News archive for Brenk lab
The Brenk lab has co-authored a paper describing the EU-Openscreen fragment library.
The Brenk lab has published an article in which they have investigated the presence of metal-coordinating groups in screening libraries and chemical spaces. This can help with the discovery for new inhibitors for metallo enzymes.
As part of a consortium lead by the EU-Openscreen head office with the overall goal to improve the services offered by EU-Openscreen, the Brenk group has got funding to work on Ribotacs. Ribotacs are small molecules that selectively bind RNAs and a RNAse and thus lead targeted RNA degradation. We look forward to a succesfull collaboration.
In March, we had a Drug Discovery meeting to showcase the research that is going on Bergen and to connect the groups active in this area. Nearly 50 people had signed up of the meeting and we had 9 different talks covering topics from target discovery all the way to clinical trials.
Ruth Brenk has given a brief update of the riboswitch research in our group at the Digital Breakfast organized by the the Center of Digital Life.
A large EU consortium got funding to integrated services for combatting current and future infectious disease outbreaks. BiSS is part of this consortium and offers fragment screening.
Project funding from the NFR to carry out a collaborative project on expert-enhanced de novo design of small molecules.
Read about druggabily predictions for RNA targets, the current state of fragment-based drug discovery for RNA, and an experimental toolbox to push drug discovery for antibiotics.
Vipul has presented an update of our JPIAMR EXPLOR project on a recent JPIAMR workshop (25:55 to 38:02)
An Experimental Toolbox for Structure-Based Hit Discovery for P. Aeruginosa FabF, a Promising Target for Antibiotics
Researchers at the Department of Biomedicine focus on large RNA structures in bacteria as a target for new antibiotics. Read the latest review article on riboswitches.
Congratulations to Illimar who got the price for the second best oral presentation at the 34. Molecular Modeling Workshop 2020 in Erlangen.
Well done!
We have received funding from the Olav Tjomslands Legat for funding for equipment and tools for the the crystallization lab.
Another paper from the Brenk group published.
Ludvik has joined the lab as PhD student in November. Welcome and good luck with your project!
The Nor-Openscreen application for this year's infrastructure call scored the highest possible marks in all categories! To quote from the reviewer comments: "This is an excellent proposal to enlarge and update existing infrastructure and services in chemical biology in Norway". Despite the very favorable evaluation, the proposal was not funded. This means, there will unfortunately be no new... Read more
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