Structural biology and drug discovery

News archive for Structural biology and drug discovery

The Brenk lab has published an article in which they have investigated the presence of metal-coordinating groups in screening libraries and chemical spaces. This can help with the discovery for new inhibitors for metallo enzymes.
As part of a consortium lead by the EU-Openscreen head office with the overall goal to improve the services offered by EU-Openscreen, the Brenk group has got funding to work on Ribotacs. Ribotacs are small molecules that selectively bind RNAs and a RNAse and thus lead targeted RNA degradation. We look forward to a succesfull collaboration.
Myelin is a crucial structure for the normal functioning of the vertebrate nervous system. Here, we have used multiple state-of-the-art technologies at large international research infrastructures, enabling methods not available in Norway, to obtain 3D structural information on some of the most hydrophobic protein molecules in the human body, which are responsible for the correct structure and... Read more