Nuclear lipids: biomolecular interactions and function

Main content

  • F Mazloumi Gavgani, M Skuseth Slinning, A Papdiné Morovicz, V Smith Arnesen, D C Turcu, S Ninzima, CS D’Santos and AE Lewis (2021). Nuclear phosphatidylinositol 3,4,5-trisphosphate interactome uncovers an enrichment in nucleolar proteins. Molecular & Cellular Proteomics. Accepted 20th May 2021. Also in bioRxiv, doi: 10.1101/2020.05.17.100446.
  • F Mazloumi Gavgani, T Karlsson, IL Tangen, A Papdiné Morovicz, V Smith Arnesen, D C Turcu, S Ninzima, K Spang, C Krakstad, J Guillermet-Guibert and AE Lewis (2021). Nuclear upregulation of class I phosphoinositide 3-kinase p110β correlates with increased 47S rRNA levels in cancer cells. Journal Cell Biology. 134(3):jcs246090. doi: 10.1242/jcs.246090. also in bioRxiv. DOI:10.1101/2019.12.20.884122.
  • RG Jacobsen, F Mazloumi Gavgani, AJ. Edson, M Goris, A Altanchimeg and AE Lewis (2019) Polyphosphoinositides in the nucleus: Roadmap of their effectors and mechanisms of interaction. Advances in Biological Regulation. 72: 7-21.

  • F Mazloumi Gavgani, V Smith Arnesen, RG Jacobsen, C Krakstad, EA Hoivik, AE Lewis (2018). Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer. Int J Mol Sci. 19(12). pii: E3931. doi: 10.3390/ijms19123931.
  • T Karlsson, C Krakstad, IL Tangen, EA Hoivik, PM Pollock, HB Salvesen & AE Lewis (2017). Endometrial cancer cells exhibit high expression of p110b and variable response to both p110a and p110b inhibition on PI3K signalling, cell survival and proliferation. Oncotarget. 8:3881-94.
  • Mjos S, Werner HMJ, Birkeland E, Holst F, Berg A, Halle MK, Tangen IL, Kusonmano K, Mauland KK, Oyan AM, Kalland KH, Lewis AE, Mills GB, Krakstad C, Trovik J, Salvesen HB, Hoivik EA (2017). PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer. Sci. Reports. 7(1):10240. doi: 10.1038/s41598-017-10717-z.
  • Jacobsen RM, Gavgani FM, Mellgren G and AE Lewis (2016). DNA Topoisomerase IIa contributes to the early steps of adipogenesis in 3T3-L1 cells. Cellular Signalling. 28:1593-1603.
  • T Karlsson, A Altanchimeg, O Dobrovolska, DC Turcu and AE Lewis (2016). A polybasic motif in ErbB3-Binding-Protein 1 (EBP1) has key functions in nucleolar localisation and polyphosphoinositide interaction. Biochemical Journal. 473: 2033-47. DOI: 10.1042/BCJ20160274.
  • AE Lewis, R Aesoy and M Bakke. (2016). Role of EPAC in cAMP-mediated actions in adrenocortical cells. Frontiers in Endocrinology, Neuroendocrine Science. Invited Mini-Review. doi 10.3389/fendo.2016.00063.
  • CS D’Santos and AE. Lewis (2012). Functional Proteomics: Mapping Lipid-Protein Interactomes. Book Chapter. Integrative Proteomics, Hon-Chiu Eastwood Leung (Ed.), ISBN: 978-953-51-0070-6, InTech, Available from: http://www.intechopen.com/articles/show/title/functional-proteomics-mapp...
  • AE Lewis, L Sommer, MØ Arntzen, Y Strahm, NA Morrice, N Divecha and CS D’Santos (2011). Identification of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins by neomycin extraction. Molecular & Cellular Proteomics. 10(2):M110.003376. doi:10.1074/mcp.M110.003376. IF: 8.8
  • VV Ardawatia, M Masià-Balagué, BF Krakstad, BB Johansson, KM Kreitzburg, E Spriet, AE Lewis, TE Meigs, AM Aragay (2011). Gα(12) binds to the N-terminal regulatory domain of p120(ctn), and downregulates p120(ctn) tyrosine phosphorylation induced by Src family kinases via a RhoA independent mechanism. Experimental Cell Research. 317:293-306. IF: 3.6
  • L Aumo, M Rusten, G Mellgren, M Bakke and AE Lewis (2010). Functional roles of PKA and EPAC2 in cAMP-mediated actions in adrenocortical cells. Endocrinology. 151:2151-61. IF: 4.7.
  • EA Hoivik, AE Lewis, L Aumo and M Bakke (2009). Molecular aspects of steroidogenic factor 1 (SF-1). Review. Molecular Cellular Endocrinology.315:27-39. IF: 3.5.
  • MØ Arntzen, CL Osland, CR Raa, R Kopperud, SO Døskeland, AE Lewis and CS D’Santos (2009). POSTMan (POST-translational Modification analysis), a software application for PTM discovery. Proteomics. 9:1400-6. IF: 4.4.
  • EA Hoivik, L Aumo, R Aesoy, H Lillefosse, AE Lewis, RM Perrett, NR Stallings, NA Hanley, M Bakke (2008). Deoxyribonucleic Acid methylation controls cell type-specific expression of steroidogenic factor 1. Endocrinology. 149:5599-609. IF: 4.7.
  • AE Lewis, M Rusten, EA Hoivik, EL Vikse, ML Hansson, AE Wallberg, and M Bakke (2008). Phosphorylation of Steroidogenic Factor 1 Is Mediated by Cyclin-Dependent Kinase 7. Molecular Endocrinology. 22: 91–104. IF: 5.3.
  • AJ Fikaris, AE Lewis, A Abulaiti, O Tsygankova and JL Meinkoth (2006). Ras triggers ATR activation and apoptosis through sustained mitogenic signaling. J. Biol. Chem. 281:34759-67. IF: 5.3.
  • AE Lewis, AJ Fikaris, G Prendergast and JL Meinkoth. (2004). TSH and serum regulate thyroid cell proliferation through differential effects on p27 expression and localization. Molecular Endocrinology. 18: 2321-2332. IF: 5.39.
  • AE Lewis, BCY Wong, MJS Langman and MC Eggo. (2004). Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205. Cellular Signalling. 17: 253-262. IF: 4.3.
  • G Cheng, AE Lewis and JL Meinkoth. (2003). Ras stimulates aberrant cell cycle progression and apoptosis in rat thyroid cells. Molecular Endocrinology. 17: 450-459. IF: 5.39.
  • AE Lewis, BCY Wong, MJS Langman and MC Eggo. (2003). Protein kinase C inhibition induces DNA fragmentation in Colo 205 cells, which is blocked by cysteine protease inhibition but not mediated through caspase-3. Experimental Cell Research. 289: 1-10. IF: 3.95.
  • Y Qiu, CE Waters, AE Lewis, MJ Langman and MC Eggo. (2002). Oestrogen-induced apoptosis in colonocytes expressing oestrogen receptor b. Journal of Endocrinology. 174: 369-377. IF: 2.79.
  • S Dearn, M Rahman, AE Lewis, Z Ahmed, MC Eggo and AS Ahmed. (2000). Activation of platelet-activating factor (PAF) receptor stimulates nitric oxide (NO) release via protein kinase C-a in HEC-1B human endometrial epithelial cell line. Molecular Medicine. 6: 37-49. IF: 3.41.