News archive for Biophysics, Structural Biology and Screening (BiSS)
This is the newest part of our journey to design FabF inhibitors with the goal to develop new antibiotics. Here, we have used X-ray crystallography to discover hit compounds which subsequently were optimized using analogue searching, chemical space searching and manual design.
CNPase is an enzyme present at high levels in myelinating cells. Novel nanobody tools developed in an international collaboration were used to identify binding epitopes at atomic resolution and visualise myelin. Additionally, the nanobodies were used as intrabodies to bind to CNPase in living cells. These nanotools will be valuable for future research on myelin and its molecules.
The Brenk lab has co-authored a paper describing the EU-Openscreen fragment library.
As part of a consortium lead by the EU-Openscreen head office with the overall goal to improve the services offered by EU-Openscreen, the Brenk group has got funding to work on Ribotacs. Ribotacs are small molecules that selectively bind RNAs and a RNAse and thus lead targeted RNA degradation. We look forward to a succesfull collaboration.
A large EU consortium got funding to integrated services for combatting current and future infectious disease outbreaks. BiSS is part of this consortium and offers fragment screening.
BiSS is growing as a core facility, and we are quite happy that our users are satisfied.
We have received funding from the Olav Tjomslands Legat for funding for equipment and tools for the the crystallization lab.
The Nor-Openscreen application for this year's infrastructure call scored the highest possible marks in all categories! To quote from the reviewer comments: "This is an excellent proposal to enlarge and update existing infrastructure and services in chemical biology in Norway". Despite the very favorable evaluation, the proposal was not funded. This means, there will unfortunately be no new... Read more
A state-of-the-art imaging system for high-throughput crystallization experiments has been installed at BiSS at the Department of Biomedicine. The system is capable of imaging samples using both visible and UV light. The imager is a significant addition to the crystallization laboratory as well as BiSS, providing a seamless workflow from the Mosquito LCP pipetting robot to automated imaging. It... Read more
- April 2025 (1)
- December 2024 (1)
- February 2024 (1)
- July 2023 (1)
- April 2022 (1)
- June 2020 (1)
- February 2020 (1)
- September 2019 (1)
- October 2017 (1)