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Biophysics, Structural Biology and Screening (BiSS)
in the press

Publications using BiSS

The list below shows published research carried out using the facilities at BiSS. We strongly encourage all users of BiSS to inform us of new publications taking advantage of the facility.

Content

2019

Brennecke P, Rasina D, Aubi O, Herzog K, et al. EU-OPENSCREEN: A Novel Collaborative Approach to FacilitateChemical Biology. SLAS Discov. 2019 Mar;24(3):398-413. doi:10.1177/2472555218816276. Epub 2019 Jan 7. PubMed PMID: 30616481.

Aubi O, Knappskog PM, Martinez A. Early Stage Discovery and Validation ofPharmacological Chaperones for the Correction of Protein Misfolding Diseases.Methods Mol Biol. 2019;1873:279-292. doi: 10.1007/978-1-4939-8820-4_18. PubMedPMID: 30341617.

Bezem MT, Johannessen FG, Jung-Kc K, Gundersen ET, Jorge-Finnigan A, Ying M,Betbeder D, Herfindal L, Martinez A. Stabilization of Human Tyrosine Hydroxylasein Maltodextrin Nanoparticles for Delivery to Neuronal Cells and Tissue.Bioconjug Chem. 2018 Feb 21;29(2):493-502. doi: 10.1021/acs.bioconjchem.7b00807.Epub 2018 Jan 31. PubMed PMID: 29299922.

2018

Klein R, Linciano P, Celenza G, Bellio P, Papaioannou S, Blazquez J, Cendron L, Brenk R, Tondi D. In silico identification and experimental validation of hits active against KPC-2 β-lactamase. PLoS One. 2018 Nov 29;13(11):e0203241. [Pubmed | DOI | bioRxiv]

Raasakka A., Ruskamo S., Kowal J., Han H., Baumann A., Myllykoski M., Fasano A., Rossano R., Riccio P., Bürck J., Ulrich A.S., Stahlberg H. & Kursula P. (2018) Molecular structure and function of myelin protein P0 in membrane stacking. Sci. Rep., in press.

Szigetvari P.D., Muruganandam G., Kallio J.P., Hallin E.I., Fossbakk A., Loris R., Kursula I., Møller L.B., Knappskog P.M., Kursula P. & Haavik J. (2018) The quaternary structure of human tyrosine hydroxylase: effects of dystonia-associated missense variants on oligomeric state and enzyme activity. J. Neurochem., in press.

Hallin E.I., Eriksen M.S., Baryshnikov S., Nikolaienko O., Grødem S., Hosokawa T., Hayashi Y., Bramham C.R. & Kursula P. (2018) Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities. J. Neurochem. 147:323-343.

Laulumaa S., Nieminen T., Raasakka A., Krokengen O.C., Safaryan A., Hallin E.I., Brysbaert G., Lensink M.F., Ruskamo S., Vattulainen I. & Kursula P. (2018) Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the β barrel in fatty acid binding proteins. BMC Struct. Biol. 18:8.

Raasakka A., Mahootchi E., Winge I., Luan W., Kursula P. & Haavik J. (2018) Structure of the mouse acidic amino acid decarboxylase GADL1. Acta Cryst. F 74:65-73. 

2017

Urbaneja M.A., Skjærven L., Aubi O., Underhaug J., López D.J., Arregi I., Alonso-Mariño M., Cuevas A., Rodrígues J.A., Martinez A. & Bañuelos S. (2017) Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia. Sci. Rep. 7:13959. doi: 10.1038/s41598-017-14497-4 

Raasakka A., Ruskamo S., Kowal J., Barker R., Baumann A., Martel A., Tuusa J., Myllykoski M., Bürck J., Ulrich A.S., Stahlberg H. & Kursula P. (2017) Membrane association landscape of myelin basic protein portrays formation of the myelin major dense line. Sci. Rep. 7:4974. doi: 10.1038/s41598-017-05364-3

Ruskamo S., Nieminen T., Kristiansen C., Vatne G., Baumann A., Hallin E., Raasakka A., Joensuu P., Bergmann U., Vattulainen I. & Kursula P. (2017) Molecular mechanisms of Charcot-Marie-Tooth neuropathy linked to mutations in human myelin protein P2. Sci. Rep. 7:6510. doi: 10.1038/s41598-017-06781-0

 

PhD theses

Frank Christian Kersten, Selectivity determining features in N-myristoyltransferases - a model system for drug targets with conserved binding sites, Johannes Gutenberg University Mainz, 2017

Thomas Wehler, Structure-based design for the discovery of novel ligands targeting the FMN riboswitch, Johannes Gutenberg University Mainz, 2017