News archive for Biorecognition
On Tuesday August 15th, Devaki defended her PhD at the University of Oulu. The opponent was Associate Professor Beáta Bugyi from the University of Pécs Medical School, Pécs, Hungary. We all very much enjoyed an insightful discussion on actins, actin depolymerizing factors, and their roles in the malaria parasite. Thanks to everyone involved and huge congratulations to Dr. Devaki Lasiwa!
As part of a consortium lead by the EU-Openscreen head office with the overall goal to improve the services offered by EU-Openscreen, the Brenk group has got funding to work on Ribotacs. Ribotacs are small molecules that selectively bind RNAs and a RNAse and thus lead targeted RNA degradation. We look forward to a succesfull collaboration.
This month, Dr. Stanley Makumire joined our group as a post-doctoral fellow. We look forward to working together in the coming years!
In March, we had a Drug Discovery meeting to showcase the research that is going on Bergen and to connect the groups active in this area. Nearly 50 people had signed up of the meeting and we had 9 different talks covering topics from target discovery all the way to clinical trials.
The second excellent news of the day was that Jane and Aatos Erkko foundation in Finland has decided to support our work with a whole 842000 € in the next three years. This decision could not have been more welcome and secures the continuation of our work. I am utmost grateful to Jane and Aatos Erkko foundation and extremely relieved. I hope one day also Norwegian funding bodies will see some... Read more
Today brought some pretty awesome news. The first came in the wee hours, telling that Henni's collaborative paper with Maddy Dans from the lab of Paul Gilson from the Burnet Institute (and a number of other collaborators) was accepted for publication in PLoS Biology. Looking forward to see this great story on inhibitors of the malaria profilactin complex finally out soon! Many thanks and huge... Read more
Last week, we got two small positive funding decisions, as we got consumable and travel money both from the Meltzer Foundation (100000 NOK) and the UiB General Medical Fund (76720 NOK). Many thanks for both foundations for continuing to support our work!
Andrea's paper on the structure and cellular localization of malaria parasite actin II was accepted for publication in PLoS Pathogens today! The work was a huge long-term collaborative effort between our lab and the lab of Inga Sidén-Kiamos at IMBB-FORTH, Heraklion, Crete, and that of Peter Rosenthal at the Francis Crick Institute, London, UK.
After years of work, we finally can see what the apicomplexan glideosome-associated connector (GAC) really looks like! Check out our latest preprint presenting the structure in two drastically different conformations. Based on its structure, we suggest a role for GAC as an elastic spring helping parasite motility and invasion.
Ruth Brenk has given a brief update of the riboswitch research in our group at the Digital Breakfast organized by the the Center of Digital Life.
Andrea's work together with collaborators from IMBB-FORTH (Heraklion, Crete) and Francis Crick Institute (London, UK) on malaria parasite actin II is out in preprint form.
Post-doctoral (or graduate student) position in structural biology of parasite motility (23.10.2022)
We are looking for a post-doctoral fellow for a 2.5-year project (possible extension for up to 1 year) in my group at the Faculty of Biochemistry and Molecular Medicine (FBMM), University of Oulu, Finland. Alternatively, an exceptionally highly-qualified PhD student could be considered. The overall aim of my group is to understand the molecular mechanism of malaria parasite gliding motility. To... Read more
Henni's recent work on characterizing compounds interfering with the malaria parasite profilin-actin complex and actin dynamics is out as a preprint on bioRxiv. The project is part of a large collaboration led by Madeline Dans and Paul Gilson from the Burnet Institute, Melbourne, Australia.
Today, we have a special pleasure to host Dr. Linda Sandblad, the Director of the Umeå Centre for Electron Microscopy, as our BBB seminar speaker. Already visited Ulriken to see Bergen from above and had exciting exchange of ideas on our projects. Now looking forward to Linda's talk at 14:30. Come by if you are nearby!
https://www.uib.no/en/biomedisin/156022/bbb-seminar-linda-sandblad
Our manuscript on the smallest malaria parasite myosin, MyoB, was accepted for publication in the Journal of Biological Chemistry. Read here a summary of Isa's nice work on this so-far uncharacterized myosin, which is important for the parasite invasion of red blood cells.
On Thursday October 6th, Atta defended his PhD thesis entitled "Structural characterization of Toxoplasma gondii armadillo repeat only protein and purification of actins from apicomplexan parasites". As the opponent, we had the pleasure of hosting Dr. Young-Hwa Song from the University of Lübeck, Germany. Huge congratulations to Atta and many thanks to the opponent and everyone who participated... Read more
We have a new PhD thesis hanging out for public display in the Tree of Science at the FBMM, University of Oulu. On October 6th, Atta will defend his thesis "Structural characterization of Toxoplasma gondii armadillo repeat only protein and purification of actins from apicomplexan parasites". The opponent will be Dr. Young-Hwa Song from the University of Lübeck, Germany. We look forward to the... Read more
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