Nuclear lipids: biomolecular interactions and function

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AE Lewis research summary

AE Lewis group

Lipid Function in the Nucleus in Health and Diseases

Lipids are essential for life. They are structural components of all cellular membranes but also function as energy stores, cellular signalling molecules, hormones and regulators of transcription factors. Recent lipidomics analyses in mammalian cells have highlighted the dynamic remodelling of different lipid species in health and diseases.

Our group studies the roles of the signaling lipids, phosphoinositides, in the nucleus using quantitative interactomics, as well as biochemical, molecular and cell biology approaches in the context of cancer biology. 

Lipids in the nucleus: what are they doing there?

The signaling lipids phosphoinositides (PI) are found within the confine of the nucleus but their roles remain unclear. To fill this gap, our lab has mapped protein-PI interactomes formed in this organelle (PMID: 2104819534048982) and aim to identify altered networks in pathologic states for which the PI metabolic pathways are known to be altered, particularly in cancer.

Our group is therefore interested in addressing the following questions:

1. What are the functions of these interactions?

3. Which protein-PI interactions are functionally disrupted in cancer and contribute its development?


To learn more about nuclear PI and PI interactomes, check our reviews on "Polyphosphoinositides in the Nucleus: Roadmap of Their Effectors and Mechanisms of Interaction" and Phosphoinositide 3-kinase signalling in the nucleolus.


Group Members

Aurélia E LEWIS - Group leader, research profile in ResearchGate, and UiB.

55 58 45 21

Diana C. Turcu - lab manager

Bachelor students


Location: Lab 2

Høyteknologisenteret i Bergen, Bioblokken, 5th floor,

Thormølensgate 55, 5008 Bergen, Location

Nucleolar PI3K signaling
Nucleolar PI3K signaling

Review PI3K signaling in the nucleolus

Our review on PI3K signaling taking place in the nucleolus
MCP graphical abstract

Our new article in Molecular & Cellular Proteomics

Nuclear phosphatidylinositol 3,4,5-trisphosphate interactome uncovers an enrichment in nucleolar proteins including PARP1.

Immunostaining PI3K p110b (green) and PIP3 (red)

Our new article in J. Cell Science

Nuclear upregulation of class I PI3K p110β correlates with increased rDNA transcription in cancer cells