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Biophysics, Structural Biology and Screening (BiSS)
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Publications using BiSS

The list below shows published research carried out using the facilities at BiSS. We strongly encourage all users of BiSS to inform us of new publications taking advantage of the facility.

2020

Mahootchi E., Raasakka A., Luan W., Muruganandam G., Loris R., Haavik J. & Kursula P. (2020) Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase. J. Struct. Biol., in press. 

Eriksen M.S., Nikolaienko O., Hallin E.I., Grødem S., Bustad H.J., Flydal M.I., Merski I., Hosokawa T., Lascu D., Akerkar S., Cuéllar J., Chambers J.J., O´Connell R., Muruganandam G., Loris R., Touma C., Kanhema T., Hayashi Y., Stratton M.M., Valpuesta J.M., Kursula P., Martinez A. & Bramham C.R. (2020) Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif. FEBS J., in press. 

Lillebostad P.A.G., Raasakka A., Hjellbrekke S.J., Patil S., Røstbø T., Hollås H., Sakya S.A., Szigetvari P.D., Vedeler A. & Kursula P. (2020) Structure of the ALS mutation target annexin A11 reveals a stabilising N-terminal segment. Biomolecules 10:660.

Ruskamo S., Krokengen O.C., Kowal J., Nieminen T., Lehtimäki M., Raasakka A., Dandey V.P., Vattulainen I., Stahlberg H. & Kursula P. (2020) Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice. J. Biol. Chem. 295:8692-8705.

Klein R, Cendron L, Montanari M, Bellio P, Celenza G, Maso L, Tondi D, Brenk R. Targeting the Class A Carbapenemase GES-5 via Virtual Screening. Biomolecules. 2020 Feb 14;10(2). pii: E304.[Pubmed | DOI]

Støve SI, Flydal, MI, Hausvik E, Underhaug J, Martinez A (2020) Differential scanning fluorimetry in the screening and validation of pharmacological chaperones for soluble and membrane proteins, In Protein Homeostasis Diseases (Pey, A. L., Ed.), pp 329-341, Academic Press. [DOI]

Bustad HJ, Toska K, Schmitt C, Vorland M, Skjærven L, Kallio JP, Simonin S, Letteron P, Underhaug J, Sandberg S, Martinez A (2020)A Pharmacological Chaperone Therapy for Acute Intermittent Porphyria. Mol Ther. 2020 Feb 5;28(2):677-689. [DOI]

2019

Kouloulia S., Hallin E.I., Simbriger K., Amorim I.S., Lach G., Amvrosiadis T., Kampaite A., Jafarnejad S.M., Truong V.T., Hooshmandi M., Skehel P., Kursula P., Khoutorsky A. & Gkogkas C. (2019) Raptor-mediated proteasomal degradation of deamidated 4E-BP2 regulates postnatal neuronal translation and NF-Kappa B activity. Cell Rep. 29: 3620-3635.

Raasakka A., Ruskamo S., Barker R., Krokengen O.C., Vatne G.H., Kristiansen C.K., Hallin E.I., Skoda M.W.A., Wacklin-Knecht H., Jones N.C., Hoffmann S.V. & Kursula P. (2019) Neuropathy-related mutations alter the membrane binding properties of the human myelin protein P0 cytoplasmic tail. PLoS ONE 14:e0216833.

Raasakka A., Jones N.C., Hoffmann S.V. & Kursula P. (2019) Ionic strength and calcium regulate membrane interactions of myelin basic protein and the cytoplasmic domain of myelin protein zero. Biochem. Biophys. Res. Commun. 511:7-12.

Raasakka A., Linxweiler H., Brophy P.J., Sherman D.L. & Kursula P. (2019) Direct binding of the flexible C-terminal segment of periaxin to β4 integrin suggests a molecular basis for CMT4F. Front. Mol. Neurosci. 12:84.

Brennecke P, Rasina D, Aubi O, Herzog K, et al. EU-OPENSCREEN: A Novel Collaborative Approach to FacilitateChemical Biology. SLAS Discov. 2019 Mar;24(3):398-413. doi:10.1177/2472555218816276. Epub 2019 Jan 7. PubMed PMID: 30616481.

Aubi O, Knappskog PM, Martinez A. Early Stage Discovery and Validation of Pharmacological Chaperones for the Correction of Protein Misfolding Diseases.Methods Mol Biol. 2019;1873:279-292. doi: 10.1007/978-1-4939-8820-4_18. PubMedPMID: 30341617.

Bezem MT, Johannessen FG, Jung-Kc K, Gundersen ET, Jorge-Finnigan A, Ying M,Betbeder D, Herfindal L, Martinez A. Stabilization of Human Tyrosine Hydroxylasein Maltodextrin Nanoparticles for Delivery to Neuronal Cells and Tissue.Bioconjug Chem. 2018 Feb 21;29(2):493-502. doi: 10.1021/acs.bioconjchem.7b00807.Epub 2018 Jan 31. PubMed PMID: 29299922.

Kersten C, Fleischer E, Kehrein J, Borek C, Jaenicke E, Sotriffer C, Brenk R. How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using N-Myristoyltransferases as a Model System. J Med Chem. 2019 Aug 19. [Epub ahead of print] [Pubmed | DOI]

Raasakka A., Ruskamo S., Kowal J., Han H., Baumann A., Myllykoski M., Fasano A., Rossano R., Riccio P., Bürck J., Ulrich A.S., Stahlberg H. & Kursula P. (2019) Molecular structure and function of myelin protein P0 in membrane stacking. Sci. Rep. 9:642.

Szigetvari P.D., Muruganandam G., Kallio J.P., Hallin E.I., Fossbakk A., Loris R., Kursula I., Møller L.B., Knappskog P.M., Kursula P. & Haavik J. (2019) The quaternary structure of human tyrosine hydroxylase: effects of dystonia-associated missense variants on oligomeric state and enzyme activity. J. Neurochem. 148:291-306.

2018

Klein R, Linciano P, Celenza G, Bellio P, Papaioannou S, Blazquez J, Cendron L, Brenk R, Tondi D. In silico identification and experimental validation of hits active against KPC-2 β-lactamase. PLoS One. 2018 Nov 29;13(11):e0203241. [Pubmed | DOI | bioRxiv]

Hallin E.I., Eriksen M.S., Baryshnikov S., Nikolaienko O., Grødem S., Hosokawa T., Hayashi Y., Bramham C.R. & Kursula P. (2018) Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities. J. Neurochem. 147:323-343.

Laulumaa S., Nieminen T., Raasakka A., Krokengen O.C., Safaryan A., Hallin E.I., Brysbaert G., Lensink M.F., Ruskamo S., Vattulainen I. & Kursula P. (2018) Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the β barrel in fatty acid binding proteins. BMC Struct. Biol. 18:8.

Raasakka A., Mahootchi E., Winge I., Luan W., Kursula P. & Haavik J. (2018) Structure of the mouse acidic amino acid decarboxylase GADL1. Acta Cryst. F 74:65-73. 

2017

Urbaneja M.A., Skjærven L., Aubi O., Underhaug J., López D.J., Arregi I., Alonso-Mariño M., Cuevas A., Rodrígues J.A., Martinez A. & Bañuelos S. (2017) Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia. Sci. Rep. 7:13959. doi: 10.1038/s41598-017-14497-4 

Raasakka A., Ruskamo S., Kowal J., Barker R., Baumann A., Martel A., Tuusa J., Myllykoski M., Bürck J., Ulrich A.S., Stahlberg H. & Kursula P. (2017) Membrane association landscape of myelin basic protein portrays formation of the myelin major dense line. Sci. Rep. 7:4974. doi: 10.1038/s41598-017-05364-3

Ruskamo S., Nieminen T., Kristiansen C., Vatne G., Baumann A., Hallin E., Raasakka A., Joensuu P., Bergmann U., Vattulainen I. & Kursula P. (2017) Molecular mechanisms of Charcot-Marie-Tooth neuropathy linked to mutations in human myelin protein P2. Sci. Rep. 7:6510. doi: 10.1038/s41598-017-06781-0

 

PhD theses

Frank Christian Kersten, Selectivity determining features in N-myristoyltransferases - a model system for drug targets with conserved binding sites, Johannes Gutenberg University Mainz, 2017

Thomas Wehler, Structure-based design for the discovery of novel ligands targeting the FMN riboswitch, Johannes Gutenberg University Mainz, 2017