Structural biology and drug discovery

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Collage relatert til Forskningsenheten structural biology and drug discovery

Our research focuses on understanding the relationships between the structure of macromolecules and their function, stability and regulation. We use an interplay of advanced methodology in molecular, structural and cell biology as well as biophysics, compound screening, computational chemistry and drug discovery applied to studies of biological systems and pathways of biomedical interest.

The Unit is composed of four groups: Ruth Brenk, Inari Kursula, Petri Kursula and Aurora Martinez. Visit the group pages to learn more about our research.

In addition, we are involved in the organization and management of the core facility for Biophysics, Structural Biology and Screening (BiSS), localized at the Department of Biomedicine.

Human membrane proteins
myelin membrane proteins

Structural biology of human myelin membrane proteins

Myelin is a crucial structure for the normal functioning of the vertebrate nervous system. Here, we have used multiple state-of-the-art technologies at large international research infrastructures, enabling methods not available in Norway, to obtain 3D structural information on some of the most...

Improving services of EU-Openscreen

Funding for work on Ribotacs

As part of a consortium lead by the EU-Openscreen head office with the overall goal to improve the services offered by EU-Openscreen, the Brenk group has got funding to work on Ribotacs. Ribotacs are small molecules that selectively bind RNAs and a RNAse and thus lead targeted RNA degradation. We...

Funding for large-scale interdisciplinary project

Escaping the Combinatorial Explosion: Expert-Enhanced Heuristic Navigation of Chemical Space (eHACS)

Project funding from the NFR to carry out a collaborative project on expert-enhanced de novo design of small molecules.

News | Research
Bilde av to mus i musemodellen holdt av to personer med blå hansker

A new mouse model gave surprising findings about Folling Disease

A new study from the University in Bergen may shed light on the comorbidities found in adults suffering from this rare disease.