:535

Nagai S, Robinson R, Rahamefy JR, Randriambeloson SJ, Ranaivomanana DA, Razafindranaivo T, Rakotobe L, Ranaivo A, Hinderaker SG, Harries AD, Zachariah R. Provider-initiated HIV testing and counselling for TB in low HIV prevalence settings: is it worthwhile? Trans R Soc Trop Med Hyg. 2014 Mar;108(3):173-5.

Oladimeji O, Isaakidis P, Obasanya OJ, Eltayeb O, Khogali M, Van den Bergh R, Kumar AM, Hinderaker SG, Abdurrahman ST, Lawson L, Cuevas LE. Intensive-Phase Treatment Outcomes among Hospitalized Multidrug-Resistant Tuberculosis Patients: Results from a Nationwide Cohort in Nigeria. PLoSOne 2014; 9(4):e94393. 

Tadele A, Beyene D, Hussein J, Gemechu T, Birhanu A, Mustafa T, Tsegaye A, Aseffa A, Sviland L. 2014. Immunocytochemical detection of Mycobacterium Tuberculosis complex specific antigen, MPT64, improves diagnosis of tuberculous lymphadenitis and tuberculous pleuritis.  BMC Infect Dis 14:585

Leversen NA, Sviland L, Wiker HG, Mustafa T. 2012. Long-term persistence of BCG Pasteur in lungs of C57BL/6 mice following intranasal infection.  Scand J Immunol. 75:489-99

Ade S, Harries AD, Trébucq A, Hinderaker SG, Ade G, Agodokpessi G, Affolabi D, Koumakpaï S, Anagonou S, Gninafon M. The burden and outcomes of childhood tuberculosis in Cotonou, Benin. Public Health Action 2013; 3(1):15-19.

Ade S, Harries AD, Trébucq A, Hinderaker SG, Adè G, Agodokpessi G, Affolabi D, Anagonou S. National profile and treatment outcomes of adult smear-negative pulmonary TB patients in Benin. Trans R Soc Trop Med Hyg. 2013;107(12):783-8.

Kilale AM, Ngowi BJ, Mfinanga GS, Egwaga S, Doulla B, Kumar AMV, Khogali M, van Griensven J, Harries AD, Zachariah R, Hinderaker SG. Are sputum samples of retreatment tuberculosis reaching the reference laboratories? A 9 year audit in Tanzania. PHA 2013; 3(2):156-9

Kilale AM, Kimaro GD, Kahwa AM, Chilagwile M, Ngowi BJ, Chande H,. Mfinanga GS, Hinderaker SG. High prevalence of tuberculosis diagnosed during autopsy examination at Muhimbili National Hospital in Dar es Salaam, Tanzania. Tanzania Journal of Health Research 2013, 15(3).

Hinderaker SG, Fatima R. Lost in time and space: the outcome of patients transferred out from large hospitals. PHA  2013; 3(1):2

Mi F, Tan S, Liang L, Harries AD, Hinderaker SG, Lin Y, Yue W, Chen X, Liang B, Gong F, Du J. Diabetes mellitus and tuberculosis: pattern of tuberculosis, two-month smear conversion and treatment outcomes in Guangzhou, China. Trop Med Int Health. 2013;  Sep 23. doi: 10.1111/tmi.12198.

Afutu FK, Zachariah R, Hinderaker SG, Ntoah-Boadi H, Obeng EA, Bonsu FA, Harries AD. High initial default in patients with smear-positive pulmonary tuberculosis at a regional hospital in Accra, Ghana. Trans R Soc Trop Med Hyg. 2012 Aug;106(8):511-3.

Bam TS, Enarson DA, Hinderaker SG, Bam DS. Longer delay in accessing treatment among current smokers with new sputum smear-positive tuberculosis in Nepal. Int J Tuberc Lung Dis. 2012

Kanyerere HS, Mpunga J, Tweya H, Edginton M, Harries AD, Hinderaker SG, Chimbwandira F, Gonani A, Mbendera K. Timing of antiretroviral therapy and effects on tuberculosis treatment outcomes in HIV-co-infected patients in Malawi. PHA 2012; 2(4):174-7.

Nagaraja SB, Kumar AMV, Sachdeva KS, Ramachandran R, Satyanarayana S, Bansal A, Parmar M, Chadha S, Nair S, Kumar A, Hinderaker SG, Eginton M, Dewan PK. Is one sputum specimen as good as two during follow-up cultures for monitoring multi drug resistant tuberculosis patients in India. PLoS One 2012; 7(9):1-5; e45554.

Purohit M, Mustafa T, Wiker HG, Sviland L. 2012. Rapid diagnosis of tuberculosis in aspirate, effusions, and cerebrospinal fluid by immunocytochemical detection of Mycobacterium tuberculosis complex specific antigen MPT64. Diagn Cytopathol. 40(9):782-91

Zachariah R, Harries AD, Srinath S, Ram S, Viney K, Singogo E, Lal P, Mendoza-Ticona A, Sreenivas A, Aung NW, Sharath BN, Kanyerere H, van Soelen N, Kirui N, Ali E, Hinderaker SG, Bissell K, Enarson DA, Edginton ME. Language in tuberculosis services: can we change to patient-centred terminology and stop the paradigm of blaming the patients? Int J Tuberc Lung Dis. 2012 Jun;16(6):714-7.

Assefa D, Melaku Z, Gadissa T, Negash A, Hinderaker SG, Harries AD. Intensified tuberculosis case finding among people living with the human immunodeficiency virus in a hospital clinic in Ethiopia. Int J Tuberc Lung Dis. 2011 Mar;15(3):411-3.

Hinderaker SG, Madland S, Ullenes M, Enarsom DA, Rusen ID, Kamara DV. Treatment delay among tuberculosis patients in Tanzania: Data from the FIDELIS initiative. BMC Public Health 2011; 11 (1):306.

Hinderaker SG, Rusen ID, Chiang CY, Yan L, Heldal E, Enarson DA. The FIDELIS initiative: innovative strategies for increased case finding. Int J Tuberc Lung Dis. 2011; 15(1):71‑6.

Qi W, Harries AD, Hinderaker SG. Performance of culture and drug susceptibility testing in pulmonary tuberculosis patients in northern China. Int J Tuberc Lung Dis. 2011; 15(1):137‑9.

Safdar N, Hinderaker SG, Baloch NA, Enarson DA, Khan MA, Mørkve O. Translating childhood tuberculosis case management research into operational policies. Int J Tuberc Lung Dis, 2011, 15(8):1127-1130.

Safdar N, Hinderaker SG, Baloch NA, Enarson DA, Khan MA. Childhood tuberculosis deskguide and monitoring: An intervention to improve case management in Pakistan. BMC-Health Services Research, 2011, 11:187.

Safdar N, Hinderaker SG, Baloch NA, Enarson DA, Khan MA, Morkve O. Are children in Pakistan managed according to National programme policy guidelines? A study from 3 districts in Punjab. BMC Research Notes 2010 Nov 30; 3:324

Safdar, N, Hinderaker SG, Baloch NA, Enarson DA, Khan MA, Morkve O. Diagnosis and outcome of childhood tuberculosis: implementing public health policy in three districts of Pakistan. Int J Tuberc Lung Dis 2010; 14(7):872-877.

Slama K, Chiang C-Y,  Hinderaker SG, Bruce N, Vedal S, Enarson DA. Indoor solid fuel combustion and tuberculosis: is there an association? Int J Tuberc Lung Dis 2010; 14(1):6‑14.

Wiker HG, Mustafa T, Bjune G, Harboe M. 2010. Evidence for waning of latency in a cohort study of tuberculosis. BMC Infect Dis. 23;10:37

Purohit M, Mustafa T, Mørkve O, Sviland L. 2009. Gender differences in the clinical diagnosis of tuberculous lymphadenitis - a hospital based study from central India. Int J Infect Dis. 13(5):600-5. (A)

Basnet R, Hinderaker SG, Enarson DA, Malla P, Mørkve O. Delay in the diagnosis of tuberculosis in Nepal. BMC Public Health 2009; 9: 236.

Harries AD, Rusen ID, Chiang CY, Hinderaker SG, Enarson DA. Registering initial defaulters and reporting on their treatment outcomes. Int J Tuberc Lung Dis 2009; 13(7):801-803.

Hinderaker SG, Ysykeeva J, Veen J, Enarson DA. Serious adverse reactions in a tuberculosis programme setting in Kyrgyzstan. Int J Tuberc Lung Dis 2009; 13(12):1560-2.

The Union, TB department. Isoniazid preventive therapy for people living with HIV: public health challenges and implementation issues. Int J Tuberc Lung Dis 2009; 13(8):927-935.

Purohit M, Mustafa T, Sviland L. 2008. Detection of Mycobacterium tuberculosis by polymerase chain reaction with DNA eluted from aspirate smears of tuberculous lymphadenitis. Diagn Mol Pathol 17:174-8. (A)

Mustafa T, Wiker HG, Mørkve O, Sviland L. 2008. Differential expression of mycobacterial antigen MPT64, apoptosis and inflammatory markers in multinucleated giant cells and epithelioid cells in granulomas caused by Mycobacterium tuberculosis. Virchows Arch. 452(4):449-56. (A)

Qureshi SA, Mørkve O, Mustafa T. 2008. Patient and health system delays: Health-care seeking behavior among pulmonary tuberculosis patients in Pakistan. J Pak Med Assoc 58:318. (A)

Baba K, Dyrhol-Riise A.M., Sviland L., Langeland N., Hoosen A.A., Wiker H.G. and Mustafa T. 2008. Rapid and specific diagnosis of tuberculous pleuritis with immunohistochemistry by detecting Mycobacterium tuberculosis complex specific antigen MPT64 in patients from a HIV endemic area. Appl Immunohistochem Mol Morphol. 16:554-561. (A) PMID:18698260

Mustafa T. Does leptin have a role in immunity to tuberculosis? Invited commentry. Indian J Med Res. 2008 Dec;128(6):691-3.

Baba K, Pathak S,  Sviland L., Langeland N. , Hoosen A.A., Asjo B, Dyrhol-Riise A.M., Mustafa T. 2008. Real-time quantitative PCR in the diagnosis of tuberculosis in formalin-fixed paraffin-embedded pleural tissue in patients from a high HIV endemic area. Diagn Mol Pathol. 17:112-7. (A)

Bam TS, Enarson D, Hinderaker SG, Chapman RS. High success rate of TB treatment among Bhutanese refugees in Nepal. Int J Tuberc Lung Dis 2007; 11(1):54-58.

Mustafa T, Wiker HG, Mørkve O, Sviland L. 2007. Reduced apoptosis and increased inflammatory cytokines in granulomas caused by tuberculous as compared to non-tuberculous mycobacteria: role of MPT64 antigen in apoptosis and immune response. Clin Exp Immunol 150(1):105-13. (A)

Mfinanga SGM, Sviland L, Chande H, Mustafa T, Mørkve O. 2007.  How does clinical diagnosis of mycobacterial adenitis correlate with histological findings? East Afr J Public Health. 4 (2) 47 -50. (A)

Purohit MR, Mustafa T, Wiker HG, Morkve O, Sviland L. 2007. Immunohistochemical diagnosis of abdominal and lymph node tuberculosis by detecting Mycobacterium tuberculosis complex specific antigen MPT64. Diagn Pathol. 25;2(1):36 (A)

Tuberculosis Division of the Union. Cochrane systematic review of directly observed therapy for treating tuberculosis: good analysis of the wrong outcome. Int.J Tuberc.Lung Dis  2007;11(2):120-1.

Wiker HG, Mustafa T, Målen H, Riise AMD. 2006. Vaccine approaches to prevent tuberculosis. Review. Scand J Immunol. 64(3):243-50

Mustafa T, Wiker HG, Mfinanga S.G., M., Mørkve O., Sviland L. 2006. Immunohistochemistry using a Mycobacterium tuberculosis complex specific antibody for improved diagnosis of tuberculous lymphadenitis. Mod. Pathol. 19(12):1606-14 (A). This paper received “publication of the year” award. PMID: 16980944

Mustafa T, Mogga S.J., Mfinanga S.G.M., Mørkve O., Sviland L. 2006. Immunohistochemical analysis of apoptosis and cytokines in tuberculous lymphadenitis. Immunology 117:454-62. (A)

Abebe F, Mustafa T, Nerland A, Bjune GA. 2005. Cytokine profile during latent and slowly progressive primary tuberculosis: a possible role for IL-15 in mediating clinical disease. Clin Exp Immunol. 143:180-92. (A)

Mustafa T, Mogga S.J., Mfinanga S.G.M., Mørkve O., Sviland L. 2005. Significance of Fas and Fas Ligand in Tuberculous Lymphadenitis. Immunology 114:255-62. (A)

Tuberculosis Division of the Union. Tuberculosis bacteriology—priorities and indications in high prevalence countries: position of the technical staff of the Tuberculosis Division of the International Union Against Tuberculosis and Lung Disease. Int J Tuberc Lung Dis 2005; 9(4):355-61.

Mogga SJ, Mustafa T, Sviland L, Nilsen R. 2003. In situ expression of CD40, CD40L (CD154), IL-12, TNF-alpha, IFN-gamma and TGF-beta1 in murine lungs during slowly progressive primary tuberculosis. Scand J Immunol. 58:327-34 (A)

Suleiman BA, Houssein AI, Mehta F, Hinderaker SG. Do doctors in north-western Somalia follow the national guidelines for tuberculosis management? Eastern Mediterranean Health Journal 2003; 9 (4):789-95.

Mogga SJ, Mustafa T, Sviland L, Nilsen R. 2002. Increased Bcl-2 and reduced Bax expression in infected macrophages in slowly progressive primary murine Mycobacterium tuberculosis infection. Scand J Immunol 56:383-91 (A) (First two author contributed equally to this study)

Mustafa T, Bjune G, Jonsson R, Pando RH, Nilsen R. 2001. Increased expression of Fas ligand in human tuberculosis and leprosy lesions: a potential novel mechanism of immune evasion in mycobacterial infection. Scand J Immunol. 54:630-9 (A)

Mustafa T, Phyu S, Nilsen R, Jonsson R and Bjune G. 2000. In situ expression of cytokines and cellullar phenotypes in the lungs of mice with slowly progressive primary tuberculosis. Scand J Immunol. 51:548-56 (A)

Phyu S, Tadesse A, Mustafa T, Jonsson R, Bjune G. 2000. Diversity of lung and spleen immune responses in mice with slowly progressive primary tuberculosis. Scand J Immunol. 51:147-154 (A)

Mustafa T, Phyu S, Nilsen R, Bjune G, Jonsson R. 1999. Increased expression of Fas ligand on Mycobacterium tuberculosis infected macrophages: A potential novel mechanism of immune evasion by Mycobacterium tuberculosis? Inflammation. 23:507-21 (A)

Phyu S, Sornes S, Mustafa T, Tadesse A, Jonsson R, Bjune G. 1999. Changes in T-lymphocyte subsets in lungs and spleens of mice with slowly progressive primary mycobacterium tuberculosis infection: involvement of unconventional T-cell subsets. Scand J Immunol. 50:137-44 (A)

Mustafa T, Phyu S, Nilsen R, Jonsson R, Bjune G. 1999. A mouse model for slowly progressive primary tuberculosis. Scand J Immunol. 50:127-36 (A)

Phyu S, Mustafa T, Hofstad T, Nilsen R,Fosse R, Bjune G. 1998. A Mouse Model for Latent Tuberculosis. Scand J Infect Dis 30:59-69. (The first two authors contributed equally to this study as documented on paper) (A)


DOTS unit
Tehmina Mustafa

This picture is taken of the group's collaborating partner/institution in TB research in Pakistancollaborating partner/institution in TB research in Pakistan, the Tuberculosis DOTS unit at the Gulab Devi Chest Hospital Research Cell.