Brenk lab
All good things come in three

Three more articles from the Brenk group in press

Read about druggabily predictions for RNA targets, the current state of fragment-based drug discovery for RNA, and an experimental toolbox to push drug discovery for antibiotics.

Photo by <a href="https://freeimages.com/photographer/Cjcj-40067">Chris Johnson</a> from <a href="https://freeimages.com">FreeImages</a>
Photo by Chris Johnson from FreeImages

Main content

Three more articles from the Brenk group went into press over the summer.

Two articles belong to the ChemMedChem special issue Nordic medicinal chemistry:

  1. Together with our colleague Mads Clausen from the Technical University Denmark and his team, we have reviewed the current state of  fragment-based drug discovery for RNA targets. (Lundquist, K. P.; Panchal, V.; Gotfredsen, C. H.; Brenk, R.; Clausen, M. H. Fragment-Based Drug Discovery for RNA Targets. ChemMedChem 2021. [Pubmed]|[DOI].)
  2. A team composed of colleagues of CSIR-IICT, the Department of Chemistry, and our group has published an experimental toolbox to push drug discovery for new antibiotics. (Espeland, L. O.; Georgiou, C.; Klein, R.; Bhukya, H.; Haug, B. E.; Underhaug, J.; Mainkar, P. S.; Brenk, R. An Experimental Toolbox for Structure-Based Hit Discovery for P. Aeruginosa FabF, a Promising Target for Antibiotics. ChemMedChem 2021. [Pubmed]|[DOI].)

Last, but not least, our article about druggability predictions for RNA targets has been accepted at JCIM. (Rekand, I. H.; Brenk, R. DrugPred_RNA-A Tool for Structure-Based Druggability Predictions for RNA Binding Sites. J Chem Inf Model 2021.[Pubmed]|[DOI].)


Enjoy the read and well done to everybody involved!