News archive for Brenk lab
Reviewers of the month, Dec 2022
Ruth Brenk has given a brief update of the riboswitch research in our group at the Digital Breakfast organized by the the Center of Digital Life.
A large EU consortium got funding to integrated services for combatting current and future infectious disease outbreaks. BiSS is part of this consortium and offers fragment screening.
Escaping the Combinatorial Explosion: Expert-Enhanced Heuristic Navigation of Chemical Space (eHACS) (10.03.2022)
Project funding from the NFR to carry out a collaborative project on expert-enhanced de novo design of small molecules.
Read about druggabily predictions for RNA targets, the current state of fragment-based drug discovery for RNA, and an experimental toolbox to push drug discovery for antibiotics.
Vipul has presented an update of our JPIAMR EXPLOR project on a recent JPIAMR workshop (25:55 to 38:02)
An Experimental Toolbox for Structure-Based Hit Discovery for P. Aeruginosa FabF, a Promising Target for Antibiotics
Researchers at the Department of Biomedicine focus on large RNA structures in bacteria as a target for new antibiotics. Read the latest review article on riboswitches.
Congratulations to Illimar who got the price for the second best oral presentation at the 34. Molecular Modeling Workshop 2020 in Erlangen. Well done!
We have received funding from the Olav Tjomslands Legat for funding for equipment and tools for the the crystallization lab.
Another paper from the Brenk group published.
Ludvik has joined the lab as PhD student in November. Welcome and good luck with your project!
The Nor-Openscreen application for this year's infrastructure call scored the highest possible marks in all categories! To quote from the reviewer comments: "This is an excellent proposal to enlarge and update existing infrastructure and services in chemical biology in Norway". Despite the very favorable evaluation, the proposal was not funded. This means, there will unfortunately be no new... Read more
Our new paper on entangling selectivity determining features and on how to use this knowledge to design selective ligands has been published in J Med Chem!
Towards better computational approaches and responsible innovation strategies in early drug discovery (18.12.2018)
Together with Nathalie Reuter and Bengt-Erik Haug from the Chemistry Department and Alexander Lundervold from the Høgskulen på Vestlandet (HVL) we got funding for the project «Towards better computational approaches and responsible innovation strategies in early drug discovery: application to antibiotics and COPD» under the Centre for Digital Life umbrella. In this project, we are aiming toward... Read more
Our EXPLORE network application aiming at targeting the TPP riboswitch for hit discovery for new antibiotics will receive funding from JPI-AMR! Other partners in the network are Daniel Lafontaine (Université de Sherbrooke, Canada), Matthias Mack (Mannheim University of Applied Sciences, Germany), Petr Bartunek (CZ-OPENSCREEN, Czech Republic), Bengt Erik Haug (University of Bergen Norway) and... Read more
Researcher's Grand Prix-cadidate Illimar Hugo Rekand is working to keep us healthy. He is investigating new opportunities for making new medicines in a world where antibiotic resistance is an increasing challenge.
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