Biophysics, Structural Biology, and Screening (BiSS) is a core facility of the Faculty of Medicine, hosted by the Department of Biomedicine. BiSS offers expertise and access to a range of instrumentation to study the interactions of small molecules with macromolecules, protein biophysics, and for crystallization.
BiSS is part of the chemical biology consortia Nor-Openscreen and EU-Openscreen. EU-Openscreen has certified BiSS as a speciliast screening site for biophysical and virtual screening. BiSS hosts a number of libraries, including the 100 000-compound European Chemical Biology Library (ECBL) and the 1000-compound fragment library, which can be accessed for either biophysical or fragment screens. BiSS also offers cheminformatic services for virtual screening and hit follow up. All instrumentation can be used by the users independently after appropriate training.
BiSS is a member of the national NORCRYST infrastructure funded by the Norwegian Research Council, and hosts instrumentation and know-how for macromolecular crystallography and complementary techniques. BiSS coordinates local BAG applications for synchrotron beamtime at various European large-scale research infrastructures.