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Centre for Cancer Biomarkers CCBIO
CCBIO Special Seminar

CCBIO Special Seminar – Bruce Baguley

Welcome to a CCBIO Special Seminar with invited speaker Bruce Baguley Wednesday September 18th at 14.30. Title: "Do human cancer cell lines really behave in the same way as clinical tumor material?" All are welcome, also to the following pizza get-together!

Content

When: Wednesday September 18th at 14:30

Place: Auditorium 4, BB-building

Speaker: Professor Bruce Baguley, University of Auckland, Auckland Cancer Society Research Centre, New Zealand

Title: Do human cancer cell lines really behave in the same way as clinical tumor material?

Abstract: Cancer cell lines have emerged as one of the main laboratory tools for the investigation of cancer behaviour and of response to therapy. We wanted to compare the behaviour of cell lines with that of short term cultures of clinical material taken during cancer surgery. We discuss the results of our study in terms of a model in which tumors contain two major populations, one in which proliferation is controlled mainly by a cell cycle restriction point, and one in which cell loss is controlled by an axis that links apoptotic tumor cells, the Axl receptor, and macrophages. The main conclusion is that the proportion of these two populations may fluctuate with time, with important implications for cancer therapy.

Chairperson: Jim Lorens

All are welcome, also to the following pizza get-together! No registration needed.