Brenk lab
New article published

On the Hunt for Metalloenzyme Inhibitors

The Brenk lab has published an article in which they have investigated the presence of metal-coordinating groups in screening libraries and chemical spaces. This can help with the discovery for new inhibitors for metallo enzymes.

TOC figure, Archiv der Pharmazie
TOC graphic
Bruna Schuck

Main content

In this study, metal-chelating groups were extracted from protein–ligand complexes and their representation in screening libraries and combinatorial spaces was analyzed. In total, 1,223 metal-chelating groups were identified, about a quarter of which were present in the examined libraries and spaces, underscoring their potential in drug discovery and offering insights for improvement. The read the full article, click here.