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Tehmina Mustafa

Professor, Centre for International Health
  • E-mailTehmina.Mustafa@uib.no
  • Phone+47 55 58 67 22
  • Visitor Address
    Overlege Danielsens hus, Årstadveien 21
    Room 
    525
  • Postal Address
    Postboks 7804
    5020 Bergen

Tehmina Mustafa has research experience on various aspects of tuberculosis, including epidemiological, clinical and basic laboratory research on immunology, pathology, and diagnosis of disease. She is the leader of the Tuberculosis Research Group at the Centre for International Health.

Medical specialist and consultant

Mustafa is a specialist in both pulmonary and internal medicine, and works as a consultant in respiratory diseases at the Department of Thoracic Medicine, Haukeland University Hospital.

 

Research

Mustafa studies various aspects of tuberculosis (TB), including epidemiology, clinical and basic laboratory research on immunology, pathology, and diagnosis of disease. Her main interest is in the development of better TB diagnostic methods. She has established research and academic partnerships with multiple institutions in Tanzania, Zanzibar, India and Pakistan, using funding from the Research Council of Norway and the Western Region Health Authorities of Norway. She has led and completed (2020) a multicenter international project in four countries on the implementation of a better diagnostic test for TB in routine clinical settings. She is currently working on increasing understanding the immunopathogenesis of TB based on studies using the human archival material from the Biobank at the Department of Pathology. 

 

Project leader and collaborator

Mustafa leads multi-centre projects on improved TB diagnosis and immunopathogenesis. See her project descriptions for more information

  • Coordinator and Teacher- Global Tuberculosis Epidemiology and Intervention (INTH328,  INTH928ELMED311)
  • Coordinator and Teacher-Research Proposal Development (INTH330), UiB

  • Teacher- Global health - challenges and responses- SDG303, UiB

  • Teacher- Methods in global health research- INTH315, UiB
  • Teacher- Medical students-respiratory medicine, UiB
  • Teacher- Global Health Course for nursing students at the Western Norway University of Applied Sciences

Research Supervision

PhD students: 11

Master students: 9

Medical students: 4

  • 2020. Xpert MTB/RIF Ultra for rapid diagnosis of extrapulmonary tuberculosis in a high-income low-tuberculosis prevalence setting. Scientific Reports.
  • 2020. Mycobacterial antigens in pleural fluid mononuclear cells to diagnose pleural tuberculosis in HIV co-infected patients. BMC Infectious Diseases. 1-13.
  • 2020. Mycobacterial antigens accumulation in foamy macrophages in murine pulmonary tuberculosis lesions: Association with necrosis and making of cavities. Scandinavian Journal of Immunology. 1-13.
  • 2020. Isoniazid resistance profile and associated levofloxacin and pyrazinamide resistance in rifampicin resistant and sensitive isolates/ from pulmonary and extrapulmonary tuberculosis patients in Pakistan: A laboratory based surveillance study 2015-19. PLOS ONE. 1-20.
  • 2020. Extrapulmonary tuberculosis in Pakistan- A nation-wide multicenter retrospective study. PLOS ONE.
  • 2020. Diagnosis of extrapulmonary tuberculosis using the MPT64 antigen detection test in a high-income low tuberculosis prevalence setting. BMC Infectious Diseases. 1-11.
  • 2019. Viable Mycobacterium tuberculosis in sputum after pulmonary tuberculosis cure. BMC Infectious Diseases. 1-8.
  • 2019. Utility of MPT64 Antigen Detection Test for Diagnosis of HIV Coinfected Extrapulmonary Tuberculosis in Tanzania .
  • 2019. Primary drug resistance in extra-pulmonary tuberculosis: a hospital-based prospective study from Pakistan. The International Journal of Tuberculosis and Lung Disease. 900-906.
  • 2019. Pre-diagnostic cost of extrapulmonary tuberculosis from patient perspective in Zanzibar, Tanzania.
  • 2019. Patient Health Seeking and Diagnostic Delay in Extrapulmonary Tuberculosis: A Hospital Based Study from Central India. Tuberculosis research and treatment. 8 pages.
  • 2019. MPT 64 Antigen Detection Test Performs Better Than Xpert MTB/RIF Assay for Extrapulmonary Tuberculosis in Adults in Tanzania.
  • 2019. IP-10 dried blood spots assay monitoring treatment efficacy in extrapulmonary tuberculosis in a low-resource setting. Scientific Reports. 1-9.
  • 2019. Evaluation of treatment response in extrapulmonary tuberculosis in a low-resource setting. BMC Infectious Diseases. 1-9.
  • 2019. Developing a new diagnostic test for extrapulmonary TB.
  • 2019. DEMOGRAPHIC CHARACTERISTICS OF PATIENTS WITH EXTRAPULMONARY TUBERCULOSIS IN PAKISTAN:RETROSPECTIVE COHORT ANALYSIS.
  • 2019. Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice. Communications Biology. 1-10.
  • 2018. Performance of MPT 64 antigen detection test compared to Xpert MTB/RIF assay and Culture for diagnosis of Extrapulmonary Tuberculosis in children in Tanzania.
  • 2018. Nye diagnostiske metoder for tuberkulose.
  • 2018. Mycobacterial antigen accumulation in foamy macrophages in pulmonary tuberculosis lesions is associated with tissue destruction and disease severity.
  • 2018. MPT64 antigen detection test improves routine diagnosis of extrapulmonary tuberculosis in a low-resource setting: A study from the tertiary care hospital in Zanzibar. PLOS ONE. 1-15.
  • 2018. Forbedring av tuberkulosediagnostikk ved bruk av immunokjemi-baserte metoder.
  • 2018. First and second line drug resistance pattern in new Extra Pulmonary TB cases, Prospective study in a tertiary care hospital in Pakistan.
  • 2018. Diagnostic delay in extrapulmonary tuberculosis and impact on patient morbidity: A study from Zanzibar. PLOS ONE. 1-17.
  • 2018. Bacteriological examination for the diagnosis of tuberculous lymphadenitis -Is it sufficient?
  • 2018. A survey of knowledge, attitude, and practices of private retail pharmacies staff in tuberculosis care: Study from Dera Ismail Khan City, Pakistan. Journal of Pharmaceutical Policy and Practice. 1-7.
  • 2017. Rapid and specific diagnosis of extrapulmonary tuberculosis by immunostaining of tissues and aspirates with anti-MPT64. Applied immunohistochemistry & molecular morphology (Print). 282-288.
  • 2017. Improved diagnosis of tuberculous lymphadenitis by mycobacterial antigen detection in fine-needle aspirates by a novel immunochemistry-based test.
  • 2017. Implementation of a new immunohistochemistry-based test for diagnosing extrapulmonary tuberculosis by detection of mycobacterial antigen MPT64.
  • 2017. IP-10 point-of-care test for monitoring treatment efficacy in tuberculosis in a low-resource setting.
  • 2015. Tuberkulosediagnostikk.
  • 2015. Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients. Tuberculosis research and treatment.
  • 2015. Laboratory Diagnosis of Extra-pulmonary Tuberculosis (EPTB) in Resource-constrained Setting: State of the Art, Challenges and the Need.
  • 2015. Improved diagnosis of extrapulmonary tuberculosis by antigen detection in extrapulmonary samples by immunochemistry-based assay.
  • 2015. Improved diagnosis of extra pulmonary tuberculosis by antigen detection in extra pulmonary samples by immunochemistry-based assay.
  • 2015. Forbedring av diagnostikk ved ekstrapulmonal tuberkulose.
  • 2014. Mycobacterial antigens disappear from host tissue during latent Mycobacterium tuberculosis infection.
  • 2014. Immunocytochemical detection of Mycobacterium Tuberculosis complex specific antigen, MPT64, improves diagnosis of tuberculous lymphadenitis and tuberculous pleuritis. BMC Infectious Diseases.
  • 2014. Differential in vivo expression of mycobacterial antigens in Mycobacterium tuberculosis infected lungs and lymph node tissues. BMC Infectious Diseases.
  • 2012. Rapid diagnosis of tuberculosis in aspirate, effusions, and cerebrospinal fluid by immunocytochemical detection of Mycobacterium tuberculosis complex specific antigen MPT64. Diagnostic Cytopathology. 782-791.
  • 2012. Long-term persistence of BCG Pasteur in lungs of C57BL/6 mice following intranasal infection. Scandinavian Journal of Immunology. 489-499.
  • 2010. Evidence for waning of latency in a cohort study of tuberculosis. BMC Infectious Diseases.
  • 2010. Comparison of Immune Response in Mice Infected with M-Bovis BCG Russia and M-Bovis BCG Pasteur. Scandinavian Journal of Immunology. 536-536.
  • 2009. Gender differences in the clinical diagnosis of tuberculous lymphadenitis-a hospital-based study from Central India. International Journal of Infectious Diseases. 600-605.
  • 2009. Differential expression of mycobacterial antigen MPT64, apoptosis and inflammatory markers in multinucleated giant cells and epithelioid cells in granulomas caused by Mycobacterium tuberculosis.
  • 2008. Real-time quantitative PCR in the diagnosis of tuberculosis in formalin-fixed paraffin-embedded pleural tissue in patients from a high HIV endemic area. Diagnostic molecular pathology (Print). 112-117.
  • 2008. Rapid, sensitive and specific test for diagnosis of tuberculosis by using immunochemistry for detection of M. tuberculosis complex specific antigen MPT64.
  • 2008. Rapid and Specific Diagnosis of Tuberculous Pleuritis With Immunohistochemistry by Detecting Mycobacterium tuberculosis Complex Specific Antigen MPT64 in Patients From a HIV Endemic Area. Applied immunohistochemistry & molecular morphology (Print). 554-561.
  • 2008. Patient and health systems delays: Health-care seeking behaviour among pulmonary tuberculosis patients in Pakistan. JOURNAL OF PAKISTAN MEDICAL ASSOCIATION. 318-321.
  • 2008. Estimating the half-life of latent Mycobacterium tuberculosis infection based on the decline of tuberculosis in Norway.
  • 2008. Does leptin have a role in immunity to tuberculosis? . Indian Journal of Medical Research (IJMR).
  • 2008. Does leptin have a role in immunity to tuberculosis? Indian Journal of Medical Research (IJMR). 691-693.
  • 2008. Differential expression of mycobacterial antigen MPT64, apoptosis and inflammatory markers in multinucleated giant cells and epithelioid cells in granulomas caused by Mycobacterium tuberculosis. Virchows Archiv. 449-456.
  • 2008. Detection of Mycobacterium tuberculosis by polymerase chain reaction with DNA eluted from aspirate smears of tuberculous lymphadenitis. Diagnostic molecular pathology (Print). 174-178.
  • 2007. Reduced apoptosis and increased inflammatory cytokines in granulomas caused by tuberculous compared to non-tuberculous mycobacteria: role of MPT64 antigen in apoptosis and immune response. Clinical and Experimental Immunology. 105-113.
  • 2007. Immunohistochemistry for the detection of Mycobacterium tuberculosis complex specific antigen (MPT64) improves the diagnosis of extrapulmonary tuberculosis caused by pathogenic mycobacteria. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). 1316-1316.
  • 2007. Immunohistochemical diagnosis of abdominal and lymph node tuberculosis by detecting Mycobacterium tuberculosis complex specific antigen MPT64. Diagnostic Pathology.
  • 2007. How does clinical diagnosis of mycobacterial adenitis correlate with histological findings? . East African Journal of Public Health.
  • 2007. How does clinical diagnosis of mycobacterial adenitis correlate with histological findings? East African Journal of Public Health. 47-50.
  • 2007. Detection of mycobacterium tuberculosis specific antigens by immunohistochemical technique: application for improved diagnosis of abdominal tuberculosis.
  • 2007. Correlation of Mycobacterium tuberculosis antigen MPT64 expression and apoptosis in human tuberculosis lesions.
  • 2006. Vaccine approaches to prevent tuberculosis. Scandinavian Journal of Immunology.
  • 2006. Vaccine approaches to prevent tuberculosis. 243-250.
  • 2006. Immunohistochemistry using a Mycobacterium tuberculosis complex specific antibody for improved diagnosis of tuberculous lymphadenitis. Modern Pathology. 1606-1614.
  • 2006. Immunohistochemical analysis of cytokines and apoptosis in tuberculous lymphadenitis. Immunology. 454-462.
  • 2005. Significance of Fas and Fas ligand in tuberculous lymphadenitis. Immunology. 255-262.
  • 2005. Significance of Fas and Fas Ligand in tuberculous lymphadenitis.
  • 2005. Mycobacterial Lymphadenitis: Host immune response and new diagnostic tools.
  • 2005. Is Mycobacterium paratuberculosis a cause of Crohn`s disease?
  • 2005. Immunohistochemistry and polymerase chain reaction based detection of Mycobacterium tuberculosis in histologic specimens.
  • 2005. Cytokine profile during latent and slowly progressive primary tuberculosis: a possible role for interleukin-15 in mediating clinical disease. Clinical and Experimental Immunology. 180-192.
  • 2004. Role of Fasligand/Fas system and apoptosis in the pathogenesis of tuberculosis. 10 pages.
  • 2003. Title: Role of apoptosis in the pathogenesis of murine and human tuberculosis lesions; immune evasion strategies of mycobacteria.
  • 2003. In situ expression of CD40, CD40L (CD154), IL-12, TNF-alpha, IFN-gamma and TGF-beta1 in murine lungs during slowly progressive primary tuberculosis. Scandinavian Journal of Immunology. 327-334.
  • 2002. Increased Bcl-2 and reduced Bax expression in infected macrophages in slowly progressive primary murine mycobacterium tuberculosis infection. Scandinavian Journal of Immunology. 383-391.
  • 2001. Increased expression of fas ligand in human tuberculosis and leprosy lesions: a potential novel mechanism of immune evasion in mycobacterial infection. Scandinavian Journal of Immunology. 630-639.
  • 2000. Murine models of chronic tuberculosis: significance of granuloma morphology, apoptosis and immune evasion.
  • 2000. In Situ Expression of cytokines and cellular phenotypes in the lungs of mice with slowly progressive primary tuberculosis. Scandinavian Journal of Immunology. 548-556.
  • 2000. Diversity of lung and spleen immune responses in mice with slowly progressive primary tuberculosis. Scandinavian Journal of Immunology. 147-154.
  • 1999. Increased expresson of Fas ligand on Mycobacterium tuberculosis infected macrophages: a potential novel mechanism of immune evation by Mycobacterium tuberculosis? Inflammation. 507-521.
  • 1999. Increased expression of FAS ligand on Mycobacterium tuberculosis infected macrophages: A potential novel mechansim of immune evasion by Mycobacterium tuberculosis? Inflammation. 507-521.
  • 1999. Changes in T-Lymphocyte Subsets in Lungs and Spleens of Mice with Slowly Progressive Primary Mycobacterium tuberculosis Infection: Involvement of Unconventional T-Cell Subsets. Scandinavian Journal of Immunology. 137-144.
  • 1999. A mouse model for slowly proressing tuberculosis. Scandinavian Journal of Immunology. 127-136.
  • 1999. A mouse model for slowly progressive primary tuberculosis. Scandinavian Journal of Immunology. 127-136.
  • 1999. A mouse model for slowly progressive primary tuberculosis. Scandinavian Journal of Immunology. 127-136.
  • 1998. TGF in primary progressive, latent and reactivated murine tuberculosis. Abstract 86.
  • 1998. Study of cytokines involved in progressive primary disease and latent tuberculosis in mice. Abstract 244 (Host response: pathogenesis, latency, immunogencicity, vaccine).
  • 1998. Compartmentalized immune responses in the spleens and lungs of chronically Mycobacterium tuberculosis infected mice.
  • 1998. Compartmentalized immune responses in the spleens and lungs of chronically Mycobacterium tuberculosis infected mice.
  • 1998. Compartmentalized immune responses in the spleens and lungs of chronically <I>mycobacterium tuberculosis</I> infected mice.
  • 1998. A novel mechanism of immune evasion by Mycobacterium tuberculosis.
  • 1998. A novel mechanism of immune evasion by <I>Mycobacterium tuberculosis</I>.
  • 1998. A Mouse Model for Latent Tuberculosis.
  • 1998. A Mouse Model for Latent Tuberculosis. Scandinavian Journal of Infectious Diseases. 59-68.
  • 1997. T cell Phenotypes in Lungs of Normal and TB Infected Mice, Compared to Spleen and Peripheral Blood.
  • 1997. Pattern of Cell Death in Mtb infected Mouse organs.
  • 1997. Lungs in Murine Latent Tuberculosis. International conference on immunopathology of mucous membranes and exocrine glands.
  • 1997. Lungs in Murine Latent Tuberculosis.
  • 1997. Histopathology of the Mouse Model for Latent TB Infection and Slowly Progressive Disease.
  • 1997. Cytokine Production and Bacillary Growth In Lungs of Mtb infected Mice Compared to Liver and Spleen.

More information in national current research information system (CRIStin)

  • Risk of infection with Mycobacterium tuberculosis in a low tuberculosis prevalence setting
  • Pathogenesis of human Post-Primary Tuberculosis: Novel insights from Norwegian archival tissue material of the pre-antibiotic era
  • Improving diagnosis of extrapulmonary tuberculosis by implementation of a sensitive and specific assay in routine tuberculosis diagnostics
  • Association between Tuberculosis and Obstructive Lung Diseases and Allergies
  • Biomarkers in tuberculosis: implications for improved diagnosis, monitoring treatment response, and host-directed therapies
  • Proteomic and bioinformatic studies of the host therapeutic response to tuberculosis treatment
  • Development of a subunit vaccine for prevention of reactivation of tuberculosis- a study of the murine models of the chronic slowly progressive tuberculosis.