Experimental Pathology Research Group


Main content


Feasibility of a Portable Electronic Nose for Detection of Oral Squamous Cell Carcinoma in Sudan. Nazar Mohamed, Rens van de Goor, Mariam El-Sheikh, Osman Elrayah, Tarig Osman, Elisabeth Sivy Nginamau, Anne Christine Johannessen Ahmed Suleiman, Daniela Elena Costea, Kenneth W. Kross Healthcare 2021, 9(5), 534; doi: 10.3390/healthcare9050534

Combined In Situ Hybridization and Immunohistochemistry on Archival Tissues Reveals Stromal microRNA-204 as Prognostic Biomarker for Oral Squamous Cell Carcinoma. Rajthala S, Dongre H, Parajuli H, Min A, Nginamau ES, Kvalheim A, Lybak S, Sapkota D, Johannessen AC, Costea DE.Cancers (Basel). 2021 Mar 15;13(6):1307. doi: 10.3390/cancers13061307.PMID: 33804049 


Establishment of a novel cancer cell line derived from vulvar carcinoma associated with lichen sclerosus exhibiting a fibroblast-dependent tumorigenic potential. Dongre H, Rana N, Fromreide S, Rajthala S, Bøe Engelsen I, Paradis J, Gutkind JS, Vintermyr OK, Johannessen AC, Bjørge L, Costea DE.Exp Cell Res. 2020 Jan 1;386(1):111684. doi: 10.1016/j.yexcr.2019.111684. Epub 2019 Oct 23.PMID: 31654625 

Metabolic reprogramming of normal oral fibroblasts correlated with increased glycolytic metabolism of oral squamous cell carcinoma and precedes their activation into carcinoma associated fibroblasts. Zhang Z, Gao Z, Rajthala S, Sapkota D, Dongre H, Parajuli H, Suliman S, Das R, Li L, Bindoff LA, Costea DE, Liang X. Cell Mol Life Sci. 2020 Mar;77(6):1115-1133. doi: 10.1007/s00018-019-03209-y. Epub 2019 Jul 3. PMID: 31270582

Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells. Haugse R, Langer A, Murvold ET, Costea DE, Gjertsen BT, Gilja OH, Kotopoulis S, Ruiz de Garibay G, McCormack E. Pharmaceutics. 2020 Nov 6;12(11):1058. doi: 10.3390/pharmaceutics12111058. PMID: 33171947 Free PMC article.

Cancer cell line-specific protein profiles in extracellular vesicles identified by proteomics. Guerreiro EM, Øvstebø R, Thiede B, Costea DE, Søland TM, Kanli Galtung H. PLoS One. 2020 Sep 4;15(9):e0238591. doi: 10.1371/journal.pone.0238591. eCollection 2020. PMID: 32886718 Free PMC article.

A combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue cancer
Bjerkli IH, Hadler-Olsen E, Nginamau ES, Laurvik H, Søland TM, Costea DE, Uhlin-Hansen L, Steigen SE. Virchows Arch. 2020 Dec;477(6):865-872. doi: 10.1007/s00428-020-02875-9. Epub 2020 Jun 30. PMID: 32607687 Free PMC article.

Trends and clinicopathological characteristics of oral squamous cell carcinomas reported at a tertiary cancer hospital in Nepal during 1999 to 2009. Gajurel R, Gautam DK, Pun CB, Dhakal HP, Petrovski BÉ, Costea DE, Sapkota D. Clin Exp Dent Res. 2020 Jun;6(3):356-362. doi: 10.1002/cre2.278. Epub 2020 Jan 12. PMID: 32488959 Free PMC article.

Helicobacter pylori was not detected in oral squamous cell carcinomas from cohorts of Norwegian and Nepalese patients. Pandey S, Follin-Arbelet B, Pun CB, Gautam DK, Johannessen AC, Petersen FC, Costea DE, Sapkota D. Sci Rep. 2020 May 26;10(1):8737. doi: 10.1038/s41598-020-65694-7. PMID: 32457404 Free PMC article.

Loss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma. Pandey S, Osman TA, Sharma S, Vallenari EM, Shahdadfar A, Pun CB, Gautam DK, Uhlin-Hansen L, Rikardsen O, Johannessen AC, Costea DE, Sapkota D. Head Neck. 2020 Aug;42(8):2088-2098. doi: 10.1002/hed.26140. Epub 2020 Mar 23. PMID: 32202693

Grading of oral squamous cell carcinomas - Intra and interrater agreeability: Simpler is better? Steigen SE, Søland TM, Nginamau ES, Laurvik H, Costea DE, Johannessen AC, Jebsen P, Bjerkli IH, Uhlin-Hansen L, Hadler-Olsen E. J Oral Pathol Med. 2020 Aug;49(7):630-635. doi: 10.1111/jop.12990. Epub 2020 Jan 19. PMID: 31899572


Fibroblasts rescue oral squamous cancer cell from metformin-induced apoptosis via alleviating metabolic disbalance and inhibiting AMPK pathway. Zhang Z, Liang X, Fan Y, Gao Z, Bindoff LA, Costea DE, Li L. Cell Cycle. 2019 May;18(9):949-962. doi: 10.1080/15384101.2019.1598727. Epub 2019 Apr 23. PMID: 31014173 

Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells. Suliman S, Ali HRW, Karlsen TA, Amiaud J, Mohamed-Ahmed S, Layrolle P, Costea DE, Brinchmann JE, Mustafa K.Sci Rep. 2019 Nov 5;9(1):16031. doi: 10.1038/s41598-019-52442-9.PMID: 31690774 

α11β1 Integrin is Induced in a Subset of Cancer-Associated Fibroblasts in Desmoplastic Tumor Stroma and Mediates In Vitro Cell Migration. Zeltz C, Alam J, Liu H, Erusappan PM, Hoschuetzky H, Molven A, Parajuli H, Cukierman E, Costea DE, Lu N, Gullberg D.
Cancers (Basel). 2019 Jun 1;11(6):765. doi: 10.3390/cancers11060765. PMID: 31159419 Free PMC article.

Expression profile and functional role of S100A14 in human cancer. Basnet S, Sharma S, Costea DE, Sapkota D. Oncotarget. 2019 Apr 26;10(31):2996-3012. doi: 10.18632/oncotarget.26861. eCollection 2019 Apr 26. PMID: 31105881

Knowledge about nanotechnology and intention to use nanomaterials: A comparative study among dental students in Norway and Romania. Xenaki V, Marthinussen MC, Costea DE, Didilescu AC, Susin C, Cimpan MR, Åstrøm AN. Eur J Dent Educ. 2020 Feb;24(1):79-87. doi: 10.1111/eje.12470. Epub 2019 Oct 16. PMID: 31574582

Use of nanomaterials in dentistry: covariates of risk and benefit perceptions among dentists and dental hygienists in Norway.
Xenaki V, Costea DE, Marthinussen MC, Cimpan MR, Åstrøm AN. Acta Odontol Scand. 2020 Mar;78(2):152-160. doi: 10.1080/00016357.2019.1668055. Epub 2019 Sep 27. PMID: 31561718


Isolation and characterization of cells derived from human epithelial rests of Malassez. Kitajima K, Das R, Liang X, Neppelberg E, Johannessen AC, Costea DE, Igarashi M. Odontology. 2018 Nov 26. doi: 10.1007/s10266-018-0397-7. [Epub ahead of print] PubMed PMID: 30478679.

Effect of glycerol on reconstructed human oral mucosa. Kvalheim SF, Xenaki V, Kvalheim A, Lie SA, Marthinussen MC, Strand GV, Costea DE. Eur J Oral Sci. 2018 Nov 19. doi: 10.1111/eos.12590. [Epub ahead of print] PubMed PMID: 30452098.

Efficient extracellular vesicle isolation by combining cell media modifications, ultrafiltration, and size-exclusion chromatography. Guerreiro EM, Vestad B, Steffensen LA, Aass HCD, Saeed M, Øvstebø R, Coste DE, Galtung HK, Søland TM. PLoS One. 2018 Sep 27;13(9):e0204276. doi: 10.1371/journal.pone.0204276. eCollection 2018. PubMed PMID: 30260987; PubMed Central PMCID: PMC6160036.

Oral Tongue Malignancies in Autoimmune Polyendocrine Syndrome Type 1. Bruserud Ø, Costea DE, Laakso S, Garty BZ, Mathisen E, Mäkitie A, Mäkitie O, Husebye ES. Front Endocrinol (Lausanne). 2018 Aug 17;9:463. doi: 10.3389/fendo.2018.00463. eCollection 2018. PubMed PMID: 30177913; PubMed Central PMCID: PMC6109689.

Alterations in desmosomal adhesion at protein and ultrastructure levels during the sequential progressive grades of human oral tumorigenesis. Sawant S, Dongre H, Ahire C, Sharma S, Jamghare S, Kansara Y, Rane P, Kanojia D, Patil A, Chaukar D, Gupta S, D'Cruz A, Vaidya M, Dongre P. Eur J Oral Sci. 2018 Aug;126(4):251-262. doi: 10.1111/eos.12426. Epub 2018 Jun 15. PubMed PMID:29905981.

Prognostic significance of elevated serum CD44 levels in patients with oral squamous cell carcinoma. Sawant S, Ahire C, Dongre H, Joshi S, Jamghare S, Rane P, Kane S, Chaukar D. J Oral Pathol Med. 2018 Aug;47(7):665-673. doi: 10.1111/jop.12731. Epub 2018 Jun 8. PubMed PMID: 29752852.

Hyperbaric oxygen treatment did not significantly affect radiation injury in the mandibular area of rats. Sønstevold T, Johannessen AC, Reed RK, Salvesen GS, Stuhr L. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Feb;125(2):112-119. doi: 10.1016/j.oooo.2017.10.014. Epub 2017 Nov 2. PubMed PMID: 29248424.

Aberrant expression of vimentin predisposes oral premalignant lesion derived cells towards transformation. Dmello C, Sawant S, Chaudhari PR, Dongre H, Ahire C, D'Souza ZC, Charles SE, Rane P, Costea DE, Chaukar D, Kane S, Vaidya M. Exp Mol Pathol. 2018 Dec;105(3):243-251. doi: 10.1016/j.yexmp.2018.08.010. Epub 2018 Sep 4. PubMed PMID: 30189187


Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor – β1 (TGF-β1) and potential effects on migration and invasion. Magnussen SN, Hadler-Olsen E, Costea DE, Berg E, Jacobsen CC, Mortensen B, Salo T, Martinez-Zubiaurre I, Winberg JO, Uhlin-Hansen L, Svineng G., BMC Cancer. 2017 May 19;17(1):350. doi: 10.1186/s12885-017-3349-7.

Integrin α11 is overexpressed by tumour stroma of head and neck squamous cell carcinoma and correlates positively with alpha smooth muscle actin expression. Parajuli H, Teh MT, Abrahamsen S, Christoffersen I, Neppelberg E, Lybak S, Osman T, Johannessen AC, Gullberg D, Skarstein K, Costea DE., J Oral Pathol Med. 2017 Apr;46(4):267-275. doi: 10.1111/jop.12493.

Nano-TiO2 penetration of oral mucosa: in vitro analysis using 3D organotypic human buccal mucosa models. Konstantinova V, Ibrahim M, Lie SA, Birkeland ES, Neppelberg E, Marthinussen MC, Costea DE, Cimpan MR, J Oral Pathol Med. 2017 Mar;46(3):214-222. doi: 10.1111/jop.12469.


Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes. Suliman S, Mustafa K, Krueger A, Steinmüller-Nethl D, Finne-Wistrand A, Osdal T, Hamza AO, Sun Y, Parajuli H, Waag T, Nickel J, Johannessen AC, McCormack E, Costea DE. Biomaterials. 2016 Jul;95:11-21. doi: 10.1016/j.biomaterials.2016.04.002.

Establishment of a bioluminescence model for microenvironmentally induced oral carcinogenesis with implications for screening bioengineered scaffolds. Suliman S, Parajuli H, Sun Y, Johannessen AC, Finne-Wistrand A, McCormack E, Mustafa K, Costea DE. Head Neck. 2016 Apr;38 Suppl 1:E1177-87. doi: 10.1002/hed.24187.

Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma. Lupu M, Caruntu C, Ghita MA, Voiculescu V, Voiculescu S, Rosca AE, Caruntu A, Moraru L, Popa IM, Calenic B, Greabu M, Costea DE. Dis Markers. 2016;2016:9831237. doi: 10.1155/2016/9831237. Review.

Establishment of 3D Co-Culture Models from Different Stages of Human Tongue Tumorigenesis: Utility in Understanding Neoplastic Progression. Sawant S, Dongre H, Singh AK, Joshi S, Costea DE, Mahadik S, Ahire C, Makani V, Dange P, Sharma S, Chaukar D, Vaidya M. PLoS One. 2016 Aug 8;11(8):e0160615. doi: 10.1371/journal.pone.0160615.

Phenotypic Plasticity Determines Cancer Stem Cell Therapeutic Resistance in Oral Squamous Cell Carcinoma.  Biddle A, Gammon L, Liang X, Costea DE, Mackenzie IC., EBioMedicine. 2016 Jan 9;4:138-45. doi: 10.1016/j.ebiom.2016.01.007. eCollection 2016 Feb.

In Vivo Host Response and Degradation of Copolymer Scaffolds Functionalized with Nanodiamonds and Bone Morphogenetic Protein 2. Suliman S, Sun Y, Pedersen TO, Xue Y, Nickel J, Waag T, Finne-Wistrand A, Steinmüller-Nethl D, Krueger A, Costea DE, Mustafa K. , Adv Healthc Mater. 2016 Mar;5(6):730-42. doi: 10.1002/adhm.201500723.

Vimentin-mediated regulation of cell motility through modulation of beta4 integrin protein levels in oral tumor derived cells. Dmello C, Sawant S, Alam H, Gangadaran P, Tiwari R, Dongre H, Rana N, Barve S, Costea DE, Chaukar D, Kane S, Pant H, Vaidya M.Int J Biochem Cell Biol. 2016 Jan;70:161-72. doi: 10.1016/j.biocel.2015.11.015.



Sapkota D, Bruland O, Parajuli H, Osman TA, Teh MT, Johannessen AC, Costea DE. S100A16 promotes differentiation and contributes to a less aggressive tumor phenotype in oral squamous cell carcinoma. BMC Cancer. 2015 Sep 9;15:631. doi: 10.1186/s12885-015-1622-1. PubMed PMID: 26353754; PubMed Central PMCID: PMC4564982.

Osman TA, Parajuli H, Sapkota D, Ahmed IA, Johannessen ACh, Costea DE. The low-affinity nerve growth factor receptor p75NTR identifies a transient stem cell-like state in oral squamous cell carcinoma cells. J Oral Pathol Med. 2015 Jul;44(6):410-9. doi: 10.1111/jop.12251. Epub 2014 Sep 12. PubMed PMID: 25212757.

Min A, Zhu C, Peng S, Rajthala S, Costea DE, Sapkota D. MicroRNAs as Important Players and Biomarkers in Oral Carcinogenesis. Biomed Res Int. 2015;2015:186904. doi: 10.1155/2015/186904. Epub 2015 Oct 4. Review. PubMed PMID: 26504785; PubMedCentral PMCID: PMC4609509.




Liang X, Graham KA, Johannessen AC, Costea DE, Labeed FH. Human oral cancer cells with increasing tumorigenic abilities exhibit higher effective membrane capacitance. Integr Biol (Camb). 2014 May;6(5):545-54. doi: 10.1039/c3ib40255j. PubMed PMID: 24663430.

Liang X, Osman TA, Sapkota D, Neppelberg E, Lybak S, Liavaag PG, Johannessen AC, Jacobsen HK, Enger PØ, Costea DE, Wang J. Rapid adherence to collagen IV enriches for tumour initiating cells in oral cancer. Eur J Cancer. 2014 Dec;50(18):3262-70. doi: 10.1016/j.ejca.2014.09.010. Epub 2014 Oct 10. PubMed PMID: 25310894.

Yang N, Yan T, Zhu H, Liang X, Leiss L, Sakariassen PØ, Skaftnesmo KO, Huang B, Costea DE, Enger PØ, Li X, Wang J. A co-culture model with brain tumor-specific bioluminescence demonstrates astrocyte-induced drug resistance in glioblastoma. J Transl Med. 2014 Oct 4;12:278. doi: 10.1186/s12967-014-0278-y. PubMed PMID: 25280402; PubMed Central PMCID: PMC4198700.



Costea DE, Hills A, Osman AH, Thurlow J, Kalna G, Huang X, Pena Murillo C, Parajuli H, Suliman S, Kulasekara KK, Johannessen AC, Partridge M. Identification of two distinct carcinoma-associated fibroblast subtypes with differential tumor-promoting abilities in oral squamous cell carcinoma. Cancer Res. 2013 Jul 1;73(13):3888-901. doi: 10.1158/0008-5472.CAN-12-4150. Epub 2013 Apr 18. PubMed PMID: 23598279.

Kidwai F, Costea DE, Hutchison I, Mackenzie I. The effects of CD44 down-regulation on stem cell properties of head and neck cancer cell lines. J Oral Pathol Med. 2013 Oct;42(9):682-90. doi: 10.1111/jop.12076. Epub 2013 Apr 30. PubMed PMID: 23627635.

Salo S, Bitu C, Merkku K, Nyberg P, Bello IO, Vuoristo J, Sutinen M, Vähänikkilä H, Costea DE, Kauppila JH, Lehenkari P, Dayan D, Vered M, Risteli J, Salo T. Human bone marrow mesenchymal stem cells induce collagen production and tongue cancer invasion. PLoS One. 2013 Oct 21;8(10):e77692. doi: 10.1371/journal.pone.0077692. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/2bacf09d-7bb8-43ac-a098-b3b9e486d854. Kauppila, Joonas [corrected to Kauppila, Joonas H]. PubMed PMID: 24204919; PubMed Central PMCID: PMC3804615.

Hwang S, Mahadevan S, Qadir F, Hutchison IL, Costea DE, Neppelberg E, Liavaag PG, Waseem A, Teh MT. Identification of FOXM1-induced epigenetic markers for head and neck squamous cell carcinomas. Cancer. 2013 Dec 15;119(24):4249-58. doi: 10.1002/cncr.28354. Epub 2013 Oct 1. PubMed PMID: 24114764.

Sapkota D, Costea DE, Ibrahim SO, Johannessen AC, Bruland O. S100A14 interacts with S100A16 and regulates its expression in human cancer cells. PLoS One. 2013 Sep 27;8(9):e76058. doi: 10.1371/journal.pone.0076058. eCollection PubMed PMID: 24086685; PubMed Central PMCID: PMC3785438.

Osman TA, Øijordsbakken G, Costea DE, Johannessen AC. Successful triple immunoenzymatic method employing primary antibodies from same species and same immunoglobulin subclass. Eur J Histochem. 2013 Sep 16;57(3):e22. doi: 10.4081/ejh.2013.e22. PubMed PMID: 24085271; PubMed Central PMCID: PMC3794353.



Dabija-Wolter G, Bakken V, Cimpan MR, Johannessen AC, Costea DE. In vitro reconstruction of human junctional and sulcular epithelium. J Oral Pathol Med. 2013 May;42(5):396-404. doi: 10.1111/jop.12005. Epub 2012 Sep 5. PubMed PMID: 22947066; PubMed Central PMCID: PMC3664418.

Litlekalsoy J, Hostmark JG, Costea DE, Illemann M, Laerum OD. Time-dependent biological differences in molecular markers of high-grade urothelial cancer over 7 decades (ras proteins, pTEN, uPAR, PAI-1 and MMP-9). Virchows Arch. 2012 Nov;461(5):541-51. doi: 10.1007/s00428-012-1323-y. Epub 2012 Oct 6. PubMed PMID: 23052373.

Dayan D, Salo T, Salo S, Nyberg P, Nurmenniemi S, Costea DE, Vered M. Molecular crosstalk between cancer cells and tumor microenvironment components suggests potential targets for new therapeutic approaches in mobile tongue cancer. Cancer Med. 2012 Oct;1(2):128-40. doi: 10.1002/cam4.24. Epub 2012 Aug 16. PubMed PMID: 23342263; PubMed Central PMCID: PMC3544451.

Teh MT, Hutchison IL, Costea DE, Neppelberg E, Liavaag PG, Purdie K, Harwood C, Wan H, Odell EW, Hackshaw A, Waseem A. Exploiting FOXM1-orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis. Int J Cancer. 2013 May 1;132(9):2095-106. doi: 10.1002/ijc.27886. Epub 2012 Oct 25. PubMed PMID: 23034676.

Osman TA, Costea DE, Johannessen AC. The use of salivary cytokines as a screening tool for oral squamous cell carcinoma : A review of the literature. J Oral Maxillofac Pathol. 2012 May;16(2):256-61. doi: 10.4103/0973-029X.99083. PubMed PMID: 22923900; PubMed Central PMCID: PMC3424944.



Dabija-Wolter G, Sapkota D, Cimpan MR, Neppelberg E, Bakken V, Costea DE. Limited in-depth invasion of Fusobacterium nucleatum into in vitro reconstructed human gingiva. Arch Oral Biol. 2012 Apr;57(4):344-51. doi: 10.1016/j.archoralbio.2011.09.015. Epub 2011 Oct 24. PubMed PMID: 22024403.

Biddle A, Liang X, Gammon L, Fazil B, Harper LJ, Emich H, Costea DE, Mackenzie IC. Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative. Cancer Res. 2011 Aug 1;71(15):5317-26. doi: 10.1158/0008-5472.CAN-11-1059. Epub 2011 Jun PubMed PMID: 21685475.

Sapkota D, Bruland O, Costea DE, Haugen H, Vasstrand EN, Ibrahim SO. S100A14 regulates the invasive potential of oral squamous cell carcinoma derived cell-lines in vitro by modulating expression of matrix metalloproteinases, MMP1 and MMP9. Eur J Cancer. 2011 Mar;47(4):600-10. doi: 10.1016/j.ejca.2010.10.012. Epub 2010 Nov 10. PubMed PMID: 21074410.

Wiklund ED, Gao S, Hulf T, Sibbritt T, Nair S, Costea DE, Villadsen SB, Bakholdt V, Bramsen JB, Sørensen JA, Krogdahl A, Clark SJ, Kjems J. MicroRNA alterations and associated aberrant DNA methylation patterns across multiple sample types in oral squamous cell carcinoma. PLoS One. 2011;6(11):e27840. doi: 10.1371/journal.pone.0027840. Epub 2011 Nov 22. PubMed PMID: 22132151; PubMed Central PMCID: PMC3222641.

Sapkota D, Costea DE, Blø M, Bruland O, Lorens JB, Vasstrand EN, Ibrahim SO. S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest. Oral Oncol. 2012 Mar;48(3):219-25. doi: 10.1016/j.oraloncology.2011.10.001. Epub 2011 Oct 26. PubMed PMID: 22032898.

Mulhall HJ, Labeed FH, Kazmi B, Costea DE, Hughes MP, Lewis MP. Cancer, pre-cancer and normal oral cells distinguished by dielectrophoresis. Anal Bioanal Chem. 2011 Nov;401(8):2455-63. doi: 10.1007/s00216-011-5337-0. Epub 2011 Aug 30. PubMed PMID: 21877186.


2010 and beyond

Harper LJ, Costea DE, Gammon L, Fazil B, Biddle A, Mackenzie IC. Normal and malignant epithelial cells with stem-like properties have an extended G2 cell cycle phase that is associated with apoptotic resistance. BMC Cancer. 2010 Apr 28;10:166. doi: 10.1186/1471-2407-10-166. PubMed PMID: 20426848; PubMed Central PMCID: PMC2868812.

Berge G, Costea DE, Berg M, Rasmussen H, Grotterød I, Lothe RA, Mælandsmo GM, Flatmark K. Coexpression and nuclear colocalization of metastasis-promoting protein S100A4 and p53 without mutual regulation in colorectal carcinoma. Amino Acids. 2011 Oct;41(4):875-84. doi: 10.1007/s00726-010-0514-6. Epub 2010 Feb 27. PubMed PMID: 20191297.

Lukandu OM, Neppelberg E, Vintermyr OK, Johannessen AC, Costea DE. Khat alters the phenotype of in vitro-reconstructed human oral mucosa. J Dent Res. 2010 Mar;89(3):270-5. doi: 10.1177/0022034509354980. Epub 2009 Dec 31. PubMed PMID: 20044580.

Costea DE, Lukandu O, Bui L, Ibrahim MJ, Lygre R, Neppelberg E, Ibrahim SO, Vintermyr OK, Johannessen AC. Adverse effects of Sudanese toombak vs. Swedish snuff on human oral cells. J Oral Pathol Med. 2010 Feb;39(2):128-40. doi: 10.1111/j.1600-0714.2009.00825.x. Epub 2009 Oct 4. PubMed PMID: 19804503.

Kulasekara KK, Lukandu OM, Neppelberg E, Vintermyr OK, Johannessen AC, Costea Cancer progression is associated with increased expression of basement membrane proteins in three-dimensional in vitro models of human oral cancer. Arch Oral Biol. 2009 Oct;54(10):924-31. doi: 10.1016/j.archoralbio.2009.07.004. Epub 2009 Aug 11. PubMed PMID: 19674736.

Lukandu OM, Bredholt T, Neppelberg E, Gjertsen BT, Johannessen AC, Vintermyr OK, Costea DE. Early loss of mitochondrial inner transmembrane potential in khat-induced cell death of primary normal human oral cells. Toxicology. 2009 Sep 19;263(2-3):108-16. doi: 10.1016/j.tox.2009.06.024. Epub 2009 Jul 8. PubMed PMID: 19591894.

Dabija-Wolter G, Cimpan MR, Costea DE, Johannessen AC, Sørnes S, Neppelberg E, Al-Haroni M, Skaug N, Bakken V. Fusobacterium nucleatum enters normal human oral fibroblasts in vitro. J Periodontol. 2009 Jul;80(7):1174-83. doi: 10.1902/jop.2009.090051. PubMed PMID: 19563299.

Costea DE, Gammon L, Kitajima K, Harper L, Mackenzie IC. Epithelial stem cells and malignancy. J Anat. 2008 Jul;213(1):45-51. doi: 10.1111/j.1469-7580.2008.00895.x. Review. PubMed PMID: 18638069; PubMed Central PMCID: PMC2475555.

Gaballah K, Costea DE, Hills A, Gollin SM, Harrison P, Partridge M. Tissue engineering of oral dysplasia. J Pathol. 2008 Jul;215(3):280-9. doi: 10.1002/path.2360. PubMed PMID: 18484684.

Lukandu OM, Costea DE, Neppelberg E, Johannessen AC, Vintermyr OK. Khat (Catha edulis) induces reactive oxygen species and apoptosis in normal human oral keratinocytes and fibroblasts. Toxicol Sci. 2008 Jun;103(2):311-24. doi: 10.1093/toxsci/kfn044. Epub 2008 Feb 29. PubMed PMID: 18310640.

Lukandu OM, Costea DE, Dimba EA, Neppelberg E, Bredholt T, Gjertsen BT, Vintermyr OK, Johannessen AC. Khat induces G1-phase arrest and increased expression of stress-sensitive p53 and p16 proteins in normal human oral keratinocytes and fibroblasts. Eur J Oral Sci. 2008 Feb;116(1):23-30. doi: 10.1111/j.1600-0722.2007.00508.x. PubMed PMID: 18186728.

Partridge M, Costea DE, Huang X. The changing face of p53 in head and neck cancer. Int J Oral Maxillofac Surg. 2007 Dec;36(12):1123-38. Epub 2007 Sep 17. Review. PubMed PMID: 17875383.

Neppelberg E, Costea DE, Vintermyr OK, Johannessen AC. Dual effects of sodium lauryl sulphate on human oral epithelial structure. Exp Dermatol. 2007 Jul;16(7):574-9. PubMed PMID: 17576237.

Costea DE, Tsinkalovsky O, Vintermyr OK, Johannessen AC, Mackenzie IC. Cancer stem cells – new and potentially important targets for the therapy of oral squamous cell carcinoma. Oral Dis. 2006 Sep;12(5):443-54. Review. Erratum in: Oral Dis. 2006 Nov-Dec;12(6):584. PubMed PMID: 16910914.

Costea DE, Kulasekara K, Neppelberg E, Johannessen AC, Vintermyr OK. Species-specific fibroblasts required for triggering invasiveness of partially transformed oral keratinocytes. Am J Pathol. 2006 Jun;168(6):1889-97. PubMed PMID: 16723704; PubMed Central PMCID: PMC1606610.

Costea DE, Johannessen AC, Vintermyr OK. Fibroblast control on epithelial differentiation is gradually lost during in vitro tumor progression. Differentiation. 2005 Apr;73(4):134-41. PubMed PMID: 15901281.

Costea DE, Dimba AO, Loro LL, Vintermyr OK, Johannessen AC. The phenotype of in vitro reconstituted normal human oral epithelium is essentially determined by culture medium. J Oral Pathol Med. 2005 Apr;34(4):247-52. PubMed PMID: 15752261.

Dimba EA, Gjertsen BT, Bredholt T, Fossan KO, Costea DE, Francis GW, Johannessen AC, Vintermyr OK. Khat (Catha edulis)-induced apoptosis is inhibited by antagonists of caspase-1 and -8 in human leukaemia cells. Br J Cancer. 2004 Nov 1;91(9):1726-34. PubMed PMID: 15477863; PubMed Central PMCID: PMC2409956.

Costea DE, Loro LL, Dimba EA, Vintermyr OK, Johannessen AC. Crucial effects of fibroblasts and keratinocyte growth factor on morphogenesis of reconstituted human oral epithelium. J Invest Dermatol. 2003 Dec;121(6):1479-86. PubMed PMID: 14675199.