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Biorecognition

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Protein ribbon model

We are interested in the molecular mechanisms behind biomolecular recognition and functional response.

The Biorecognition group is divided into four labs. Please visit the lab pages to learn more about our research.

News
Full-length human PAH

The structure of the enzyme implicated in phenylketonuria (PKU)

The structure of full-length phenylalanine hydroxylase in complex with the cofactor BH4 is presented in the most recent issue of PNAS. As the cofactor is also used as a therapy for PKU, this structure is of medical importance.

Research news
Back cover of April 2019 issue of Human Mutation

Novel interaction of the co-chaperone DNAJC12 with phenylalanine hydroxylase variants

Researchers from the lab of Aurora Martinez describe a novel mechanism for the degradation of enzymes involved in phenylketonuria and other neurometabolic disorders.

Funding news
DLN

Towards better computational approaches and responsible innovation strategies in early drug discovery

Together with Nathalie Reuter and Bengt-Erik Haug from the Chemistry Department and Alexander Lundervold from the Høgskulen på Vestlandet (HVL) we got funding for the project «Towards better computational approaches and responsible innovation strategies in early drug discovery: application to...

Research news
TOC selectivity

New resarch article on selectivity

Our new paper on entangling selectivity determining features and on how to use this knowledge to design selective ligands has been published in J Med Chem!