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Translational Protein Research

News archive for Translational Protein Research

NAA10 - A Jack-of-all-trades protein in human cells
A Jack of all Trades in Cancer Cells (14.03.2019)
Cancer is a complex disease caused by a multitude of factors gone wrong in the cell. NAA10 may be one such factor. This is a protein that performs many different tasks, including the most common which is catalyzing the acetylation of cellular proteins. NAA10 can therefore be viewed as a ”Jack of all trades”-protein. For two decades it has been linked to cancer progression, but recent data puts... Read more
Schematic figure showing a Naa60 protein attached to the golgi membrane by an alpha-helix, while acetylating the N-terminus of another transmembrane protein sitting in the golgi membrane
Hangin’ out at the Golgi (02.03.2017)
Many proteins have the Golgi apparatus as their favorite hangout place. For N-terminal acetyltransferases (NATs), however, this is a rather unique characteristic as only one NAT, Naa60, was shown to localize to intracellular organelles.
Naa10 homology model highlighting Tyr43 which was found mutated in two patients with intellectual disabilities
MBI-researchers contribute in the identification and characterization of a new NAA10 mutation causing a novel intellectual disability syndrome (02.12.2015)
New hope for creating drought-resistant plants
New hope for creating drought-resistant plants (27.07.2015)
Drought is an increasing problem all over the world and the main reason for crop failure, thus there is a need to develop plants that are highly resistant to drought. We have found targeting of the NatA enzyme to be a way to develop highly drought resistant plants since NatA controls the stress imposed on plants by drought.
Illustrasjon
Tension release by N-terminal acetylation (02.06.2015)
Hypertension or high blood pressure is a major health problem that can result in cardiovascular diseases including hypertensive crisis and stroke. A recent paper in Science by Hwang and Varshavsky shows that the molecular signaling underlying regulation of blood pressure involves N-terminal acetylation of specific proteins and their consecutive degradation by the N-end rule pathway.
Illustration of Nat's to the golgi apparatus
Cellular GPS-system reveals new territory for an influential enzyme family (03.03.2015)
UiB researchers have developed a “GPS system” to find protein-positions in cells. The method was used to reveal a special localization the newest member of an enzyme family with important tasks in the human body. This new enzyme knowledge may be useful in medicine and the cellular "GPS system" could become a useful tool in both basic biological and biotechnological research.
To forskere i et laboratorium
MBI-researchers uncover molecular mechanisms involved in Ogden syndrome (10.12.2014)
This week, Line Merethe Myklebust, Svein Isungset Støve and colleagues in the Arnesen and Reuter groups of the Protein modifications, Metabolism and Disease (ProtMetD) research programme at MBI, presented novel findings on the Ogden syndrome in Human Molecular Genetics.
Bisubstrate analogues specifically inhibit the different NAT-enzymes
First NAT-inhibitors developed & first NAT-complex structure solved (05.11.2014)
DynaMito 2013 poster award to MBI's Thomas Kalvik (13.12.2013)
MBI TiBS paper Editor's choice (03.04.2013)
Book on protein acetylation (19.02.2013)
New protein tricks from an old enzyme (02.01.2013)
Small chemical groups are commonly attached to proteins in order to control their function. In eukaryotic cells, N-terminal acetyltransferases (NATs) attach acetyl groups to the very first amino acid (the N-terminus) of a majority of proteins. Now, researchers at MBI (UiB) and VIB-Gent have discovered that NATs also carry out other types of protein modifications.

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