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Biorecognition

Protein ribbon model

We are interested in the molecular mechanisms behind biomolecular recognition and functional response.

The Biorecognition group is divided into four labs. Please visit the lab pages to learn more about our research.

Research project
PRIME logo

New mental health project aims to uncover insulin-related mechanisms linking disorders of body and brain.

An important European-funded initiative has been launched to explore how common molecular mechanisms may link metabolic disorders, especially type 2 diabetes and obesity, with brain disorders such as Alzheimer's disease, obsessive-compulsive disorder, and autism spectrum disorders. Jan Haavik...

News
graphical abstract mol therapy

From molecule to medicine

Martinez and collaborators are developing a pharmacological chaperone therapy for acute intermittent porphyria

News
Full-length human PAH

The structure of the enzyme implicated in phenylketonuria (PKU)

The structure of full-length phenylalanine hydroxylase in complex with the cofactor BH4 is presented in the most recent issue of PNAS. As the cofactor is also used as a therapy for PKU, this structure is of medical importance.

Research news
Back cover of April 2019 issue of Human Mutation

Novel interaction of the co-chaperone DNAJC12 with phenylalanine hydroxylase variants

Researchers from the lab of Aurora Martinez describe a novel mechanism for the degradation of enzymes involved in phenylketonuria and other neurometabolic disorders.

Research news
TOC selectivity

New resarch article on selectivity

Our new paper on entangling selectivity determining features and on how to use this knowledge to design selective ligands has been published in J Med Chem!