Biophysics, Structural Biology and Screening (BiSS) is a core facility of the Faculty of Medicine and hosted by the Department of Biomedicine. BiSS offers access to a range of instrumentation to determine the interactions of small molecules with macromolecules and for crystallization.
BiSS is part of the chemical biology consortia Nor-Openscreen and EU-Openscreen. EU-Openscreen has certified BiSS as a speciliast screening site for biophysical and virtual screening. BiSS hosts a number of libraries, including the 100k European Chemical Biology Library (ECBL) and the 1000-member fragment library which can be accessed for either biophysical or fragment screens. BiSS also offers cheminformatic services for virtual screening and hit follow. All instrumentation can be used by the users themselves after training.
BiSS is a member of the national NORCRYST infrastructure funded by the Norwegian Research Council, and hosts instrumentation and know-how for macromolecular crystallography and complementary techniques. BiSS coordinates local BAG applications for synchrotron beamtime at various European large-scale research infrastructures.