Exosome-derived miRNAs in the pre-metastatic niche formation in melanoma brain metastases
Exosomes released from the primary tumour into circulation have been documented to promote pre-metastatic niche formation. We have identified a miRNA in exosomes from melanoma brain metastases that can play a vital role in this process. Knock-down (KD) of this miRNA results in an inhibition of brain metastatic growth. We are in the process of identifying potential drugs inhibiting the expression level of this miRNA, and aim to bring one of these to the clinics.