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The Research Group of Immunology and Rheumatology

Post Translational Modification Group

The group believes in interdisciplinary cooperation with medical and dental clinicians, epidemiologists, bio-scientists, industrial scientists to achieve our goals of elucidating the role of post-translational modifications in the aetiology of auto­ immune diseases.

Background

Taking into account that up to 30% of the adult population worldwide suffers from severe periodontitis, the impact of this disease on human health is immense. Periodontitis (PD) is largely caused by infection, in which Porphyromonas gingivalis is a major pathogen, and is the most prevalent infectious inflammatory disease of mankind.

Mounting evidence suggests a causative link between PD and rheumatoid arthritis (RA), as well as periodontitis and cardiovascular disease.

P. gingivalis is the only bacterium expressing the enzyme peptidylarginine deiminase (PAD) which converts arginine to citrulline, a process referred to as citrullination. Antibodies torwards such citrullinated proteins, i.e ACPAs/aCCP, are of central importance in RA a chronic autoimmune disease which affect 0.5-1% worldwide. The presence of ACPAs or aCCP autoantibodies is not only highly specific for RA but the presence is also related to a more severe and destructive disease progression.

We hypothesise that anti-citrullinated protein antibodies can be generated, in genetically susceptible individuals, as a consequence of P.gingivalis-induced citrullination in the gingiva.

We believe that through interdisciplinary cooperation with medical and dental clinicians, epidemiologists, bio-scientists, industrial scientists, media and commercialization specialists, we will have the best opportunity to achieve our goals.

 

PTM in the media

Dårlige tenner øker faren for leddgikt (BT)- Article

God tannhelse kan gi mindre revmatisme Revmatikeren; utgitt av Norsk Revmatikerforbund, 2:2012- Article

Tannhelse og leddgikt - Schrödingers katt (NRK TV)

Dårlig tannpuss kan gi leddgikt (BA) - Article

Tannpuss slurv kan gje laddgikt (page 7) -Hubro 1/2012, Tema: Økonomi: Fortid og fremtid

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