Kusche-Gullberg Lab

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Marion's Fig

Heparan sulfate (HS) proteoglycans (PGs) are composed of HS polysaccharide chains attached to a core protein. The HS chains interact with growth factors and present them to their high affinity signaling receptors. The interactions influence cell survival, proliferation, migration, and differentiation. HS chains also store proteins and protect bound proteins from proteolytic degradation. Functionally important processes during development and homeostasis depend on the fine structure of HS chains, that provide binding sites for proteins. In addition, there are clearly strong relationships between HS and cancer. HS contributes to conditions for tumor growth and progression in the tumor microenvironment.

We study the molecular mechanisms controlling the formation of cell specific HS structures by which HS influences cell-matrix and HS-growth factor interaction interactions. We use cellular models and, biochemical, molecular and immunohistochemical methods.



Digital BMED904/DIKU course 2021

Successful digital completion of BMED904

BMED904, the Graduate Course in Extracellular Matrix, was this year run jointly with the DIKU Summer School in Fibrosis, June 7-11, 2021. This was the first time the course was held through a digital platform, a bit of a challenge as parts of the course are lab based

Photo of Marion Kusche-Gullberg

Principal Investigator

Visit the personal page of professor Marion Kusche-Gullberg (personal page).