Systems Biology and Translational Cell Signaling

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Collage av bilder relatert til Forskningsenheten Systembiologi og Translasjonell Cellesignalering

The Systems Biology and Translational Cell Signaling Unit (STC) investigates how proteins and metabolites steer cellular processes.

Biomolecules are studied in molecular, cellular and organismal perspectives using approaches within genetics, cell biology, structural biology, bioinformatics, proteomics and metabolomics.

We study healthy cells and disease states such as cancer and neurodegenerative disease with the aim of uncovering basic molecular principles as well as disease mechanisms and biomarkers.

New research
Impact of N-terminal acetylation in yeast

Removing protein N-terminal acetylation increases the turnover of ribosomal proteins

The impact of the most common protein modification, N-terminal acetylation, has remained a conundrum in the field since its very origin. A new UiB article adds a piece to this puzzle.

News | Research
spergillus fumigatus vokser på en petriskål.

New discoveries on deadly fungus – might be a key for treatment

Scientists at the University of Bergen (UiB) have discovered a new enzyme on the deadly fungus Aspergillus fumigatus that might unlock new treatment. The fungus kills around one million people per year worldwide, and is found “everywhere”.

New research
Feil ved NAA20 genet fører til at NatB komplekset av proteinene NAA20 og NAA25 ikke dannes optimalt. Derved blir NatB sin evne til å utføre acetylering av cellulære proteiner redusert og dette fører til sykdom.

Pathogenic variants of novel gene causative of developmental delay

Variants in different genes may cause developmental delay and various syndromes. Researchers from USA, Saudi Arabia and Norway recently uncovered pathogenic gene variants causing developmental delay and intellectual disabilities in a gene not previously linked to genetic disease.

International research collaboration
Crystal structure of an enzyme. Background animal and plant shapes

Why evolution invented a paradoxical enzyme that eats up vitamin B3

Mathematical modeling and systems biology explain the evolutionary transition from a four-step to a two-step pathway for the synthesis of NAD from vitamin B3.

News | Research
Marc Niere og Mathias Ziegler

Discovered a shuttle that brings the "batteries" into the cell's power houses

Researchers at the University of Bergen have made a major contribution to the discovery of a protein that plays a fundamental role in human energy metabolism.