Biophysics, Structural Biology and Screening (BiSS)

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BiSS logo

Biophysics, Structural Biology, and Screening (BiSS) is a core facility of the Faculty of Medicine, hosted by the Department of Biomedicine. BiSS offers expertise and access to a range of instrumentation to study the interactions of small molecules with macromolecules, protein biophysics, and for crystallization.

BiSS is part of the chemical biology consortia Nor-Openscreen and EU-Openscreen. EU-Openscreen has certified BiSS as a speciliast screening site for biophysical and virtual screening. BiSS hosts a number of libraries, including the 100 000-compound European Chemical Biology Library (ECBL) and the 1000-compound fragment library, which can be accessed for either biophysical or fragment screens. BiSS also offers cheminformatic services for virtual screening and hit follow up. All instrumentation can be used by the users independently after appropriate training.

BiSS is a member of the national NORCRYST infrastructure funded by the Norwegian Research Council, and hosts instrumentation and know-how for macromolecular crystallography and complementary techniques. BiSS coordinates local BAG applications for synchrotron beamtime at various European large-scale research infrastructures.

Use cases for the EU-OS fragment screening library
TOC figure, RSC Med Chem

Design, Quality and Validation of the EU-OPENSCREEN Fragment Library Poised to a High-Throughput Screening Collection

The Brenk lab has co-authored a paper describing the EU-Openscreen fragment library.

Improving services of EU-Openscreen

Funding for work on Ribotacs

As part of a consortium lead by the EU-Openscreen head office with the overall goal to improve the services offered by EU-Openscreen, the Brenk group has got funding to work on Ribotacs. Ribotacs are small molecules that selectively bind RNAs and a RNAse and thus lead targeted RNA degradation. We...


Fragment screening for pandemic prepardness

A large EU consortium got funding to integrated services for combatting current and future infectious disease outbreaks. BiSS is part of this consortium and offers fragment screening.

Results from survey
How was the service?

Feedback in Nor-Openscreen survey

BiSS is growing as a core facility, and we are quite happy that our users are satisfied.

High-throughput crystallization
The crystal imaging system at BiSS

Crystal plate imaging system installed

A state-of-the-art imaging system for high-throughput crystallization experiments has been installed at BiSS at the Department of Biomedicine. The system is capable of imaging samples using both visible and UV light. The imager is a significant addition to the crystallization laboratory as well as...